June 2026

Cover articles

    1. Developmental Biology

    Testing the blood-brain barrier

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    1. Evolutionary Biology

    Evolution in eutherian mammals

    Z Jack Tseng, Qian Li, Suyin Ting
    1. Neuroscience

    Context-dependent behavior

    Pol Bech, Robin F Dard ... Carl CH Petersen
    1. Ecology

    Selection of spatial cognition

    Carrie L Branch, Benjamin R Sonnenberg ... Vladimir V Pravosudov

Highlights controls:

Research articles

    1. Immunology and Inflammation
    2. Cancer Biology

    Integrin-deficient T cell leukemia accumulates in the central nervous system

    Samantha Y Lux, Cynthia Chen ... Susan R Schwab
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    A Single-Cell Signaling Atlas of Spinal Cord BDNF Responses Reveals Determinants Beyond Receptor Expression

    Jonathon M Sewell, Autumn C Bissett ... Chris D Deppmann
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Plant Biology

    Dissecting oligogenic and polygenic indirect genetic effects through the lens of neighbor genotypic identity

    Yasuhiro Sato, Kosuke Hamazaki
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Evolutionary Biology

    Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod

    Gaoke Lei, Huiling Zhou ... Shijun You
    Long-term thermal selection in Plutella xylostella drives coordinated genetic, epigenetic, and metabolic adaptations that enhance climate resilience, revealing mechanisms potentially shared across arthropod pests.
    1. Evolutionary Biology

    Brawn before bite in endemic Asian eutherian mammals after the end-Cretaceous extinction

    Z Jack Tseng, Qian Li, Suyin Ting
    Eutherian mammals living in China after the end-Cretaceous extinctions evolved larger tooth sizes first before becoming more specialized in their biting performance, mirroring a similar pattern in brain evolution.
    1. Cancer Biology

    Restraint of melanoma progression by cells in the local skin environment

    Yilun Ma, Mohita Tagore ... Richard M White
    Keratinocytes, which activate an EMT-like program in the skin, can prevent melanoma invasion, highlighting how changes in the tumor microenvironment can act as restraining forces in cancer.
    1. Neuroscience

    Meaning-based guidance of attention in rhesus monkeys during naturalistic scene viewing

    Orhan Soyuhos, Taylor R Hayes ... Xiaomo Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    LiFE, a multimodal circadian intervention, improves sleep, glycemic control, and recognition memory

    Yu Shi, Stephen D Rozen ... Ali D Güler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Tonic feedback motor commands predict visuomotor learning

    Yuto Makino, Toshiki Kobayashi, Daichi Nozaki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Medicine
    2. Immunology and Inflammation

    A surviving beta cell subpopulation enriched in patients with T1D

    Maxwell Spurrell, John S Tsang, Kevan C Herold
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Developmental Biology

    Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis

    Changle Zhao, Yongxun Chen ... Jing Wei
    Desert Hedgehog signaling promotes stem Leydig cell differentiation through a Ptch2-Gli1-Sf1 regulatory axis in Nile tilapia.
    1. Neuroscience

    Frequency-dependent modulation of foveal contrast sensitivity by fine-scale exogenously triggered attention

    Yue Guzhang, T Florian Jaeger, Martina Poletti
    Fine-scale exogenous attention within the foveola selectively enhances contrast gain at low-to-mid spatial frequencies while increasing response gain across a broad spatial frequency range.
    1. Neuroscience

    Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation

    Pol Bech, Robin F Dard ... Carl CH Petersen
    Optical imaging and optogenetic inactivation of dorsal mouse neocortex reveal an unexpected role for retrosplenial cortex in the context-dependent transformation of whisker sensory information into licking for a water reward.
    1. Immunology and Inflammation

    Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

    Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
    Co-culturing pluripotent stem cell-derived hepatocytes and macrophages establishes a physiologically relevant liver model that captures macrophage–hepatocyte interactions, significantly improves hepatocyte maturation, and enables more accurate prediction of immune-mediated drug toxicity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Correlates of protection against African swine fever virus identified by a systems immunology approach

    Kirill Lotonin, Francisco Brito ... Artur Summerfield
    Dissecting protective versus detrimental immune responses uncovers biomarkers and mechanisms that can inform the rational design and evaluation of live attenuated vaccines against African swine fever virus.
    1. Neuroscience

    Disinformation elicits learning biases

    Juan Vidal-Perez, Raymond J Dolan, Rani Moran
    Learning from potential disinformation introduces specific cognitive biases, causing individuals to systematically deviate from an idealized Bayesian updating strategy.
    1. Immunology and Inflammation

