August 2023

Research articles

1. 1. Neuroscience

   Genetically defined nucleus incertus neurons differ in connectivity and function

   Emma D. Spikol, Ji Cheng ... Marnie E. Halpern
2. 1. Neuroscience
   2. Ecology

   Unsupervised discovery of family specific vocal usage in the Mongolian gerbil

   Ralph E Peterson, Aman Choudhri ... Dan H Sanes
3. 1. Neuroscience

   Multi-level processing of emotions in life motion signals revealed through pupil responses

   Tian Yuan, Li Wang, Yi Jiang
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

   Roberto Efraín Díaz, Andrew K. Ecker ... James S. Fraser
5. 1. Neuroscience

   Task-specific invariant representation in auditory cortex

   Charles R. Heller, Gregory R. Hamersky, Stephen V. David
6. 1. Ecology

   Non-visual camouflage predicts hunting success in a wild predator

   Kim Schalcher, Estelle Milliet ... Emily L. C. Shepard
7. 1. Neuroscience

   Social navigation: distance and grid-like codes support navigation of abstract social space in human brain

   Zilu Liang, Simeng Wu ... Chao Liu
8. 1. Microbiology and Infectious Disease

   Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis

   Mariano Maio, Joaquina Barros ... Luciana Balboa
9. 1. Developmental Biology

   The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila CNS

   Sanjay Kumar Sukumar, Vimala Antonydhason ... Ruth H. Palmer
10. 1. Neuroscience

    Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions

    Dániel Veréb, Mite Mijalkov ... Joana B Pereira

    A gradient-based approach is employed to characterize the organization of functional connectivity in the human locus coeruleus, revealing age-related differences and associations with cognitive and affective functions independently from age.
11. 1. Cancer Biology

    Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

    Xiangmudong Kong, Wensheng Yan ... Xinbin Chen

    Mouse model reveals that TAp73γ functions as an oncogene to promote tumorigenesis and alter lipid metabolism by modulating leptin expression.
12. 1. Cell Biology
    2. Chromosomes and Gene Expression

    The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

    Maikel Castellano-Pozo, Georgios Sioutas ... Enrique Martinez-Perez

    Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.
13. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

    Xinle Zou, Sri Karthika Shanmugam ... Henry M Colecraft

    Targeted recruitment of protein kinase A subunits enables distinctive regulation of the functional expression of a potassium channel depending on whether the enzyme is targeted to a pore-forming or auxiliary subunit.
14. 1. Evolutionary Biology

    Selection and the direction of phenotypic evolution

    François Mallard, Bruno Afonso, Henrique Teotónio

    Predicting multivariate phenotypic evolution.
15. 1. Chromosomes and Gene Expression

    A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

    Sana Ahmed-Seghir, Manisha Jalan ... Simon N Powell

    Cells exhibit a localized ATR-dependent DNA damage response to a site-specific stalled replication fork that is distinct from that observed after global replication stress.
16. 1. Neuroscience

    Balancing true and false detection of intermittent sensory targets by adjusting the inputs to the evidence accumulation process

    Anna C Geuzebroek, Hannah Craddock ... Simon P Kelly

    In order to adjust for expected difficulty level while detecting unpredictably timed target within continuous streams of noisy information, people regulate the transfer of the sensory inputs to the accumulation process.
17. 1. Genetics and Genomics
    2. Medicine

    IQCH regulates spermatogenesis by interacting with CaM to promote the expression of RNA-binding proteins

    Tiechao Ruan, Ruixi Zhou ... Ying Shen
18. 1. Medicine
    2. Microbiology and Infectious Disease

    The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

    Hsiao-Fan Chen, Wei-Jan Wang ... Mien-Chie Hung

    Two natural tannins, oligomeric proanthocyanidins and punicalagin, acted as potent inhibitors against SARS-CoV-2 infection, and grape seed extract supplementation could serve as a healthy food for infection prevention.
19. 1. Microbiology and Infectious Disease

    Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

    Somnath Shee, Reshma T Veetil ... Amit Singh

    Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.
20. 1. Cell Biology
    2. Genetics and Genomics

    Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

    Priyanka Das, Alejandro Aballay, Jogender Singh
21. 1. Neuroscience

    Retrieval of developmental social memories requires activation of the adult-born granule cell-CA2 circuit in mice

    Blake J. Laham, Isha R. Gore ... Elizabeth Gould
22. 1. Structural Biology and Molecular Biophysics

    Martinize2 and Vermouth: Unified Framework for Topology Generation

    P C Kroon, F Grunewald ... S J Marrink
23. 1. Structural Biology and Molecular Biophysics

    Ab initio prediction of specific phospholipid complexes and membrane association of HIV-1 MPER antibodies by multi-scale simulations

