Sarah R Mullinax, Andrea M Darby ... Robert L Unckless
Genetic variation in an immune peptide is maintained by multiple selective forces including an interplay between systemic immunity, sex, and the microbiome.
ACVR2A downregulation disrupts the TCF7/c-JUN pathway, impairing trophoblast invasion and proliferation in pre-eclampsia, revealing a genetic susceptibility-associated mechanism of placental dysfunction.
Highly compulsive individuals set fewer reminders, partly due to inflated confidence and partly due to compulsivity itself, revealing how individual differences shape the strategic reminder use in daily life.
Claudia Barth, Liisa AM Galea ... Ann-Marie G de Lange
A big-data approach shows the effects of menopausal hormone therapy on female brain health might vary depending on the duration of use and history of gynaecological surgery.
AgRP1, a feeding-related peptide in the brain, facilitates feeding behavior of female medaka in the breeding season, which is important for reproductive success.
PriC provides a bypass mechanism for compromised helicase loading at the origin of the Escherichia coli chromosome, which ensures the robustness of the chromosome replication initiation.
Inhibiting the p38 MAPK-MK2 signaling pathway significantly boosts the efficacy of microtubule-targeting agents specifically in breast cancer cells, highlighting a potential new therapeutic strategy for improved cancer treatment.
Elise Miedlar, Grace E Hamilton ... Trisha N Davis
Biochemical reconstitution and laser trapping show that centromeric DNA sequences are important for the transmission of microtubule-based forces to chromosomes.
Infant attention during naturalistic social interactions is supported by their own endogenous neural activity and extended with the micro-contingent behavioural responsivity of their caregiver.
Cryo-EM structures of HsNCX1 in complex with either phosphatidylinositol 4,5-bisphosphate (a physiological activator) or SEA0400 (a pharmacological inhibitor) provide mechanistic insights into the cellular regulation and pharmacology of NCX proteins.
Shinichi Nakagawa, William K Cornwell, Corey T Callaghan
Analysis of 3 billion bird observations finds no intrinsic abundance-occupancy relationship, overturning a famous macroecological rule and redefining approaches to biodiversity assessment and conservation.
Hemodynamic occlusion introduces a spatially heterogenous confound to activity measurements using two-photon and widefield imaging in mouse cortex, and needs to be taken into consideration when interpreting functional imaging data.
Leafhoppers evade predators using nanostructured brochosomes that reduce ultraviolet reflectance through morphology shaped by four novel structural proteins originating from evolutionary duplication–divergence processes.
Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
Combining phylogenetic analyses and functional assays to study the receptor interacting protein kinase family reveals conserved and non-conserved functions in immune signaling across vertebrates.
Jingbo Kan, Adrian Morales-Amador ... Sean F Brady
Oxydifficidin presents potent activity against multidrug-resistant Neisseria gonorrhea with a new mode of action, which opens a new avenue for potentially addressing antibiotic resistant gonorrhea.
Johannes Jacobus Fahrenfort, Philippa A Johnson ... Simon van Gaal
The neural basis of consciousness is confounded by the mismatch between what participants report about their experience versus what they actually experience.
A single protein can switch cellular behaviors from protrusion to retraction based on its concentration and dynamics, revealing a novel mechanism for controlling antagonistic phenotypes in cell signaling.
IFN-β-induced WTAP phase transition bridges STAT1 and MTC, which orchestrates m6A dynamics on ISG mRNAs to suppress excessive immune response and sustain immune homeostasis.
Robert G Stewart, Matthew James Marquis ... Jon T Sack
Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.
Madeline M Keenen, Liheng Yang ... Carolyn B Coyne
Trophoblast organoids recapitulate syncytiotrophoblast nuclear heterogeneity and reveal environment-dependent gene regulation critical for placental hormone production and differentiation.
Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
Targeting EMC10 restores neuronal function in 22q11.2DS patient-derived neurons and reverses cognitive deficits in adult mice, highlighting its potential as a therapeutic strategy for mitigating disease-related cognitive impairments.
Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
Household clustering and seasonal parasite dynamics highlight the need to target asymptomatic carriers for community-based malaria elimination strategies.