    Deciphering interferon functions in avian influenza using receptor knockout models in the natural host

    Mohanned Naif Alhussien, Hanna Kaisa Vikkula ... Benjamin Schusser
    Interferon receptor knockout chickens uncover how type I and III interferons differentially shape avian antiviral immunity and influenza disease outcomes.
    1. Medicine

    Differential regulation of hepatic macrophage fate by Chi3l1 in metabolic dysfunction-associated steatotic liver disease

    Jia He, Bo Chen ... Zhao Shan
    Chi3l1 binding to glucose protects Kupffer cells and limits MASLD progression.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating probabilities of malaria importation in southern Mozambique through modelling P. falciparum genomics and mobility patterns

    Arnau Pujol, Arlindo Chidimatembue ... Alfredo Mayor
    Malaria importation in Matutuine district from southern Mozambique is strongly contributing to sustaining transmission, with Inhambane province being the main source of importation.
    1. Structural Biology and Molecular Biophysics

    Conformational variability of HIV-1 Env trimer and viral vulnerability

    Yiwei Cao, Wonpil Im
    Large-scale all-atom simulations of a full-length, glycosylated HIV-1 Env trimer in an asymmetric membrane reveal a rigid ectodomain and highly diverse conformational landscapes in the membrane-proximal region and transmembrane domain.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis partitions the Krebs cycle under iron starvation

    Agnese Serafini, Acely Garza-Garcia ... Riccardo Manganelli
    Mycobacterium tuberculosis rewires central carbon metabolism to circumvent iron-dependent metabolic routes during iron starvation.
    1. Developmental Biology

    A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivatives

    Rotem Leshem, Syed Murtuza-Baker ... Nicoletta Bobola
    Transcriptomic profiling of the developing human outflow tract and adult aortic valves reveals that adult valve cells retain distinct embryonic molecular signatures.
    1. Physics of Living Systems

    Controlling the synchronization and symmetry breaking of coupled bacterial pili on active biofilm carpets

    Baha Altın, Enes Talha Günay ... Askin Kocabas
    Active biofilm carpets generate Mexican-wave-like synchronized dynamics and topological defects through nonreciprocal pili interactions.
    1. Neuroscience

    Intrinsic properties link a network model to zebra finch song

    Nelson D Medina, Dan Margoliash
    Whole-cell recordings paired with a network model show that post-inhibitory rebound excitation in premotor neurons couples intrinsic excitability to the temporal structure of learned birdsong.
    1. Cell Biology

    PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

    Jimena Druker, Hao Jiang ... Angus I Lamond
    Proline hydroxylation of RepoMan (CDCA2) at P604 by PHD1 is shown to be important for mitotic progression and regulating interaction with PP2A regulatory subunit B56 gamma.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    The viral type 2 internal ribosome entry site uses a unique mechanism to hijack the host ribosomal machinery by interacting with initiator tRNA and 40S head.
    1. Neuroscience

    SynaptoTagMe, a toolkit for in vivo mapping and modulating neurotransmission at single-cell resolution

    Andrea Cuentas-Condori, Patricia Chanabá-López ... Daniel A Colón-Ramos
    Endogenous tagging and conditional silencing of vesicular transporters reveal widespread, conserved co-transmission, and enable causal dissection of transmitter-specific synaptic function, linking molecular identity to circuit dynamics and behavior in vivo.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Systematic characterisation of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

    Hao Jiang, Jimena Druker ... Angus I Lamond
    A robust workflow for the identification of proline hydroxylation sites in proteins was established, using hydrophilic interaction chromatography enrichment and LC-MS/MS together with refining and filtering parameters during data analysis.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acyl Carrier Protein is Essential for Apicoplast Biogenesis in Malaria Parasites Independent of Fatty Acid Synthesis

    Sage WR Geher, Seyi Falekun ... Paul A Sigala
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Hippocampal neuronal and astrocytic responses to noradrenaline and natural arousal

    Sian N Duss, Maria Wilhelm ... Peter Rupprecht
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Feedback control of recurrent circuits imposes dynamical constraints on learning

    Harsha Gurnani, Weixuan Liu, Bingni W Brunton
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Arousal modulates functional connectivity through structured and hemispherically asymmetric community architecture during wakefulness