    Colleen Maillie, Jay Golden ... Marco Mravic
24. 1. Medicine

    PYCR1 Levels Track with Premature and Chronological Skin Aging

    Kortessa Sotiropoulou, Saniye Yumlu ... Bruno Reversade
25. 1. Computational and Systems Biology

    A new pipeline SPICE identifies novel JUN-IKZF1 composite elements

    Peng Li, Sree H. Pulugulla ... Warren J. Leonard
26. 1. Evolutionary Biology

    Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

    Tian Yue, Yongbo Guo ... Bing Su
27. 1. Immunology and Inflammation

    SPOP targets the immune transcription factor IRF1 for proteasomal degradation

    Irene Schwartz, Milica Vunjak ... Gijs A Versteeg

    SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.
28. 1. Genetics and Genomics
    2. Computational and Systems Biology

    DGRPool: A web tool leveraging harmonized Drosophila Genetic Reference Panel phenotyping data for the study of complex traits

    Vincent Gardeux, Roel P.J. Bevers ... Bart Deplancke
29. 1. Neuroscience

    Corticotropin Releasing Factor in the Bed Nucleus of the Stria Terminalis modulates the behavioral consequences of unpredictable threat

    Olivia J. Hon, Meghan E. Flanigan ... Thomas L. Kash
30. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

    Marisa S. Egan, Emily A. O’Rourke ... Sunny Shin
31. 1. Neuroscience

    The songbird lateral habenula projects to dopaminergic midbrain and is important for normal vocal development

    Andrea Roeser, Han Kheng Teoh ... Jesse Goldberg
32. 1. Evolutionary Biology

    Improved inference of population histories by integrating genomic and epigenomic data

    Thibaut Sellinger, Frank Johannes, Aurélien Tellier
33. 1. Cancer Biology

    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

    Fan Sun, Pengrong Yan ... Zhaoxia Qu
34. 1. Cancer Biology

    YAP/TAZ enhance P-body formation to promote tumorigenesis

    Xia Shen, Xiang Peng ... Chen-Ying Liu
35. 1. Neuroscience

    Longitudinal Changes in Value-based Learning in Middle Childhood: Distinct Contributions of Hippocampus and Striatum

    Johannes Falck, Lei Zhang ... Yee Lee Shing
36. 1. Cell Biology

    Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1

    Alice M Budden, Murat Eravci ... Antony M Carr

    Rtf2 is shown to associate with multiple splicing factors and influence splicing of a subset of introns explaining why previous work erroneously assigned it as a replication restart factor in fission yeast.
37. 1. Neuroscience

    Inferential eye movement control while following dynamic gaze

    Nicole Xiao Han, Miguel Patricio Eckstein

    When looking at another person shifting their gaze, humans use the gazer's head direction, velocity, and peripheral visual information to infer potential gaze goals and execute anticipatory eye movements.
38. 1. Epidemiology and Global Health
    2. Medicine

    Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study

    Riku Klén, Ivan A Huespe ... David Gómez-Varela

    The new early warning system, COEWS, will improve the early identification and management of high-risk COVID-19 patients compared to the widely used NEWS2 by using easy-to-obtain clinical parameters that have been externally validated in a diverse multicontinental cohort of patients.
39. 1. Neuroscience

    Determinantal Point Process Attention Over Grid Cell Code Supports Out of Distribution Generalization

    Shanka Subhra Mondal, Steven Frankland ... Jonathan D. Cohen
40. 1. Immunology and Inflammation
    2. Medicine

    Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

    Erin J Ciampa, Padraich Flahardy ... Samir M Parikh

    The role of placental aging and metabolic stress in driving labor onset is demonstrated, with a novel mouse model of preterm labor in which injection of a prolyl hydroxylase inhibitor stabilizes placental hypoxia-inducible factor 1 and significantly shortens gestational length.
41. 1. Neuroscience

    Statistical inference on representational geometries

    Heiko H Schütt, Alexander D Kipnis ... Nikolaus Kriegeskorte

    New methods for statistical inference in representational similarity analysis were developed, tested thoroughly, and are made available in an open-source Python toolbox.
42. 1. Developmental Biology

    Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

    Wilma Tixi, Maricela Maldonado ... Hung Ping Shih

    ECM-Itgb1 signaling and cell-cell adhesion are pivotal and coordinate together to regulate pancreatic islet aggregation, architecture, and functional maturation during development.
43. 1. Developmental Biology

    Identification of quiescent FOXC2⁺ spermatogonial stem cells in adult mammals

    Zhipeng Wang, Cheng Jin ... Wei Song

    The FOXC2⁺ quiescent spermatogonial stem cells are essential for the maintenance of spermatogenesis.
44. 1. Neuroscience

    Using adversarial networks to extend brain computer interface decoding accuracy over time

