August 2023

Research articles

1. 1. Neuroscience

   Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions

   Dániel Veréb, Mite Mijalkov ... Joana B Pereira

   A gradient-based approach is employed to characterize the organization of functional connectivity in the human locus coeruleus, revealing age-related differences and associations with cognitive and affective functions independently from age.
2. 1. Cell Biology
   2. Chromosomes and Gene Expression

   The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

   Maikel Castellano-Pozo, Georgios Sioutas ... Enrique Martinez-Perez

   Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.
3. 1. Cancer Biology

   Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

   Xiangmudong Kong, Wensheng Yan ... Xinbin Chen

   Mouse model reveals that TAp73γ functions as an oncogene to promote tumorigenesis and alter lipid metabolism by modulating leptin expression.
4. 1. Evolutionary Biology

   Selection and the direction of phenotypic evolution

   François Mallard, Bruno Afonso, Henrique Teotónio

   Predicting multivariate phenotypic evolution.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

   Xinle Zou, Sri Karthika Shanmugam ... Henry M Colecraft

   Targeted recruitment of protein kinase A subunits enables distinctive regulation of the functional expression of a potassium channel depending on whether the enzyme is targeted to a pore-forming or auxiliary subunit.
6. 1. Chromosomes and Gene Expression

   A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

   Sana Ahmed-Seghir, Manisha Jalan ... Simon N Powell

   Cells exhibit a localized ATR-dependent DNA damage response to a site-specific stalled replication fork that is distinct from that observed after global replication stress.
7. 1. Neuroscience

   Balancing true and false detection of intermittent sensory targets by adjusting the inputs to the evidence accumulation process

   Anna C Geuzebroek, Hannah Craddock ... Simon P Kelly

   In order to adjust for expected difficulty level while detecting unpredictably timed target within continuous streams of noisy information, people regulate the transfer of the sensory inputs to the accumulation process.
8. 1. Medicine
   2. Microbiology and Infectious Disease

   The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

   Hsiao-Fan Chen, Wei-Jan Wang ... Mien-Chie Hung

   Two natural tannins, oligomeric proanthocyanidins and punicalagin, acted as potent inhibitors against SARS-CoV-2 infection, and grape seed extract supplementation could serve as a healthy food for infection prevention.
9. 1. Microbiology and Infectious Disease

   Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

   Somnath Shee, Reshma T Veetil ... Amit Singh

   Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.
10. 1. Structural Biology and Molecular Biophysics

    Ab initio prediction of specific phospholipid complexes and membrane association of HIV-1 MPER antibodies by multi-scale simulations

    Colleen Maillie, Jay Golden ... Marco Mravic
11. 1. Medicine

    PYCR1 Levels Track with Premature and Chronological Skin Aging

    Kortessa Sotiropoulou, Saniye Yumlu ... Bruno Reversade
12. 1. Structural Biology and Molecular Biophysics

    Martinize2 and Vermouth: Unified Framework for Topology Generation

    PC Kroon, F Grunewald ... SJ Marrink
13. 1. Immunology and Inflammation

    SPOP targets the immune transcription factor IRF1 for proteasomal degradation

    Irene Schwartz, Milica Vunjak ... Gijs A Versteeg

    SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.
14. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

    Marisa S Egan, Emily A O’Rourke ... Sunny Shin
15. 1. Neuroscience

    Corticotropin Releasing Factor in the Bed Nucleus of the Stria Terminalis modulates the behavioral consequences of unpredictable threat

    Olivia J. Hon, Meghan E. Flanigan ... Thomas L. Kash
16. 1. Neuroscience

    The songbird lateral habenula projects to dopaminergic midbrain and is important for normal vocal development

    Andrea Roeser, Han Kheng Teoh ... Jesse Goldberg
17. 1. Neuroscience

    Inferential eye movement control while following dynamic gaze

    Nicole Xiao Han, Miguel Patricio Eckstein

    When looking at another person shifting their gaze, humans use the gazer's head direction, velocity, and peripheral visual information to infer potential gaze goals and execute anticipatory eye movements.
18. 1. Epidemiology and Global Health
    2. Medicine

    Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study

    Riku Klén, Ivan A Huespe ... David Gómez-Varela

    The new early warning system, COEWS, will improve the early identification and management of high-risk COVID-19 patients compared to the widely used NEWS2 by using easy-to-obtain clinical parameters that have been externally validated in a diverse multicontinental cohort of patients.
19. 1. Cell Biology

    Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1

    Alice M Budden, Murat Eravci ... Antony M Carr

    Rtf2 is shown to associate with multiple splicing factors and influence splicing of a subset of introns explaining why previous work erroneously assigned it as a replication restart factor in fission yeast.
20. 1. Immunology and Inflammation
    2. Medicine

    Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

    Erin J Ciampa, Padraich Flahardy ... Samir M Parikh

    The role of placental aging and metabolic stress in driving labor onset is demonstrated, with a novel mouse model of preterm labor in which injection of a prolyl hydroxylase inhibitor stabilizes placental hypoxia-inducible factor 1 and significantly shortens gestational length.
21. 1. Developmental Biology

    Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

    Wilma Tixi, Maricela Maldonado ... Hung Ping Shih

    ECM-Itgb1 signaling and cell-cell adhesion are pivotal and coordinate together to regulate pancreatic islet aggregation, architecture, and functional maturation during development.
22. 1. Neuroscience

    Statistical inference on representational geometries

    Heiko H Schütt, Alexander D Kipnis ... Nikolaus Kriegeskorte

    New methods for statistical inference in representational similarity analysis were developed, tested thoroughly, and are made available in an open-source Python toolbox.
23. 1. Developmental Biology

    Identification of quiescent FOXC2⁺ spermatogonial stem cells in adult mammals

    Zhipeng Wang, Cheng Jin ... Wei Song

    The FOXC2⁺ quiescent spermatogonial stem cells are essential for the maintenance of spermatogenesis.
24. 1. Neuroscience

    Using adversarial networks to extend brain computer interface decoding accuracy over time

    Xuan Ma, Fabio Rizzoglio ... Ann Kennedy

    Incorporating cycle-consistency loss into a generative adversarial network creates a high-performance and robust 'aligner' of neural population activity, permitting a fixed intracortical brain computer interface to be used for months without recalibration and without requiring inference of a latent manifold.
25. 1. Evolutionary Biology

    The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction

    Lucy A Winder, Mirre JP Simons, Terry Burke
26. 1. Neuroscience

    Functional imaging of conduction dynamics in cortical and spinal axons

    Milos Radivojevic, Anna Rostedt Punga

    Reconstruction of axonal morphologies based on extracellular action potentials enables label-free electrical visualization of axonal conduction trajectories, providing a noninvasive method for functional profiling of cortical and spinal axons.
27. 1. Medicine

    Electronic data review, client reminders, and expanded clinic hours for improving cervical cancer screening rates after the COVID-19 pandemic shutdowns: A multicomponent quality improvement program

    Sue Ghosh, Jackie Fantes ... Rebecca B Perkins

    The largest federally qualified health center in Massachusetts was able to improve cervical cancer screening rates during the COVID-19 pandemic by creating clinical sessions devoted only to screenings.
28. 1. Genetics and Genomics

    Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

    Lucydalila Cedillo, Fasih M Ahsan ... Alexander A Soukas

    Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.
29. 1. Developmental Biology
    2. Evolutionary Biology

    Coronary artery established through amniote evolution

    Kaoru Mizukami, Hiroki Higashiyama ... Hiroki Kurihara

    During the evolution of amniotes, the transformation of branchial arches coincided with the drastic remodeling of the ancestral extrinsic cardiac arteries, giving rise to novel ventricular coronary arteries that are unique to amniotes.
30. 1. Neuroscience

    Sex-dependent noradrenergic modulation of premotor cortex during decision-making

    Ellen M Rodberg, Carolina R den Hartog ... Elena M Vazey

    Female rats express higher levels of β noradrenergic receptor RNA in premotor cortex than males, and systemic blockade of these receptors diminished neural representation of action plans in premotor cortex and impaired decision-making performance, especially in females.
31. 1. Neuroscience

    Neural Correlates and Reinstatement of Recent and Remote Memory: A Comparison Between Children and Young Adults

    Iryna Schommartz, Philip F Lembcke ... Yee Lee Shing
32. 1. Cell Biology

    The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15)

    Ilja Vietor, Domagoj Cikes ... Lukas A Huber

    Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.
33. 1. Cell Biology
    2. Microbiology and Infectious Disease