    Xiangyu Kong, Siyu Li, Gaolang Gong
    Rather than exerting a uniform influence, arousal modulates the connectome through a structured, low-dimensional community architecture characterized by discrete topological patterns and intrinsic hemispheric asymmetries.
    1. Genetics and Genomics

    A pilot study for whole proteome tagging in Caenorhabditis elegans

    Matthew Eroglu, Oliver Hobert
    Simultaneous tagging of multiple genes with different fluorophores provides a proof of concept for the scalability of tagging all genes in the Caenorhabditis elegans genome.
    1. Neuroscience

    Verbal Episodic Processing in Newborns

    Emma Visibelli, Ana Fló ... Silvia Benavides-Varela
    Speaker identity is a distinguishing feature at birth and highlights the episodic nature of humans’ first-stored verbal memories.
    1. Neuroscience

    Opposing BOLD signals and oxygen metabolism largely arise from statistical uncertainty in metabolic estimates

    Ole Goltermann, Alexander Huth, Christian Büchel
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer

    Ningjun Duan, Yijia Hua ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Physics of Living Systems

    Cell strain-stiffening drives cell breakout from embedded spheroids

    Shabeeb Ameen, Kyungeun Kim ... Tao Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Confidence phenotypes: a unified computational account of value and decision certainty in reinforcement learning

    Nicolás A Comay, Guillermo Solovey, Pablo Barttfeld
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in C. elegans

    Sarah J Benbow, Aleen D Saxton ... Brian C Kraemer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    How local antibiotic use, carriage duration, resistance costs and international travel shape resistance frequency in E. coli in France

    Olivier Cotto, André Birgy ... François Blanquart
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response

    Rui Yang, Kaiyuan Zheng ... Jie Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    RNF25 is activated as a response to amino acid starvation-induced ribosome collisions in competition with GCN2

    Ivan Kisly, Ivo Zemp, Ulrike Kutay
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Cognitive control networks in human and macaque

    Valentina Mione, Freja Holm Prins ... John Duncan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Temporal Dynamics of Cortical State Plasticity Following Adult Vision Loss

    Ismaël Djerourou, Maurice Ptito, Matthieu P Vanni
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Training neural networks from scratch in a videogame leads to brittle brain encoding

    François Paugam, Basile Pinsard ... Lune Bellec
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Physics of Living Systems
    2. Evolutionary Biology

    Ecological diversification in rapidly evolving populations

    Daniel PGH Wong, Benjamin H Good
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Hierarchical priors enable neural prediction of perceived biological motion

    Ingmar EJ de Vries, Floris P de Lange, Moritz F Wurm
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Proteolytic remodeling by Yme1 enables mitochondrial-derived compartment formation

    Sai Sangeetha Balasubramaniam, Amy E Curtis ... Adam L Hughes
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Physiology

    Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand

    Harsharan Dhillon, Richard S Lewis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Neuroscience

    Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception

    Tony Carricarte, Siying Xie ... Radoslaw M Cichy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Solid
    1. Structural Biology and Molecular Biophysics

    In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

    Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa
    Revised
    Reviewed Preprint v2
    • Important
    • Convincing
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    From multiplicity of infection to force of infection in sparsely sampled high-transmission Plasmodium falciparum populations

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Queuing theory links multiplicity of infection (MOI) to force of infection (FOI), enabling the estimation of transmission intensity for falciparum malaria (and other infectious diseases) from sparsely sampled surveys.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies

    Yi Lin, Benjamin Liou ... Ying Sun
    Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.
    1. Neuroscience

    Layer-specific wide-field calcium imaging of neocortical activity

    Dayra A Lorenzo, Yasir Gallero-Salas ... Fritjof Helmchen
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of extraocular motor neurons reveals sim1a as a candidate strabismus-related gene

    Emily Gershowitz, Kyla Rose Hamling ... David Schoppik
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Dopamine ramps as a normative consequence of dual-process control

    Luke Priestley, Thomas Akam
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Evolutionary Biology

    Essential function reflected in the phylodynamics of a multigene family – the pir genes of malaria parasites

    Andrew P Jackson, Deirdre A Cunningham ... Christiaan van Ooij
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Reduction of complex dynamic touch information to a single stable perceptual feature

    Naghmeh Zamini, Benjamin Stephens-Fripp ... Jess Hartcher-O’Brien
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    Uncovering the Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveals an Unexpected Early Checkpoint Role

    Helen Wang, Vinothkumar Rajan ... Juan Carlos Zúñiga-Pflücker
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Paraventricular thalamus hyperactivity mediates stress-induced sensitization of unlearned fear but not stress-enhanced fear learning (SEFL)

