March 2024

Cover articles

    1. Biochemistry and Chemical Biology

    Reducing prestige bias

    Anne E Hultgren, Nicole MF Patras, Jenna Hicks
    1. Developmental Biology
    2. Neuroscience

    mTOR signaling and autism

    Smrithi Prem, Bharati Dev ... Emanuel DiCicco-Bloom
    1. Developmental Biology

    Insights into sperm formation

    Zhiming Li, Xingping Liu ... Shuiqiao Yuan

Highlights controls:

Research articles

    1. Neuroscience

    High-resolution awake mouse fMRI at 14 Tesla

    David Hike, Xiaochen Liu ... Xin Yu
    1. Neuroscience

    Neural encoding of multiple motion speeds in visual cortical area MT

    Xin Huang, Bikalpa Ghimire ... Steven Wiesner
    1. Neuroscience

    Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

    Harry Clark, Matthew F Nolan
    Anchoring of grid firing fields to task environments is consistent with roles specifically in path integration rather than spatial localisation in general.
    1. Neuroscience

    Neurophysiological trajectories in Alzheimer’s disease progression

    Kiwamu Kudo, Kamalini G Ranasinghe ... Srikantan S Nagarajan
    Event-based sequencing models for Alzheimer’s disease progression revealed that abnormal neural synchrony occurs during the earliest preclinical stages of the disease, preceding brain atrophy and cognitive decline.
    1. Medicine
    2. Neuroscience

    The importance of individual beliefs in assessing treatment efficacy

    Luisa Fassi, Shachar Hochman ... Roi Cohen Kadosh
    Participants' subjective beliefs about the treatment received in an intervention study can explain variability in mental health symptoms and cognition.
    1. Genetics and Genomics

    Meta-Research: Understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results

    Reese Richardson, Heliodoro Tejedor Navarro ... Thomas Stoeger
    Find My Understudied Genes (FMUG) is a data-driven tool created to counteract the abandonment of understudied genes in -omics research.
    1. Cancer Biology

    Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

    Jing Xie, Yafei Xu ... Qiancheng Song
    Osteocytes, sensing mechanical stimulation generated by exercise, inhibit the proliferation of non-small cell lung cancer cells and sustain their dormancy by releasing small extracellular vesicles containing tumor-suppressive micro-RNAs.
    1. Neuroscience

    Body size as a metric for the affordable world

    Xinran Feng, Shan Xu ... Jia Liu
    The human body shapes how we perceive and interact with the environment, with body size serving as a boundary for defining potential actions, hereby enlightening research on foundation agents.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues

    Arthur L Schneider, Rita Martins-Silva ... Nuno L Barbosa-Morais
    voyAGEr is an online platform that facilitates the exploration of age-related gene expression dynamics in human tissues, allowing users to analyse tissue- and sex-specific changes alongside donor medical histories.
    1. Cell Biology
    2. Physics of Living Systems

    Mitosis sets nuclear homeostasis of cancer cells under confinement

    Malèke Mouelhi, Alexis Saffon ... Charlotte Rivière
    1. Neuroscience

    Effects of noise and metabolic cost on cortical task representations

    Jake P. Stroud, Michał Wójcik ... Máté Lengyel
    1. Neuroscience

    Complementary cognitive roles for D2-MSNs and D1-MSNs in interval timing

    R. Austin Bruce, Matthew A. Weber ... Nandakumar S. Narayanan
    1. Neuroscience
    2. Computational and Systems Biology

    High frequency spike inference with particle Gibbs sampling

    Giovanni Diana, B. Semihcan Sermet, David A. DiGregorio
    1. Cell Biology

    Wound-Induced Syncytia Outpace Mononucleate Neighbors during Drosophila Wound Repair

    James S. White, Jasmine J. Su ... Andrea Page-McCaw
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

    Zhenyong Wu, Grant F Kusick ... Shigeki Watanabe
    The calcium-binding proteins synaptotagmin 7 and Doc2α act sequentially during asynchronous neurotransmitter release.
    1. Cancer Biology

    Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

    Wanyoung Lim, Inwoo Hwang ... Sungsu Park
    A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    Xinjian Ye, Yijing Bai ... Qianming Chen
    Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

    Karolina Honzejkova, Dalibor Kosek ... Tomas Obsil
    Thioredoxin functions as a negative allosteric effector of ASK1 by altering the interaction between the thioredoxin-binding and tetratricopeptide repeats domains, thereby reducing access to the kinase domain's activation segment.
    1. Developmental Biology
    2. Neuroscience

    Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells

    Tariq Zaman, Daniel Vogt ... Michael R Williams
    The transmembrane protein Kit Ligand and the Kit receptor tyrosine kinase are required for synapse function between specific cell types in the mouse cerebellum.
    1. Cell Biology

    Membrane contact sites regulate vacuolar fission via sphingolipid metabolism

    Kazuki Hanaoka, Kensuke Nishikawa ... Kouichi Funato
    Sphingolipids regulate vacuolar fission via nuclear vacuole junction to adapt to intracellular and extracellular environments in budding yeast.
    1. Genetics and Genomics

    Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production

    Nina K Jain, Pierce J Ogden, George M Church
    Measurement of the effect of all single-codon variants of the AAV2 rep gene on recombinant adeno-associated virus production identifies novel beneficial variants, which may facilitate improvement of gene therapy production.
    1. Developmental Biology
    2. Genetics and Genomics

    Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

    Zian Liao, Suni Tang ... Martin Matzuk
    Mouse models reveal fundamental roles of SMAD1/5 in mediating both bone morphogenetic protein signaling pathways and the transcriptional response to progesterone during decidualization.
    1. Biochemistry and Chemical Biology

    Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

    Jake W Anderson, David Vaisar ... Natalie G Ahn
    New ATP-competitive inhibitors show properties of conformation selection when complexed with the MAP kinase, ERK2, altering movements around the activation loop.
    1. Medicine

    Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

    Hong Chen, Lijun Sun ... Yue Yin
    Intermittent fasting affects intestinal immunity through new interactions between macrophages and ILC3s, increasing ILC3 secretion of IL-22 and thus promoting white adipose tissue beigeing, and improving metabolism.
    1. Developmental Biology
    2. Physics of Living Systems

    The Geometric Basis of Epithelial Convergent Extension

    Fridtjof Brauns, Nikolas H. Claussen ... Boris I. Shraiman
    1. Biochemistry and Chemical Biology

    Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

    Jonathan G. Van Vranken, Jiaming Li ... Devin K. Schweppe
    1. Cell Biology

    Atlas of Fshr Expression from Novel Reporter Mice

    Hong-Qian Chen, Hui-Qing Fang ... Peng Liu
    1. Neuroscience

    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

    Hideo Hagihara, Hirotaka Shoji ... Tsuyoshi Miyakawa
    Brain lactate and pH changes, identified as common features in diverse neuropsychiatric animal models, may represent transdiagnostic endophenotypes associated with cognitive impairment.
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.
    1. Ecology

    Synthetic eco-evolutionary dynamics in simple molecular environment

    Luca Casiraghi, Francesco Mambretti ... Tommaso Bellini
    A variant of SELEX introduced here to induce abiotic evolution in a molecular system enables to observe and study speciation, the nature of fitness, and the interplay between use of resources and interactions between individuals.
    1. Evolutionary Biology

    Emergence of catalytic function in prebiotic information-coding polymers

    Alexei V Tkachenko, Sergei Maslov
    Theoretical scenario for prebiotic polymers capable of nonenzymatic replication to acquire an early catalytic function, specifically cleavage activity.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presence

    Monica Salinas-Pena, Elena Rebollo, Albert Jordan
    Imaging analysis confirms ChIP-Seq data on the distinct genomic distribution of histone H1 variants in AT-rich, nuclear peripheral regions (H1.2, H1.3, H1.5, H1.0) or GC-rich, throughout the nucleus (H1.4, H1X).
    1. Neuroscience

    Disruption of awake sharp-wave ripples does not affect memorization of locations in repeated-acquisition spatial memory tasks

    Lies Deceuninck, Fabian Kloosterman
    Hippocampal sharp-wave ripples are not required for rats to successfully perform spatial tasks that rely on memorization of locations at short timescales.
    1. Cell Biology

    Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

    Kanako Shinno, Yuri Miura ... Kanae Ando
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock

    Daniyal Tariq, Nicole Maurici ... Brian R Crane
    The intrinsic disorder of the circadian clock protein Frequency organizes binding partners, facilitates liquid–liquid phase separation, modulates Frequency phosphorylation, and derives from sequence properties conserved with homologous clock components.
    1. Cell Biology

    A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit

    Damien Laporte, Aurelie Massoni-Laporte ... Isabelle Sagot
    In quiescent yeast, a stable bundle of parallel microtubules is assembled from the centrosome by an original multistep mechanism that follows a precise temporality and involves Aurora B and various kinesins.
    1. Neuroscience

    Dopamine lesions alter the striatal encoding of single-limb gait

    Long Yang, Deepak Singla ... Sotiris C Masmanidis
    Striatal neurons preferentially fire at specific phases of the gait cycle, and the strength of gait encoding is selectively increased in indirect pathway neurons following dopamine lesions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

    Yuting Zhang, Min Zhang ... Guojiang Chen
    A novel antibody recognizing receptor-binding region of MARV glycoprotein was developed and displays broad-spectrum neutralizing activity to filovirus species when NPC2 was fused to the N-terminus of the mAb.
    1. Developmental Biology

    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

    Namsuk Kim, Yan Li ... Won-Jong Oh
    Repulsive guidance cues enhance a dual-functioning axonal trafficking facilitator, allowing navigating axons to ensure proper pathfinding by coordinating positive extension and negative steering during nervous system development.
    1. Developmental Biology
    2. Immunology and Inflammation

    Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

    Amir Hossein Kayvanjoo, Iva Splichalova ... Elvira Mass
    Identification of distinct yolk sac-derived macrophage subpopulations in the fetal liver reveals their crucial role in shaping the hematopoietic niche, impacting erythropoiesis and granulopoiesis through direct interactions with long-term hematopoietic stem cells.
    1. Developmental Biology
    2. Neuroscience

    Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells

    Smrithi Prem, Bharati Dev ... Emanuel DiCicco-Bloom
    Alterations in mTOR signaling drive similar dysregulations in the critical mid-fetal neurodevelopmental processes of neurite outgrowth and cell migration in two distinct subsets of autism, idiopathic and 16p11.2 deletion.
    1. Neuroscience

    PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

    Typhaine Comyn, Thomas Preat ... Pierre-Yves Plaçais
    1. Genetics and Genomics
    2. Neuroscience

    Sibling chimerism among microglia in marmosets

    Ricardo C.H. del Rosario, Fenna M. Krienen ... Steven A. McCarroll
    1. Cell Biology
    2. Genetics and Genomics

    Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress

    Showkat A. Dar, Sulochan Malla ... Manolis Maragkakis
    1. Neuroscience

    Multimodal mismatch responses in mouse auditory cortex

    Magdalena Solyga, Georg B. Keller
    1. Plant Biology

    OsNF-YB7 inactivates OsGLK1 to inhibit chlorophyll biosynthesis in rice embryo

    Zongju Yang, Tianqi Bai ... Chen Chen
    1. Microbiology and Infectious Disease

    Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

    Chiara Andolina, Wouter Graumans ... Teun Bousema
    The number of sporozoites expelled by mosquitoes that are infected with lab-cultured or naturally circulating Plasmodium falciparum gametocytes is heterogeneous and associated with the sporozoite load in their salivary glands.
    1. Cell Biology
    2. Physics of Living Systems

    Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

    Camille Morel, Eline Lemerle ... Emmanuel Lemichez
    Caveolin-1 controls the width of transendothelial cell tunnels via a direct or indirect effect on membrane bending rigidity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

