April 2024

Cover articles

    1. Genetics and Genomics

    Pigmentation in caterpillars

    Songyuan Wu, Xiaoling Tong ... Fangyin Dai
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Iron metabolism and cancer

    Natalia Dolgova, Eva-Maria E Uhlemann ... Oleg Y Dmitriev
    1. Immunology and Inflammation

    Insights into ulcerative colitis

    Preksha Gaur, Yesheswini Rajendran ... Chittur Srikanth

Highlights controls:

Research articles

    1. Evolutionary Biology

    Synthetic analysis of trophic diversity and evolution in Enantiornithes with new insights from Bohaiornithidae

    Case Vincent Miller, Jen A Bright ... Michael Pittman
    Enantiornithine birds reached similar dietary diversity to modern birds in a similar amount of time many millions of years earlier, but how exactly they did that requires further research.
    1. Neuroscience

    Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

    Yu-Feng Xie, Jane Yang ... Steven A Prescott
    Because nociceptors can achieve similar excitability using different sodium channel subtypes, it is difficult to know which channels are being used yet this information is critical for predicting if subtype-selective drugs will reduce pain.
    1. Neuroscience

    Conditional chemoconnectomics (cCCTomics) as a strategy for efficient and conditional targeting of chemical transmission

    Renbo Mao, Jianjun Yu ... Yi Rao
    New toolkits have been developed to enable cell-type-specific manipulation of CCT genes with remarkable efficiency while also uncovering the role of CNMa signal in regulating morning anticipation.
    1. Cancer Biology
    2. Genetics and Genomics

    Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

    Ting Zhang, Alisa Ambrodji ... Steven M Offer
    A genetic variant within a newly identified enhancer regulates the expression of a key pharmacogene and alters the balance between resistance and sensitivity to a widely used chemotherapeutic.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study

    Lijun Bian, Zhimin Ma ... Guangfu Jin
    Older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle.
    1. Structural Biology and Molecular Biophysics

    A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation

    Xiao-Ru Chen, Karuna Dixit ... Tatyana I Igumenova
    Integrated biophysical, structural, and in-cell approaches demonstrate a non-canonical and non-isomerizable binding motif-dependent mode of protein kinase C regulation by the peptidyl-prolyl isomerase Pin1 in mammalian cells.
    1. Microbiology and Infectious Disease

    Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

    Magdalena Podkowik, Andrew I Perault ... Bo Shopsin
    A new framework for examining tolerance in the context of quorum-sensing that may ultimately help predict and manage bacterial tolerance and, therefore, improve clinical outcome during infection.
    1. Neuroscience

    Aberrant cortical activity, functional connectivity, and neural assembly architecture after photothrombotic stroke in mice

    Mischa Vance Bandet, Ian Robert Winship
    Longitudinal calcium imaging in awake mice after stroke suggests impairments in neuronal activity, functional connectivity, and neural assembly architecture is transient and limited to cortex immediately adjacent to the stroke.
    1. Cancer Biology
    2. Cell Biology

    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

    Timothy J Walker, Eduardo Reyes-Alvarez ... Lois M Mulligan
    TMEM127 depletion alters membrane dynamics, promoting cell surface accumulation and constitutive activity of growth factor receptors, and ultimately providing a novel paradigm for oncogenesis through aberrant receptor localization and signaling.
    1. Developmental Biology
    2. Neuroscience

    Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development

    Amy R. Poe, Lucy Zhu ... Matthew S. Kayser
    1. Neuroscience

    Neural representations of predicted events: Evidence from time-resolved EEG decoding

    Ai-Su Li, Jan Theeuwes, Dirk van Moorselaar
    1. Neuroscience

    Using normative models pre-trained on cross-sectional data to evaluate longitudinal changes in neuroimaging data

    Barbora Rehák Bučková, Charlotte Fraza ... Jaroslav Hlinka
    1. Developmental Biology
    2. Neuroscience

    Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

    Denise M. Poltavski, Alexander T. Cunha ... Takako Makita
    1. Microbiology and Infectious Disease

    Deep-sea bacteriophages facilitate host utilization of polysaccharides

    Chong Wang, Rikuan Zheng ... Chaomin Sun
    1. Neuroscience

    A septo-hypothalamic-medullary circuit directs stress-induced analgesia

    Devanshi Piyush Shah, Pallavi Raj Sharma ... Arnab Barik
    1. Cell Biology
    2. Developmental Biology

    BEND2 is a crucial player in oogenesis and reproductive aging

    Yan Huang, Nina Bucevic ... Ignasi Roig
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

    Gregory Caleb Howard, Jing Wang ... William P Tansey
    Analysis of the action of WDR5 inhibitors in leukemia cells reveals decreased ribosome inventory, impaired protein synthesis, induction of nucleolar stress, and activation of p53 via alternative splicing of MDM4.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans

    Taegon Chung, Iksoo Chang, Sangyeol Kim
    ElegansBot, a two-dimensional rigid body chain model, simulates various locomotion of C. elegans, including omega and delta turns, using Newtonian equations of motion.
    1. Neuroscience

    A new ‘CFS tracking’ paradigm reveals uniform suppression depth regardless of target complexity or salience

    David Alais, Jacob Coorey ... Matthew J Davidson
    A new and efficient continuous flash suppression (CFS) method is presented that provides breakthrough and suppression thresholds to quantify depth of target suppression.
    1. Cell Biology

    HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging

    John H. Day, Catherine Marin Della Santina ... Laurie A. Boyer
    1. Physics of Living Systems

    Modelling collective behavior in groups of mice housed under semi-naturalistic conditions

    Xiaowen Chen, Maciej Winiarski ... Aleksandra M. Walczak
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A modular platform to display multiple hemagglutinin subtypes on a single immunogen

    Dana Thornlow Lamson, Faez Amokrane Nait Mohamed ... Aaron G. Schmidt
    1. Microbiology and Infectious Disease