    Kenji J Nishimura, Denisse Paredes ... Michael R Drew
    Chemogenetic and in vivo recording approaches reveal how persistent hyperactivity in the posterior paraventricular thalamus promotes sensitization of fear responses to unlearned threats after stress exposure.
    1. Biochemistry and Chemical Biology

    Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers

    Megan S Laham, Martha S Ackerman-Berrier ... Gregory RJ Thatcher
    Coregulator TR-FRET profiling reveals ligand-specific LXR signaling signatures that can guide the therapeutic design of ABCA1-inducing LXR agonists with attenuated risk of hepatic lipogenesis.
    1. Ecology

    Dopamine and its receptor DcDop2 are involved in the coevolution between ‘Candidatus Liberibacter asiaticus’ and Diaphorina citri

    Xiaoge Nian, Jiayun Li ... Songdou Zhang
    CLas hijacks the DA/DcDop2-miR-31a-AKH-JH signaling cascade to improve D. citri lipid metabolism and fecundity, while simultaneously promoting its replication.
    1. Neuroscience

    Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum

    Bruno Miranda, James L Butler ... Steven W Kennerley
    Single-neuron recordings reveal that anterior cingulate cortex and caudate nucleus encode the interaction between rewards, state transitions, and choices that underlies flexible, goal-directed decision-making.
    1. Structural Biology and Molecular Biophysics

    Optimising the tilt-increment for in situ cryo-electron tomography

    Maarten W Tuijtel, Tomáš Majtner ... Martin Beck
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

    Koichi Hashikawa, Yoshiko Hashikawa ... Garret D Stuber
    Esr1 directs adolescent transcriptional maturation of medial preoptic GABAergic neurons, enabling the normal development of mating behavior in male and female mice.
    1. Neuroscience

    Material damage to multielectrode arrays after electrolytic lesioning is insignificant

    Alice Tor, Stephen E Clarke ... Paul Nuyujukian
    An analysis of the largest publicly available collection of scanning electron microscopy images of explanted multielectrode arrays reveals that electrolytic lesioning causes no significant additional damage to array electrodes.
    1. Neuroscience

    Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization

    Roland Philipp, Yuki Hara ... Kazuhiko Seki
    Long-term motor recovery after musculoskeletal alteration relies on gradually developing novel compensatory movements to overcome the rigid, maladaptive timing of stable muscle synergies.
    1. Immunology and Inflammation

    Metabolic support of trained immune responses in myeloid cells

    Aitor Jarit-Cabanillas, Gillian Dunphy ... David Sancho
    A review of literature regarding trained immunity (TI) differentiates two distinct stages of metabolic immune regulation, with primary metabolic changes influencing early epigenetic adaptations that drive TI induction and secondary metabolic adaptations providing building blocks required for enhanced immune function.
    1. Neuroscience

    Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics

    Mengyang Jacky Li, Jinghui Wang ... Tian-Ming Fu
    Tunable Bessel beam two-photon fluorescence microscopy enables high-speed volumetric intravital imaging of subcellular dynamics within living mouse brains with fully tunable spatial resolution and volume coverage, allowing flexible sampling and measurements of vascular, neuronal, and immune dynamics.
    1. Neuroscience

    Synaptotagmin isoforms differentially regulate glutamate and GABA release in the lateral habenula

    Dustin N White, J Keenan Kushner ... Michael HB Stowell
    Not revised
    Reviewed Preprint v1
    • Useful
    • Inadequate
    1. Neuroscience

    Head before heart: cognitive empathy emerges before affective empathy in the developing brain

    Chiara Bulgarelli, Paola Pinti ... Emily J Jones
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Virus specific impacts on honey bee flight performance are mediated by the octopamine pathway

    Naomi G Kaku, Michelle L Flenniken
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Genetics and Genomics

    The cistrome response to hypoxia in human umbilical vein endothelial cells

    Ayush Singh, Viktor Pastukh ... Hank W Bass
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Fragile polyQ assemblies cause Golgipathy in Huntington’s disease

    Lixiang Ma, Xinyu Chen ... Hexige Saiyin
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Immunology and Inflammation

    Simplifying principles that underlie the highly complex peptide motif of the promiscuous chicken class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

    Ryo Masumura, Kyosuke Goda ... Naofumi Uesaka
    Disrupting oligodendrocytes during a narrow early-life window leaves cerebellar circuits permanently mistimed, but adult re-synchronization restores social and motor behavior.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity

    Katrina M Zinn, Mathew W McLaren ... Matthew J Elrick
    Enterovirus D68, a cause of acute flaccid myelitis, disrupts the composition and function of the nuclear pore complex primarily through its 2A protease, which is also toxic to motor neurons.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype

    Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
    A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation itself.
    1. Biochemistry and Chemical Biology

    Single-step in vitro reconstitution of the Escherichia coli ribosome mediated by two GTPase factors, EngA and ObgE

    Aya Sato, Weng Yu Lai ... Yoshihiro Shimizu
    A multi-step ribosome assembly method involving changes in ion concentration and temperature can now be carried out in a single step using the two GTPase factors, EngA and ObgE.
    1. Plant Biology

    Story about honest mistakes: The cyanobacterium Synechocystis has a promiscuous Entner-Doudoroff (ED) aldolase but no functional ED pathway

    Ravi Shankar Ojha, Marius Theune ... Kirstin Gutekunst
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Developmental Biology

    The Par complex regulates apical-basal cell polarity through modulation of FAK signaling homeostasis

    Meiai He, Lining Liang ... Hui Zheng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    Tracheal terminal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

    Judith Bossen, Larissa Fritz ... Thomas Roeder
    Terminal tracheal cells in Drosophila evade innate immune activation, revealing a fundamental trade-off in which suppression of canonical immune signaling preserves Foxo-dependent plasticity and sustains respiratory function.
    1. Physics of Living Systems

    Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering

    Elaheh Zare-Eelanjegh, Renard TM Lewis ... Tomaso Zambelli
    Cellular mechanotransmission depends on nuclear lamina composition, where A-type and B-type lamins define distinct nuclear mechanical responses, and microtubules dynamically buffer intracellular tension.
    1. Cell Biology
    2. Neuroscience

    Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

    Javier Emperador-Melero, Steven J Del Signore ... Avital A Rodal
    Presynaptic endocytic machinery is constitutively deployed to periactive zones, indicating independent assembly pathways for the exo- and endocytic machineries of nerve terminals.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Atomistic simulations reveal sub-µs contact dynamics in MUT-16 condensates

    Kumar Gaurav, Lucia Baltz ... Lukas S Stelzl
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Dendritic delay lines shape the computation of sound location in neurons of the gerbil medial superior olive

    Jared Casarez, Rebecca L Voglewede ... Nace L Golding
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Development of a genetically encoded fluorescent indicator for facilitating deorphanization of GPR52

    Guangyi Lan, Huan Wang ... Yulong Li
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Ecology

    Benefit Transfer Loops Turn Cheating into a Scaffold for Microbial Diversity

    Jiqi Shao, Yinxiang Li ... Zhiyuan Li
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Convincing
    1. Neuroscience

    Bayesian causal inference unifies perceptual and neuronal processing of center-surround motion in area MT

    Gabor Lengyel, Sabyasachi Shivkumar ... Ralf M Haefner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Ecology

    Male chickadees with better spatial cognition sire more extra-pair young

    Carrie L Branch, Benjamin R Sonnenberg ... Vladimir V Pravosudov
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

    Dirk EM Geurts, Hanneke EM den Ouden ... Roshan Cools
    Catecholaminergic modulation by methylphenidate affects appetitive and aversive Pavlovian biases of approach and avoidance in humans depending on individual differences in working memory capacity.
    1. Microbiology and Infectious Disease

    A rapid transfer of virions coated with heparan sulfate from the ECM to CD151 defines an early step in the human papillomavirus infection cascade

    Annika Massenberg, Yahya Homsi ... Thorsten Lang
    In an assay focusing on active virus recruitment rather than passive binding, STED microscopy reveals early association of virions to CD151, indicating its early involvement in viral entry platforms formation.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Host and antibiotic jointly select for greater virulence in Staphylococcus aureus

    Michelle Su, Kim L Hoang ... Timothy D Read
    Antibiotic resistance alters pathogen evolutionary trajectory.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Faroese whole genomes provide insight into ancestry and recent selection

    Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
    Present-day Faroese genomes reveal ancestry, bottleneck history, and signatures of selection, and offer a foundation for understanding the genetic architecture of health and disease in this North Atlantic founder population.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome reorganization and its functional impact during breast cancer progression

    Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
    Genome-wide maps of chromatin structure in a cell-based model of breast cancer reveal chromatin reorganization accompanied by changes in transcription and epigenetic marks.
    1. Neuroscience

    Linear and categorical coding units in the mouse gustatory cortex drive population dynamics and behavior in taste decision-making

    Liam Lang, Camelia Yuejiao Zheng ... Alfredo Fontanini
    Linear or categorical activity from neurons in the gustatory cortex is necessary for network dynamics and performance.
    1. Evolutionary Biology

    Are interphylum spiralian relationships resolvable?