    Veronica Teresa Ober, George Boniface Githure ... Michael Boshart
    A minimal subset of two to three residues in cyclic nucleotide binding (CNB) domains controls nucleoside vs. cyclic nucleotide specificity, repurposing PKA of certain pathogens for novel nucleoside signaling pathways or sensing.
    1. Cell Biology

    Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

    Wayne Mitchell, Ludger JE Goeminne ... Vadim N Gladyshev
    Partial chemical reprogramming is able to reduce the biological age of cells by diverting them to a different metabolic state marked by a strong upregulation of mitochondrial oxidative phosphorylation.
    1. Biochemistry and Chemical Biology

    Structural mechanisms for VMAT2 inhibition by tetrabenazine

    Michael P Dalton, Mary Hongying Cheng ... Jonathan A Coleman
    The structure of the vesicular monoamine transporter 2 bound to Huntington’s chorea drug tetrabenazine elucidates mechanisms of inhibition and neurotransmitter transport.
    1. Cell Biology
    2. Evolutionary Biology

    The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals

    Jonathan E Phillips, Duojia Pan
    Genetic analysis of Hippo pathway kinases in a close unicellular relative of animals suggests an ancestral role of this ancient pathway in regulating cytoskeletal dynamics and density of multicellular aggregates.
    1. Microbiology and Infectious Disease

    A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein

    Markéta Častorálová, Jakub Sýs ... Tomas Ruml
    Biochemical and instrumental analysis showed that the membrane-induced exposure of myristoyl from the MA protein of Mason-Pfizer monkey virus triggers allosteric conformational changes resulting in MA oligomerization and unfolding of the cleavage site between MA and downstream domains of Gag.
    1. Neuroscience

    Neural activity ramps in frontal cortex signal extended motivation during learning

    Josue M. Regalado, Ariadna Corredera Asensio ... Priya Rajasethupathy
    1. Neuroscience

    Context dependent contributions of the direct and indirect pathways in the associative and sensorimotor striatum

    Nisa Cuevas, Argelia Llanos-Moreno ... Fatuel Tecuapetla
    1. Neuroscience

    Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

    Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen
    1. Neuroscience

    Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions

    Veronika Pak, Quadri Adewale ... Yasser Iturria-Medina
    Major cell types across various brain regions distinctively associate with tissue loss in 13 neurodegenerative conditions.
    1. Medicine
    2. Neuroscience

    A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition

    Marvin Petersen, Felix Hoffstaedter ... Bastian Cheng
    Structural neuroimaging of 40,087 individuals identifies a distinct brain morphological profile associated with metabolic syndrome, linking cardiometabolic risk to cognitive performance, microscale tissue composition, and macroscale brain network architecture.
    1. Neuroscience

    Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons

    Vasileios Glykos, Shigeyoshi Fujisawa
    Dopamine and GABA neurons in the ventral tegmental area encode short-term memory in the T-maze task, which cannot be explained by reward-related processes, motivated behavior, or motor-related activities.
    1. Neuroscience

    The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A

    Andrea Salazar Lázaro, Thorsten Trimbuch ... Christian Rosenmund
    Structure–function studies on the synaptic vesicle release protein syntaxin-1 identified structural motifs on the surface of the SNARE complex controlling vesicle priming and spontaneous release unique for synaptic signaling.
    1. Cell Biology
    2. Immunology and Inflammation

    Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate

    Mina O Seedhom, Devin Dersh ... Jonathan W Yewdell
    Quantitative protein and ribosome 'accounting' in T cells highlights a gap in our understanding of how activated T cells sufficiently replicate their proteome during rapid cell division driven by infection.
    1. Neuroscience

    Comparative brain-wide mapping of ketamine- and isoflurane-activated nuclei and functional networks in the mouse brain

    Yue Hu, Wenjie Du ... Yingwei Wang
    Brain-wide activation patterns reveal the distinct and shared neurophysiological impacts of ketamine and isoflurane, highlighting key nuclei involved in the modulation of general anesthesia.
    1. Microbiology and Infectious Disease

    Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation

    Volker Winstel, Evan R Abt ... Caius G Radu
    Host-directed therapy neutralizes a refined immuno-evasive maneuver of pathogenic staphylococci.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Assembly of neuron- and radial glial-cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons

    Ayumu Mubuchi, Mina Takechi ... Shinji Miyata
    The extracellular matrix formed during embryonic brain development facilitates the migration of cortical neurons.
    1. Neuroscience

    A neurotransmitter atlas of the nervous system of C. elegans males and hermaphrodites

    Chen Wang, Berta Vidal ... Oliver Hobert
    1. Cell Biology

    Actin dynamics switches two distinct modes of endosomal fusion in yolk sac visceral endoderm cells

    Seiichi Koike, Masashi Tachikawa ... Masayuki Masu
    1. Genetics and Genomics
    2. Evolutionary Biology

    Refining the resolution of the yeast genotype-phenotype map using single-cell RNA-sequencing

    Arnaud N’Guessan, Wen Yuan Tong ... Alex N Nguyen Ba
    1. Neuroscience

    A previously undescribed scene-selective site is the key to encoding ego-motion in naturalistic environments

    Bryan Kennedy, Sarala N Malladi ... Shahin Nasr
    There are many fine-scale scene-selective areas within the visual system, beyond the occipital, temporal, and medial place areas, whose function may be key to performing complex tasks in dynamic environments.
    1. Immunology and Inflammation

    Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

    Chung Park, Il-Young Hwang ... John H Kehrl
    The SARS-CoV-2 Spike proteins demonstrate in vivo cellular tropism, ascertain targets within human mononuclear cells, and provide insights into their functional consequences, thereby enhancing comprehension of their impact on humans.
    1. Cell Biology

    Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

    Martin Wohlwend, Pirkka-Pekka Laurila ... Johan Auwerx
    CERS1 reduction in aging skeletal muscle contributes to impaired muscle function, myogenesis and increases inflammation and fibrosis, highlighting the significance of very long chain ceramides in age-related muscle homeostasis.
    1. Developmental Biology

    Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition

    Anastasiia Lozovska, Ana Nóvoa ... Moises Mallo
    1. Cancer Biology

    Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

    Fei Yue, Amy T. Ku ... Yi Li
    1. Neuroscience

    Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

    Jian Dong, Miao Chen ... Matthijs Verhage
    1. Neuroscience

    Bidirectional fear modulation by discrete anterior insular circuits in male mice

    Sanggeon Park, Yeowool Huh ... Jeiwon Cho
    1. Neuroscience

    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

    Kristine Oevel, Svea Hohensee ... Volker Haucke
    Genetic and pharmacological tools are used to dissect the mechanisms by which the presynaptic actin cytoskeleton facilitates membrane internalization at synapses and, thereby, neurotransmission.
    1. Physics of Living Systems

    Structural basis for the preservation of a subset of topologically associating domains in interphase chromosomes upon cohesin depletion

    Davin Jeong, Guang Shi ... D Thirumalai
    The finding that deletion of the genome folding motor leaves a significant fraction of a key structural feature of chromosome at the single cell and ensemble level has been explained.
    1. Microbiology and Infectious Disease

    The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

    Hui Dong, Jiong Yang ... Shaojun Long
    Combined cutting-edge technologies discovered a pair of carboxylate transporters that appears evolutionarily different among novel transporters and that is essential for parasite physiology.
    1. Cell Biology

    Spatiotemporal dissection of the Golgi apparatus and the ER-Golgi intermediate compartment in budding yeast

    Takuro Tojima, Yasuyuki Suda ... Akihiko Nakano
    Spatiotemporal mapping of a variety of proteins in and around the Golgi apparatus in budding yeast was performed using super-resolution live imaging microscopy and identified the ER-Golgi intermediate compartment that matures into the Golgi.
    1. Neuroscience

    Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision making

    Miguel Barretto García, Marcus Grueschow ... Christian C. Ruff
    1. Neuroscience

    Kilohertz Transcranial Magnetic Perturbation (kTMP): A New Non-invasive Method to Modulate Cortical Excitability

    Ludovica Labruna, Christina Merrick ... Daniel Sheltraw
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Transformer-based spatial–temporal detection of apoptotic cell death in live-cell imaging

    Alain Pulfer, Diego Ulisse Pizzagalli ... Santiago Fernandez Gonzalez
    ADeS, a novel deep learning approach for apoptosis detection, achieves 98% accuracy in vitro and in vivo while providing unprecedented insights into the spatial–temporal foundation of cell death.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

    Raphael Trenker, Devan Diwanji ... Natalia Jura
    Cryo-EM structures uncover glycosylation in the ectodomains of full-length HER4 homodimer and HER2/HER4 heterodimer complexes, revealing how the binding of various growth factors alters dynamics at the dimerization interface.
    1. Developmental Biology
    2. Neuroscience

    Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

    Sergi Llambrich, Birger Tielemans ... Greetje Vande Velde
    Ts65dn mice exhibit structural, functional, molecular, and genetic alterations that are modulated but unrecovered by prenatal chronic GTE-EGCG, highlighting the importance of holistic studies to understand complex disorders and treatments.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Dynamic 1D search and processive nucleosome translocations by RSC and ISW2 chromatin remodelers

    Jee Min Kim, Claudia C Carcamo ... Carl Wu
    Single-particle imaging of RSC and ISW2 chromatin remodelers on DNA stretched between dual optical tweezers reveals distinctive 1D diffusion and opposing push–pull nucleosome translocation on engagement with sparse nucleosome arrays.
    1. Immunology and Inflammation

    Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

    Chongbin Hu, Nan Zhang ... Jian-zhong Shao
    scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.
    1. Ecology

    Habitat loss weakens the positive relationship between grassland plant richness and above-ground biomass

    Yongzhi Yan, Scott Jarvie, Qing Zhang
    Habitat loss rather than fragmentation per se can weaken the positive BEF relationship by reducing the percentage of grassland specialists in the community.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Caspase-1 activates gasdermin A in non-mammals

    Zachary Paul Billman, Stephen Bela Kovacs ... Edward A Miao
    Amphibians, reptiles, and birds engage pyroptosis using caspase-1 and GSDMA, filling an evolutionary gap in which caspase-1 cleaves GSDME in fish and GSDMD in mammals.
    1. Genetics and Genomics
    2. Evolutionary Biology

    The recombination landscape of introgression in yeast

    Enrique J. Schwarzkopf, Nathan Brandt, Caiti Smukowski Heil
    1. Neuroscience

    The pelvic organs receive no parasympathetic innervation

    Margaux Sivori, Bowen Dempsey ... Jean-François Brunet
    Of the two divisions proposed long ago to describe the autonomic nervous system, thoraco-lumbar sympathetic and cranio-sacral parasympathetic, the latter finds no support from transcriptionally defined neuron types.
    1. Computational and Systems Biology

    Sensitive remote homology search by local alignment of small positional embeddings from protein language models

    Sean R Johnson, Meghana Peshwa, Zhiyi Sun
    Protein language deep learning models can quickly and accurately translate amino acid sequences into profile hidden Markov models or a structure alphabet, dramatically improving remote homology search sensitivity without compromising space or time efficiency.
    1. Cell Biology

    WRNIP1 prevents transcription-associated genomic instability

    Pasquale Valenzisi, Veronica Marabitti ... Annapaola Franchitto
    WRNIP1 has been identified as a pivotal factor in preventing the pathological persistence of R-loop-induced transcription-replication conflicts and the accumulation of DNA damage, thereby ensuring genome integrity.
    1. Genetics and Genomics

    Mitochondrial genomes of Pleistocene megafauna retrieved from recent sediment layers of two Siberian lakes

    Peter Andreas Seeber, Laura Batke ... Laura S Epp
    Abundant mitochondrial DNA of long-extinct large mammals in recent sediment of Siberian lakes suggests complex taphonomic redistribution.
    1. Neuroscience

    Multiple objects evoke fluctuating responses in several regions of the visual pathway

