June 2025

Research articles

1. 1. Microbiology and Infectious Disease

   RBMX2: A Pivotal Regulator Linking Mycobacterium bovis Infection to Epithelial-Mesenchymal Transition and Lung Cancer Progression

   Chao Wang, Yongchong Peng ... Yingyu Chen
2. 1. Neuroscience

   Perinatal environmental enrichment affects murine neonates’ brain structure before their active engagement with environment

   Malte S Kaller, Clémence Ligneul ... Jason P Lerch
3. 1. Neuroscience

   Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

   Matthew Davenport, Ha Na Choe ... Erich Jarvis

   Hormonal manipulation, laser microdissection, and bulk RNA sequencing indicate that Z chromosome dosage in the brain region HVC during development regulates the subsequent sexually dimorphic transcriptional specialization of zebra finch song nuclei.
4. 1. Biochemistry and Chemical Biology

   Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

   Prateeka Borar, Tapan Biswas ... Smarajit Polley

   Autocatalytic dual specificity of kinase IKK2/β, a Serine/Threonine kinase, is important for its substrate phosphorylation activity through an uncommon phosphorelay mechanism.
5. 1. Neuroscience

   Effects of experiencing the COVID-19 pandemic on optimistically biased belief updating

   Iraj Khalid, Orphee Morlaas ... Liane Schmidt

   Exposure to a real-life adversity, such as the COVID-19 pandemic, reduced the optimism bias typically observed in belief updating about future life events, shifting behavior toward more rational, Bayesian-like learning.
6. 1. Computational and Systems Biology

   Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

   David Dierks, Ran Shachar ... Schraga Schwartz

   A quantitative model explains intra- and intercellular changes in m6A gene methylation as passive consequences of mRNA metabolism.
7. 1. Immunology and Inflammation

   CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration

   Zhiyuan Wu, Lindi Liu ... Xiaodong Tan

   CD131 contributes to intestinal inflammation in ulcerative colitis, possibly by promoting the infiltration of macrophages, while targeting CD131 might potentially be a treatment remedy for ulcerative colitis.
8. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

   Laura Sophie Kremer, Guanbin Gao ... Nils-Göran Larsson

   Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.
9. 1. Developmental Biology

   Evolution of lateralized gustation in nematodes

   Marisa Mackie, Vivian Vy Le ... Ray L Hong

   A comparison of how two nematode species sense salts highlights how evolution can find different ways to establish asymmetry in small nervous systems to optimize the processing of chemosensory cues.
10. 1. Structural Biology and Molecular Biophysics

    Expanding automated multiconformer ligand modeling to macrocycles and fragments

    Jessica Flowers, Nathaniel Echols ... Stephanie A Wankowicz

    qFit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).
11. 1. Neuroscience

    Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    Adam Glaser, Jayaram Chandrashekar ... Karel Svoboda

    Large-scale microscopy combined with tissue clearing and expansion enables nanoscale imaging of centimeter scale specimens.
12. 1. Neuroscience

    When do measured representational distances reflect the neural representational geometry?

    Veronica Bossio Botero, Nikolaus Kriegeskorte
13. 1. Epidemiology and Global Health

    Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis

    Pablo Ruiz Cuenca, Fabio Neves Souza ... Emanuele Giorgi
14. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

    Céline Fombellida-Lopez, Aurelija Valaitienė ... Gilles Darcis
15. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
16. 1. Neuroscience
    2. Computational and Systems Biology

    Individuality transfer: Predicting human decision-making across tasks

    Hiroshi Higashi
17. 1. Microbiology and Infectious Disease

    SIRT2 protects against Japanese encephalitis virus infection in mice

    Perumal Arumugam Desingu, Lavanya Dindi ... Nagalingam R Sundaresan
18. 1. Evolutionary Biology

    Species biology and demographic history determines species vulnerability to climate change in tropical island endemic birds

    Ratnesh Karjee, Vikram Iyer ... Balaji Chattopadhyay
19. 1. Cancer Biology

    Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

    Cassandra C Taber, Wenguang He ... Michael Ohh
20. 1. Neuroscience

    Neurons throughout the brain embed robust signatures of their anatomical location into spike trains

    Gemechu Bekele Tolossa, Aidan M Schneider ... Keith B Hengen

    Machine learning analysis reveals that individual neurons throughout the brain embed information about their anatomical location in their spike trains, a feature that generalizes across animals, experimental conditions, and laboratories.
21. 1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates

    Samantha J Ziegler, Brandon C Knott ... Yannick J Bomble

    Understanding the dynamics of AdhE enzymes is essential to be able to control the metabolic and energy fluxes in microorganisms used to produce biofuels and biochemicals.
22. 1. Genetics and Genomics
    2. Evolutionary Biology

    Divergent C. elegans toxin alleles are suppressed by distinct mechanisms

    Stefan Zdraljevic, Laura Walter-McNeill ... Leonid Kruglyak
23. 1. Genetics and Genomics
    2. Evolutionary Biology

    Minus the Error: Testing for Positive Selection in the Presence of Residual Alignment Errors

    Avery Selberg, Nathan L Clark ... Sergei L Kosakovsky Pond
24. 1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Functionally-Coupled Ion Channels Begin Co-assembling at the Start of Their Synthesis

    Roya Pournejati, Jessica M Huang ... Oscar Vivas
25. 1. Cell Biology

    FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall

    Jewel T-Y Li, Mehdi Amiri ... Wayne S Sossin
26. 1. Medicine

    Serum, Cell-Free, HPV-Human DNA Junction Detection and HPV Typing for Predicting and Monitoring Cervical Cancer Recurrence

