March 2016

Research articles

    1. Biochemistry
    2. Cell Biology
    3. Biophysics and Structural Biology

    Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

    Ruzbeh Mosadeghi et al
    The general principles that underlie the mechanism of action of the COP9-Signalosome, a key regulator of the largest family of ubiquitin ligase enzymes in human cells, have been identified using structural and kinetic techniques.
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    1. Neuroscience

    mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

    Linqing Miao et al
    The kinase AKT acts as a nodal point that coordinates both positive and negative cues to regulate the regeneration of central nervous system axons in adult mice.
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    1. Biophysics and Structural Biology
    2. Cell Biology

    Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

    Daniel Coutandin et al
    p63 uses an intricate network of domain-domain interactions to control its function in long-term quality maintenance of resting oocytes.
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    1. Neuroscience

    Mesolimbic confidence signals guide perceptual learning in the absence of external feedback

    Matthias Guggenmos et al
    Neural confidence signals can take the role of reward signals and explain perceptual learning without external feedback as a form of internal reinforcement learning.
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Molecular basis for multimerization in the activation of the epidermal growth factor receptor

    Yongjian Huang et al
    Multimerization plays a functional role in EGFR activation and can be blocked by mutations in a specific region of Domain IV.
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    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

    Claude Philippe et al
    The expression of human L1 retrotransposons is highly locus-specific and variable between different cell types.
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    1. Cell Biology
    2. Genomics and Evolutionary Biology

    An extensive program of periodic alternative splicing linked to cell cycle progression

    Daniel Dominguez et al
    Extensive periodic regulation of alternative splicing during the cell cycle in genes is linked to cell cycle functions, and involves an auto-inhibitory mechanism that uses the protein kinase CLK1.
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    1. Cell Biology

    A new class of cyclin dependent kinase in Chlamydomonas is required for coupling cell size to cell division

    Yubing Li et al
    CDKG1 is a D-cyclin dependent retinoblastoma related protein kinase whose abundance scales with cell size and controls cell division cycle number during multiple fission.
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    1. Immunology
    2. Microbiology and Infectious Disease

    Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

    Laura E Sanman et al
    A signal for inflammatory cell death is induced by the disruption of cellular metabolism.
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    1. Immunology
    2. Microbiology and Infectious Disease

    Comparative analysis of viral RNA signatures on different RIG-I-like receptors

    Raul Y Sanchez David et al
    An experimental approach allowing characterization of viral RNA ligands recognized by RIG-I-like receptors during infection by any RNA viruses is established and validated.
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    1. Neuroscience

    Sensitive red protein calcium indicators for imaging neural activity

    Hod Dana et al
    Protein engineering and large-scale screening has led to the development of sensitive red fluorescent indicators that detect neural activity with high sensitivity in various animal models.
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    1. Neuroscience

    Postnatal development of retrosplenial projections to the parahippocampal region of the rat

    Jørgen Sugar, Menno P Witter
    Retrosplenial axons arriving in the parahippocampal region around the first day after birth are topographically organized, similarly to what has been reported in the adult.
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    1. Human Biology and Medicine

    Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

    Xinde Zheng et al
    Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
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    1. Biochemistry
    2. Cell Biology

    A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes

    Michaela Gschweitl et al
    The poorly characterized BTB-protein SPOPL is required to maintain the function of the late endosomal system and the endocytic adaptor EPS15 is therein targeted by the SPOPL/Cullin-3 ubiquitin ligase complex for degradation.
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    1. Neuroscience

    Behavioral training promotes multiple adaptive processes following acute hearing loss

    Peter Keating et al
    Training enables adult humans to rapidly adapt their sound localization abilities to unilateral hearing loss by combining different strategies that rely on partially distinct neurophysiological substrates.
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    1. Neuroscience

    PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

    Yevgeniya A Mironova et al
    The signaling lipid PI(3,5)P2 supports the formation of the myelin sheath, by regulating trafficking of myelin building blocks within oligodendrocytes and communication between oligodendrocytes and neuronal axons.
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    1. Biophysics and Structural Biology
    2. Cell Biology