    Meredith N Schmehl, Valeria C Caruso ... Jennifer M Groh
    Neural fluctuations in multiple areas along the visual cortical hierarchy could allow the brain to represent distinct co-occurring visual stimuli.
    1. Cancer Biology

    Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

    Carolyn M Jablonowski, Waise Quarni ... Jun Yang
    Genetic analyses and biochemical studies show that JMJD6 promotes MYC-mediated transformation and is required for neuroblastoma growth by complexing with pre-mRNA splicing factors.
    1. Evolutionary Biology
    2. Neuroscience

    Comparative neuroimaging of sex differences in human and mouse brain anatomy

    Elisa Guma, Antoine Beauchamp ... Jason P Lerch
    Comparative neuroimaging quantifies the congruence of regional neuroanatomical sex differences between humans and mice.
    1. Cancer Biology
    2. Medicine

    Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

    Won Yeong Park, Jieun Yun ... Ki Hean Kim
    Open-top Bessel beam two-photon light sheet microscopy have the potential for rapid and accurate nondestructive pathology by visualizing 3D histological information.
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

    Fangyan Wang, Xiujie Liu ... Wantie Wang
    Gut microbiota-derived gamma-aminobutyric acid is identified as a key metabolite that metformin protect from hepatic ischemia/reperfusion injury.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

    Hang Xu, Zihao Yuan ... Li Sun
    Functional divergence of caspase 3 and 7 in vertebrate is mediated by key residue mutation.
    1. Developmental Biology

    TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

    Jing Wang, Yingying Yin ... Zhaojian Liu
    1. Developmental Biology
    2. Neuroscience

    Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival

    Guangqin Wang, Yunpeng Gu, Zhiyong Liu
    Rbm24 is controlled by Pou4f3 but not Gfi1 during cochlear hair cell development.
    1. Neuroscience
    2. Physics of Living Systems

    C9orf72 polyPR directly binds to various nuclear transport components

    Hamidreza Jafarinia, Erik van der Giessen, Patrick R Onck
    Length-dependent interference of arginine-containing dipeptide repeat proteins with multiple components of the nucleocytoplasmic transport machinery is a potential mechanistic pathway of C9orf72 amyotrophic lateral sclerosis or frontotemporal dementia toxicity.
    1. Medicine
    2. Neuroscience

    Plasma extracellular vesicle synaptic proteins as biomarkers of clinical progression in patients with Parkinson’s disease

    Chien-Tai Hong, Chen-Chih Chung ... Lung Chan
    The promising potential of plasma extracellular vesicle synaptic proteins as clinical biomarkers of disease progression in Parkinson's disease has been presented.
    1. Immunology and Inflammation

    TLR2 regulates hair follicle cycle and regeneration via BMP signaling

    Luyang Xiong, Irina Zhevlakova ... Tatiana V Byzova
    Cell and animal-based models revealed the new function of TLR2 andcarboxyethylpyrrole as an endogenous TLR2 ligand in the hair follicle cycle in homeostasis and hair follicle regeneration in injury.
    1. Developmental Biology
    2. Evolutionary Biology

    A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis

    Jaaved Mohammed, Neha Arora ... Joanna Wysocka
    SNP-editing of human embryonic stem cells reveals cell type specific function of a genetic variant associated with changes in human jaw shape.
    1. Cell Biology
    2. Neuroscience

    Activity-dependent mitochondrial ROS signaling regulates recruitment of glutamate receptors to synapses

    Rachel L Doser, Kaz M Knight ... Frederic J Hoerndli
    In response to neuronal activity in vivo, mitochondria in dendrites of excitatory neurons inhibit recruitment of ionotropic glutamate receptors through a reactive oxygen signaling mechanism.
    1. Cell Biology
    2. Computational and Systems Biology

    Unbiased identification of cell identity in dense mixed neural cultures

    Sarah De Beuckeleer, Tim Van De Looverbosch ... Winnok H. De Vos
    1. Biochemistry and Chemical Biology

    Balanced Interplay Between Hsp110, Hsp70 and Class B J-Domain Protein Improves Aggregate Disassembly

    Wiktoria Sztangierska, Hubert Wyszkowski ... Agnieszka Kłosowska
    1. Neuroscience

    Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia

    Maria Ardaya, Marie-Catherine Tiveron ... Fabio Cavaliere
    1. Neuroscience

    Aligned and oblique dynamics in recurrent neural networks

    Friedrich Schuessler, Francesca Mastrogiuseppe ... Omri Barak
    1. Neuroscience

    Indistinguishable network dynamics can emerge from unalike plasticity rules

    Poornima Ramesh, Basile Confavreux ... Jakob H. Macke
    1. Microbiology and Infectious Disease

    Un1Cas12f1 and Cas9 gene drive in HSV1: viruses that ‘infect’ viruses

    Qiaorui Yao, Zhuangjie Lin ... Hongsheng Dai
    1. Cell Biology
    2. Developmental Biology

    Ciliary length regulation by intraflagellar transport in zebrafish

    Yi Sun, Zhe Chen ... Chengtian Zhao
    1. Neuroscience

    Learned response dynamics reflect stimulus timing and encode temporal expectation violations in superficial layers of mouse V1

    Scott G. Knudstrup, Catalina Martinez, Jeffrey P. Gavornik
    1. Neuroscience

    Causal role of the frontal eye field in attention-induced ocular dominance plasticity

    Fangxing Song, Xue Dong ... Min Bao
    A series of experiments suggest that the fronto-parietal attentional network is involved in controlling eye-based attention, and FEF plays a crucial causal role in generating the attention-induced ocular dominance shift.
    1. Neuroscience

    Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice

    Nicolas Gutierrez-Castellanos, Dario Sarra ... Zachary F Mainen
    Anatomical tracing, in combination with a genetic ablation approach, identifies a critical maturation period for neocortex to dorsal raphe afferents pivotal for the development of behavioral persistence over adolescence in mice.
    1. Neuroscience

    Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

    Mattia Privitera, Lukas M von Ziegler ... Johannes Bohacek
    Targeted manipulation of the locus coeruleus noradrenaline circuitry combined with extensive transcriptomic analyses in the mouse hippocampus reveal a unique set of noradrenaline-dependent, stress-related genes and point to astrocytic engagement.
    1. Neuroscience

    Structural constraints on the emergence of oscillations in multi-population neural networks

    Jie Zang, Shenquan Liu ... Arvind Kumar
    An odd number of inhibitory links in a network are necessary and sufficient to make a network of neuron populations oscillate.
    1. Ecology

    The push–pull intercrop Desmodium does not repel, but intercepts and kills pests

    Anna L Erdei, Aneth B David ... Teun Dekker
    Instead of repelling, Desmodium, a hallmark of pest suppressive sustainable intercropping, acts as a mechanical and developmental barrier to larvae, thereby truncating population development.
    1. Neuroscience

    Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

    Timothy J. Abreo, Emma C. Thompson ... Edward C. Cooper
    1. Neuroscience

    Prediction error determines how memories are organized in the brain: a study of Pavlovian fear extinction in rats

    Nicholas G. W. Kennedy, Jessica C. Lee ... Nathan M. Holmes
    1. Neuroscience

    Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex

    Marie-Sophie H van der Goes, Jakob Voigts ... Mark T Harnett
    Dual site recordings of mouse anterodorsal thalamic nucleus and retrosplenial cortex reveal near 0-ms lag between the head direction representations of the two regions after cue rotations and correlated drift in darkness.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

    Florian Bénitière, Anamaria Necsulea, Laurent Duret
    Variation in the rate of alternative splicing across animals are mainly driven by differences in the rate of splicing errors.
    1. Cell Biology
    2. Developmental Biology

    Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion

    Houyu Zhang, Yan Li ... Meng Xie
    A brown-to-white adipogenic transdifferentiation process in the periureter region of mouse renal adipose tissue gives rise to a population of cold-inducible adipocytes with a transcriptome distinct from subcutaneous beige adipocytes.
    1. Neuroscience
    2. Physics of Living Systems

    Neural criticality from effective latent variables

    Mia C Morrell, Ilya Nemenman, Audrey Sederberg
    Signatures of criticality that have been observed across diverse neural systems, such as power-law avalanche distributions and exponent relationships, can arise without fine-tuning in networks coupled to latent, dynamical variables.
    1. Neuroscience

    Neural attentional filters and behavioural outcome follow independent individual trajectories over the adult lifespan

    Sarah Tune, Jonas Obleser
    Individual listening behaviour and neural filtering ability follow independent developmental trajectories in a large, N = 105, cohort of ageing individuals.
    1. Neuroscience

    Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex

    Yi-jun Zhu, Cai-yun Deng ... Hua-tai Xu
    For neurons to prevent undesirable synaptic connections in the brain, the combinatorial expression of γ-PCDH is essential.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression plasticity followed by genetic change during colonization in a high-elevation environment

    Huishang She, Yan Hao ... Yanhua Qu
    An integrative approach allows investigations of the relationship between an initial plasticity and the subsequent adaptive evolution during rapid adaptive modification of complex systems in the wild.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The catalytic mechanism of the RNA methyltransferase METTL3

    Ivan Corbeski, Pablo Andrés Vargas-Rosales ... Amedeo Caflisch
    A multidisciplinary study reveals the reaction mechanism and transition state of adenosine-N6 methyl transfer catalyzed by human METTL3-14, deepening our insight into RNA methyltransferases and paving the way for similar studies on related enzymes.
    1. Developmental Biology

    FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility

    Zhiming Li, Xingping Liu ... Shuiqiao Yuan
    Animal models and molecular data reveal how FBXO24 regulates mRNA expression and MIWI degradation in the round spermatids.
    1. Immunology and Inflammation

    Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

    Izumi Ohigashi, Andrea J White ... Yousuke Takahama
    Thymocyte-attracting CCL21-expressing embryonic mTECs carry a developmental potential to give rise to self-antigen-displaying Aire-expressing mTECs.
    1. Cell Biology

    Sorting of secretory proteins at the trans-Golgi network by human TGN46

    Pablo Lujan, Carla Garcia-Cabau ... Felix Campelo
    TGN46 is a cargo receptor, with its luminal domain being necessary and sufficient to load soluble secretory proteins into transport carriers for export out of the trans-Golgi network.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

    Zhi Li, Yuedi Wang ... Zeyang Zhou
    Molecular and biochemical methods provide the first evidence of toxicity of imidacloprid causing developmental retardation in honeybee larvae, highlighting the potential risks of prolonged exposure to insecticides during animal development.
    1. Cell Biology

    A novel imaging method (FIM-ID) reveals that myofibrillogenesis plays a major role in the mechanically induced growth of skeletal muscle

    Kent W Jorgenson, Jamie E Hibbert ... Troy A Hornberger
    A novel imaging method for measuring myofibril size/number reveals that the radial growth of muscle fibers that occurs in response to increased mechanical loading is largely mediated by myofibrillogenesis.
    1. Structural Biology and Molecular Biophysics

    A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels

    Yiechang Lin, Elaine Tao ... Ben Corry
    Simulations reveal where phosphoinositide lipids bind to voltage-gated sodium channels and how they reduce channel activity.
    1. Medicine

    Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

    Kentaro Homan, Tomohiro Onodera ... Norimasa Iwasaki
    Corefucosylation contributes to the maintenance of the articular cartilage phenotype and depletion of FUT8 inhibits recovery from cartilage damage and promotes cartilage degeneration.
    1. Developmental Biology

    Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation

    Satoshi Yamashita, Shuji Ishihara, François Graner
    1. Evolutionary Biology

    Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation

    Tanya M Smith, Manish Arora ... Daniel R Green
    A new high-resolution approach to probing tooth chemistry shows real potential to uncover changing rainfall patterns and environmental conditions during human prehistory.
    1. Neuroscience

    TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves

    Matthew Grove, Hyukmin Kim ... Young-Jin Son
    TEAD1 is a major partner transcription factor of YAP/TAZ crucial for developmental myelination and remyelination of peripheral nerves.
    1. Structural Biology and Molecular Biophysics

    Structural basis for the phase separation of the chromosome passenger complex

    Nikaela W Bryan, Aamir Ali ... Ben E Black
    The utilization of hydrogen/deuterium exchange mass spectrometry reveals dynamic insights and interactions driving liquid-liquid demixing of the chromosome passenger complex.
    1. Cancer Biology

    Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

    Ryan R. Kawalerski, Mariana Torrente Gonçalves ... Luisa F. Escobar-Hoyos
    1. Neuroscience

    Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

    Rein I. Hoogstraaten, Adlin Abramian ... Matthijs Verhage
    1. Neuroscience

    Shaping the physical world to our ends: The left PF technical-cognition area

    François Osiurak, Giovanni Federico ... Mathieu Lesourd
    1. Physics of Living Systems

    Emergence of ion-channel mediated electrical oscillations in Escherichia coli biofilms

    Emmanuel U. Akabuogu, Victor Martorelli ... Thomas A. Waigh
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Identification of fallopian tube microbiota and its association with ovarian cancer

    Bo Yu, Congzhou Liu ... David N Fredricks
    A prospective study of intraoperative swab collections from 187 patients identified a putative fallopian tube microbiota and a clear shift in ovarian cancer patients compared to non-cancer patients.
    1. Neuroscience

    Interactions between circuit architecture and plasticity in a closed-loop cerebellar system

    Hannah L Payne, Jennifer L Raymond, Mark S Goldman
    A comprehensive modeling approach reconciles experimental observations with classic plasticity mechanisms in the cerebellar cortex, demonstrating how learning-related changes in neural activity can appear to contradict the sign of the underlying plasticity when feedback is present.
    1. Medicine
    2. Neuroscience

    Acute ampakines increase voiding function and coordination in a rat model of SCI

    Sabhya Rana, Firoj Alom ... Aaron D Mickle
    Ampakines demonstrate efficacy in enhancing bladder function in animal models of spinal cord injury, presenting promising prospects for innovative pharmacotherapy to alleviate post-injury bladder dysfunction.
    1. Neuroscience

    Sequentially activated discrete modules appear as traveling waves in neuronal measurements with limited spatiotemporal sampling

    Yuval Orsher, Ariel Rom ... Mark Shein-Idelson
    Multi-electrode recordings and modeling work indicate that sequentially activated discrete modules of spiking neurons may appear as traveling waves in low spatial resolution measurements, suggesting caution when interpreting phase delay measurements as continuously propagating wavefronts.
    1. Ecology
    2. Epidemiology and Global Health

    Exploring factors shaping antibiotic resistance patterns in Streptococcus pneumoniae during the 2020 COVID-19 pandemic

    Aleksandra Kovacevic, David RM Smith ... Lulla Opatowski
    The mathematical modeling approach disentangles the impacts of the COVID-19 pandemic on antibiotic resistance in Streptococcus pneumoniae in the community setting and identifies the three most plausible driving mechanisms responsible for the observed trends in invasive isolates and pneumococcal carriage.
    1. Neuroscience

    Establishment of transgenic fluorescent mice for labeling synapses and screening synaptogenic adhesion molecules

    Lei Yang, Jingtao Zhang ... Chen Zhang
    A Syt1-tdTomato transgenic mice with normal synaptic transmission is established to label synapse in situ and screen synaptogenic adhesion molecules.
    1. Computational and Systems Biology
    2. Neuroscience

    Disrupting abnormal neuronal oscillations with adaptive delayed feedback control

    Domingos Leite de Castro, Miguel Aroso ... Paulo Aguiar
    Adaptive delayed feedback control is presented as a new real-time, closed-loop control algorithm for neurostimulation which can disrupt oscillations and reduce network synchrony in neuronal populations.
    1. Cell Biology

    Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screening

    Ramon Lorenzo D. Labitigan, Adrian L. Sanborn ... Julie A. Theriot
    1. Neuroscience

    Dorsolateral prefrontal activity supports a cognitive space organization of cognitive control

    Guochun Yang, Haiyan Wu ... Jiefeng Jiang
    The dorsolateral prefrontal cortex represents different conflict types within an organized cognitive space of cognitive control, positioning more similar conflict types closer together.
    1. Stem Cells and Regenerative Medicine

    Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype

    Qinyu Zhang, Rasmus Olofzon ... David Bryder
    Application of a polyvinyl alcohol-based culture system reveals extensive differentiation but simultaneous robust murine hematopoietic stem cell (HSC) expansion, which are characterized by phenotypic, functional, and molecular properties shared with freshly isolated bone marrow HSCs.
    1. Structural Biology and Molecular Biophysics

    The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Johannes N Greve, Anja Marquardt ... Dietmar J Manstein
    Mutation E334Q in cytoskeletal γ-actin leads to impaired interaction of actin filaments with actin-binding proteins belonging to the myosin and ADF/cofilin families.
    1. Cell Biology

    The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

    Hugo Siegfried, Georges Farkouh ... Mélina L Heuzé
    Depletion of VAPA in cancer cells induces defects in actin organization, adhesion dynamics and cell migration, together with a perturbation of phosphoinositide levels at the plasma membrane and a lack of anchoring of ER-PM contact sites to focal adhesions.
    1. Immunology and Inflammation
    2. Neuroscience

    Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis in C. elegans

    Benson Otarigho, Anna Frances Butts, Alejandro Aballay
    Molecular and genetics approaches reveal a dual regulatory role of neuronal G-protein-coupled receptor NPR-15 in both immunity and avoidance behavior, independent of aerotaxis, mediated by amphid sensory neurons, ASJ.
    1. Neuroscience

    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

    Erin R Cullen, Mona Safari ... Matthew C Weston
    Epilepsy caused by focal Pten deletion is only prevented when both mTOR complexes are simultaneously inhibited, but not alone, suggesting they play independent roles in the development of epilepsy.
    1. Neuroscience