    Ana Serra Silva, Maximilian J Telford
    Analyses of two independent phylogenomic datasets suggest an explosive radiation at the origin of Spiralia, with implications for understanding the group's evolutionary history.
    1. Structural Biology and Molecular Biophysics

    Myristoylation licenses disordered viral VP4 protein to anchor to and perforate the membrane through phase separation

    Sichao Huang, Fengzhen Deng ... Bin Sun
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    More than just a passive brick in the wall: the nucleosome facilitates DNA polymerase β activity in linker DNA and its PARP-dependent regulation in the BER pathway choice

    Danil M Shtanov, Tatyana A Kurgina ... Olga I Lavrik
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Glutamate receptor composition at Drosophila neuromuscular junctions depends on developmental stage and muscle identity

    Anne Sustar, Chengjie Qiu ... John C Tuthill
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Human decision-makers terminate evidence accumulation using flexible decision rules

    Ishan Kalburge, Alice Dallstream ... Joshua I Gold
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat

    Chelsey C Damphousse, Olivia L Calvin, A David Redish
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency

    Eleonora Parrotta, Patric Bach ... Francesca Ferri
    Interoceptive predictions can bias both the subjective experience of pain and physiological preparation.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
    A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
    1. Biochemistry and Chemical Biology

    Nuclear CK1δ as a critical determinant of PER:CRY complex dynamics and circadian period

    Fidel Emmanuel Serrano, Daniela Marzoll ... Michael Brunner
    Repressive PER2:CRY1:CK1δ complexes assembling in the cytosol enter the nucleus, where PER2 hyperphosphorylation eventually disrupts the complex, causing PER2 to relocalize to the cytoplasm, allowing nuclear accumulation of CRY1.
    1. Ecology

    Moderate density of small mammalian herbivores facilitates livestock growth by improving vegetation composition in grasslands

    Zhiwei Zhong, Bingbo Ni ... Zhibin Zhang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Perceiving animacy in ‘identical’ images

    Tal Boger, Chaz Firestone
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience
    2. Ecology

    The neuronal clock network in the polar key species Antarctic krill (Euphausia superba)

    Lukas Hüppe, Nils Reinhard ... Charlotte Helfrich-Förster
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Ramping-up hippocampal ripples and their neocortical coupling support human visual short-term memory

    Jing Liu, Xianhui He ... Ying Cai
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning

    Jackson Scheib, Zachary L Newman ... Aaron Kerlin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Betrayal is worse than loss during cooperation

    Rumeng Tang, Jingbin Tan ... Dingguo Gao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Physics of Living Systems

    Optimal chemotactic navigation in disordered landscapes

    Yang Bai, Caiyun He ... Xiongfei Fu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Disrupted hippocampal theta-gamma coupling and spike-field coherence following experimental traumatic brain injury

    Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
    Experimental TBI results in distinct patterns of network-level pathophysiology in the hippocampus that may contribute to TBI-associated cognitive deficits.
    1. Microbiology and Infectious Disease

    Starvation of the bacterium Vibrio atlanticus induces simultaneous attacks on the dinoflagellate Alexandrium pacificum

    Jean-Luc Rolland, Estelle Masseret ... Raphael Lami
    Vibrio bacteria act as predators of ecologically significant algae that contribute to harmful blooms.
    1. Microbiology and Infectious Disease

    Identifying and targeting the Mg-Fe-PmrAB regulatory circuit reverses phosphate starvation-driven polymyxin resistance in Enterobacteriaceae

    Guangming Zhang, Ziqing Deng ... Aixin Yan
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Structural basis of CO2 valence coding in Drosophila

    Javorski Dominik, Bergkirchner Beate ... Hummel Thomas
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Contractile perinuclear actomyosin network promotes peripheral and polar chromosome interaction with the mitotic spindle

    Nooshin Sheidaei, John K Eykelenboom ... Tomoyuki U Tanaka
    An actomyosin network (PANEM) forms around the nucleus in prophase, and its contraction repositions peripheral and polar chromosomes to facilitate their interaction with the mitotic spindle, ensuring their correct segregation.
    1. Neuroscience