    Xuan Ma, Fabio Rizzoglio ... Ann Kennedy

    Incorporating cycle-consistency loss into a generative adversarial network creates a high-performance and robust 'aligner' of neural population activity, permitting a fixed intracortical brain computer interface to be used for months without recalibration and without requiring inference of a latent manifold.
45. 1. Evolutionary Biology

    The optimal clutch size revisited: separating individual quality from the costs of reproduction

    Lucy A. Winder, Mirre J.P. Simons, Terry Burke
46. 1. Neuroscience

    Human iPSC-derived Microglia Cells Integrated into Mouse Retina and Recapitulated Features of Endogenous Microglia Cells

    Wenxin Ma, Lian Zhao ... Wei Li
47. 1. Neuroscience

    Midbrain encodes sound detection behavior without auditory cortex

    Tai-Ying Lee, Yves Weissenberger ... Johannes C Dahmen
48. 1. Neuroscience

    A neuronal least-action principle for real-time learning in cortical circuits

    Walter Senn, Dominik Dold ... Mihai A. Petrovici
49. 1. Neuroscience

    Inferring control objectives in a virtual balancing task in humans and monkeys

    Mohsen Sadeghi, Reza Sharif Razavian ... Dagmar Sternad
50. 1. Developmental Biology
    2. Evolutionary Biology

    Coronary artery established through amniote evolution

    Kaoru Mizukami, Hiroki Higashiyama ... Hiroki Kurihara

    During the evolution of amniotes, the transformation of branchial arches coincided with the drastic remodeling of the ancestral extrinsic cardiac arteries, giving rise to novel ventricular coronary arteries that are unique to amniotes.
51. 1. Genetics and Genomics

    Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

    Lucydalila Cedillo, Fasih M Ahsan ... Alexander A Soukas

    Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.
52. 1. Neuroscience

    Functional imaging of conduction dynamics in cortical and spinal axons

    Milos Radivojevic, Anna Rostedt Punga

    Reconstruction of axonal morphologies based on extracellular action potentials enables label-free electrical visualization of axonal conduction trajectories, providing a noninvasive method for functional profiling of cortical and spinal axons.
53. 1. Medicine

    Electronic data review, client reminders, and expanded clinic hours for improving cervical cancer screening rates after the COVID-19 pandemic shutdowns: A multicomponent quality improvement program

    Sue Ghosh, Jackie Fantes ... Rebecca B Perkins

    The largest federally qualified health center in Massachusetts was able to improve cervical cancer screening rates during the COVID-19 pandemic by creating clinical sessions devoted only to screenings.
54. 1. Neuroscience

    Sex-dependent noradrenergic modulation of premotor cortex during decision-making

    Ellen M Rodberg, Carolina R den Hartog ... Elena M Vazey

    Female rats express higher levels of β noradrenergic receptor RNA in premotor cortex than males, and systemic blockade of these receptors diminished neural representation of action plans in premotor cortex and impaired decision-making performance, especially in females.
55. 1. Neuroscience

    Neural Correlates and Reinstatement of Recent and Remote Memory: A Comparison Between Children and Young Adults

    Iryna Schommartz, Philip F. Lembcke ... Yee Lee Shing
56. 1. Neuroscience

    Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism

    Laura Boi, Yvonne Johansson ... Gilad Silberberg
57. 1. Cell Biology

    The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15)

    Ilja Vietor, Domagoj Cikes ... Lukas A Huber

    Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.
58. 1. Cell Biology
    2. Microbiology and Infectious Disease

    Synchronization of oscillatory growth prepares fungal hyphae for fusion

    Valentin Wernet, Marius Kriegler ... Reinhard Fischer

    Fungal hyphae constantly undergo signal oscillations, comparable to a cell 'monologue' until they meet another hypha with which they then coordinate signal oscillations and transit into a cell-to-cell dialogue.
59. 1. Neuroscience

    Interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks

    Han Lu, Sandra Diaz ... Andreas Vlachos
60. 1. Neuroscience

    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    Arnaud P. J. Giese, Wei-Hsiang Weng ... Zubair M. Ahmed
61. 1. Epidemiology and Global Health

    A review of HPV and HBV vaccine hesitancy, intention, and uptake in the era of social media and COVID-19

    Emily K Vraga, Sonya S Brady ... Shalini Kulasingam

    A review of the current empirical literature underscores the need for longitudinal research examining potential spillover effects between hesitancy, intention, or uptake for the COVID vaccine and HPV and HBV vaccines, especially to account for social media misinformation.
62. 1. Microbiology and Infectious Disease

    Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

    Yuu Ishii, Hironori Ishii ... Shinichiro Maruyama

    Coral symbiotic alga is capable of degrading the own cell wall components by cellulase-related enzymes and releasing sugars as a simple and autonomous environmental response, even when the host-derived signals are not present.
63. 1. Physics of Living Systems