Precise protein quality control in the endoplasmic reticulum is crucial for Cryptococcus neoformans pathogenicity by modulating glycoprotein processing and extracellular vesicle-mediated transport of virulence factors.
Identification of two molecularly distinct retroperitoneal liposarcoma subtypes, stratifiable via LEP and PTTG1 biomarkers, enables prognosis prediction and informs precision surgical strategies to improve clinical outcomes.
Catherine Suzanne Forconi, Christina Nixon ... Ann M Moormann
Pf-GARP antigen seems to be a better malaria vaccine candidate compared to PfSEA-1A, as it triggered the activation of cTFH17, involved in the maintenance of memory antibody responses in adults.
Monkeys are sensitive to foods coated with tooth-damaging sand and will invest time and energy to eliminate sand, but dominance rank affects the effort allocated to cleaning behaviors.
A femur transplantation model of bone marrow regeneration highlights the plasticity of periosteal skeletal stem cells and their ability to contribute to bone marrow niche regeneration, ultimately facilitating hematopoietic regeneration.
Subcortical brain structures contain neurons encoding subjective reports of stimulus detection in human participants, suggesting a role for conscious perception.
AACDB provides a comprehensive, manually curated antigen-antibody interface dataset with rich metadata, interaction annotations, and therapeutic target annotations to advance antibody drug development.
Co-culture between donor-derived iPSC-induced macrophages and forebrain organoids revealed microglial impairment leading to the degenerative neuro-environment in HDLS.
For the first time, mouse models reveal the metabolic dependency of photoreceptors on glutamine catabolism in vivo and further demonstrate the flexibility of photoreceptors to utilize fuel sources beyond glucose.
Jordina Rincon-Torroella, Marco Dal Molin ... Surojit Sur
Monocarboxylate transporter 1 overexpressed pancreatic cancers can be therapeutically targeted with ME3BP-7, a promising new agent with unique mode of action.
A computational study reveals that the kinetic models of Escherichia coli metabolism show strong responsiveness to perturbations and that it originates from cofactor dynamics and network sparsity.
Marius Seidenthal, Jasmina Redzovic ... Alexander Gottschalk
Caenorhabditis elegans FLWR-1/Flower is required for efficient synaptic vesicle recycling and does so through a functional and possibly direct physical interaction with the plasma membrane Ca2+ ATPase, MCA-3.
Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.
Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
A technique that enables single-particle cryo-EM analysis of targets on a magnetic bead and a particle curation method that helps structural classification of small particles has been developed.
Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford
Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
The SUN1-ALLAN complex serves as a nuclear envelope–spanning tether that coordinates the segregation of a bipartite microtubule organising center (MTOC) during the unusual mitosis of Plasmodium.
It is proposed that place cells are arranged in a hexagonal grid for large surfaces devoid of landmarks, which produces grid cell receptive fields as an artifact of memory retrieval.
Solution biophysics defines the influence of local dynamics and allosteric regulation on guide RNA binding affinity and DNA cleavage specificity in a thermophilic Cas9 from Geobacillus stearothermophilus.
Tendon regeneration is supported by human CD29+/CD56+ myogenic progenitors through tenogenic differentiation, representing a distinct stem cell population with therapeutic potential.
Sarah Benkeder, Son-Michel Dinh ... Jean-Christophe Comte
MorphoCellSorter is a versatile, user-friendly tool that automates microglial morphology ranking, enabling standardized, reproducible analysis across diverse models, imaging techniques, and conditions using principal component analysis and Andrews plots.
As a group, inattentionally blind participants can successfully report the location, color, and shape of stimuli they deny noticing, and exhibit a systematic bias to report not noticing.
The determination of GAGases structure facilitates the elucidation of the catalytic mechanism of PL35 family lyases and provides potential evidence for the hypothesis that GAG lyase evolved from alginate lyase.
Daniela Piña Novo, Mang Gao ... Gordon MG Shepherd
'Phototactile' hand stimulation rapidly activates first the somatosensory then the motor cortex, broadly consistent with constraints suggested by the previously described circuit architecture of this transcortical loop.
Bird species with higher plasma glucose show comparatively lower albumin glycation, suggesting the evolution of glycation resistance mechanisms, and terrestrial carnivores present higher glycation than omnivores.