    Birnaviral Hijacking of Endosomal Membranes

    Flavia A. Zanetti, Ignacio Fernández ... Laura R. Delgui
    1. Neuroscience

    Unraveling the impact of congenital deafness on individual brain organization

    Lénia Amaral, Xiaosha Wang ... Ella Striem-Amit
    1. Plant Biology

    Pectin methylesterase activity is required for RALF1 peptide signalling output

    Ann-Kathrin Rößling, Kai Dünser ... Jürgen Kleine-Vehn
    1. Immunology and Inflammation

    Functional identification of soluble uric acid as an endogenous inhibitor of CD38

    Shijie Wen, Hiroshi Arakawa ... Ikumi Tamai
    1. Genetics and Genomics

    Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner

    Liana Senaldi, Nora Hassan ... Matthew Smith-Raska
    1. Plant Biology

    A shade-responsive microProtein in the Arabidopsis ATHB2 gene regulates elongation growth and root development

    Ashleigh Edwards, Maurizio Junior Chiurazzi ... Stephan Wenkel
    1. Neuroscience

    Recording γ-secretase activity in living mouse brains

    Steven S. Hou, Yuya Ikegawa ... Masato Maesako
    1. Evolutionary Biology

    Stochastic parabolic growth promotes coexistence and a relaxed error threshold in RNA-like replicator populations

    Mátyás Paczkó, Eörs Szathmáry, András Szilágyi
    An individual-based model framework of sub-exponentially growing replicator systems suggests that parabolic dynamics could have been able to maintain genetic diversity and circumvent the error threshold problem during early evolution.
    1. Ecology
    2. Evolutionary Biology

    Evolutionary trade-offs in dormancy phenology

    Théo Constant, F Stephen Dobson ... Sylvain Giroud
    Dormancy during non-life-threatening periods that are unfavorable for reproduction may be more widespread than previously appreciated.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

    Lauren Kuffler, Daniel A Skelly ... Gregory W Carter
    Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies

    Christian Galicia, Giambattista Guaitoli ... Wim Versées
    Conformation-specific nanobodies enable to capture and solve the first GTP-bound active structure of a bacterial homolog of the Parkinson-associated LRRK2 protein, providing insights into the activation mechanism of these proteins.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

    Arne Elofsson, Ling Han ... Luca Jovine
    AlphaFold-Multimer was used to investigate extracellular protein interactions involved in mammalian egg-sperm recognition, suggesting a putative pentameric complex that includes TMEM81, a sperm protein not previously involved in gamete recognition.
    1. Neuroscience

    Episodic long-term memory formation during slow-wave sleep

    Flavio J Schmidig, Simon Ruch, Katharina Henke
    Sleep-encoded vocabulary influences awake decision-making 36 hr later, particularly when targeting the vocabulary to slow-wave troughs, which suggests that unconscious episodic memory formation during deep sleep is possible.
    1. Stem Cells and Regenerative Medicine

    Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation

    Sangeetha Kandoi, Cassandra Martinez ... Deepak A Lamba
    Stem cell-derived retinal organoids are a useful tool to understand the pathobiology of devastating retinal degenerations and can aid to identify and validate therapeutics to promote rescue.
    1. Medicine

    Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

    Anika Shimonty, Fabrizio Pin ... Lynda F Bonewald
    Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
    1. Cell Biology

    Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice

    Ang Li, Jianxun Yi ... Jingsong Zhou
    The distinct transcriptomic features of extraocular muscle satellite cells, partially mimicked by NaBu treatment, endow enhanced self-renewal and axon attraction, contribute to neuromuscular junction preservation during ALS progression.
    1. Cell Biology

    Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling

    Simona Bolamperti, Hiroaki Saito ... Hanna Taipaleenmäki
    A novel mechanism underlying the regulation of osteoblast morphology, adherence, and migration that has implications in bone remodeling, regeneration, and response to the pharmacological effects of PTH treatment.
    1. Neuroscience

    Emergence of brain-like mirror-symmetric viewpoint tuning in convolutional neural networks

    Amirhossein Farzmahdi, Wilbert Zarco ... Tal Golan
    1. Ecology

    Intra- and interspecific diversity in a tropical plant clade alter herbivory and ecosystem resilience

    Ari Grele, Tara J Massad ... Lora A Richards
    Experimental Piper gardens across five neotropical sites reveal complex contingencies in the influence of species and population-level biodiversity on the flow of resources to insect herbivores and ecosystem resilience to changes in water availability.
    1. Cell Biology
    2. Neuroscience

    Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

    Mariana I Tsap, Andriy S Yatsenko ... Halyna R Shcherbata
    Drosophila model reveals that NTE/SWS-associated neurodegeneration is a lysosomal storage disorder accompanied by a leaky brain permeability barrier, abnormal fatty acid metabolism, and inflammation.
    1. Neuroscience

    Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

    Alyssa D Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
    Glutamatergic–cholinergic neurons in the postinspiratory complex are critical for swallow motor patterning and the coordination of swallow and breathing, which is disrupted by chronic intermittent hypoxia, a condition seen in many disorders associated with dysphagia and aspiration pneumonia.
    1. Structural Biology and Molecular Biophysics

    Dependence of nucleosome mechanical stability on DNA mismatches

    Thuy TM Ngo, Bailey Liu ... Taekjip Ha
    The mechanical stability of a nucleosome is enhanced upon the introduction of a single base pair mismatch that makes DNA more bendable, with implications on mismatch repair in vivo.
    1. Medicine
    2. Microbiology and Infectious Disease

    Altered transcriptomic immune responses of maintenance hemodialysis patients to the COVID-19 mRNA vaccine

    Yi-Shin Chang, Kai Huang ... David L Perkins
    Differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance hemodialysis subjects are comparable to healthy controls and identify transcriptomic and clinical predictors of anti-spike IgG titers in hemodialysis subjects.
    1. Medicine

    Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study

    Marco Bergamini, Alberto Dalla Volta ... Alfredo Berruti
    Follicle-stimulating hormone in the reference range influences body composition in men exposed to hormone-deprivation therapy for prostate cancer.
    1. Neuroscience

    Unifying network model links recency and central tendency biases in working memory

    Vezha Boboeva, Alberto Pezzotta ... Athena Akrami
    Seemingly disparate working memory biases, including short-term serial and contraction biases, may arise from a common mechanism via the interaction of multiple networks, each operating over a distinct timescale.
    1. Genetics and Genomics

    Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions in Saccharomyces cerevisiae

    Can Hu, Xue-Ting Zhu ... Jin-Qiu Zhou
    Subtelomeric sequences in the yeast S. cerevisiae are dispensable for either cell proliferation or homologous recombination-mediated telomere maintenance in telomerase-null cells, suggesting that these sequences represent remnants of genome evolution.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

    Marcel Proske, Robert Janowski ... Dierk Niessing
    Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

    Rajan M Thomas, Matthew C Pahl ... Andrew D Wells
    Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
    1. Neuroscience

    Octopamine integrates the status of internal energy supply into the formation of food-related memories

    Michael Berger, Michèle Fraatz ... Henrike Scholz
    Intense starvation with high internal energy levels results in remarkably stable food-related memories that persist beyond actual food intake and are associated with overeating.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

    Alexander D Cook, Mark Carrington, Matthew K Higgins
    A structure derived from cryogenic electron microscopy shows how ISG65, an African trypanosome receptor that aids virulence, binds C3b and suggests mechanisms through which ISG65 might aid complement resistance.
    1. Immunology and Inflammation

    Formin-like 1 β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse

    Javier Ruiz-Navarro, Sara Fernández-Herinira ... Manuel Izquierdo
    1. Ecology

    Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

    Lan Pang, Gangqi Fang ... Jianhua Huang
    1. Neuroscience

    Regional response to light illuminance across the human hypothalamus

    Islay Campbell, Roya Sharifpour ... Gilles Vandewalle
    1. Biochemistry and Chemical Biology

    A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

    Pattama Wiriyasermkul, Satomi Moriyama ... Shushi Nagamori
    An unbiased approach unveils a non-canonical substrate of the known transporters, highlighting the mechanism behind the use of D-serine as a kidney biomarker.
    1. Developmental Biology

    Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis

    Amandine Jarysta, Abigail LD Tadenev ... Basile Tarchini
    Sensory hair cells in the inner ear use inhibitory G proteins with different regulators at different stages of development to break symmetry, adopt a proper orientation, and grow stereocilia.
    1. Structural Biology and Molecular Biophysics

    LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction

    Colin H Peters, Rohit K Singh ... John R Bankston
    A combination of patch clamp electrophysiology and FRET determine critical interactions between HCN4 channels and the ER resident protein LRMP and suggest a possible mechanism for reduced cAMP sensitivity.
    1. Cell Biology

    Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies

    Mathieu C Husser, Nhat P Pham ... Alisa Piekny
    The split mNeonGreen system enables fast and efficient endogenous tagging in human iPSCs and facilitates the study of proteins in human stem cells and differentiated cells by live imaging.
    1. Cancer Biology

    Recording and classifying MET receptor mutations in cancers

    Célia Guérin, David Tulasne
    Classification of MET mutations allows a better understanding of sensitivity and resistance to targeted therapies used in cancer.
    1. Computational and Systems Biology
    2. Developmental Biology

    A logic-incorporated gene regulatory network deciphers principles in cell fate decisions

    Gang Xue, Xiaoyi Zhang ... Zhiyuan Li
    A top-down model-guided framework unveils the role of regulatory logics underlying gene regulatory networks in cell fate decisions.
    1. Cancer Biology

    Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

    Han V. Han, Richard Efem ... Richard Z. Lin
    1. Developmental Biology

    Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization

    Dena Goldblatt, Başak Rosti ... David Schoppik
    1. Neuroscience

    Experience transforms crossmodal object representations in the anterior temporal lobes

    Aedan Yue Li, Natalia Ladyka-Wojcik ... Morgan D Barense
    Anterior temporal lobe structures differentiated learned from non-learned crossmodal objects, evidence of integrated crossmodal object representations.
    1. Medicine

    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

    Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown
    MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
    1. Genetics and Genomics
    2. Neuroscience

    Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

    Bohan Zhu, Richard I Ainsworth ... Javier González-Maeso
    Age and antipsychotic treatment effects on chromatin organization in the frontal cortex of schizophrenia subjects.
    1. Cancer Biology
    2. Genetics and Genomics

    Convergent epigenetic evolution drives relapse in acute myeloid leukemia

    Kevin Nuno, Armon Azizi ... Ravindra Majeti
    Integrated analyses of acute myeloid leukemia genetics and epigenetics demonstrate that epigenetic evolution occurs in a convergent manner in the absence of DNA mutations at relapse post-chemotherapy.
    1. Ecology

    Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

    Yang Ruan, Ning Ling ... Zhibiao Nan
    Warming and altered precipitation reduce the growth rates of alpine soil bacteria by 40-90%, and the growth of ~70% taxa is influenced by antagonistic interactions between factors.
    1. Cell Biology
    2. Computational and Systems Biology

    De novo-designed minibinders expand the synthetic biology sensing repertoire

    Zara Y. Weinberg, Sarah S. Soliman ... Hana El-Samad
    1. Immunology and Inflammation

    Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

    Harshavardhan Lingegowda, Katherine B Zutautas ... Chandrakant Tayade
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MEMO1 binds iron and modulates iron homeostasis in cancer cells

    Natalia Dolgova, Eva-Maria E Uhlemann ... Oleg Y Dmitriev
    Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