    Anne Van Arsdale, Olga Mescheryakova ... Jack Lenz
27. 1. Cell Biology

    Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

    Hannah Neiswender, Rajalakshmi Veeranan-Karmegam ... Graydon B Gonsalvez
28. 1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
29. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ADMA-histones play a crucial role in the initial recognition of dual-strand piRNA cluster regions by Rhino

    Raku Saito, Hirotsugu Ishizu ... Mikiko C Siomi
30. 1. Biochemistry and Chemical Biology

    Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

    Jia He, Bo Chen ... Zhao Shan
31. 1. Cell Biology

    Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation

    Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz

    Focal adhesion derived p130Cas condensates regulate translation in an adhesion strength dependent manner.
32. 1. Cancer Biology
    2. Medicine

    Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan

    Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.
33. 1. Physics of Living Systems

    The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients

    Majid Malboubi, Mohammad Hadi Esteki ... Guillaume Charras
34. 1. Genetics and Genomics

    WRN and WRNIP1 ATPases impose high fidelity on translesion synthesis by Y-family DNA polymerases

    Jung-Hoon Yoon, Karthi Sellamuthu ... Satya Prakash
35. 1. Developmental Biology

    Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas Foxg1 represses an electrosensory fate

    Martin Minařík, Alexander S Campbell ... Clare VH Baker
36. 1. Evolutionary Biology

    mirror determines the far posterior domain in butterfly wings

    Martik Chatterjee, Xin Yi Yu ... Robert D Reed

    The selector gene mirror defines the far posterior wing domain in butterflies, revealing how ancestral axial subdivisions have been evolutionarily reduced in Drosophila.
37. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

    Cheryll M Sia, Rebecca L Ambrose ... Danielle J Ingle

    The most comprehensive analysis of Salmonella Dublin to date uncovers distinct genotypic adaptations, antimicrobial resistance patterns, and virulence strategies that influence epidemiological success.
38. 1. Neuroscience

    Learning and cognition in highspeed decision making

    Martin Krause, Wolfram Schulze, Stefan Schuster

    Studying a decision in archerfish reveals an impressive potential of learning capacities and cognitive aspects that are unexpected for decisions made at reflex speed.
39. 1. Neuroscience

    Investigating working memory updating processes of the human subcortex using 7T MRI

    Anne C Trutti, Zsuzsika Sjoerds ... Birte U Forstmann

    Neuroimaging evidence enhances understanding of the subcortex’s role in the neural mechanisms of working memory updating, providing new insights into midbrain function.
40. 1. Cell Biology
    2. Microbiology and Infectious Disease

    Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

    Lan Yao, Wanwan Zhang ... Kuntong Jia

    MYL3 is identified as a novel receptor enabling nervous necrosis virus (NNV) entry via macropinocytosis, revealing a therapeutic target for combating NNV outbreaks in aquaculture.
41. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tissue-resident memory CD4⁺ T cells are sustained by site-specific levels of self-renewal and continuous replacement

    Jodie Chandler, M Elise Bullock ... Andrew J Yates

    Memory CD4 T cells within tissues are highly dynamic, and their continuous replacement may erode immunity to previous infections.
42. 1. Neuroscience

    Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output

    Nirvik Sinha, Sharon Israely ... Yifat Prut

    Reversible cerebellar disruption in non-human primates reveals an acute muscle torque deficit and an adaptive slowing strategy to manage limb dynamics, underscoring distinct primary, and compensatory mechanisms underlying motor impairment.
43. 1. Physics of Living Systems

    Role of intercellular adhesion in modulating tissue fluidity

    Soumyadipta Ray, Santidan Biswas, Dipjyoti Das
44. 1. Neuroscience

    Gamma Synchrony Mediates Figure-Ground Perception

    Maryam Karimian, Mark J Roberts ... Mario Senden
45. 1. Cell Biology

    SMC5/6-Mediated Plasmid Silencing is Directed by SIMC1-SLF2 and Antagonized by LT

    Martina Oravcová, Minghua Nie ... Michael N Boddy
46. 1. Computational and Systems Biology
    2. Physics of Living Systems

    Designing biochemical circuits with tree search

    Pranav S Bhamidipati, Matthew Thomson
47. 1. Neuroscience

    Midbrain somatostatin-expressing cells control pain-suppression during defensive states

    Nanci Winke, Frank Aby ... Cyril Herry
48. 1. Neuroscience

    Distinct neural bases of subcomponents of the attentional blink

    Swagata Halder, Deepak Velgapuni Raya, Devarajan Sridharan

    The attentional blink selectively impairs one component of attention, and impacts both target detection and discrimination via separable neural signatures.
49. 1. Cell Biology
    2. Neuroscience

    CellSeg3D, Self-supervised 3D cell segmentation for fluorescence microscopy

    Cyril Achard, Timokleia Kousi ... Mackenzie Weygandt Mathis

    Self-supervised deep learning models can accurately perform 3D segmentation of cell nuclei in complex biological tissues, enabling scalable analysis in settings with limited or no ground truth annotations.
50. 1. Neuroscience

    Group identification drives brain integration for collective performance

    Enhui Xie, Shuyi Zha ... Xianchun Li

    Group identification enhances collective performance through increased individual brain activation in the dorsolateral prefrontal cortex and neural synchronization in the orbitofrontal cortex, with connectivity between these regions linking individual and group decision-making processes.
51. 1. Neuroscience

    Neural dynamics of visual working memory representation during sensory distraction

    Jonas Karolis Degutis, Simon Weber ... John-Dylan Haynes

    Dynamic shifts in neural coding combined with stable population subspaces enable visual areas to concurrently represent sensory inputs and working memory without mutual interference.
52. 1. Neuroscience

    TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

    Christopher Nass Rudzitis, Monika Lakk ... David Krizaj

    The TRPV4 channel was identified as an obligatory regulator of physiological and pathological increases in intraocular pressure.
53. 1. Neuroscience

    Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism

    Cecilia Tubert, Rodrigo Manuel Paz ... Mario Gustavo Murer

    Restoring the Kv1-mediated pause in striatal cholinergic interneurons by reducing D5 receptor activity may help recover striatal function lost in dyskinetic parkinsonian mice.
54. 1. Cell Biology

    Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli

    Alexandros Papagiannakis, Qiwei Yu ... Christine Jacobs-Wagner

    Polysome formation within the nucleoid and repulsion between these major cytoplasmic components provide a self-organizing mechanism for chromosome segregation and modulation of its timing across growth rates in Escherichia coli.
55. 1. Neuroscience

    Sigh generation in preBötzinger complex

    Yan Cui, Evgeny Bondarenko ... Jack L Feldman

    Activation of NMB/GRP receptors is not necessary for sigh generation, while SST preBötC neurons are critical for generation of sighs.
56. 1. Cell Biology

    The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

    Yutaro Hama, Yuko Fujioka ... Nobuo N Noda

    AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.
57. 1. Immunology and Inflammation

    Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

    Nobuyuki Nosaka, Vanessa Borges ... Kenichi Shimada

    Therapeutic hypothermia mitigates ventilator-induced lung injury by suppressing macrophage-derived IL-1β release, thereby reducing neutrophil extracellular trap formation, vascular leakage, and hypoxemia in a two-hit acute lung injury model.
58. 1. Microbiology and Infectious Disease

    HIV-specific CD8+ T-cell responses soon after treatment initiation during acute HIV infection are associated with viral reservoir decline

    Pien M van Paassen, Alexander O Pasternak ... the Netherlands Cohort Study on Acute HIV Infection (NOVA) study team
59. 1. Developmental Biology
    2. Neuroscience

    FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrain

    Rosanna CG Smith, Maryam Clark ... Stephen R Price
60. 1. Neuroscience

    Hyperpolarized ¹³C metabolic imaging detects long-lasting metabolic alterations following mild repetitive traumatic brain injury

    Caroline Guglielmetti, Kai Qiao ... Susanna Rosi
61. 1. Neuroscience

    Inhibitory circuits generate rhythms for leg movements during Drosophila grooming

    Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
62. 1. Neuroscience

    Dynamic fMRI networks of emotion

    Niels Janssen, Uriel KA Elvira ... Theo GM van Erp
63. 1. Cell Biology
    2. Neuroscience

    Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

    Javier Emperador-Melero, Steven J Del Signore ... Avital A Rodal
64. 1. Ecology
    2. Evolutionary Biology

    Weak evidence for heritable changes in response to selection by aphids in Arabidopsis accessions

    Marc W Schmid, Klara Kropivšek ... Ueli Grossniklaus
65. 1. Neuroscience

    A direct neural signature of serial dependence in working memory

    Cora Fischer, Jochen Kaiser, Christoph Bledowski

    Magnetoencephalographic recordings revealed a direct neural signature of serial dependence, that is, an attractive bias of current toward previous representations, which emerged at late, post-encoding stages of processing in working memory.
66. 1. Neuroscience

    Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

    Zhengming Tian, Yuning Li ... Jia Liu

    Exosomal mRNA transfer from non-neuronal cells to neurons under hypoxia drives hemoglobin expression and preserves mitochondrial homeostasis as an intercellular protective mechanism.
67. 1. Neuroscience
    2. Physics of Living Systems

    The geometry and dimensionality of brain-wide activity

    Zezhen Wang, Weihao Mai ... Quan Wen

    Neural activity patterns in randomly sampled neuron groups statistically match whole-brain dynamics, revealing a scale-invariant organizational principle that enables robust and efficient computation across brain regions and species.
68. 1. Microbiology and Infectious Disease

    Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis

    Xingye Wang, Jie Wang ... Beinan Wang

    Streptococcus suis enhances its pathogenicity by dynamically expressing capsular polysaccharides.
69. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman

    Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.
70. 1. Neuroscience

    Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex

    Eun Hye Park, Kally C O'Reilly Sparks ... André A Fenton

    Rodent medial prefrontal cortex is not crucial for an active place avoidance task requiring cognitive control evidenced by hippocampal activity that purposefully alternates between task-relevant and task-irrelevant representations of the environment.
71. 1. Neuroscience

    Synaptic connectivity of sensorimotor circuits for vocal imitation in the songbird

    Massimo Trusel, Ziran Zhao ... Todd F Roberts

    Optogenetic circuit mapping identifies the synaptic connectivity of input/output pathways in the songbird premotor region HVC, providing a basis for understanding information flow through brain circuits for song.
72. 1. Microbiology and Infectious Disease

    Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

    Sourav Banerjee, Nicola Minshall ... Mark Carrington
73. 1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR

    Yan Zhang, Jingwan Han ... Zhihu Zhao

    HiCapR uncovers HIV RNA homodimers and long-range interactions that show structural dynamics critical for viral packaging and assembly.
74. 1. Computational and Systems Biology
    2. Neuroscience

    Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches

    Gabriel Wainstein, Christopher J Whyte ... James M Shine

    Phasic neuromodulatory bursts actively drive adaptive perceptual updating by triggering large-scale brain network reconfigurations, as demonstrated through integrated pupillometry, fMRI, and computational modelling.
75. 1. Neuroscience

    Homosensory and heterosensory dishabituation engage distinct circuits in Drosophila

    Alexandros Charonitakis, Sofia Pasadaki ... Efthimios MC Skoulakis
76. 1. Microbiology and Infectious Disease

    Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages

    Shuai Ma, Bin Yang ... Lingyan Jiang

    Salmonella orchestrates synergistic exploitation of host- and bacterial-derived β-alanine enhancing ZnuABC-mediated zinc assimilation to drive intracellular replication and systemic infection.
77. 1. Microbiology and Infectious Disease

    Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

    Hang Li, Shengwei Ji ... Xuenan Xuan

    The potential of repurposing cipargamin for treating Babesia species offers both theoretical advancements and practical applications in combating parasitic infections.
78. 1. Cell Biology

    Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis

    Marisa J Brothwell, Guoshen Cao ... Katsuhiko Funai
79. 1. Medicine

    Addressing cultural and knowledge barriers to enable preclinical sex inclusive research

    Brianna N Gaskill, Benjamin Phillips ... Natasha A Karp
80. 1. Developmental Biology
    2. Neuroscience

    In mice, discrete odors can selectively promote the neurogenesis of sensory neuron subtypes that they stimulate

    Kawsar Hossain, Madeline Smith ... Stephen W Santoro

    The neurogenesis rates of some olfactory sensory neuron subtypes are selectively accelerated in mice that are exposed to odors that stimulate those subtypes.
81. 1. Cancer Biology

    A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

    Kailai Li, Junyi Liang ... Hui Meng

    A machine learning-derived multi-gene score effectively predicts radiation sensitivity in nasopharyngeal carcinoma by integrating immune characteristics and radiosensitivity-related pathways.
82. 1. Developmental Biology

    Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

    Akiko Hozumi, Nozomu M Totsuka ... Yasunori Sasakura

    Ascidian larvae use cAMP as the molecular timer to infer the timing initiating metamorphosis.
83. 1. Neuroscience

    A causal role of the NMDA receptor in recurrent processing during perceptual integration

    Samuel Noorman, Timo Stein ... Simon van Gaal

    Memantine selectively improves neural decoding of attended illusory contours, revealing NMDA receptor-dependent enhancement of feedback processing in human visual perception.
84. 1. Immunology and Inflammation

    Trained immunity: A new player in cancer immunotherapy

    Shu Li, Yi Zou ... Jun Yan

    Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.
85. 1. Stem Cells and Regenerative Medicine

    Glycogen Engineering Improves the Starvation Resistance of Mesenchymal stem cells and their Therapeutic Efficacy in Pulmonary Fibrosis

    Yongyue Xu, Mamatali Rahman ... Qiong Wu
86. 1. Structural Biology and Molecular Biophysics

    Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty-acyltransferase

    Wenjie W Zeng, Garrison Komaniecki ... Yuxin Mao
87. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
88. 1. Neuroscience

    Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease

    Julia J van Adrichem, Rolinka J van der Loo ... Ronald E van Kesteren
89. 1. Neuroscience

    SpikeMAP: An unsupervised spike sorting pipeline for cortical excitatory and inhibitory neurons in high-density multielectrode arrays with ground-truth validation

    Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
90. 1. Cell Biology

    Altair-LSFM: A High-Resolution, Easy-to-Build Light-Sheet Microscope for Sub-Cellular Imaging

    John Haug, Seweryn Gałecki, Kevin M Dean
91. 1. Microbiology and Infectious Disease

    A SHERLOCK toolbox for the eco-epidemiological surveillance of animal African trypanosomosis reveals a similar parasite diversity in domestic pigs in two ancient sleeping sickness foci in Western Africa

    Roger-Junior Eloiflin, Elena Pérez-Antón ... Brice Rotureau
92. 1. Cell Biology
    2. Neuroscience

    Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

    Masaya Muramoto, Nozomi Hanawa ... Natsuki Shinoda

    Subcellular sequestration of caspase near membrane-associated proteins enables its non-lethal activation, which modulates neuronal function and innate olfactory behavior in the adult Drosophila olfactory receptor neurons.
93. 1. Stem Cells and Regenerative Medicine

    PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

    José Antonio Valer, Alexandre Deber ... Francesc Ventura

    PI3Kα inhibitors show promise as therapeutic agents for the treatment of heterotopic ossification.
94. 1. Cancer Biology

    Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

    Xin Zhang, Guangyu Zhang ... Chunjie Liu

    iCAF-mediated immune escape and promoted tumor angiogenesis via VEGFA/B-VEGFR1 pathway indicate that a combination of immunotherapies and anti-angiogenic targeted therapy may be effective for H. pylori infection-associated gastric cancer.
95. 1. Developmental Biology

    Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

    Joseph Hanna, Yacine Touahri ... Carol Schuurmans

    Transgenic and pharmacological approaches reveal developmental elevations in glycolytic flux have an instructive role in promoting rod photoreceptor differentiation and maturation via activation of Wnt signaling.
96. 1. Neuroscience

    A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality

    Seetha Krishnan, Can Dong ... Mark Sheffield

    A novel virtual reality-based contextual fear conditioning paradigm for head-fixed mice that elicits robust freezing behavior and enables multiphoton imaging of neural circuits underlying learning, memory, and fear.
97. 1. Neuroscience

    The distinct role of human PIT in attention control

    Siyuan Huang, Lan Wang, Sheng He
98. 1. Neuroscience

    Local Inhibitory Dynamics Underpin Temporal Integration and Functional Segregation between Barrels and Septa in the Mouse Barrel Cortex

    Ali Özgür Argunşah, Tevye Jason Stachniak ... Theofanis Karayannis
99. 1. Neuroscience
    2. Computational and Systems Biology

    Biologically informed cortical models predict optogenetic perturbations

    Christos Sourmpis, Carl CH Petersen ... Guillaume Bellec
100. 1. Plant Biology

     Archaeological Bolivian maize genomes suggest Inca cultural expansion augmented maize diversity in South America