    Synchronization of oscillatory growth prepares fungal hyphae for fusion

    Valentin Wernet, Marius Kriegler ... Reinhard Fischer

    Fungal hyphae constantly undergo signal oscillations, comparable to a cell 'monologue' until they meet another hypha with which they then coordinate signal oscillations and transit into a cell-to-cell dialogue.
34. 1. Neuroscience

    The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks

    Han Lu, Sandra Diaz ... Andreas Vlachos
35. 1. Microbiology and Infectious Disease

    Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

    Yuu Ishii, Hironori Ishii ... Shinichiro Maruyama

    Coral symbiotic alga is capable of degrading the own cell wall components by cellulase-related enzymes and releasing sugars as a simple and autonomous environmental response, even when the host-derived signals are not present.
36. 1. Epidemiology and Global Health

    A review of HPV and HBV vaccine hesitancy, intention, and uptake in the era of social media and COVID-19

    Emily K Vraga, Sonya S Brady ... Shalini Kulasingam

    A review of the current empirical literature underscores the need for longitudinal research examining potential spillover effects between hesitancy, intention, or uptake for the COVID vaccine and HPV and HBV vaccines, especially to account for social media misinformation.
37. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Olfactory detection of viruses shapes brain immunity and behavior in zebrafish

    Aurora Kraus, Benjamin Garcia ... Irene Salinas
38. 1. Physics of Living Systems

    Effects of growth feedback on adaptive gene circuits: A dynamical understanding

    Ling-Wei Kong, Wenjia Shi ... Ying-Cheng Lai
39. 1. Neuroscience
    2. Computational and Systems Biology

    A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics

    Yuri Elias Rodrigues, Cezar M Tigaret ... Romain Veltz

    A computational model of glutamatergic synapse uncovers a new plasticity rule which takes into account the various experimental conditions.
40. 1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi

    Functional assays using zebrafish reveal that various microbial channelrhodopsins, guanylyl cyclase rhodopsin, and photoactivated adenylyl cyclases function as potent optogenetic tools, effectively controlling neural activity and cardiac function in zebrafish.
41. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

    Valeria Scagliotti, Maria Lillina Vignola ... Marika Charalambous

    Pituitary gland size and stem cell number is modulated during early life in the mouse by the imprinted gene Dlk1, which acts in multiple developmental compartments in a dosage-sensitive manner.
42. 1. Cell Biology

    A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

    Chaojun Yan, Jingjing Xiong ... Jing Zhang

    Molecular biology experiments identified a cleaved METTL3, which mediates the METTL3–METTL3 interaction, a prerequisite step for recruitment of WTAP in MTC assembly, controlling m6A deposition and cancer progression.
43. 1. Genetics and Genomics
    2. Immunology and Inflammation

    Epigenetic signature of human immune aging in the GESTALT study

    Roshni Roy, Pei-Lun Kuo ... Luigi Ferrucci

    Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
44. 1. Epidemiology and Global Health

    Nationwide mammography screening participation in Denmark during the COVID-19 pandemic: An observational study

    Tina Bech Olesen, Henry Jensen ... Sisse H Njor

    Only a minor reduction in mammography screening participation was observed during the COVID-19 pandemic in Denmark.
45. 1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi

    Animal G-protein-coupled bistable rhodopsins can regulate Gq- and Gi-mediated signaling in a light-dependent manner in neurons and cardiomyocytes, making them useful for analyzing the roles of GPCR signaling in vivo.
46. 1. Neuroscience
    2. Physics of Living Systems

    Annihilation of action potentials induces electrical coupling between neurons

    Moritz Schlötter, Georg Maret, Christoph J Kleineidam
47. 1. Cell Biology

    Coalescent RNA-localizing and transcriptional activities of SAM68 modulate adhesion and subendothelial basement membrane assembly

    Zeinab Rekad, Michaël Ruff ... Ellen Van Obberghen-Schilling

    Distinct and direct functions of the RNA binding protein SAM68 regulate integrin signaling and focal adhesion dynamics that condition basement membrane deposition and angiogenic behavior of endothelial cells.
48. 1. Computational and Systems Biology
    2. Neuroscience

    Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus

    Diego M Arribas, Antonia Marin-Burgin, Luis G Morelli

    Heterogeneity in the population of granule cells in the dentate gyrus, which includes immature and mature neurons with distinct intrinsic properties, contributes to the population's enhanced encoding capabilities and ability to discriminate correlated stimuli.
49. 1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley

    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
50. 1. Computational and Systems Biology

    Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing

    Masaaki Uematsu, Jeremy M. Baskin
51. 1. Neuroscience

    Optogenetic Stimulation of Single Ganglion Cells in the Living Primate Fovea

    Peter J. Murphy, Juliette E. McGregor ... David R. Williams
52. 1. Neuroscience

    Variability of visual field maps in human early extrastriate cortex challenges the canonical model of organization of V2 and V3

    Fernanda Lenita Ribeiro, Ashley York ... Alexander Puckett

    The representation of the retina in early visual cortex shows that human brains have diverse functional organizations, raising questions about developmental mechanisms for visual map formation and how reliably these can be described by average templates.
53. 1. Cell Biology
    2. Medicine

    Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)

    Mengyao Wu, Tak-Ho Lo ... Chi-Ming Wong

    The novel role of Adgrf1 in the progression of fatty liver was revealed and targeting Adgrf1 is a promising therapeutic strategy for treating NAFLD patients.
54. 1. Neuroscience

    Per-ischemic changes in penumbral blood supply and its microscopic distribution

    Nina K. Iversen, Eugenio Gutierréz Jimenéz ... Leif Østergaard
55. 1. Developmental Biology
    2. Medicine

    Normal and dysregulated crosstalk between iron metabolism and erythropoiesis

    Yelena Ginzburg, Xiuli An ... Adam Goldfarb

    The expansion of our understanding about the regulation of iron metabolism, erythropoiesis, and the crosstalk between them has enabled delineating the pathophysiology of multiple diseases and provided rationale for novel therapeutic interventions.
56. 1. Neuroscience

    Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe

    Lucija Rapan, Sean Froudist-Walsh ... Nicola Palomero-Gallagher

    3D atlas of the macaque frontal lobe, based on the novel quantitative parcellation, integrates anatomical, neurochemical, and functional connectivity data.
57. 1. Biochemistry and Chemical Biology
    2. Neuroscience

    CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

    Iva Lučić, Léonie Héluin ... Andrew JR Plested

    CaMKII is capable of spreading activity between holoenzymes without exchanging subunits.
58. 1. Neuroscience

    Analogue signaling of somatodendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons

    Federico Trigo, Shin-ya Kawaguchi

    In cerebellar interneurons, somatodendritic subthreshold synaptic activity travels down the axon and augments AP-dependent GABA release by a modulation of the intermediate states of voltage-dependent Ca⁺⁺ channels in the presynaptic boutons.
59. 1. Immunology and Inflammation

    TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

    William D Jackson, Chiara Giacomassi ... Marina Botto

    A novel pathway of emergency myelopoiesis is induced by repetitive virus stimulation at peripheral barrier sites which bypasses the requirement of conventional pathways and expands myeloid infiltration in tissues.
60. 1. Neuroscience

    Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing

    Sydney M Bailes, Daniel EP Gomez ... Laura D Lewis

    The frequency content of resting-state fMRI signals contains information that can characterize and predict local variations in hemodynamic response timing which enhances the temporal precision of fMRI.
61. 1. Genetics and Genomics

    Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos

    Oana Pelea, Sarah Mayes ... Tatjana Sauka-Spengler
62. 1. Cell Biology

    Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells

    Kai M. Bracey, Pi’illani Noguchi ... Irina Kaverina
63. 1. Epidemiology and Global Health
    2. Genetics and Genomics

    Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

    Jenny van Dongen, Gonneke Willemsen ... Michael C Neale

    Analysis of data from monozygotic twins reveals that DNA methylation level in human blood cells is reactive to cigarette smoking.
64. 1. Cell Biology
    2. Medicine

    Sclerostin small-molecule inhibitors promote osteogenesis by activating canonical Wnt and BMP pathways

    Sreedhara Sangadala, Chi Heon Kim ... Steven M Presciutti

    Locally delivered small-molecule sclerostin inhibitors are able to promote local osteogenesis in vitro and in clinically relevant in vivo models by simultaneously activating the canonical Wnt and BMP signaling pathways.
65. 1. Epidemiology and Global Health