    Mark S Lee, Peter J Tuohy ... Michael S Kuhns
    Evolution-guided structure-function analyses reveal that CD4 transmembrane and intracellular juxtamembrane motifs play a more profound role in initiating pMHCII-specific TCR-CD3 signaling than previously characterized CD4-Lck interactions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    X-ray structure and enzymatic study of a bacterial NADPH oxidase highlight the activation mechanism of eukaryotic NOX

    Isabelle Petit-Hartlein, Annelise Vermot ... Franck Fieschi
    Detailed molecular characterization of a constitutively active bacterial NADPH oxidase (NOX) provides clues to the activation mechanism required to trigger electron transfer and reactive oxygen species (ROS) production in tightly regulated eukaryotic NOX.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

    Weichen Song, Yongyong Shi, Guan Ning Lin
    Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
    1. Developmental Biology
    2. Evolutionary Biology

    The rapidly evolving X-linked MIR-506 family fine-tunes spermatogenesis to enhance sperm competition

    Zhuqing Wang, Yue Wang ... Wei Yan
    The rapidly evolving X-linked MIR-506 family miRNAs function to enhance sperm competitiveness and male reproductive fitness in mice.
    1. Microbiology and Infectious Disease

    Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

    Michael D Sacco, Lauren R Hammond ... Yu Chen
    The N-terminal domain of Staphylococcus aureus GpsB, a scaffolding protein, forms an atypical asymmetric dimer and binds to the C-termini of FtsZ and PBP4, influencing the localization and regulation of both the Z-ring and cell wall synthesis.
    1. Neuroscience

    Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

    Sergio Casas-Tintó, Nuria García-Guillen, Maria Losada-Pérez
    1. Neuroscience

    Lesions in a songbird vocal circuit increase variability in song syntax

    Avani Koparkar, Timothy L Warren ... Lena Veit
    A forebrain nucleus contributes specifically to the variability of syllable sequencing in songs of Bengalese finches, a songbird with complex syntactic song structure.
    1. Developmental Biology

    Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration

    Edgar M Pera, Josefine Nilsson-De Moura ... Ivana Milas
    An extracellular proteolytic pathway involving the serine protease HtrA1, its inhibitor SerpinE2, and the transmembrane proteoglycan Syndecan-4 control collective migration of neural crest cells in the developing embryo.
    1. Neuroscience

    Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila

    Katharina Eichler, Stefanie Hampel ... Andrew M Seeds
    A synaptic resolution somatotopic map of nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations and collectively elicit a head grooming sequence.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Transposable elements regulate thymus development and function

    Jean-David Larouche, Céline M Laumont ... Claude Perreault
    Multiomic analyses provide new insights into the involvement of transposable elements in T-cell development in the thymus and central tolerance induction.
    1. Neuroscience

    Species -shared and -unique gyral peaks on human and macaque brains

    Songyao Zhang, Tuo Zhang ... Tianming Liu
    Having compared cross-species cortical folding patterns between humans and macaques, it is shown that 'Gyral Peaks' can stably exist across different species.
    1. Microbiology and Infectious Disease

    Tools and methods for high-throughput single-cell imaging with the mother machine

    Ryan Thiermann, Michael Sandler ... Suckjoon Jun
    A user-friendly pipeline for analysis of time-lapse imaging data from the microfluidic mother machine.
    1. Neuroscience

    Chronic activation of a negative engram induces behavioral and cellular abnormalities

    Alexandra L. Jellinger, Rebecca L. Suthard ... Steve Ramirez
    1. Medicine
    2. Neuroscience

    Ketamine induces multiple individually distinct whole-brain functional connectivity signatures

    Flora Moujaes, Jie Lisa Ji ... Alan Anticevic
    There is substantial individual variation in behavioral and neural responses to acute ketamine administration in healthy controls, which emphasises the need for personalized approaches when harnessing ketamine as a treatment for depression.
    1. Computational and Systems Biology

    Genome-scale annotation of protein binding sites via language model and geometric deep learning

    Qianmu Yuan, Chong Tian, Yuedong Yang
    Integration of language model and geometric deep learning enables accurate and efficient genome-scale annotation of comprehensive protein-ligand binding sites.
    1. Cell Biology

    High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen

    Wan-ping Yang, Mei-qi Li ... Qian-qian Luo
    Hypobaric hypoxia exposure initiates splenic ferroptosis, reducing red pulp macrophages and exacerbating high-altitude polycythemia by impairing erythrophagocytosis and increasing red blood cell retention.
    1. Neuroscience

    Plastic vasomotion entrainment

    Daichi Sasaki, Ken Imai ... Ko Matsui
    Entrainment of global synchronization of vasomotion induced by repeated presentation of oscillating visual stimuli may facilitate efficient energy delivery to meet the demand for coordinated neuronal activity and circuit reorganization.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis

    Lucie Crhak Khaitova, Pavlina Mikulkova ... Karel Riha
    The sensitivity of Arabidopsis meiotic centromeres to heat stress suggests that centromere function is one of the key determinants of plant reproduction under rising temperatures.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural analysis of the dynamic ribosome-translocon complex

    Aaron J. O. Lewis, Frank Zhong ... Ramanujan S. Hegde
    1. Epidemiology and Global Health

    A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients

    Zhanwei Du, Lin Wang ... Lauren A Meyers
    Broader global access to Paxlovid, coupled with appropriately timed treatment, can mitigate the severity and transmission of SARS-Cov-2 as the virus and the landscape of immunity continue to evolve.
    1. Microbiology and Infectious Disease

    High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

    Nguyen Thi Khanh Nhu, Minh-Duy Phan ... Mark A Schembri
    E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    N-Terminus of Drosophila Melanogaster MSL1 Is Critical for Dosage Compensation

    Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko
    1. Neuroscience

    Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury

    Qing Zhao, Yanjing Zhu ... Ning Xie
    1. Neuroscience

    Age-Related Decline in BBB Function is More Pronounced in Males than Females

    Xingfeng Shao, Qinyang Shou ... Danny JJ Wang
    1. Medicine

    Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice

    Jinjing Chen, Ruoyu Wang ... Jongsook Kemper
    Pharmacological activation of farnesoid X (FXR) receptor by hammerhead-type agonists induces a novel enhancer RNA, termed Fincor, contributing to the amelioration of nonalcoholic steatohepatitis in mice.
    1. Cell Biology

    Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

    Fabian Link, Alyssa Borges ... Markus Engstler
    The endosomal apparatus of African trypanosomes consists a continuous membrane system with functional subdomains rather than distinct compartments for early, late, and recycling endosomes.
    1. Microbiology and Infectious Disease

    A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

    Swati Jain, Gherman Uritskiy ... Venigalla B Rao
    HIV escapes human immune pressure through a single mutation in V2 domain of envelope protein leading to emergence of mutant-specific broadly reactive antibodies, a phenomenon recapitulated in combinatorial vaccine design.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Guanidine production by plant homoarginine-6-hydroxylases

    Dietmar Funck, Malte Sinn ... Jörg S Hartig
    2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.
    1. Cancer Biology
    2. Cell Biology

    Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2

    Ibtisam Ibtisam, Alexei F Kisselev
    Genetic and biochemical approaches reveal that mammalian cells possess a novel DDI2 and transcription-independent pathway for the rapid recovery of proteasome activity after clinically relevant pulse treatment with proteasome inhibitors.
    1. Cell Biology
    2. Neuroscience

    Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning

    Haibin Yu, Dandan Liu ... Kai Yuan
    Brain region-specific profiling of O-GlcNAcylation interactome in Drosophila mushroom body suggests that hypo-O-GlcNAcylation impacts cognitive function by regulating translational activity.
    1. Microbiology and Infectious Disease

    A Modified BPaL Regimen for Tuberculosis Treatment replaces Linezolid with Inhaled Spectinamides

    Malik Zohaib Ali, Taru S. Dutt ... Mercedes Gonzalez-Juarrero
    1. Cell Biology

    BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

    Dianyuan Zhao, Ziwei Huang ... Li Tang
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states

    Junjun Yao, Shaoxing Dai ... Tianqing Li
    A single-nucleus transcriptomic atlas reveals the molecular signatures and trajectory dynamics of the neurogenic lineage in the human hippocampus during neonatal development, adulthood, aging, and after injury.
    1. Evolutionary Biology

    The evolution of transposable elements in Brachypodium distachyon is governed by purifying selection, while neutral and adaptive processes play a minor role

    Robert Horvath, Nikolaos Minadakis ... Anne C Roulin
    Disentangling the different selective forces shaping the evolutionary dynamics of transposable elements (TEs) in the wild grass Brachypodium distachyon.
    1. Immunology and Inflammation

    Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis

    Toyoshi Yanagihara, Kentaro Hata ... Isamu Okamoto
    Increased CD16+ T cell populations in bronchoalveolar lavage fluid highlight a potential biomarker and immune response mechanism in Pneumocystis jirovecii pneumonia.
    1. Microbiology and Infectious Disease

    Stratification of viral shedding patterns in saliva of COVID-19 patients

    Hyeongki Park, Raiki Yoshimura ... Taiga Miyazaki
    1. Neuroscience

    Cardiac afferent signals can facilitate visual dominance in binocular rivalry

    John P. Veillette, Fan Gao, Howard C. Nusbaum
    1. Neuroscience

    Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis

    Cuong Pham, Yuji Komaki ... Dongdong Li
    1. Developmental Biology
    2. Neuroscience

    Fetal influence on the human brain through the lifespan

    Kristine B Walhovd, Stine K Krogsrud ... Didac Vidal-Pineiro
    Greater early developmental growth, as indexed by birth weight, relates to greater cortical volume and area in a stable way through the human lifespan.
    1. Cell Biology
    2. Medicine

    Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

    Chun Wang, Khushpreet Kaur ... Gabriel Mbalaviele
    Inflammasome-mediated inflammation is critically involved in bone loss caused by doxorubicin.
    1. Neuroscience

    Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species

    Hans Martin Kjer, Mariam Andersson ... Tim B. Dyrby
    1. Physics of Living Systems

    Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum

    Pyae Hein Htet, Edward Avezov, Eric Lauga
    1. Cell Biology
    2. Computational and Systems Biology

    Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies

    Thomas Grandits, Christoph M Augustin ... Alexander Jung
    Neural networks can emulate normal and abnormal human ventricular action potentials accurately and potentially much faster than regular simulations paving the way for more efficient quantitative systems pharmacology studies.
    1. Cell Biology
    2. Immunology and Inflammation

    ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

    Cristina Cacho-Navas, Carmen López-Pujante ... Jaime Millán
    ICAM-1 engagement controls hepatic cell polarity, but this receptor can also signal without prior leukocyte interaction, thanks to its confinement into apical, microvilli-enriched, bile-canalicular domains and its actin connector EBP50.
    1. Physics of Living Systems

    Substrate evaporation drives collective construction in termites

    Giulio Facchini, Alann Rathery ... Andrea Perna
    Evidence of a relationship between substrate curvature, water evaporation and the building behavior of termites capable of mediating collective nest-building with no need for a building pheromone.
    1. Evolutionary Biology

    Evolution and diversity of biomineralized columnar architecture in early Cambrian phosphatic-shelled brachiopods

    Zhiliang Zhang, Zhifei Zhang ... Guoxiang Li
    Columnar architectures, developed in early Cambrian phosphatic-shelled brachiopods, are highly biologically controlled and organic-matrix mediated, which sheds new light on the evolution and adaptation of biomineralization during the Cambrian explosion.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Effect of α-tubulin acetylation on the doublet microtubule structure