    Tactile localization of the breast, areola, and nipple

    Katie H Long, Emily E Fitzgerald ... Charles M Greenspon
    The breast, despite its importance in sexual and affective touch, exhibits poor tactile localization and demonstrates a relationship between size and innervation density.
    1. Neuroscience

    Neural bases of space-specific distractor biases in visual working memory

    Deepak V Raya, Sanchit Gupta, Devarajan Sridharan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Pregistered movie-fMRI analyses reveal altered visual feature encoding in autism in pSTS

    Jeff Mentch, Yibei Chen ... Satrajit S Ghosh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Neuromodulatory systems partially account for the topography of cortical networks of learning under uncertainty

    Alice Hodapp, Florent Meyniel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Purified zymogens reveal mechanisms of snake venom metalloproteinase auto-activation

    Sophie Hall, Iara Aime Cardoso ... Christiane Schaffitzel
    A generic strategy for producing functional snake venom metalloproteinases opens the field to reproducible mechanistic studies and inhibitor discovery.
    1. Neuroscience

    Altered cognitive processes shape tactile perception in autism

    Ourania Semelidou, Mathilde Tortochot-Megne Fotso ... Andreas A Frick
    Altered tactile decision-making in autism reflects context-dependent weighting of sensory inputs and diminished integration of sensory history, enhancing low-salience discrimination while reducing category-based perceptual facilitation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    A comprehensive mutational scan of TYK2 identifies novel allosteric sites, elucidates functional drug-protein interactions, and links autoimmune disease protection to reduced TYK2 protein abundance.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell size modulates ferroptosis susceptibility

    Evgeny Zatulovskiy, Magdalena B Murray ... Jan M Skotheim
    Cellular sensitivity to cell death stimuli depends on cell-size-dependent proteome changes - specifically, cell size can modulate ferroptosis susceptibility through changes in glutathione biosynthetic enzymes, ferritin, and cathepsin B concentrations.
    1. Ecology

    Beyond Acoustic Cues: Olfactory-Mediated Avoidance of Bats by Crickets

    Yannan Li, Wenhao Zhang ... Aiqing Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation

    Hannah Brunsdon, Nuoya Wang ... E Elizabeth Patton
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Cell Biology

    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

    Xiaoning Gao, Wuyan Guo ... Jun Kang
    Non-covalent targeting of KEAP1 by capsaicin provides a reversible and safe NRF2 agonist for treating oxidative damage.
    1. Neuroscience

    Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

    Eleonore Schiltz, Martijn Broux ... Haesler Sebastian
    The representation of stimulus identity and experience is transformed from primary olfactory cortex to memory-related multisensory areas in the hippocampus.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Neuroscience

    Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque

    Richard Johnston, Matthew A Smith
    Arousal signals are present in the superior colliculus but appear to be organized in a way that they avoid directly triggering motor plans that lead to saccades.
    1. Microbiology and Infectious Disease

    Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis

    Helge Feddersen, Charlotte Dyckmans, Marc Bramkamp
    Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min system dynamics.
    1. Microbiology and Infectious Disease

    A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms

    Fernanda T Subtil, Teresa FG Machado ... Luiz Pedro S de Carvalho
    Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.
    1. Neuroscience

    A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

    Steven A Calle-Schuler, Alexis Santana-Cruz ... Andrew M Seeds
    A synaptic-resolution map reveals how spatially organized touch pathways in the fly brain shape aimed head grooming through parallel excitatory circuits and inhibitory control.
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.
    1. Chromosomes and Gene Expression

    Uncoupling the TFIIH Core and Kinase Modules leads to misregulated RNA polymerase II CTD Serine 5 phosphorylation

    Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
    The TFIIH subunit Tfb3/MAT1 can be split into two parts to uncouple the TFIIH kinase and DNA translocase modules, resulting in unfocused C-terminal domain phosphorylation.
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Integrative structural analysis identifies the structural basis and key residues responsible for IDE conformational dynamics that control the unfolding and selective degradation of amyloid peptides.
    1. Developmental Biology
    2. Computational and Systems Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

    Catherine G Triandafillou, Pranav Sompalle ... Arjun Raj
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood

    Chiara Bulgarelli, Anna Blasi ... The BRIGHT Study Team
    In Gambian infants, positive growth from 0 to 5 months of age predicted more mature brain networks, which in turn predicted cognitive outcomes at 3-5 years.
    1. Developmental Biology