    Understanding disruptions in cancer care to reduce increased cancer burden

    Kia L Davis, Nicole Ackermann ... Vetta L Sanders Thompson

    Many people canceled cancer screening and cancer care appointments during the pandemic, but cancer prevention and control practitioners must proactively facilitate their return to care to avoid widening cancer health disparities.
66. 1. Chromosomes and Gene Expression
    2. Developmental Biology

    lncRNA read-through regulates the BX-C insulator Fub-1

    Airat Ibragimov, Xin Yang Bing ... Paul Schedl

    A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the Drosophila HOX gene cluster.
67. 1. Neuroscience

    Object representation in a gravitational reference frame

    Alexandriya MX Emonds, Ramanujan Srinath ... Charles E Connor

    Neural recordings in monkey IT show that the primate visual system transforms object representations into a reference frame aligned with gravity and independent of how the head and eyes are tilted.
68. 1. Cell Biology

    Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition

    Tianze Xu, Jing Cai ... Kuanyu Li

    Post-menopausal women with atherosclerosis need to take the correct timing for hormone replacement therapy.
69. 1. Cell Biology
    2. Immunology and Inflammation

    FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

    Dongyang Wang, Xiaojing Zheng ... Haibin Xia

    Genetic and biochemical analyses in vitro and in vivo reveal how the novel protein FAM76B regulates inflammation.
70. 1. Epidemiology and Global Health

    Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP

    Agnieszka Lemanska, Colm Andrews ... Alex J Walker

    COVID-19 negatively affected pancreatic cancer care by reducing surgical resections and pre-diagnostic testing with BMI and HbA1c, and it also negatively affected the quality of data for research.
71. 1. Genetics and Genomics
    2. Immunology and Inflammation

    CD8⁺ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network

    Maofeng Qing, Dan Yang ... Qianming Chen

    CD8+ Trm cells' erosion role in oral lichen planus via IFN-γ, TNF-α, and IL17 cytokines has been revealed, addressing a gap in recurrent erosion studies.
72. 1. Immunology and Inflammation
    2. Neuroscience

    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

    Yuanyuan Wang, Tiffany Wu ... Jesse E Hanson

    Preventing activity of the kinase tumor progression locus 2 modulates microglial activation, reduces T-cell brain infiltration, and is neuroprotective in disease models.
73. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

    Daniel A Kramer, Heidy Y Narvaez-Ortiz ... Baoyu Chen

    The dendrite branching receptor HPO-30 modulates actin dynamics by binding to both WAVE complex and actin filaments.
74. 1. Neuroscience

    Enhancing precision in human neuroscience

    Stephan Nebe, Mario Reutter ... Gordon B Feld

    Measurement precision offers a comprehensive perspective on good scientific practices to improve reproducibility of research results by providing means to optimize design and analysis parameters (e.g. sample size, trial count, or sample heterogeneity) in accordance with the researcher’s goals.
75. 1. Neuroscience

    An open-source platform for head-fixed operant and consummatory behavior

    Adam Gordon-Fennell, Joumana M Barbakh ... Garret D Stuber

    A customizable open-source hardware and software platform for conducting diverse behavioral experiments in head-fixed mice.
76. 1. Immunology and Inflammation

    Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

    Godfrey S Temba, Nadira Vadaq ... Quirijn de Mast

    Comparing the inflammatory proteome of healthy Tanzanian and Dutch adults highlights a pro-inflammatory phenotype and metabolic differences in Tanzanians, with the potential role of food-derived metabolites in driving inflammation.
77. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant

    Hiroyuki Yamamoto, Tetsuro Matano
78. 1. Cell Biology
    2. Microbiology and Infectious Disease

    The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

    Madel V. Tutor, Gerald J. Shami ... Stuart A. Ralph
79. 1. Computational and Systems Biology

    Convergent evolution in silico reveals shape and dynamic principles of directed locomotion

    Renata B Biazzi, André Fujita, Daniel Y Takahashi
80. 1. Evolutionary Biology

    An armoured marine reptile from the Early Triassic of South China and its phylogenetic and evolutionary implications

    Andrzej S Wolniewicz, Yuefeng Shen ... Jun Liu

    A new fossil sheds light on the evolution of an aquatic lifestyle in extinct reptiles and supports a close phylogenetic relationship between archosaurs (crocodiles, dinosaurs, birds, and kin) and turtles.
81. 1. Cancer Biology

    Precision RNAi using synthetic shRNAmir target sites

    Thomas Hoffmann, Alexandra Hörmann ... Ralph A Neumüller

    Artificial RNA interference is a novel loss-of-function method for highly stringent target validation in oncology and beyond.
82. 1. Neuroscience

    Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae

    Yingtao Liu, Eri Hasegawa ... Hiroshi Kohsaka

    GABAergic interneurons coordinate synchronous muscle contractions along the length of the fruit fly larva to control the duration between peristaltic waves and locomotion speed.
83. 1. Cancer Biology
    2. Cell Biology

    EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

    Marianne Mazevet, Anissa Belhadef ... Eric Morel

    The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering with its antitumoral activity.
84. 1. Neuroscience

    BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI

    Alena U. Uus, Vanessa Kyriakopoulou ... Maria Deprez
85. 1. Ecology
    2. Evolutionary Biology

    Megafaunal extinctions, not climate change, may explain Holocene genetic diversity declines in Numenius shorebirds

    Hui Zhen Tan, Justin JFJ Jansen ... Frank E Rheindt

    Application of museomics facilitates characterization of the contribution of historical factors to genetic diversity declines in Numenius shorebirds and highlights that extinction of ecosystem-engineering megafauna may have been detrimental for open-landscape species.
86. 1. Cell Biology
    2. Physics of Living Systems

    Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

    Artur Ruppel, Dennis Wörthmüller ... Martial Balland

    Combining micropatterning, traction force microscopy, and optogenetics, it is shown that epithelial cells actively respond to mechanical signals from neighboring cells.
87. 1. Cell Biology
    2. Immunology and Inflammation

    CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation

    Francesco Andreata, Marc Clément ... Giuseppina Caligiuri

    CD31 plays a pivotal role in neutrophil migration to inflamed sites by localizing to the uropod and promoting effective actin/integrin polarization and detachment, shedding light on the molecular mechanisms underlying extravasation and inflammation response.
88. 1. Neuroscience

    No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation

    Lilya Andrianova, Steliana Yanakieva ... Michael T Craig

    A combination of anterograde and retrograde anatomical-tracing methods failed to provide evidence of a recently described projection from the anterior cingulate area to the hippocampus.
89. 1. Neuroscience

    The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation

    Ida L Barlow, Eirinn Mackay ... Jason Rihel

    The small, highly conserved transmembrane protein disrupted in zebrafish dreammist mutants regulates the activity of the sodium-potassium pump, leading to changes in sleep behaviour.
90. 1. Biochemistry and Chemical Biology

    Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins

    Gautam Susarla, Priyanka Kataria ... Patrick D'Silva

    Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.
91. 1. Cancer Biology
    2. Immunology and Inflammation

    Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

    Kim Bich Nguyen, Malte Roerden ... Stefani Spranger

    In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.
92. 1. Ecology
    2. Evolutionary Biology

    Novel pathogen introduction triggers rapid evolution in animal social movement strategies

    Pratik Rajan Gupte, Gregory F Albery ... Franz J Weissing

    The introduction of infectious pathogens to a simulated animal population leads to rapid evolutionary transitions in how individuals move in a social context, with distinct movement morphs evolved that make trade-offs between sociality and infection risk.
93. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

    Maire Gavagan, Noel Jameson, Jesse G Zalatan

    A biochemical approach using the Wnt pathway as a model system demonstrates a new mechanism for specificity in interconnected signaling networks through scaffold-mediated shielding of bound proteins.
94. 1. Cell Biology
    2. Developmental Biology

    Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

    James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann

    Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
95. 1. Genetics and Genomics

    Is competition for cellular resources a driver of complex trait heritability?

    Olivier Naret, Yuval Simons ... Jonathan K Pritchard
96. 1. Biochemistry and Chemical Biology

    Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism

    Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia

    Cryo-EM structures reveal GC-C associates with regulatory heat shock proteins similarly to bona fide protein kinases and this can guide the further development of mGC-targeted therapeutics.
97. 1. Neuroscience
    2. Physics of Living Systems

    Continuous, long-term crawling behavior characterized by a robotic transport system

    James Yu, Stephanie Dancausse ... Mason Klein

    Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
98. 1. Neuroscience

    Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism

    Jin Liu, Hyesang Chang ... Vinod Menon

    Learning in children with autism spectrum disorder (ASD) was achieved by fundamentally different cognitive and neural mechanisms from typically developing children, and insistence on sameness, a core symptom of ASD, contributed to such atypical mechanisms of learning in affected children.
99. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the connexin-43 gap junction channel in a putative closed state