     Huan Chen, Amy Baetsen-Young ... Gabriel Wrobel
101. 1. Neuroscience

     Behavioural and neurogenetic evidence for emotion primitives in the fruit fly Drosophila: insights from the Open Field Test

     Yi Lueningschroer-Wang, Emilia Derksen ... Christian Wegener
102. 1. Neuroscience

     Cross-species Standardised Cortico-Subcortical Tractography

     Stephania Assimopoulos, Shaun Warrington ... Stamatios N Sotiropoulos
103. 1. Neuroscience

     Morphology and ultrastructure of external sense organs of Drosophila larvae

     Vincent Richter, Anna Rist ... Andreas S Thum

     Advanced electron microscopy techniques have been applied to comprehensively describe the cellular details and ultrastructural characteristics of all sensilla within the external sensory system of Drosophila larvae.
104. 1. Microbiology and Infectious Disease

     Stumpy forms are the predominant transmissible forms of Trypanosoma brucei

     Jean Marc Tsagmo Ngoune, Parul Sharma ... Brice Rotureau

     According to experimental and field observations, stumpy forms appear to be the most adapted forms for African trypanosome transmission from the mammalian host to the tsetse fly in natural conditions.
105. 1. Neuroscience

     Four individually identified paired dopamine neurons signal taste punishment in larval Drosophila

     Denise Weber, Katrin Vogt ... Andreas S Thum

     A neurogenetic approach reveals the cellular division of labor between individual Drosophila larval dopaminergic neurons encoding an averive teaching signal, reflecting principles in the adult insect and vertebrate brain.
106. 1. Neuroscience

     Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences

     Toshitake Asabuki, Tomoki Fukai

     Biologically plausible synaptic plasticity rules enable recurrent neural networks to spontaneously replay sensory experiences with appropriate probabilistic structure.
107. 1. Immunology and Inflammation
     2. Microbiology and Infectious Disease

     CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

     Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell

     During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.
108. 1. Developmental Biology
     2. Neuroscience

     Microglia are required for developmental specification of AgRP innervation in the hypothalamus of offspring exposed to maternal high-fat diet during lactation

     Haley N Mendoza-Romero, Jessica E Biddinger ... Richard Simerly

     Hypothalamic microglia play an essential role in mediating changes to feeding circuitry caused by exposure to maternal HFD that may contribute to developmental programming of metabolic phenotype.
109. 1. Developmental Biology
     2. Physics of Living Systems

     Spectral decomposition unlocks ascidian morphogenesis

     Joel Dokmegang, Emmanuel Faure ... Madhav Mani

     The blueprint and narrative of shape formation during early development can be objectively observed by quantifying and analyzing whole-embryo dynamics.
110. 1. Computational and Systems Biology
     2. Neuroscience

     A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm

     Sara Z Mehrhof, Camilla L Nord

     Individuals with a late circadian rhythm show the same deficits in motivational decision-making as those with neuropsychiatric symptoms, but only when tested in the morning.
111. 1. Neuroscience

     Rate of brain aging associates with future executive function in Asian children and older adults

     Susan F Cheng, Wan Lin Yue ... Juan Helen Zhou

     A longitudinal, deep learning approach reveals challenges and opportunities in establishing brain age as an effective metric of aging, with particular consideration given to underrepresented populations in Asia.
112. 1. Biochemistry and Chemical Biology

     Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening

     Han Zhou, Tonglian Zhou ... Michael J Bollong

     A high-throughput chemical screen identifies ligands of the Kelch domain of E3 ligase KLHDC2 capable of being modified as proteolysis-targeting chimeras.
113. 1. Immunology and Inflammation

     Susceptibility of Kit-mutant mice to sepsis caused by enteral dysbiosis, not mast cell deficiency

     Thorsten B Feyerabend, Fabienne Schochter ... Hans-Reimer Rodewald
114. 1. Genetics and Genomics

     Independent Validation of Transgenerational Inheritance of Learned Pathogen Avoidance in Caenorhabditis elegans

     Aalimah Akinosho, Joseph Alexander ... Andrés Vidal-Gadea
115. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

     David W Wolfson, Joshua A Hull ... Kenneth D Poss
116. 1. Epidemiology and Global Health

     Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study

     Fernanda Morales-Berstein, Jasmine Khouja ... Rebecca C Richmond
117. 1. Neuroscience

     Neural substrates of cold nociception in Drosophila larva

     Atit A Patel, Albert Cardona, Daniel N Cox

     Functional neural circuit dissection identifies sensorimotor responses to noxious cold in Drosophila larvae revealing complex mechanisms by which nervous systems sense and respond to cold.
118. 1. Neuroscience

     Precise spatial tuning of visually driven alpha oscillations in human visual cortex

     Kenichi Yuasa, Iris IA Groen ... Jonathan Winawer

     Separating alpha oscillations from broadband activity reveals that alpha suppression in the human visual cortex is highly localized, and modulates cortical state in a manner consistent with exogenous spatial attention.
119. 1. Neuroscience

     Fingertip viscoelasticity enables human tactile neurons to encode loading history alongside current force

     Hannes P Saal, Ingvars Birznieks, Roland S Johansson

     Fingertip tactile neurons collectively encode the skin's viscoelastic state alongside current touch, potentially enabling the brain to better interpret forces during manipulation.
120. 1. Neuroscience

     A multiplex of connectome trajectories enables several connectivity patterns in parallel

     Parham Mostame, Jonathan Wirsich ... Sepideh Sadaghiani

     Parallel connectome trajectories unfold asynchronously across timescales, sustaining a multiplex of functionally distinct brain networks operating at different speeds.
121. 1. Developmental Biology

     BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

     Guozhu Ning, Yu Lin ... Qiang Wang

     BCAS2 directly binds to the Armadillo repeats 9–12 of β-catenin via the coiled-coil domains, sequestering β-catenin within the nucleus and thereby promoting Wnt signaling during primitive hematopoiesis.
122. 1. Computational and Systems Biology

     Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra

     Namrata Bhattacharya, Anja Rockstroh ... Debarka Sengupta

     SCellBOW is a language model-based scRNA-seq analysis method that identifies malignant cell subpopulations and infers marker-free survival risks using transfer learning.
123. 1. Neuroscience

     Low-Frequency Tibial Neuromodulation Increases Voiding Activity - a Human Pilot Study and Computational Model

     Aidan McConnell-Trevillion, Milad Jabbari ... Kianoush Nazarpour
124. 1. Immunology and Inflammation

     Layers of immunity: Deconstructing the Drosophila effector response

     Faustine Ryckebusch, Yao Tian ... Bruno Lemaitre
125. 1. Microbiology and Infectious Disease

     The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

     Ayaka Itani, Haruto Motomura ... Norio Takeshita
126. 1. Cell Biology
     2. Developmental Biology

     BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD

     Uyen Tran, Andrew J Streets ... Oliver Wessely
127. 1. Cell Biology

     CCDC32 stabilizes clathrin-coated pits and drives their invagination

     Ziyan Yang, Changsong Yang ... Zhiming Chen
128. 1. Computational and Systems Biology

     A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging

     Sergiy Libert, Alex Chekholko, Cynthia Kenyon

     A model was developed to predict human biological age from physiological traits, enabling the prediction of future health and mortality and the identification of genetic loci that influence aging.
129. 1. Neuroscience

     Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity

     Toshitake Asabuki, Claudia Clopath

     A computational model shows how synaptic plasticity shapes spontaneous activity to encode the transition statistics of sensory experience.
130. 1. Neuroscience

     Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI

     Joonas A Autio, Ikko Kimura ... Takuya Hayashi

     Ferumoxytol-enhanced MRI enables high-resolution, laminar mapping of cerebral blood volume in the primate brain, validating core neurovascular features and advancing noninvasive tools for neurometabolic imaging.
131. 1. Developmental Biology

     Single cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l

     Chen-wei Hsu, Ho Hao ... Bon-Chu Chung
132. 1. Microbiology and Infectious Disease

     Caffeic acid phenethyl ester protects Clostridioides difficile infection by toxin inhibition and microbiota modulation

     Yan Guo, Yong Zhang ... Jiazhang Qiu

     Caffeic acid phenethyl ester treats Clostridioides difficile infection by neutralizing Clostridioides difficile toxin B and altering the gut microbiota and metabolites.
133. 1. Cell Biology
     2. Genetics and Genomics

     Kinesin-2 autoinhibition requires elbow phosphorylation

     Guanghan Chen, Zhengyang Guo ... Guangshuo Ou

     Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
134. 1. Epidemiology and Global Health

     A sex-specific Mendelian randomization-phenome-wide association study of body mass index

     Zhu Liduzi Jiesisibieke, Io Ieong Chan ... C Mary Schooling

     Higher body mass index has a wide range of harmful health effects, which sometimes appear to be more pronounced in men, suggesting that higher BMI may be one of the factors contributing to differences in lifespan between men and women.
135. 1. Cancer Biology
     2. Cell Biology

     RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

     Junjun Huang, Rong Jia, Jihua Guo

     Upregulated by HOXA10, RUNX2 isoform II transactivates PRDX2 expression and inhibits ferroptosis and apoptosis in oral squamous cell carcinoma.
136. 1. Evolutionary Biology

     Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)

     Kip D Lacy, Jina Lee ... Daniel JC Kronauer
137. 1. Genetics and Genomics
     2. Computational and Systems Biology

     Systematic analysis of transcription factor combinatorial binding uncovers TEAD1 as an antagonist of tissue-specific transcription factors in human organogenesis

     Araceli Garcia-Mora, Joshua Mallen ... Nicoletta Bobola
138. 1. Neuroscience

     Hatching with Numbers: Pre-natal Light Exposure Affects Number Sense and the Mental Number Line in young domestic chicks

     Rosa Rugani, Matteo Macchinizzi ... Lucia Regolin
139. 1. Cell Biology
     2. Genetics and Genomics

     Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

     San Pin Steve Wu, Elvis Quiroz ... Francesco J DeMayo

     Genome-wide epigenetic profiling reveals chromatin regions in the human myometrium involved in functional regulation and hormonal control during pregnancy.
140. 1. Neuroscience

     Human brain ancestral barcodes

     Darryl Shibata

     A dynamic DNA methylation 'barcode' on the X chromosome can distinguish thousands of individual adult male neurons and may record aspects of their development.
141. 1. Developmental Biology
     2. Neuroscience

     Activity-dependent synapse elimination requires caspase-3 activation

     Zhou Yu, Andrian Gutu ... Erin K O'Shea

     Caspase-3 activation links synapse weakening to synapse elimination.
142. 1. Developmental Biology
     2. Neuroscience

     A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord

     Jelly HM Soffers, Erin Beck ... Haluk Lacin

     A temporally stable and cell-type-specific genetic driver library provides the means to access and manipulate neuronal lineages in the fly nervous system during development and adulthood.
143. 1. Physics of Living Systems

     Theory of non-dilute binding and surface phase separation applied to membrane-binding proteins

     Xueping Zhao, Daxiao Sun ... Christoph A Weber
144. 1. Neuroscience

     Material Damage to Multielectrode Arrays after Electrolytic Lesioning is in the Noise

     Alice Tor, Stephen E Clarke ... the Brain Interfacing Laboratory
145. 1. Neuroscience