Viral-mediated Oct4 overexpression induces direct conversion of wildtype mammalian Müller glia to bipolar neurons, and this process is synergistically enhanced by loss of Notch signaling.
Rare individuals treated for congenital cataracts demonstrated shifts in the visual cortex’s excitatory/inhibitory balance even decades post-surgery, reflected by alterations in the neurotransmitter concentration ratio and aperiodic electroencephalogram activity.
Higher biosynthetic capacity of gut microbes in individuals diagnosed with noncommunicable diseases or taking antibiotics suggests that diversity loss and 'dysbiosis' result from microbiome restructuring in response to ecosystem disruption.
Katarzyna Tutak, Izabela Broniarek ... Krzysztof Sobczak
Identification of ribosomal proteins RPS26 and RPS25, along with chaperone TSR2, as new important modifiers in the noncanonical translation process linked to fragile X premutation disorders.
Rachel Kaletsky, Rebecca S Moore ... Coleen T Murphy
Deviating from established protocols is the most likely reason why Gainey et al. (2024) could not reproduce earlier results in a Caenorhabditis elegans transgenerational inheritance paradigm, and the earlier findings are also supported by tests with over 30 new genes.
Derek G Epiney, Gonzalo Morales Chaya ... Chris Q Doe
The central complex of the adult Drosophila brain, required for sensorimotor integration, is transcriptionally complex as detected by single-cell transcriptome analysis.
AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
Lili Karashchuk, Jing Shuang Li ... Bingni W Brunton
A model that simulates realistic fly walking uses an anatomically-inspired layered architecture to achieve robust walking, quantifying the tolerance of this circuit to sensorimotor delays.
Matthew Rosenblatt, Saloni Mehta ... Dustin Scheinost
Self-citation rates differed by geographic region, seniority, gender, and field, which may ultimately affect the perceived influence of authors in these subgroups in neuroscience literature.
Cody J Warren, Arturo Barbachano-Guerrero ... Sara L Sawyer
Resurrection of ancient forms of CD4 reveals how retroviruses have placed selective pressure on this gene in apes, acting to propagate infection-resistant alleles.
Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.
Dendritic cell (DC)-derived IL-27 establishes CD4+ T cell bias against IFN-γ via STAT1 and epigenetics, linking thymic development to autoimmune mechanisms.
Structural and biochemical analyses suggest the association of homotrimeric CesAs of different isoforms into cellulose biosynthesis complexes via their class-specific regions.
Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and pre-exposure history.
Noëmie Mermet-Joret, Andrea Moreno ... Sadegh Nabavi
An optogenetic system capable of precise, high-frequency neuronal excitation using red pulsed light and rapid, millisecond inhibition using blue light.
Julia M Marchingo, Laura Spinelli ... Doreen A Cantrell
Parallel proteomics and transcriptomics data reveal that PIM kinases have a context-dependent role in promoting mouse CD8 T cell protein translation, effector function, and cell homing.
Epidermal mechanosensory responses contribute to acute detection of noxious mechanical stimuli and promote a form of prolonged mechanical hypersensitivity.
Paleodemographic analyses in a hypothesis-testing framework show that the major life-history trait of seasonal migration has strong effects on long-term effective population sizes in a clade of songbirds.
Rtf1 HMD is related to H2B ubiquitination and its downstream H3K4 methylation in both C. neoformans and C. deneoformans, thereby affecting its yeast-to-hypha transition and virulence.
A high-resolution atlas of the mouse dopaminergic system was obtained using single-nuclei RNA sequencing and spatial transcriptomics revealing molecular changes in a prodromal model of Parkinson's disease.
International Brain Laboratory, Kush Banga ... Yizi Zhang
An electrophysiology dataset generated by 10 laboratories from mice during perceptual decision-making reveals that reproducibility of systems neuroscience data requires stringent histological and electrophysiological quality-control criteria and careful analytical choices.
Shahriar Mowla, Linda Farahani ... Channa N Jayasena
There are common seminal microbiome clusters in both healthy men and those with infertility and recurrent pregnancy loss, and some specific microbiota perturbations are associated with impaired semen quality.
J Daniel Obray, Erik T Wilkes ... L Judson Chandler
Adolescent alcohol exposure reduced basolateral amygdala-driven inhibition of pyramidal neurons projecting from the prefrontal cortex to the periaqueductal gray and increased inhibition of prefrontal parvalbumin interneurons.