    The NTR/prodrug revolution: Tools for controlling cell loss and regeneration

    Gha-Hyun J Kim, Michael Parsons
    Improved nitroreductase variants, optimized prodrugs, and careful experimental design enable scalable, precise cell ablation across model systems for disease modeling, regeneration studies, and high-throughput discovery.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A genetic toolkit for stable transgenesis in the anaerobic gut parasite Blastocystis ST7-B

    M Rey Toleco, Kevin SW Tan, Mark van der Giezen
    Revised
    Reviewed Preprint v2
    • Valuable
    • Convincing
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Direct MRI of collagen

    Jason Daniel Van Schoor, Markus Weiger ... Klaas P Pruessmann
    The direct observation of collagen using magnetic resonance imaging is possible, presenting a new method to study the protein in vivo.
    1. Microbiology and Infectious Disease

    Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species

    Letong Xu, Shenghai Shen ... Xin Deng
    Transcriptome-wide profiling of bacterial RNA pseudouridylation maps modification landscapes and nominates candidate regulatory sites, offering a resource and foundation for future mechanistic studies of Ψ function in bacteria.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Real-Time Embodied Experience Shapes High-Level Reasoning Under Altered Gravity

    Hélène Grandchamp des Raux, Tommaso Ghilardi ... Ori Ossmy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    Somatic Programmed DNA Elimination is widespread in free-living Rhabditidae nematodes

    Caroline Launay, Eva Wenger ... Marie Delattre
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology

    HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

    Yuqian Shen, Ziyang Wang ... Dong Liu
    HSD17B7-dependent cholesterol biosynthesis is essential for hair cell function, implicating HSD17B7 disruption in the pathogenesis of hearing loss.
    1. Cell Biology
    2. Neuroscience

    CO2-dependent opening of connexin 43 hemichannels

    Valentin Mihai Dospinescu, Alexander Mascarenhas ... Nicholas Dale
    Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.
    1. Developmental Biology
    2. Neuroscience

    ARHGEF6-dependent cytoskeletal regulation underlies a conserved program of forebrain interneuron development

    Carla Liaci, Beatrice Savarese ... Giorgio R Merlo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Divergent spatiotemporal integration of whole-field visual motion in medaka and zebrafish larvae

    Yasuko Isoe, Yasmine Fatima Mabene ... Florian Engert
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Intron Retention Controls Localization of lncRNAs PURPL and MALAT1 to Promote Cell Proliferation and Migration

    Ioannis Grammatikakis, Chosita Norkaew ... Ashish Lal
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    • Compelling
    1. Neuroscience

    Modality-Specific and Amodal Language Processing by Single Neurons

    Yair Lakretz, Naama Friedmann ... Itzhak Fried
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    A validated antibody toolbox for ALS research

    Riham Ayoubi, Emma J MacDougall ... Carl Laflamme
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein

    Zhongying Han, Sabrina Panhans ... Thorben Cordes
    A range of biophysical techniques is used in combination with computational analysis to understand whether glutamine-binding protein binds its ligand via the induced-fit or conformational selection mechanism.
    1. Cell Biology

    Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

    Fangqing Deng, Rong Yang ... Lianbing Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Mural cells protect the adult brain from hemorrhage but do not control the blood–brain barrier in developing zebrafish

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
    1. Immunology and Inflammation

    Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitis

    Yinyin Lv, Yanyun Fan ... Hongzhi Xu
    Trained monocytes alleviate DSS-induced colitis via bacterial clearance and monocyte differentiation reprogramming.
    1. Evolutionary Biology
    2. Neuroscience

    Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

    Max S Farnworth, Yi Peng Toh ... Stephen H Montgomery
    A cognitive adaptation in Heliconius butterflies, accompanied by strikingly divergent changes in two principal insect integration centres, reveals that neural circuits can differ strongly in their propensity for evolutionary change.
    1. Chromosomes and Gene Expression

    Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

    Dorian Besson, Sabine Vaur ... Jean-Paul Javerzat
    A conserved kinase network links nutrient sensing to chromosome segregation and gene regulation by modulating cohesin dynamics through phosphorylation.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing

Magazine

    1. Physics of Living Systems

    Actin Filaments: Building bundles by the numbers

    Christian Vanhille-Campos, Anđela Šarić
    1. Neuroscience

    Hippocampal Network: Stronger memories through smarter stimulation

    Justin Riddle