    A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

    Matthias Christoph Munder et al
    The cytoplasm behaves as an adaptable fluid that can reversibly transition into a protective solid-like state upon stress.
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    1. Neuroscience

    Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion

    Timothy W Dunn et al
    Whole-brain activity imaging in larval zebrafish reveals brain regions that influence patterns of spontaneous movement to increase local exploration efficiency.
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    1. Biochemistry
    2. Cell Biology

    A glucose-starvation response regulates the diffusion of macromolecules

    Ryan P Joyner et al
    During stress conditions, eukaryotic cells dramatically alter their biophysical properties to regulate diffusion of macromolecules.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

    Hideo Imamura et al
    Genome sequencing reveals the evolution and epidemiology of Leishmania donovani in the Indian subcontinent, where epidemics have caused up to 30,000 deaths per year.
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    1. Cell Biology

    A novel biosensor to study cAMP dynamics in cilia and flagella

    Shatanik Mukherjee et al
    A new FRET-based cAMP biosensor with nanomolar sensitivity makes it possible to measure cAMP dynamics in miniscule subcellular compartments like cilia and flagella.
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    1. Biophysics and Structural Biology
    2. Neuroscience

    Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

    Ravi Vijayvargia et al
    Structural and biochemical analysis of full-length huntingtin protein illuminates the impact of the polyglutamine region on its structure and function.
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    1. Cell Biology
    2. Human Biology and Medicine

    Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

    Jianguo Wu et al
    Overexpression of PLK1 triggers oncogenic transformation and transcriptional reprogramming of prostate epithelial cells, which stimulates cell migration and invasion.
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    1. Developmental Biology and Stem Cells
    2. Microbiology and Infectious Disease

    Stem cell progeny contribute to the schistosome host-parasite interface

    James J Collins III et al
    Stem cells are found to continually rejuvenate the epidermis of the human parasite Schistosoma mansoni.
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    1. Biophysics and Structural Biology
    2. Immunology

    Structural basis for germline antibody recognition of HIV-1 immunogens

    Louise Scharf et al
    Structural and computational analyses of germline antibody/HIV-1 gp120 complexes provide both general principles relevant to the unusual evolution of potent CD4-binding site antibodies and guidelines for structure-based immunogen design.
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    1. Immunology

    Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

    Ingeborg Streng-Ouwehand et al
    Controlled neo-glycosylation of antigens can influence intracellular routing of antigens and the nature and strength of immune response, and should therefore be considered as a major determinant in the design of vaccines against cancer and infectious diseases.
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    1. Neuroscience

    The hierarchical organization of the lateral prefrontal cortex

    Derek Evan Nee, Mark D'Esposito
    Areas in the middle of the lateral prefrontal cortex select behaviors by taking into account both current and future needs.
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    1. Neuroscience

    A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types

    Yasuyuki Shima et al
    A novel transposon-based enhancer trap screen in mice permits high throughput development of highly restricted driver strains targeting specific neuronal cell types.
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    1. Cell Biology
    2. Plant Biology

    Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import

    Yamuna D Paila et al
    The conserved polypeptide transport associated (POTRA) domains of the protein import channel, Toc75, are essential for protein import into chloroplasts.
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    1. Cell Biology
    2. Immunology

    Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

    Alejandro Villarino et al
    Asymmetrical expression dictates functional dominance of one STAT5 paralog at cellular and tissue levels despite redundancy at molecular and genomic levels.
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    1. Neuroscience

    Transcranial magnetic stimulation (TMS) inhibits cortical dendrites

    Sean C Murphy et al
    Studying the activity of cortical neurons in rats reveals the subcellular effects of transcranial magnetic stimulation, which is used for the non-invasive treatment of a variety of brain disorders.
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    1. Neuroscience

    Quantitative neuroanatomy for connectomics in Drosophila

    Casey M Schneider-Mizell et al
    A new method that uses the cellular neuroanatomy of neuronal connectivity to quickly and robustly reconstruct neuronal circuits in Drosophila from large electron microscopy volumes.
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    1. Genes and Chromosomes