    Shun Kai Yang, Shintaroh Kubo ... Khanh Huy Bui
    Cryo-EM studies of doublet microtubules from wild-type and acetylation mutants suggest that acetylation of K40 affects the lateral rotational angle between protofilaments, leading to changes in the structure and stability.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength

    Giulia Leanza, Francesca Cannata ... Nicola Napoli
    In individuals with type 2 diabetes, downregulation of bone canonical Wnt signaling is linked to higher levels of advanced glycation end-products within the bone, contributing to lower bone strength.
    1. Biochemistry and Chemical Biology

    The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase

    Valentin Bohl, Nele Merret Hollmann ... Axel Mogk
    The bacterial AAA+ chaperone ClpL recognizes aggregated proteins via multiple contacts of its unique N-terminal domain and refolds them with high efficiency providing superior heat resistance.
    1. Cell Biology
    2. Neuroscience

    KIS counteracts PTBP2 and regulates alternative exon usage in neurons

    Marcos Moreno-Aguilera, Alba M Neher ... Carme Gallego
    KIS, a kinase upregulated in the developmental brain, phosphorylates the PTBP2 splicing complex and modulates alternative exon usage for proper synaptic spine emergence and maturation.
    1. Neuroscience

    LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    1. Neuroscience

    Mining the neuroimaging literature

    Jérôme Dockès, Kendra Oudyk ... Jean-Baptiste Poline
    1. Neuroscience

    Neonatal sensitivity to vocal emotions: A milestone at 37 weeks of gestational age

    Xinlin Hou, Peng Zhang ... Dandan Zhang
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Chemokine expression profile of an innate granuloma

    Megan E. Amason, Carissa K. Harvest ... Edward A. Miao
    1. Neuroscience

    Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus

    Jacob H Wilmot, Cassiano RAF Diniz ... Brian Joseph Wiltgen
    Locus coeruleus responses to salient environmental stimuli drive increases in hippocampal dopamine that are important for long-term memory formation during trace fear conditioning.
    1. Genetics and Genomics

    Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence

    Pianpian Zhao, Zhifeng Sheng ... Hou-Feng Zheng
    Genetically determined type 2 diabetes (T2D) may not increase the risk of fracture, but managing T2D-related risk factors is crucial to prevent fracture in patients with T2D.
    1. Immunology and Inflammation

    Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

    Tatyana O Nakonechnaya, Bruno Moltedo ... Dmitriy M Chudakov
    Digitalized TCR repertoire-based view on antigenic specificity, plasticity, and tissue residence of regulatory T cells.
    1. Medicine

    Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast–osteoblast communication and potential clinical implications

    Valentina Daponte, Katrin Henke, Hicham Drissi
    A comprehensive review focusing on the role of osteoclasts as active regulators of bone homeostasis by influencing osteoblast function explores the currently known mechanisms and coupling factors involved in osteoclast–osteoblast communication and their potential as treatments for bone diseases.
    1. Structural Biology and Molecular Biophysics

    Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli

    Sebastian Jojoa-Cruz, Adrienne E Dubin ... Andrew B Ward
    Structural comparison and electrophysiology of OSCA channels shed light on potential structural features influencing response to poke stimulus.
    1. Neuroscience

    Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure

    Rafael Naime Ruggiero, Danilo Benette Marques ... Joao Pereira Leite
    The enduring impacts of early-life seizures on cognition and behavior are not attributed to neuronal loss but to disrupted hippocampus-prefrontal cortex network dynamics, heightened neuroinflammation, and altered dopaminergic transmission.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

    Tien M Phan, Young C Kim ... Jeetain Mittal
    Despite highly conserved sequences, subtle variations in HP1 paralog charge distribution influence distinct liquid-liquid phase separation behaviors, ultimately impacting DNA-mediated heterochromatin organization.
    1. Immunology and Inflammation

    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

    Preksha Gaur, Yesheswini Rajendran ... Chittur Srikanth
    Rab7-mediated changes in goblet cell function play a crucial role in triggering gut inflammation during colitis.
    1. Neuroscience

    Neural correlates of perceptual similarity masking in primate V1

    Spencer Chin-Yu Chen, Yuzhi Chen ... Eyal Seidemann
    Optical imaging from macaque monkeys performing a detection task reveals the contribution of neural populations in V1 to the phenomenon of camouflage, where detectability decreases with target-background similarity.
    1. Cancer Biology
    2. Cell Biology

    N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion

    Julian JA Hoving, Elizabeth Harford-Wright ... Alison C Lloyd
    N-cadherin and Slit2/3/Robo interactions provide the outward force to drive collective Schwann cell migration during nerve regeneration, identifying a dual role for N-cadherin in both adhesion and repulsion processes during Schwann cell collective migration.
    1. Neuroscience

    Mapping long-term changes in inputs to the ventral tegmental area after a single drug exposure

    Katrina Bartas, May Hui ... Kevin T. Beier
    1. Neuroscience

    Identification of an early subset of cerebellar nuclei neurons in mice

    Maryam Rahimi-Balaei, Shayan Amiri ... Hassan Marzban
    1. Genetics and Genomics

    The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars

    Songyuan Wu, Xiaoling Tong ... Fangyin Dai
    The BTB zinc finger gene Bm-mamo regulates melanin pigmentation in silkworm caterpillars from multiple aspects, including melanin synthesis, pigment granules maturation, and cuticle construction.
    1. Neuroscience

    Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model

    Behzad Yaghmaeian Salmani, Laura Lahti ... Thomas Perlmann
    Single nuclei RNA sequencing unmasks 16 variants of midbrain dopamine neurons within a continuum of their gene expression landscape and resolves their differential vulnerability.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    The molecular basis of Abelson kinase regulation by its αI-helix

    Johannes Paladini, Annalena Maier ... Stephan Grzesiek
    High-resolution NMR data and precise kinase activity assays on Abelson kinase bearing mutations in its αI-helix identify the αI-helix parts involved in disassembly of Abelson’s regulatory core and kinase activation.
    1. Neuroscience