    Effects of growth feedback on gene circuits: A dynamical understanding

    Ling-Wei Kong, Wenjia Shi ... Ying-Cheng Lai
64. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Olfactory detection of viruses shapes brain immunity and behavior in zebrafish

    Aurora Kraus, Benjamin Garcia ... Irene Salinas
65. 1. Cell Biology

    A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

    Chaojun Yan, Jingjing Xiong ... Jing Zhang

    Molecular biology experiments identified a cleaved METTL3, which mediates the METTL3–METTL3 interaction, a prerequisite step for recruitment of WTAP in MTC assembly, controlling m6A deposition and cancer progression.
66. 1. Neuroscience
    2. Computational and Systems Biology

    A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics

    Yuri Elias Rodrigues, Cezar M Tigaret ... Romain Veltz

    A computational model of glutamatergic synapse uncovers a new plasticity rule which takes into account the various experimental conditions.
67. 1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi

    Animal G-protein-coupled bistable rhodopsins can regulate Gq- and Gi-mediated signaling in a light-dependent manner in neurons and cardiomyocytes, making them useful for analyzing the roles of GPCR signaling in vivo.
68. 1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi

    Functional assays using zebrafish reveal that various microbial channelrhodopsins, guanylyl cyclase rhodopsin, and photoactivated adenylyl cyclases function as potent optogenetic tools, effectively controlling neural activity and cardiac function in zebrafish.
69. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

    Valeria Scagliotti, Maria Lillina Vignola ... Marika Charalambous

    Pituitary gland size and stem cell number is modulated during early life in the mouse by the imprinted gene Dlk1, which acts in multiple developmental compartments in a dosage-sensitive manner.
70. 1. Genetics and Genomics
    2. Immunology and Inflammation

    Epigenetic signature of human immune aging in the GESTALT study

    Roshni Roy, Pei-Lun Kuo ... Luigi Ferrucci

    Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
71. 1. Epidemiology and Global Health

    Nationwide mammography screening participation in Denmark during the COVID-19 pandemic: An observational study

    Tina Bech Olesen, Henry Jensen ... Sisse H Njor

    Only a minor reduction in mammography screening participation was observed during the COVID-19 pandemic in Denmark.
72. 1. Neuroscience

    Three-dimensional single-cell transcriptome imaging of thick tissues

    Rongxin Fang, Aaron R. Halpern ... Xiaowei Zhuang
73. 1. Neuroscience
    2. Physics of Living Systems

    Annihilation of action potentials induces electrical coupling between neurons

    Moritz Schlötter, Georg Maret, Christoph J. Kleineidam
74. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site

    Ornella Bimaï, Ipsita Banerjee ... Derek T. Logan
75. 1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley

    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
76. 1. Cell Biology

    Coalescent RNA-localizing and transcriptional activities of SAM68 modulate adhesion and subendothelial basement membrane assembly

    Zeinab Rekad, Michaël Ruff ... Ellen Van Obberghen-Schilling

    Distinct and direct functions of the RNA binding protein SAM68 regulate integrin signaling and focal adhesion dynamics that condition basement membrane deposition and angiogenic behavior of endothelial cells.
77. 1. Computational and Systems Biology
    2. Neuroscience

    Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus

    Diego M Arribas, Antonia Marin-Burgin, Luis G Morelli

    Heterogeneity in the population of granule cells in the dentate gyrus, which includes immature and mature neurons with distinct intrinsic properties, contributes to the population's enhanced encoding capabilities and ability to discriminate correlated stimuli.
78. 1. Neuroscience

    Optogenetic Stimulation of Single Ganglion Cells in the Living Primate Fovea

    Peter J. Murphy, Juliette E. McGregor ... David R. Williams
79. 1. Computational and Systems Biology

    Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing

    Masaaki Uematsu, Jeremy M. Baskin
80. 1. Neuroscience

    Variability of visual field maps in human early extrastriate cortex challenges the canonical model of organization of V2 and V3

    Fernanda Lenita Ribeiro, Ashley York ... Alexander Puckett

    The representation of the retina in early visual cortex shows that human brains have diverse functional organizations, raising questions about developmental mechanisms for visual map formation and how reliably these can be described by average templates.
81. 1. Cell Biology
    2. Medicine

    Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)

    Mengyao Wu, Tak-Ho Lo ... Chi-Ming Wong

    The novel role of Adgrf1 in the progression of fatty liver was revealed and targeting Adgrf1 is a promising therapeutic strategy for treating NAFLD patients.
82. 1. Evolutionary Biology

    Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

    Rafael F. Guerrero, Tandin Dorji ... C. Brandon Ogbunugafor
83. 1. Neuroscience

    Per-ischemic changes in penumbral blood supply and its microscopic distribution

    Nina K. Iversen, Eugenio Gutierréz Jimenéz ... Leif Østergaard
84. 1. Neuroscience
    2. Computational and Systems Biology