    Nucleosomes impede Cas9 access to DNA in vivo and in vitro

    Max A Horlbeck et al
    Nucleosomes provide a direct and profound block to the activity of the CRISPR effector protein Cas9, suggesting future sophisticated design rules for CRISPR targeting.
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    1. Cell Biology

    The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation

    Tsung-Chieh Lin et al
    NIFK promotes lung cancer metastasis via Runx1-dependent repression of CK1α, which activates TCF4/β-catenin signaling.
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    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system

    Abhishek Kulkarni et al
    Timing in the formation of neurons influences synaptic connectivity.
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    1. Cancer biology

    Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

    Sophia M Blake et al
    Deletion of the ATM cofactor ATMIN reduces PDGFRA expression and strongly suppresses tumorigenesis in a TP53-deficient mouse model of glioblastoma.
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

    Deborah Morena et al
    The functional relevance of stem cell niche perturbation in sarcomagenesis is defined and the mouse model presented provides a rationale for the use of combination therapy for the treatment of genetically heterogeneous sarcomas.
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    1. Immunology

    The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB

    Dominik Schmiedel et al
    The well-established oncogene IMP3 impairs the interaction between cancer cells and the immune system.
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    1. Cell Biology
    2. Genes and Chromosomes

    The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

    Sushama Sivakumar et al
    Microtubule binding by the Spindle and Kinetochore Associated (Ska) complex concentrates protein phosphatase 1 at metaphase kinetochores to overcome the spindle checkpoint thus driving anaphase onset and mitotic exit.
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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Sequestration of host metabolism by an intracellular pathogen

    Lena Gehre et al
    The bacterium Chlamydia trachomatis, a human pathogen, hijacks its host’s energy supplies by using the parasitophorous vacuole as a glycogen synthesis and storage compartment.
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    1. Neuroscience

    Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex

    Antoine M Valera et al
    Functional synaptic organization in the cerebellar cortex is stereotyped and associates distant modules through parallel fibers.
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    1. Neuroscience

    Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

    Margarita C Dinamarca et al
    A protein called RNF10 relays messages from synapses to neuron cell nuclei, and is responsible for long-lasting modifications of dendritic spines as observed after activation of synaptic glutamate receptors.
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    1. Cell Biology
    2. Neuroscience

    Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

    Toshihide Kurihara et al
    Mouse models in which hypoxia can be genetically triggered in retinal pigmented epithelial cells show that hypoxia-induced metabolic stress alone can lead to photoreceptor atrophy/dysfunction.
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Cooperation between distinct viral variants promotes growth of H3N2 influenza in cell culture

    Katherine S Xue et al
    The frequent co-occurrence of two variants of influenza is due to the fact that they cooperate, meaning that a mixed population grows better than either variant alone.
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    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system

    Haluk Lacin, James W Truman
    Mapping individual neural stem cells to their corresponding embryonic and postembryonic progeny shows that these sets of neurons have profound molecular and anatomical similarities despite building different central nervous systems.
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    1. Biochemistry
    2. Biophysics and Structural Biology

    A bacteriophage endolysin that eliminates intracellular streptococci

    Yang Shen et al
    Unlike other similar enzymes, the antimicrobial enzyme PlyC can interact with and translocate eukaryotic membranes, and then lyse and kill intracellular bacteria.
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    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species

    Eric T Domyan et al
    Feathered feet of pigeons and chickens result from a partial molecular and morphological transformation of legs to a wing-like identity.
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    1. Neuroscience

    Massive cortical reorganization in sighted Braille readers

    Katarzyna Siuda-Krzywicka et al
    Teaching a tactile alphabet to sighted adults reveals the brain’s unexpected potential for change.
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    1. Computational and Systems Biology
    2. Neuroscience

    A simple generative model of the mouse mesoscale connectome

    Sid Henriksen et al
    A realistic model of the connections between local populations of neurons in the adult mouse brain can be constructed based on just two biologically plausible rules.
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    1. Neuroscience