    Circadian regulation of endoplasmic reticulum calcium response in mouse cultured astrocytes

    Ji Eun Ryu, Kyu-Won Shim ... Eun Young Kim
    1. Neuroscience

    Optogenetic silencing hippocampal inputs to the retrosplenial cortex causes a prolonged disruption of working memory

    Bárbara Pinto-Correia, Patricia Caldeira, Miguel Remondes
    1. Neuroscience

    Selective recruitment: Evidence for task-dependent gating of inputs to the cerebellum

    Ladan Shahshahani, Maedbh King ... Jörn Diedrichsen
    1. Neuroscience

    Finding structure during incremental speech comprehension

    Bingjiang Lyu, William D Marslen-Wilson ... Lorraine K Tyler
    Structural representations of sentences generated by deep language models correlate with human listeners' behaviours and neural activity, providing a quantifiable framework to uncover the neural dynamics underpinning incremental speech comprehension.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    DePARylation is critical for S phase progression and cell survival

    Litong Nie, Chao Wang ... Junjie Chen
    DePARylation is essential for cell survival and thus poly(ADP-ribose) glycohydrolase (PARG) expression correlates with cytotoxicity induced by PARG inhibition, which will benefit the development of PARG inhibitors for cancer treatment.
    1. Chromosomes and Gene Expression

    Post-transcriptional splicing can occur in a slow-moving zone around the gene

    Allison Coté, Aoife O'Farrell ... Arjun Raj
    The existence of a slow-moving zone around the transcription site may unify conflicting models of co-transcriptional versus post-transcriptional mRNA splicing.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

    Maria L Adelus, Jiacheng Ding ... Casey E Romanoski
    Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
    1. Neuroscience

    Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers

    Matthias Heindorf, Georg B Keller
    Cell type-specific effects of antipsychotic drugs in cortex could provide a basis for a functional screen of antipsychotic efficacy.
    1. Epidemiology and Global Health

    Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank

    Yuchen Zhang, Yitang Sun ... Kaixiong Ye
    Individuals with higher blood levels of omega-3 and omega-6 fatty acids, especially omega-3, are less likely to die, either from any cause, cancer or cardiovascular disease.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists

    Danqi Sheng, Chen-Xi Yue ... Motoyuki Hattori
    Structural insights into the orthosteric inhibition and subtype specificity of P2X receptors by classical P2X antagonists facilitate the rational design of novel competitive antagonists for P2X receptors.
    1. Stem Cells and Regenerative Medicine

    A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell-derived cardiomyocytes

    Magali Seguret, Patricia Davidson ... Jean-Sébastien Hulot
    A novel hydrogel-based platform uses a limited number of cells for tissue generation and offers unique advantages for high-throughput cardiac tissue culture.
    1. Neuroscience

    Subcortical correlates of consciousness with human single neuron recordings

    Michael Pereira, Nathan Faivre ... Olaf Blanke
    1. Physics of Living Systems

    Theory of active self-organization of dense nematic structures in the actin cytoskeleton

    Waleed Mirza, Marco De Corato ... Marino Arroyo
    1. Developmental Biology
    2. Genetics and Genomics

    Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

    Hui-Juan Jin, Yong Fan ... Su-Ren Chen
    Cylicin-1, a perinuclear theca protein, is critical for acrosome attachment and sperm head morphology.
    1. Chromosomes and Gene Expression

    Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system

    Fujun Zhou, Julie M Bocetti ... Jon R Lorsch
    A new in vitro approach allows measurement of the efficiency of the early steps of translation initiation on every messenger RNA in yeast simultaneously.
    1. Neuroscience

    A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster

    Jiun Sang, Subash Dhakal ... Youngseok Lee
    Fruit flies have special neurons in their pharynx with ionotropic receptors to prevent consuming too much salt, which was confirmed using a variety of behavioral and physiological assays.
    1. Developmental Biology
    2. Evolutionary Biology

    ROCK and the actomyosin network control biomineral growth and morphology during sea urchin skeletogenesis

    Eman Hijaze, Tsvia Gildor ... Smadar Ben-Tabou de-Leon
    ROCK and the actomyosin network are essential for multiple aspects of sea urchin skeletogenesis, suggesting an independent deployment of these factors in biomineralization across Eukaryotes.
    1. Cancer Biology

    STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

    Stephen D'Amico, Varvara Kirillov ... Nancy C Reich
    Results show that STAT3 and KRAS jointly regulate oncogenic dependency of mutant KRAS cancer cells.
    1. Medicine

    Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

    Ling Zhou, Chengyang Ni ... Jianming Wu
    Vilazodone could bind to the 5-Hydroxtrayptamine receptor 1A receptor and further regulate the SRC/MAPK signaling pathway to facilitate megakaryocyte differentiation and platelet production.
    1. Stem Cells and Regenerative Medicine

    Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis

    Shintaro Watanuki, Hiroshi Kobayashi ... Keiyo Takubo
    Isotope tracing, mathematical modeling, and single-cell ATP analysis reveal changes in blood cell metabolism under various conditions, showing stressed hematopoietic stem cells support hematopoiesis through glycolytic ATP production via PFKFB3.
    1. Neuroscience

    Brain white matter pathways of resilience to chronic back pain: a multisite validation

    Mina Mišić, Noah Lee ... Herta Flor
    1. Neuroscience

    ‘Hidden’ HCN channels permit pathway-specific synaptic amplification in L2/3 pyramidal neurons

    Viktor János Oláh, Jing Wu ... Matthew JM Rowan
    1. Cell Biology

    Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

    Joan Chang, Adam Pickard ... Karl E. Kadler
    1. Evolutionary Biology

    Discarded sequencing reads uncover natural variation in pest resistance in Thlaspi arvense