    Basolateral amygdala oscillations enable fear learning in a biophysical model

    Anna Cattani, Don B Arnold ... Nancy Kopell
85. 1. Immunology and Inflammation
    2. Neuroscience

    Spontaneous and inducible CD8 T cell lesions in the brain and spinal cord of HLA-DR15-positive MS PBMC humanized mice

    Irini Papazian, Maria Kourouvani ... Lesley Probert
86. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish

    Laura Massoz, David Bergemann ... Isabelle Manfroid
87. 1. Neuroscience

    Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe

    Lucija Rapan, Sean Froudist-Walsh ... Nicola Palomero-Gallagher

    3D atlas of the macaque frontal lobe, based on the novel quantitative parcellation, integrates anatomical, neurochemical, and functional connectivity data.
88. 1. Developmental Biology
    2. Medicine

    Normal and dysregulated crosstalk between iron metabolism and erythropoiesis

    Yelena Ginzburg, Xiuli An ... Adam Goldfarb

    The expansion of our understanding about the regulation of iron metabolism, erythropoiesis, and the crosstalk between them has enabled delineating the pathophysiology of multiple diseases and provided rationale for novel therapeutic interventions.
89. 1. Neuroscience

    Analogue signaling of somatodendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons

    Federico Trigo, Shin-ya Kawaguchi

    In cerebellar interneurons, somatodendritic subthreshold synaptic activity travels down the axon and augments AP-dependent GABA release by a modulation of the intermediate states of voltage-dependent Ca⁺⁺ channels in the presynaptic boutons.
90. 1. Immunology and Inflammation

    TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

    William D Jackson, Chiara Giacomassi ... Marina Botto

    A novel pathway of emergency myelopoiesis is induced by repetitive virus stimulation at peripheral barrier sites which bypasses the requirement of conventional pathways and expands myeloid infiltration in tissues.
91. 1. Biochemistry and Chemical Biology
    2. Neuroscience

    CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

    Iva Lučić, Léonie Héluin ... Andrew JR Plested

    CaMKII is capable of spreading activity between holoenzymes without exchanging subunits.
92. 1. Neuroscience

    Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing

    Sydney M Bailes, Daniel EP Gomez ... Laura D Lewis

    The frequency content of resting-state fMRI signals contains information that can characterize and predict local variations in hemodynamic response timing which enhances the temporal precision of fMRI.
93. 1. Neuroscience

    When and why does motor preparation arise in recurrent neural network models of motor control?

    Marine Schimel, Ta-Chu Kao, Guillaume Hennequin
94. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Temporally resolved early BMP-driven transcriptional cascade during human amnion specification

    Nikola Sekulovski, Jenna C. Wettstein ... Kenichiro Taniguchi
95. 1. Cell Biology

    Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells

    Kai M. Bracey, Pi’illani Noguchi ... Irina Kaverina
96. 1. Genetics and Genomics

    Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos

    Oana Pelea, Sarah Mayes ... Tatjana Sauka-Spengler
97. 1. Developmental Biology
    2. Chromosomes and Gene Expression

    Unified bursting strategies in ectopic and endogenous even-skipped expression patterns

    Augusto Berrocal, Nicholas C Lammers ... Michael B Eisen
98. 1. Chromosomes and Gene Expression

    Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors

    Miin S. Lin, Se-Young Jo ... Vineet Bafna
99. 1. Developmental Biology
    2. Physics of Living Systems

    Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair

    Jake Turley, Isaac V. Chenchiah ... Helen Weavers
100. 1. Neuroscience

     Object representation in a gravitational reference frame

     Alexandriya MX Emonds, Ramanujan Srinath ... Charles E Connor

     Neural recordings in monkey IT show that the primate visual system transforms object representations into a reference frame aligned with gravity and independent of how the head and eyes are tilted.
101. 1. Epidemiology and Global Health

     Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP

     Agnieszka Lemanska, Colm Andrews ... Alex J Walker

     COVID-19 negatively affected pancreatic cancer care by reducing surgical resections and pre-diagnostic testing with BMI and HbA1c, and it also negatively affected the quality of data for research.
102. 1. Cell Biology

     Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition

     Tianze Xu, Jing Cai ... Kuanyu Li

     Post-menopausal women with atherosclerosis need to take the correct timing for hormone replacement therapy.
103. 1. Cell Biology
     2. Medicine

     Sclerostin small-molecule inhibitors promote osteogenesis by activating canonical Wnt and BMP pathways

     Sreedhara Sangadala, Chi Heon Kim ... Steven M Presciutti

     Locally delivered small-molecule sclerostin inhibitors are able to promote local osteogenesis in vitro and in clinically relevant in vivo models by simultaneously activating the canonical Wnt and BMP signaling pathways.
104. 1. Cell Biology
     2. Immunology and Inflammation

     FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

     Dongyang Wang, Xiaojing Zheng ... Haibin Xia

     Genetic and biochemical analyses in vitro and in vivo reveal how the novel protein FAM76B regulates inflammation.
105. 1. Epidemiology and Global Health

     Understanding disruptions in cancer care to reduce increased cancer burden

     Kia L Davis, Nicole Ackermann ... Vetta L Sanders Thompson

     Many people canceled cancer screening and cancer care appointments during the pandemic, but cancer prevention and control practitioners must proactively facilitate their return to care to avoid widening cancer health disparities.
106. 1. Chromosomes and Gene Expression
     2. Developmental Biology

     lncRNA read-through regulates the BX-C insulator Fub-1

     Airat Ibragimov, Xin Yang Bing ... Paul Schedl

     A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the Drosophila HOX gene cluster.
107. 1. Epidemiology and Global Health
     2. Genetics and Genomics

     Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

     Jenny van Dongen, Gonneke Willemsen ... Michael C Neale

     Analysis of data from monozygotic twins reveals that DNA methylation level in human blood cells is reactive to cigarette smoking.
108. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

     Daniel A Kramer, Heidy Y Narvaez-Ortiz ... Baoyu Chen

     The dendrite branching receptor HPO-30 modulates actin dynamics by binding to both WAVE complex and actin filaments.
109. 1. Neuroscience

     Enhancing precision in human neuroscience

     Stephan Nebe, Mario Reutter ... Gordon B Feld

     Measurement precision offers a comprehensive perspective on good scientific practices to improve reproducibility of research results by providing means to optimize design and analysis parameters (e.g. sample size, trial count, or sample heterogeneity) in accordance with the researcher’s goals.
110. 1. Immunology and Inflammation
     2. Neuroscience

     TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

     Yuanyuan Wang, Tiffany Wu ... Jesse E Hanson

     Preventing activity of the kinase tumor progression locus 2 modulates microglial activation, reduces T-cell brain infiltration, and is neuroprotective in disease models.
111. 1. Genetics and Genomics
     2. Immunology and Inflammation

     CD8⁺ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network

     Maofeng Qing, Dan Yang ... Qianming Chen

     CD8+ Trm cells' erosion role in oral lichen planus via IFN-γ, TNF-α, and IL17 cytokines has been revealed, addressing a gap in recurrent erosion studies.
112. 1. Immunology and Inflammation

     Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

     Godfrey S Temba, Nadira Vadaq ... Quirijn de Mast

     Comparing the inflammatory proteome of healthy Tanzanian and Dutch adults highlights a pro-inflammatory phenotype and metabolic differences in Tanzanians, with the potential role of food-derived metabolites in driving inflammation.
113. 1. Neuroscience

     An open-source platform for head-fixed operant and consummatory behavior

     Adam Gordon-Fennell, Joumana M Barbakh ... Garret D Stuber

     A customizable open-source hardware and software platform for conducting diverse behavioral experiments in head-fixed mice.
114. 1. Immunology and Inflammation
     2. Microbiology and Infectious Disease

     AIDS virus-neutralizing antibody induction reciprocal to a PI3K gain-of-function disease

     Hiroyuki Yamamoto, Tetsuro Matano
115. 1. Cell Biology
     2. Microbiology and Infectious Disease

     The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

     Madel V. Tutor, Gerald J. Shami ... Stuart A. Ralph
116. 1. Computational and Systems Biology

     Convergent evolution in silico reveals shape and dynamic principles of directed locomotion

     Renata B. Biazzi, André Fujita, Daniel Y. Takahashi
117. 1. Developmental Biology

     Essential Function of Transmembrane Transcription Factor MYRF in Promoting Transcription of miRNA lin-4 during C. elegans Development

     Zhimin Xu, Zhao Wang ... Yingchuan B. Qi
118. 1. Microbiology and Infectious Disease

     Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics

     Tomoko Kubori, Kohei Arasaki ... Hiroki Nagai
119. 1. Neuroscience

     Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae

     Yingtao Liu, Eri Hasegawa ... Hiroshi Kohsaka

     GABAergic interneurons coordinate synchronous muscle contractions along the length of the fruit fly larva to control the duration between peristaltic waves and locomotion speed.
120. 1. Cancer Biology

     Precision RNAi using synthetic shRNAmir target sites

     Thomas Hoffmann, Alexandra Hörmann ... Ralph A Neumüller

     Artificial RNA interference is a novel loss-of-function method for highly stringent target validation in oncology and beyond.
121. 1. Evolutionary Biology

     An armoured marine reptile from the Early Triassic of South China and its phylogenetic and evolutionary implications