    Modulation of anxiety and fear via distinct intrahippocampal circuits

    Elif Engin et al
    The hippocampus features a double dissociation in its circuits with respect to the regulation of fear and anxiety, with CA3 and the dentate gyrus implicated in anxiety and CA1 in fear.
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    1. Developmental Biology and Stem Cells

    Localized JNK signaling regulates organ size during development

    Helen Rankin Willsey et al
    JNK signaling is active in developing Drosophila tissues and is required for achieving proper organ size.
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    1. Neuroscience

    GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

    Xinzheng Guo et al
    The AKT-GSK3β-eIF2Bε signaling module plays a key role in promoting axon regeneration in the adult mammalian central nervous system.
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    1. Neuroscience

    Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

    Giuseppe D'Agostino et al
    A novel and distinct cholecystokinin brain circuit critically modulates food intake and body weight.
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    1. Computational and Systems Biology
    2. Neuroscience

    Mixed-mode oscillations and population bursting in the pre-Bötzinger complex

    Bartholomew J Bacak et al
    Computational modeling reveals the mechanisms by which a diverse group of neurons in the brainstem generates rhythmic breathing in mammals.
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    1. Immunology
    2. Microbiology and Infectious Disease

    Serotonin modulates insect hemocyte phagocytosis via two different serotonin receptors

    Yi-xiang Qi et al
    Insects use serotonin signaling in blood cells to help defend themselves against pathogens.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

    Duy Pham Thanh et al
    A fluoroquinolone resistant variant of Salmonella Typhi has emerged that is likely to be widespread in the Indian subcontinent; therefore fluoroquinolones should not be recommended for empirical typhoid fever therapy in this setting.
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    1. Human Biology and Medicine
    2. Neuroscience

    Rhodopsin targeted transcriptional silencing by DNA-binding

    Salvatore Botta et al
    Photoreceptor genomic binding of a 20 base-pair-long DNA sequence by a synthetic DNA-binding protein turns off Rhodopsin expression.
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    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions

    Xintong Dong et al
    The enzyme KPC-1/Furin down-regulates the DMA-1 receptor in neurons, allowing growing dendrites to migrate away from intermediate targets.
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    1. Genes and Chromosomes
    2. Human Biology and Medicine

    Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

    Shi Yun Yeo et al
    Loss-of-function screening identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway and revealed that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two critical barriers that prevent oncogenic transformation.
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    1. Neuroscience

    Extracting grid cell characteristics from place cell inputs using non-negative principal component analysis

    Yedidyah Dordek et al
    Computational modeling of the brain’s navigation system reveals that place cells can drive the formation of hexagonal patterns experimentally observed in grid cells activity.
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    1. Neuroscience

    Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

    Calogero Maria Oddo et al
    Delivering specific patterns of electrical activity to the median nerve of the arm triggers reliable sensations of texture, suggesting that it may ultimately be possible to restore complex tactile information to users of prosthetic limbs.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Resistome diversity in cattle and the environment decreases during beef production

    Noelle R Noyes et al
    Interventions in feedlots and abattoirs place selective pressure on the beef cattle resistome, which differentially impacts the public health risk of antimicrobial resistance from beef production sources.
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Tracking interspecies transmission and long-term evolution of an ancient retrovirus using the genomes of modern mammals

    William E Diehl et al
    Endogenous virus sequences in the genomes of modern mammals reveal the global spread of an ancient virus lineage, including frequent interspecies transmission, adaptation, and emergence spanning several million years of mammalian evolution
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    1. Cell Biology

    Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

    Jonathan O Nelson et al
    Excess expression of the Gadd45 mRNA accounts for lethality when nonsense-mediated decay is lost in Drosophila and mammalian cells, revealing that this pathway is a critical gene regulatory mechanism.
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans

    Maxime J Kinet et al
    A pathway controlling non-apoptotic developmental cell death engages non-canonical death-promoting activities of the stress factor HSF-1, which, in turn, activates specific components of the ubiquitin-mediated degradation machinery.
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    1. Biophysics and Structural Biology

    Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states

    Dan Tan et al
    An enrichable cross-linker with optional isotope labeling quadruples the number of cross-linked peptides identified from high-complexity samples, enhancing proteome-wide analysis of protein-protein interactions and protein conformational changes by mass spectrometry.
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    1. Computational and Systems Biology
    2. Genomics and Evolutionary Biology

    Further support for aneuploidy tolerance in wild yeast and effects of dosage compensation on gene copy-number evolution

    Audrey P Gasch et al
    Many natural isolates of budding yeast carry extra chromosome copies and show lower-than-expected expression at a subset of amplified genes, which show unique evolutionary signatures.
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    1. Cell Biology

    The cell proliferation antigen Ki-67 organises heterochromatin

    Michal Sobecki et al
    Antigen Ki-67, which is widely used as a cell proliferation marker, controls heterochromatin organisation and gene expression.
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    1. Neuroscience

    Neural signatures of perceptual inference

    William Sedley et al
    Changes to sensory predictions are encoded by beta oscillations, surprise due to prediction violations by gamma oscillations, and alpha oscillations may have a role in controlling the precision of predictions.
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

    Moitrayee Bhattacharyya et al
    Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
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    1. Neuroscience

    Midbrain dopamine neurons compute inferred and cached value prediction errors in a common framework

    Brian F Sadacca et al
    Midbrain dopamine neurons in rats signal discrepancies between predicted and actual rewards, regardless of whether the rewards are predicted on the basis of experience or inference.
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    1. Biochemistry
    2. Microbiology and Infectious Disease

    Acquisition of exogenous haem is essential for tick reproduction

    Jan Perner et al
    The lack of haem biosynthetic and degradative pathways in ticks offers new strategies to combat these parasites.
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    1. Cell Biology
    2. Genes and Chromosomes

    No current evidence for widespread dosage compensation in S. cerevisiae

    Eduardo M Torres et al
    Dosage compensation does not take place in wild yeast strains.
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    1. Genomics and Evolutionary Biology
    2. Neuroscience

    Epigenomic landscapes of retinal rods and cones

    Alisa Mo et al
    Genome-wide analysis of DNA methylation and accessible chromatin shows that retinal rods and cones have distinct epigenomic features that reflect differences in their development and function.
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    1. Biochemistry
    2. Developmental Biology and Stem Cells

    SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

    Samuel A Myers et al
    A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.
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    1. Biophysics and Structural Biology

    Cryo-EM single particle analysis with the Volta phase plate

    Radostin Danev, Wolfgang Baumeister
    The Volta phase plate enables in-focus single particle analysis at near atomic resolutions, which could expand the capabilities of cryo-EM, especially for small, flexible or heterogeneous macromolecular samples.
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    1. Neuroscience

    Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep

    Michal Turek et al
    The mechanisms of specification and sleep induction by the single sleep-active neuron are revealed in C. elegans.
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    1. Biophysics and Structural Biology
    2. Immunology

    The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

    Beth M Stadtmueller et al
    The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
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    1. Biochemistry
    2. Cell Biology

    The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

    Ryo Yonashiro et al
    Rqc2-mediated modification of ribosome-stalled nascent chains with "CAT tails" promotes formation of insoluble aggregates suggesting that proteins can become specifically marked for aggregation.
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    1. Neuroscience

    Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

    Eitan S Kaplan et al
    Parvalbumin-containing inhibitory neurons are crucial for expression of plasticity in adult visual cortex that supports visual recognition memory, but not for expression of ocular dominance plasticity that results from monocular deprivation.
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Genomic epidemiology of artemisinin resistant malaria

    MalariaGEN Plasmodium falciparum Community Project
    Plasmodium falciparum kelch13 mutations that cause artemisinin resistant malaria in Southeast Asia show markedly different patterns of evolutionary selection in Africa.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    The auditory representation of speech sounds in human motor cortex

    Connie Cheung et al
    Brain activity patterns in motor cortex differ when we listen to speech as opposed to produce it.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf

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