     Neuroanatomical foundations of social tolerance across macaque species

     Sarah Silvère, Julien Lamy ... Sebastien Ballesta
146. 1. Neuroscience

     Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

     Yevheniia Ishchenko, Amanda T Jeng ... Anthony J Koleske

     Heterozygosity for Trio variants leads to overlapping but distinct impacts on behavior, neuronal structure, and synaptic transmission, including newly characterized defects in presynaptic function.
147. 1. Epidemiology and Global Health

     Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar

     Hiam Chemaitelly, Houssein H Ayoub ... Laith J Abu-Raddad

     A pronounced and consistent healthy vaccinee effect has been identified in rigorously conducted vaccine effectiveness studies, specifically within the first 6 months post-vaccination and among older or clinically vulnerable individuals, likely driven by lower vaccination rates among severely ill populations.
148. 1. Genetics and Genomics

     Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression

     Shengze Yao, Yesu Jeon ... Jeannie T Lee

     Xist RNA’s influence extends beyond the X-chromosome and its autosomal influence can be perturbed genetically and pharmacologically.
149. 1. Developmental Biology

     Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

     Pengzhen Dong, Yue Li ... Hai Huang

     Long-range communication between neighboring organs orchestrates the disciplined migration of stem cells.
150. 1. Developmental Biology

     Oviductin sets the species-specificity of the mammalian zona pellucida

     Daniel de la Fuente, Maria Maroto ... Alfonso Gutierrez-Adan

     The oocyte zona pellucida needs to interact with an oviduct protein called OVGP1 to ensure that only sperm from the same species can fertilize the egg.
151. 1. Neuroscience

     Modeling flexible behavior with remapping-based hippocampal sequence learning

     Yoshiki Ito, Taro Toyoizumi
152. 1. Neuroscience

     Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns

     F David Wandler, Benjamin K Lemberger ... James M Murray
153. 1. Neuroscience

     The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms

     Colin Bredenberg, Fabrice Normandin ... Guillaume Lajoie
154. 1. Neuroscience

     Trial-level Representational Similarity Analysis

     Shenyang Huang, Cortney M Howard ... Simon W Davis
155. 1. Cell Biology

     Clearance of protein aggregates during cell division

     Shoukang Du, Yuhan Wang ... Ting Gang Chew

     ER aggregates confined in the nucleus are cleared via ER reorganization when cells progress through mitosis and cytokinesis.
156. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     A general mechanism for initiating the bacterial general stress response

     Rishika Baral, Kristin Ho ... Niels Bradshaw

     A coiled-coil-based transduction mechanism is identified for a serine/threonine phosphatase that controls a bacterial stress response, suggesting that phosphatases are part of a modularly exchangeable toolkit for bacterial signaling.
157. 1. Neuroscience

     Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles

     Lizi Zhang, Yishan Qu ... Fa-Dao Tai

     In male mandarin voles, D1 and D2 medium spiny neurons within the nucleus accumbens shell exert distinct influences on pair bond formation.
158. 1. Evolutionary Biology
     2. Genetics and Genomics

     Upstream open reading frames buffer translational variability during Drosophila evolution and development

     Yuanqiang Sun, Yuange Duan ... Jian Lu

     Upstream open reading frames (uORFs) function as regulatory elements that buffer translation variability, stabilizing protein expression across animal developmental stages and evolutionary timescales.
159. 1. Medicine

     The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

     Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
160. 1. Chromosomes and Gene Expression

     Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

     Haihui Zhang, Zhengyang Lei ... Peiwu Qin
161. 1. Structural Biology and Molecular Biophysics

     The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides

     Elena Spinetti, G Elif Karagöz, Roberto Covino
162. 1. Ecology

     Assessing plant phenological changes based on drivers of spring phenology

     Yong Jiang, Stephen J Mayor ... Qing-Lai Dang
163. 1. Medicine
     2. Computational and Systems Biology

     Calibration and validation strategy for electromechanical cardiac digital twins

     Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
164. 1. Biochemistry and Chemical Biology

     A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

     Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
165. 1. Neuroscience

     Hierarchy between forelimb premotor and primary motor cortices and its manifestation in their firing patterns

     Akiko Saiki-Ishikawa, Mark Agrios ... Andrew Miri

     During reaching in mice, forelimb premotor cortex has a stronger influence on primary motor cortex than vice versa, but several functional connectivity measures fail to reflect this asymmetry.
166. 1. Microbiology and Infectious Disease

     Chalkophore-mediated respiratory oxidase flexibility controls M. tuberculosis virulence

     John A Buglino, Yaprak Ozakman ... Michael S Glickman

     M. tuberculosis produces a copper binding diisonitrile chalkophore to maintain the copper-dependent respiratory oxidase during infection, identifying a pathogen strategy that defends oxidative phosphorylation against host attack.
167. 1. Neuroscience

     Uncertainty-modulated prediction errors in cortical microcircuits

     Katharina Anna Wilmes, Mihai A Petrovici ... Walter Senn

     A new model of how the brain's circuits compute uncertainty and use it during learning by modulating prediction error responses.
168. 1. Neuroscience
     2. Physics of Living Systems

     Imaging of brain electric field networks with spatially resolved EEG

     Lawrence R Frank, Vitaly L Galinsky ... Antigona Martinez

     A physics-based solution to the electroencephalography (EEG) inverse problem enables whole-brain electric field imaging with high spatial and temporal resolution using standard EEG systems.
169. 1. Computational and Systems Biology

     Dynamical mechanisms of growth-feedback effects on adaptive gene circuits

     Ling-Wei Kong, Wenjia Shi ... Ying-Cheng Lai

     Systematic simulations reveal how growth feedback undermines the stability of adaptive gene circuits in a topology-dependent manner.
170. 1. Neuroscience