     Andrzej S Wolniewicz, Yuefeng Shen ... Jun Liu

     A new fossil sheds light on the evolution of an aquatic lifestyle in extinct reptiles and supports a close phylogenetic relationship between archosaurs (crocodiles, dinosaurs, birds, and kin) and turtles.
122. 1. Cancer Biology
     2. Cell Biology

     EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

     Marianne Mazevet, Anissa Belhadef ... Eric Morel

     The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering with its antitumoral activity.
123. 1. Neuroscience

     Dynamic control of sequential retrieval speed in networks with heterogeneous learning rules

     Maxwell Gillett, Nicolas Brunel
124. 1. Neuroscience

     BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI

     Alena U. Uus, Vanessa Kyriakopoulou ... Maria Deprez
125. 1. Ecology
     2. Evolutionary Biology

     Megafaunal extinctions, not climate change, may explain Holocene genetic diversity declines in Numenius shorebirds

     Hui Zhen Tan, Justin JFJ Jansen ... Frank E Rheindt

     Application of museomics facilitates characterization of the contribution of historical factors to genetic diversity declines in Numenius shorebirds and highlights that extinction of ecosystem-engineering megafauna may have been detrimental for open-landscape species.
126. 1. Neuroscience

     No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation

     Lilya Andrianova, Steliana Yanakieva ... Michael T Craig

     A combination of anterograde and retrograde anatomical-tracing methods failed to provide evidence of a recently described projection from the anterior cingulate area to the hippocampus.
127. 1. Neuroscience

     The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation

     Ida L Barlow, Eirinn Mackay ... Jason Rihel

     The small, highly conserved transmembrane protein disrupted in zebrafish dreammist mutants regulates the activity of the sodium-potassium pump, leading to changes in sleep behaviour.
128. 1. Cell Biology
     2. Immunology and Inflammation

     CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation

     Francesco Andreata, Marc Clément ... Giuseppina Caligiuri

     CD31 plays a pivotal role in neutrophil migration to inflamed sites by localizing to the uropod and promoting effective actin/integrin polarization and detachment, shedding light on the molecular mechanisms underlying extravasation and inflammation response.
129. 1. Biochemistry and Chemical Biology

     Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins

     Gautam Susarla, Priyanka Kataria ... Patrick D'Silva

     Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.
130. 1. Biochemistry and Chemical Biology
     2. Cell Biology

     The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

     Maire Gavagan, Noel Jameson, Jesse G Zalatan

     A biochemical approach using the Wnt pathway as a model system demonstrates a new mechanism for specificity in interconnected signaling networks through scaffold-mediated shielding of bound proteins.
131. 1. Ecology
     2. Evolutionary Biology

     Novel pathogen introduction triggers rapid evolution in animal social movement strategies

     Pratik Rajan Gupte, Gregory F Albery ... Franz J Weissing

     The introduction of infectious pathogens to a simulated animal population leads to rapid evolutionary transitions in how individuals move in a social context, with distinct movement morphs evolved that make trade-offs between sociality and infection risk.
132. 1. Cell Biology
     2. Physics of Living Systems

     Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

     Artur Ruppel, Dennis Wörthmüller ... Martial Balland

     Combining micropatterning, traction force microscopy, and optogenetics, it is shown that epithelial cells actively respond to mechanical signals from neighboring cells.
133. 1. Cancer Biology
     2. Immunology and Inflammation

     Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

     Kim Bich Nguyen, Malte Roerden ... Stefani Spranger

     In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.
134. 1. Cell Biology
     2. Developmental Biology

     Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

     James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann

     Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
135. 1. Genetics and Genomics

     Is competition for cellular resources a driver of complex trait heritability?

     Olivier Naret, Yuval Simons ... Jonathan K Pritchard
136. 1. Cell Biology
     2. Developmental Biology

     E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation

     Vartika Sharma, Nalani Sachan ... Ashim Mukherjee
137. 1. Ecology

     Deciphering deep-sea chemosynthetic symbiosis by single-nucleus RNA-sequencing

     Hao Wang, Kai He ... Chaolun Li
138. 1. Neuroscience
     2. Physics of Living Systems

     Continuous, long-term crawling behavior characterized by a robotic transport system

     James Yu, Stephanie Dancausse ... Mason Klein

     Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
139. 1. Biochemistry and Chemical Biology

     Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism

     Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia

     Cryo-EM structures reveal GC-C associates with regulatory heat shock proteins similarly to bona fide protein kinases and this can guide the further development of mGC-targeted therapeutics.
140. 1. Structural Biology and Molecular Biophysics

     Structural and mechanistic insights into the MCM8/9 helicase complex

     Zhuangfeng Weng, Jiefu Zheng ... Yingfang Liu

     The hexametric structures of MCM8/9, revealed through cryo-electron microscopy single particle analysis, provide a foundational understanding of its helicase activity and offer novel insights into its mechanistic role.
141. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Structure of the connexin-43 gap junction channel in a putative closed state