    Chao Qi, Silvia Acosta Gutierrez ... Volodymyr M Korkhov

    Cryo-EM structures and molecular dynamics simulations of Cx43 gap junction channel and hemichannel reveal a putative closed state.
100. 1. Epidemiology and Global Health
     2. Medicine

     Association between bisphosphonate use and COVID-19 related outcomes

     Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian

     A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
101. 1. Structural Biology and Molecular Biophysics

     Structural and mechanistic insights into the MCM8/9 helicase complex

     Zhuangfeng Weng, Jiefu Zheng ... Yingfang Liu

     The hexametric structures of MCM8/9, revealed through cryo-electron microscopy single particle analysis, provide a foundational understanding of its helicase activity and offer novel insights into its mechanistic role.
102. 1. Epidemiology and Global Health
     2. Medicine

     Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis

     Surabhi Yadav, Olivia Delau ... Ricardo Azziz

     Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.
103. 1. Neuroscience
     2. Stem Cells and Regenerative Medicine

     Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

     Dong Wang, Tiemei Zheng ... Bin Yu

     Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.
104. 1. Neuroscience

     The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

     Lydia Gruber, Rafael Cantera ... Jürgen Rybak
105. 1. Neuroscience

     A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

     Marito Hayashi, Miriam Gullo ... Graziana Gatto
106. 1. Cell Biology

     Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics

     Raymond Laboy, Marjana Ndoci ... Adam Antebi
107. 1. Chromosomes and Gene Expression
     2. Genetics and Genomics

     Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader

     Pragyan Singh, Inbal Gazy, Martin Kupiec

     SUMOylated PCNA and the Elg1 PCNA unloader interact with the CST complex to coordinate DNA replication and telomere length maintenance.
108. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome

     Sophia Gessner, Zela Alexandria-Mae Martin ... Digby F Warner

     The interaction of ImuB with the β sliding clamp is essential for induced mutagenesis in mycobacteria and could be a novel target for new anti-tuberculosis drugs designed to inhibit the emergence of genetic resistance.
109. 1. Cancer Biology

     Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer

     José Manuel García-Martínez, Ana Chocarro-Calvo ... Custodia García-Jiménez

     Vitamin D bound to its receptor interacts with SIRT1 to induce its auto deacetylation and catalytic activity, which drives anti-proliferative effects in colorrectal cancer and this may lead to new therapeutic approaches for colorrectal and perhaps other cancers.
110. 1. Developmental Biology

     scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border

     Alexandre P Thiery, Ailin Leticia Buzzi ... Andrea Streit

     Neural plate border cells co-express neural, neural crest, and placodal transcriptional programs before cell fate decisions occur and are transcriptionally heterogeneous along the antero-posterior and medial-lateral axis.
111. 1. Genetics and Genomics

     Deterministic Genetic Barcoding for Multiplexed Behavioral and Single-Cell Transcriptomic Studies

     Jorge Blanco Mendana, Margaret Donovan ... Daryl M Gohl
112. 1. Medicine

     Deep Learning Using High-Resolution Images of Forearm Predicts Fracture

     Roland Chapurlat, Serge Ferrari ... Ego Seeman
113. 1. Neuroscience

     Subcortico-amygdala pathway processes innate and learned threats

     Valentina Khalil, Islam Faress ... Sadegh Nabavi

     The subcortical amygdala pathway, which has been traditionally associated with learning threats, is also required for processing an innate threat.
114. 1. Neuroscience

     Fine-grained functional parcellation maps of the infant cerebral cortex

     Fan Wang, Han Zhang ... Gang Li

     Advanced computational processing and analysis of functional MRI create the first comprehensive set of high-resolution cortical parcellations maps of infant brains.
115. 1. Ecology

     Plant secondary metabolite-dependent plant-soil feedbacks can improve crop yield in the field

     Valentin Gfeller, Jan Waelchli ... Matthias Erb

     A 2-year field experiment reveals that plant secondary metabolites can be harnessed to increase crop productivity through plant-soil feedbacks under agronomically realistic conditions.
116. 1. Neuroscience

     How inhibitory and excitatory inputs gate output of the inferior olive

     Sebastián Loyola, Tycho M Hoogland ... Chris I De Zeeuw

     Experimental work and computational models reveal how the timing between the inhibitory and excitatory inputs modulates the function of the inferior olive nucleus, a key structure for motor learning and cognition.