    Dario Galanti, Jun Hee Jung ... Oliver Bossdorf
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Yeast cell responses and survival during periodic osmotic stress are controlled by glucose availability

    Fabien Duveau, Céline Cordier ... Pascal Hersen
    Microfluidic methods are used to quantitatively probe single yeast cells' response to either simultaneous or sequential stresses, revealing the dynamic interplay between two antagonistic inputs, osmotic stress and glucose starvation.
    1. Neuroscience

    Ocular dominance-dependent binocular combination of monocular neuronal responses in macaque V1

    Sheng-Hui Zhang, Xing-Nan Zhao ... Cong Yu
    Binocular combination of monocular neuronal responses involves response suppression for neurons more preferring one eye and response enhancement for neurons more preferring both eyes in macaque V1.
    1. Structural Biology and Molecular Biophysics

    Ligand bias underlies differential signaling of multiple FGFs via FGFR1

    Kelly Karl, Nuala Del Piccolo ... Kalina Hristova
    Fibroblast growth factor (FGF) ligands exhibit different preferences for signaling cascades triggered through FGFR1, a receptor which is critical for skeletal development, and these differences likely contribute to the amazing complexity of developmental processes.
    1. Genetics and Genomics

    Expanding the Drosophila toolkit for dual control of gene expression

    Jonathan Zirin, Barbara Jusiak ... Norbert Perrimon
    A CRISPR knock-in approach enables the efficient generation of tissue-specific LexA and QF driver lines which can simultaneously control gene expression in multiple tissues.
    1. Neuroscience

    Space as a scaffold for rotational generalisation of abstract concepts

    Jacques Pesnot Lerousseau, Christopher Summerfield
    Spatial mapping serves as a cognitive scaffold for acquiring abstract conceptual invariances across sensory domains, shedding light on the mechanisms of human learning.
    1. Chromosomes and Gene Expression

    Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

    Mengxue Tian, Zhenjia Wang ... Chongzhi Zang
    The ~20,000 origins of replication in human cell lines that are reproducibly identified by multiple techniques in multiple cell lines are distant from known origin recognition complex and MCM2-7-binding sites.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells

    Atikul Islam, Yu-Chun Chang ... Pin Ju Chueh
    Multifaceted properties of the water-soluble derivative of antibiotic heliomycin enable it to offer greater antitumor value than its parent compound by inhibiting the tNOX-NAD+-SIRT1 axis to induce apoptosis.
    1. Neuroscience

    Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

    Masaya Harada, Laia Serratosa Capdevila ... Tommaso Patriarchi
    Optogenetic manipulation and photometry recordings in the lateral hypothalamus show how interactions between dopamine and orexin systems underlie reward expectation revealing dopaminergic modulation of orexinergic activity via D2 receptors.
    1. Chromosomes and Gene Expression

    A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

    Kamil Pabis, Diogo Barardo ... Brian K Kennedy
    A majority of transcribed transposons during aging are derived from transcriptional defects, most notably intron retention and transcriptional readthrough.
    1. Developmental Biology

    The embryonic role of juvenile hormone in the firebrat, Thermobia domestica, reveals its function before its involvement in metamorphosis

    James W Truman, Lynn M Riddiford ... Michelle Herko
    This sesquiterpene hormone likely acted as a morphogenesis-to-differentiation switch in archaic embryos before it evolved its postembryonic function as the status quo regulator of insect metamorphosis.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1

    Ayse Kilic, Arda Halu ... Scott T Weiss
    Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.
    1. Medicine

    Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

    Duilio M. Potenza, Xin Cheng ... Xiu-Fen Ming
    1. Microbiology and Infectious Disease

    Malaria parasite resistance to azithromycin is not readily transmitted by mosquitoes

    Hayley D. Buchanan, Robyn McConville ... Christopher D. Goodman
    1. Cell Biology

    Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

    Kyounghee Min, Batuhan Yenilmez ... Michael P Czech
    Stellate cell lactate transporter MCT1 significantly contributes to liver fibrosis through increased collagen 1 protein expression in vitro and in vivo.
    1. Cell Biology

    Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-B

    Daniel Ballmer, Bungo Akiyoshi
    The kinetoplastid parasite Trypanosoma brucei employs a unique mechanism to target the conserved Aurora B kinase to kinetochores and the central spindle.
    1. Neuroscience

    Prior probability cues bias sensory encoding with increasing task exposure

    Kevin Walsh, David P McGovern ... Redmond G O'Connell
    With extended practice, stimulus expectations modulate activity in early visual areas that encode the sensory evidence for perceptual choices.
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

    Sara Latini, Veronica Venafra ... Francesca Sacco
    Acute myeloid leukemia-specific predictive logic models reveal new therapeutic targets involved in cancer resistance mechanisms paving the way for personalized precision medicine.
    1. Neuroscience

    Sensorimotor mechanisms selective to numerosity derived from individual differences

    Giovanni Anobile, Irene Petrizzo ... Guido Marco Cicchini
    Evidence for a selective sensorimotor brain mechanism responsible for translating sensory numerical information into the number of actions in a sequence.
    1. Ecology
    2. Evolutionary Biology

    Risk-sensitive learning is a winning strategy for leading an urban invasion

    Alexis J Breen, Dominik Deffner
    Animals can thrive alongside humans by being expert judges of risk.
    1. Evolutionary Biology
    2. Neuroscience

    Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off

    Laure Mignerot, Clotilde Gimond ... Christian Braendle
    Caenorhabditis elegans egg-laying behaviour shows pronounced variation in natural populations, making it a promising model to investigate the microevolution of a simple neural circuit.
    1. Computational and Systems Biology

    Protein language model-embedded geometric graphs power inter-protein contact prediction

    Yunda Si, Chengfei Yan
    Integrating multiple protein language models using protein geometric graphs can dramatically improve the model performance for predicting the contacting residue pairs between interacting proteins.