     Chao Qi, Silvia Acosta Gutierrez ... Volodymyr M Korkhov

     Cryo-EM structures and molecular dynamics simulations of Cx43 gap junction channel and hemichannel reveal a putative closed state.
142. 1. Epidemiology and Global Health
     2. Medicine

     Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis

     Surabhi Yadav, Olivia Delau ... Ricardo Azziz

     Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.
143. 1. Neuroscience
     2. Stem Cells and Regenerative Medicine

     Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

     Dong Wang, Tiemei Zheng ... Bin Yu

     Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.
144. 1. Neuroscience

     Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism

     Jin Liu, Hyesang Chang ... Vinod Menon

     Learning in children with autism spectrum disorder (ASD) was achieved by fundamentally different cognitive and neural mechanisms from typically developing children, and insistence on sameness, a core symptom of ASD, contributed to such atypical mechanisms of learning in affected children.
145. 1. Epidemiology and Global Health
     2. Medicine

     Association between bisphosphonate use and COVID-19 related outcomes

     Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian

     A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
146. 1. Neuroscience

     The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

     Lydia Gruber, Rafael Cantera ... Jürgen Rybak
147. 1. Neuroscience

     A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

     Marito Hayashi, Miriam Gullo ... Graziana Gatto
148. 1. Cell Biology

     Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics

     Raymond Laboy, Marjana Ndoci ... Adam Antebi
149. 1. Medicine
     2. Immunology and Inflammation

     Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

     Tobias Weinberger, Denise Messerer ... Christian Schulz
150. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome

     Sophia Gessner, Zela Alexandria-Mae Martin ... Digby F Warner

     The interaction of ImuB with the β sliding clamp is essential for induced mutagenesis in mycobacteria and could be a novel target for new anti-tuberculosis drugs designed to inhibit the emergence of genetic resistance.
151. 1. Developmental Biology

     scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border

     Alexandre P Thiery, Ailin Leticia Buzzi ... Andrea Streit

     Neural plate border cells co-express neural, neural crest, and placodal transcriptional programs before cell fate decisions occur and are transcriptionally heterogeneous along the antero-posterior and medial-lateral axis.
152. 1. Chromosomes and Gene Expression
     2. Genetics and Genomics

     Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader

     Pragyan Singh, Inbal Gazy, Martin Kupiec

     SUMOylated PCNA and the Elg1 PCNA unloader interact with the CST complex to coordinate DNA replication and telomere length maintenance.
153. 1. Cancer Biology

     Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer

     José Manuel García-Martínez, Ana Chocarro-Calvo ... Custodia García-Jiménez

     Vitamin D bound to its receptor interacts with SIRT1 to induce its auto deacetylation and catalytic activity, which drives anti-proliferative effects in colorrectal cancer and this may lead to new therapeutic approaches for colorrectal and perhaps other cancers.
154. 1. Neuroscience

     Stochastic characterization of navigation strategies in an automated variant of the Barnes maze

     Ju-Young Lee, Dahee Jung, Sébastien Royer
155. 1. Medicine

     Deep Learning Using High-Resolution Images of Forearm Predicts Fracture

     Roland Chapurlat, Serge Ferrari ... Ego Seeman
156. 1. Genetics and Genomics

     Deterministic Genetic Barcoding for Multiplexed Behavioral and Single-Cell Transcriptomic Studies

     Jorge Blanco Mendana, Margaret Donovan ... Daryl M. Gohl
157. 1. Neuroscience

     How inhibitory and excitatory inputs gate output of the inferior olive

     Sebastián Loyola, Tycho M Hoogland ... Chris I De Zeeuw

     Experimental work and computational models reveal how the timing between the inhibitory and excitatory inputs modulates the function of the inferior olive nucleus, a key structure for motor learning and cognition.
158. 1. Neuroscience

     Fine-grained functional parcellation maps of the infant cerebral cortex

     Fan Wang, Han Zhang ... Gang Li

     Advanced computational processing and analysis of functional MRI create the first comprehensive set of high-resolution cortical parcellations maps of infant brains.
159. 1. Ecology

     Plant secondary metabolite-dependent plant-soil feedbacks can improve crop yield in the field

     Valentin Gfeller, Jan Waelchli ... Matthias Erb

     A 2-year field experiment reveals that plant secondary metabolites can be harnessed to increase crop productivity through plant-soil feedbacks under agronomically realistic conditions.
160. 1. Neuroscience

     Subcortico-amygdala pathway processes innate and learned threats

     Valentina Khalil, Islam Faress ... Sadegh Nabavi

     The subcortical amygdala pathway, which has been traditionally associated with learning threats, is also required for processing an innate threat.