Visual sequence exposure induces non-feature-specific elevated responses and time-compressed feature-specific backward replay, revealing twofold brain plasticity in the human brain.
Characterization of recurrent fusion proteins in rhabdomyosarcoma identified a Hippo pathway-independent mechanism involving VGLL2 and TEAD1 driving oncogenic transformation.
Analysis of monoclonal immunoglobulin A (IgA) antibodies after intranasal immunization highlights the crucial role of secretory IgA in mucosal immunity, enhancing our understanding of how intranasal vaccines can protect against SARS-CoV-2 infection.
Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra
Transcriptomic profiling of HERV elements at the loci level differentiates ME/CFS, fibromyalgia, and their overlap, revealing distinct immuno-epigenetic landscapes.
A cross-talk is revealed between two branches of metabolisms, amino acid limitation suppressing fatty acid biosynthesis, via posttranslational modifications of an enzyme involved in fatty acid biosynthesis.
MARK2-mediated phosphorylation of CAMSAP2 dynamically controls Golgi orientation by altering microtubule anchoring and polarity during directional cell migration.
ADPT enhances the robustness of animal pose estimation by minimizing keypoint tracking drift, enabling more accurate multi-animal tracking and facilitating refined behavioral analysis across species.
Gene expression in nematodes during cold-induced dormancy is proposed to be regulated at the transcription level, partly involving the activation of unfolded protein response (UPR) through the IRE-1/XBP-1 signaling pathway.
Simon Rethemeier, Sonja Fritzsche ... Vera S Hunnekuhl
Genetic labeling and molecular analyses characterize the dynamics of embryonic central complex-forming type II neuroblast lineages in Tribolium castaneum.
Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
Dip2 regulates PKC signalling through specific DAG acyl chain compositions—a crucial pathway, which emerged approximately 1.2 billion years ago, marking the advent of selective DAG-based signalling in eukaryotes.
Distinct seasonal peaks and sex-specific interactions reveal that cohesive female groups drive rapid local spread while male connectors facilitate intergroup transmission, underscoring the need for tailored disease control strategies.
The novel pre-training framework integrating sequential and geometric encoders significantly enhances protein engineering by accurately predicting variant effects and thermostability, outperforming existing zero-shot learning methods with minimal computational cost.
Sulfakinin-receptor1 signaling system alters the expression of odorant receptors in antenna to modulate the behavioral switch between foraging and mating in the oriental fruit fly.
Endothelial-specific supplementation with Aff3ir-ORF2 significantly ameliorated disturbed flow-induced endothelial activation and the development of atherosclerotic plaques, highlighting its promising therapeutic potential for the treatment of atherosclerosis.
A built-in solution for correcting optical aberrations in long (> 6 mm) gradient index (GRIN) lenses enables unbiased two-photon functional recordings of large neuronal populations in the deep mouse brain.
Target motion modulates monkey M1 neural dynamics during reaching, characterized by an orbital neural geometry composed of target-velocity-dependent tilting rings, suggesting that sensory information can be independently incorporated during motor generation.
The enhanced taste and flavor of food induced by the addition of L-ornithine, referred to as 'kokumi' in humans, may be mediated by GPRC6A receptors expressed in taste cells.
William R Thomas, Troy Richter ... Liliana M Davalos
Adaptive gene expression in the common shrew hypothalamus connects energy homeostasis with reversible brain size changes in response to seasonal environmental challenges.
When performance is matched, the attentional blink allows for greater integration of complex stimulus features than masking, reflecting spared recurrent processing during attentional versus perceptual impairments of conscious access.
Agnese Codutti, Mohammad A Charsooghi ... Stefan Klumpp
Microfluidics experiments and simulations show that magnetotactic bacteria are adapted to the geomagnetic field strength for optimal navigation in sediment environments.
Sromona D Mukherjee, Carlos Batagello ... Aaron W Miller
Microbiome composition through the redundancy of oxalate-degrading bacteria, critically influence oxalate metabolism, explaining variable outcomes of Oxalobacter formigenes therapy and offers insights for improving probiotic selection and clinical trial strategies.