     Location- and feature-based selection histories make independent, qualitatively distinct contributions to urgent visuomotor performance

     Emily E Oor, Emilio Salinas, Terrence R Stanford

     During visual search, the choice of where to look next is biased to a remarkable degree by the location and color histories of recently viewed target stimuli.
171. 1. Neuroscience

     Context-dependent modulations of subthalamo-cortical synchronization during rapid reversals of movement direction in Parkinson’s disease

     Lucie Winkler, Markus Butz ... Jan Hirschmann

     Beta synchrony between motor cortex and the subthalamic nucleus is intensified when instructional cues within a continuous motor sequence become less predictable, calling for more cautious behavior.
172. 1. Computational and Systems Biology
     2. Physics of Living Systems

     Overflow metabolism originates from growth optimization and cell heterogeneity

     Xin Wang

     The combination of growth optimization and cell heterogeneity enables a quantitative explanation of overflow metabolism in microbes and the classical Warburg effect in cancer cells, resolving this long-standing puzzle.
173. 1. Plant Biology

     The influence of heavy metal stress on the evolutionary transition of teosinte to maize

     Jonathan Acosta-Bayona, Miguel Vallebueno-Estrada, Jean-Philippe Vielle-Calzada
174. 1. Neuroscience

     A ventral hippocampal-lateral septum pathway regulates social novelty preference

     Maha Rashid, Sarah Thomas ... Malavika Murugan

     Projection-specific optogenetic and chemogenetic experiments reveal a hippocampal-lateral septal pathway that potentially acts via the ventral tegmental area to regulate social novelty preference behaviors.
175. 1. Cancer Biology

     Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

     Yijia Hua, Ningjun Duan ... Yongmei Yin

     Targeting cysteine metabolism could provide novel strategies for treating trastuzumab-resistant HER2-positive breast cancer.
176. 1. Cell Biology
     2. Developmental Biology

     The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice

     Atsuko Kageyama, Narumi Ogonuki ... Junya Ito
177. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

     Janelle JY Chuah, Madalena R Daugherty, David M Smith
178. 1. Microbiology and Infectious Disease
     2. Evolutionary Biology

     High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains

     Caroline Kikawa, Andrea N Loes ... Jesse D Bloom
179. 1. Genetics and Genomics

     Confirmation of HLA-II associations with TB susceptibility in admixed African samples

     Dayna Adrienne Croock, Yolandi Swart ... Caitlin Uren

     A local-ancestry-aware association model identified a suggestive association peak within the HLA class II region linked to TB in a complex, highly admixed Southern African population.
180. 1. Neuroscience

     The role of GABA in semantic memory and its neuroplasticity

     JeYoung Jung, Steve Williams, Matthew A Lambon Ralph

     GABAergic inhibition in the anterior temporal lobe shapes semantic memory and its neuroplasticity through a non-linear relationship, revealing a neurochemical basis for individual differences.
181. 1. Computational and Systems Biology

     Pathway activation model for personalized prediction of drug synergy

     Quang Thinh Trac, Yue Huang ... Trung Nghia Vu

     Drug synergy Interaction Prediction improves personalized drug synergy prediction by utilizing drug-specific pathway activation scores to predict personalized drug synergy and reveals mechanistic pathways underlying synergistic effects.
182. 1. Cell Biology

     HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes

     Hongchen Li, Xinchao Zhang ... Yanping Xu

     Functional analyses reveal the HNF4α-TET2-FBP1 axis as a critical regulator of gluconeogenesis, type 2 diabetes (T2D) progression, and metformin’s therapeutic effects, which proposes TET2 as a promising therapeutic target for T2D.
183. 1. Biochemistry and Chemical Biology

     Daptomycin forms a stable complex with phosphatidylglycerol for selective uptake to bacterial membrane

     Pragyansree Machhua, Vignesh Gopalakrishnan Unnithan ... Zhihong Guo

     The drug-phospholipid interaction is fully elucidated at molecular level as an important part of the mode of action of daptomycin and the mechanism of its resistance in bacterial pathogens.
184. 1. Chromosomes and Gene Expression
     2. Evolutionary Biology

     Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2

     Hisato Kobayashi, Tatsushi Igaki ... Kazuki Kurimoto

     A novel mechanism for the establishment of species-specific imprinting emerged through LTR insertion and post-fertilization activation.
185. 1. Cancer Biology

     Ferroptosis-related genes mediate tumor microenvironment and prognosis in triple-negative breast cancer via integrated RNA-seq analysis

     Xuantong Gong, Lishuang Gu ... Yong Wang

     Integrated single-cell RNA-seq analysis identifies ferroptosis-driven tumor microenvironment features, enabling a prognostic risk model and therapeutic targets to advance precision medicine for triple-negative breast cancer.
186. 1. Cancer Biology
     2. Cell Biology

     Image-based identification and isolation of micronucleated cells to dissect cellular consequences

     Lucian DiPeso, Sriram Pendyala ... Emily M Hatch

     The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
187. 1. Neuroscience

     Chemogenetic stimulation of phrenic motor output and diaphragm activity

     Ethan S Benevides, Prajwal P Thakre ... David D Fuller

     DREADD-mediated activation of phrenic motor output produces sustained increases in diaphragm activity and tidal volume, highlighting a potential strategy to restore breathing in clinical conditions associated with impaired diaphragm activation.
188. 1. Neuroscience

     Otoacoustic emissions but not behavioral measurements predict cochlear nerve frequency tuning in an avian vocal communication specialist

     Diana M Karosas, Leslie Gonzales ... Kenneth S Henry

     Otoacoustic emissions recorded noninvasively from the ear canal accurately predict cochlear frequency tuning in an avian species, in contrast to previously tested classical behavioral methods.