    Diverging roles of TRPV1 and TRPM2 in warm-temperature detection

    Muad Y. Abd El Hay, Gretel B. Kamm ... Jan Siemens
    1. Neuroscience

    Heron: A Knowledge Graph editor for intuitive implementation of python based experimental pipelines

    George Dimitriadis, Ella Svahn ... Athena Akrami
    1. Developmental Biology

    Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification

    Imran S. Khan, Christopher Molina ... Dean Sheppard
    1. Neuroscience

    Accelerated signal propagation speed in human neocortical microcircuits

    Gáspár Oláh, Rajmund Lákovics ... Gábor Tamás
    1. Developmental Biology
    2. Neuroscience

    The Lateral Ganglionic Eminence Does Not Generate Cortical Oligodendrocytes

    Jialin Li, Feihong Yang ... Zhuangzhi Zhang
    1. Medicine
    2. Neuroscience

    Gene–environment pathways to cognitive intelligence and psychotic-like experiences in children

    Junghoon Park, Eunji Lee ... Jiook Cha
    Genetics, socioeconomic conditions, and family and school environments influence cognitive intelligence in children, and this impact may lead to the individual variability of the current and future PLEs.
    1. Immunology and Inflammation

    Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

    Hui Yan, Yao Liu ... Daiwen Chen
    Bone marrow-derived macrophages reveal that leucine promotes M2 polarization through mTORC1/LXRα/Arg1 signaling pathway, establishing a fundamental link between metabolism and immunity.
    1. Developmental Biology

    Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland

    Qiang Lan, Ewelina Trela ... Marja L Mikkola
    Live imaging, transcriptional profiling and mouse models demonstrated that the mesenchyme controls the growth pace but not the mode of branching of the mammary epithelium and unveiled a unique function for Igf1/Igfr1 in embryonic development mammary gland.
    1. Neuroscience

    Behavioral discrimination and olfactory bulb encoding of odor plume intermittency

    Ankita Gumaste, Keeley L Baker ... Justus Verhagen
    Mice are able to discriminate plume intermittency, which may be used for odor-guided navigation.
    1. Cell Biology
    2. Genetics and Genomics

    Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

    Jana Muroňová, Zine Eddine Kherraf ... Christophe Arnoult
    CCDC146 is a structural component of the flagellum in sperm, located in the doublet microtubules of the axoneme, whose absence leads to multiple morphological anomalies of the flagellum.
    1. Plant Biology

    Rapid translocation of NGR proteins driving polarization of PIN-activating D6 protein kinase during root gravitropism

    Ivan Kulich, Julia Schmid ... Jiří Friml
    Negative Gravitropic Response of roots (NGRs), pivotal for root gravitropic bending, are indispensable for the gravity-induced translocation of D6 protein kinase, a key regulator of PIN3 auxin efflux carrier activity.
    1. Cancer Biology

    Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

    Tiesuo Zhao, Pengkun Wei ... Huijie Jia
    A cellular experiment and animal model reveals that nifuroxazide can inhibit the expression of PD-L1 through the proteasome pathway, rather than at the genetic level.
    1. Structural Biology and Molecular Biophysics

    Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists

    Shristi Pawnikar, Brenda S. Magenheimer ... Yinglong Miao
    1. Neuroscience

    A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments

    Gabriel Loewinger, Erjia Cui ... Francisco Pereira
    1. Neuroscience

    Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments

    Jordan Breffle, Hannah Germaine ... Paul Miller
    1. Neuroscience

    Heterosynaptic plasticity of the visuo-auditory projection requires cholecystokinin released from entorhinal cortex afferents

    Wenjian Sun, Haohao Wu ... Jufang He
    Visuo-auditory associative memories in the neocortex are formed through cholecystokinin-mediated heterosynaptic plasticity, primarily involving entorhinal cortex projections to the auditory cortex, highlighting intricate neural dynamics in multisensory memory processing.
    1. Neuroscience

    Obesogenic diet induces circuit-specific memory deficits in mice

    Ioannis Bakoyiannis, Eva Gunnel Ducourneau ... Guillaume Ferreira
    Obesogenic diet intake throughout adolescence impairs different types of memory through overactivation of specific hippocampal efferent pathways and targeting these overactive pathways has therapeutic potential.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Enhancing TCR specificity predictions by combined pan- and peptide-specific training, loss-scaling, and sequence similarity integration

    Mathias Fynbo Jensen, Morten Nielsen
    NetTCR 2.2 demonstrates advances in predicting MHC-peptide-TCR interactions through integration of pan- and peptide-specific training strategies, loss-scaling and sequence similarity scoring.
    1. Cell Biology

    An open-source, high-resolution, automated fluorescence microscope

    Ando Christian Zehrer, Ana Martin-Villalba ... Helge Ewers
    High-quality fluorescence live-cell and single molecule imaging via computer-controlled, user-assembled microscope that fits in incubator, can in large parts be 3D printed and employs open source software and electronics.
    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H. Peter Larsson
    1. Neuroscience

    Tracking subjects’ strategies in behavioural choice experiments at trial resolution

    Silvia Maggi, Rebecca M Hock ... Mark D Humphries
    A new Bayesian algorithm for tracking subjects’ choice strategies on every trial reveals when subjects learn and what they tried while doing so, providing strong evidence that reward- and loss-driven exploration change independently.
    1. Cell Biology
    2. Physics of Living Systems

    The positioning mechanics of microtubule asters in Drosophila embryo explants

    Jorge de-Carvalho, Sham Tlili ... Ivo A Telley
    Using cytosolic explants from Drosophila syncytial embryos combined with quantitative microscopy and perturbations, the mechanical forces separating Drosophila microtubule asters are revealed.

Magazine

  1. Cartoon figures of various people working in research as they sit or stand on a cartoon brains with items reflecting the diversity of activities in academia. Vicky Bowskill (CC BY-NC-ND 4.0)

    Being Neurodivergent in Academia

    Edited by Elsa Loissel et al.