November 2023

Research articles

1. 1. Microbiology and Infectious Disease

   Bacteria Are a Major Determinant of Orsay Virus Transmission and Infection in Caenorhabditis elegans

   Brian G. Vassallo, Noémie Scheidel ... Dennis H. Kim
2. 1. Developmental Biology

   Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

   Andrew Liu, Jessica O’Connell ... Richard W. Carthew
3. 1. Physics of Living Systems

   Interface resistance of biomolecular condensates

   Yaojun Zhang, Andrew G.T. Pyo ... Ned S. Wingreen
4. 1. Biochemistry and Chemical Biology

   Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

   Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
5. 1. Cancer Biology

   Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

   Pirunthan Perampalam, James I. MacDonald ... Frederick A. Dick
6. 1. Cell Biology
   2. Immunology and Inflammation

   WASP facilitates tumor mechanosensitivity in T lymphocytes

   Srishti Mandal, Mariane Melo ... Sudha Kumari
7. 1. Genetics and Genomics
   2. Cancer Biology

   Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

   Rebecca Warfvinge, Linda Geironson Ulfsson ... Göran Karlsson
8. 1. Plant Biology

   Natural genetic variation underlying the negative effect of elevated CO₂ on ionome composition in Arabidopsis thaliana

   Océane Cassan, Léa-Lou Pimparé ... Antoine Martin
9. 1. Neuroscience

   Human attention during goal-directed reading comprehension relies on task optimization

   Jiajie Zou, Yuran Zhang ... Nai Ding

   When reading natural passages with or without a question in mind, the time reading each word is explained by deep neural networks optimized for information-retrieval or word prediction tasks, respectively.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosome-specific maturation of the epigenome in the Drosophila male germline

    James T Anderson, Steven Henikoff, Kami Ahmad

    Chromatin profiling of Drosophila testes reveals activation of the transcriptional program of the germline, widespread changes in RNA polymerase progression, and the absence of chromosomal regulation across the X chromosome.
11. 1. Microbiology and Infectious Disease
    2. Epidemiology and Global Health

    The inter-continental population dynamics of Neisseria gonorrhoeae

    Magnus N Osnes, Ola B Brynildsrud ... Vegard Eldholm
12. 1. Structural Biology and Molecular Biophysics

    Cell chirality reversal through tilted balance between polymerization of radial fibers and clockwise-swirling of transverse arcs

    Hoi Kwan Kwong, Miu Ling Lam ... Ting-Hsuan Chen
13. 1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

    Abdoulie O Touray, Rishi Rajesh ... Igor Cestari

    Nuclear phosphoinositide signaling controls telomeric gene repression and activation essential for switching expression of surface antigen genes and thus antigenic variation.
14. 1. Medicine

    Resistance exercise protects mice from protein-induced fat accretion

    Michaela E Trautman, Leah N Braucher ... Dudley W Lamming

    A high-protein diet promotes unfavorable metabolic effects in mice, but resistance exercise training protects from some of these effects while promoting muscle hypertrophy and increased strength.
15. 1. Ecology
    2. Evolutionary Biology

    Sensory collectives in natural systems

    Hannah J Williams, Vivek H Sridhar ... Amanda D Melin

    A synthetic, prospective article considers how the fields of sensory ecology and collective behaviour can combine when considering animal collective movements and interactions, and how these fields can inspire each other to advance understanding of animal behaviour, adaptation and evolution.
16. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A

    Daniel Muñoz-Reyes, Levi J McClelland ... Maria Jose Sanchez-Barrena

    Biochemical, biophysical, and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.
17. 1. Neuroscience

    Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells

    Louise Schenberg, Aïda Palou ... Mathieu Beraneck

    Ototoxic transient loss of inner ear inputs leads to suboptimal visuo-vestibular integration despite visual substitution and demonstrates the fundamental role of type I hair cells in the vestibulo-ocular reflexes.
18. 1. Neuroscience

    Eelbrain, a Python toolkit for time-continuous analysis with temporal response functions

    Christian Brodbeck, Proloy Das ... Jonathan Z Simon

    Brain activity is modelled as a function of stimuli that evolve continuously in time, in experimental designs without repeated trials.
19. 1. Computational and Systems Biology
    2. Physics of Living Systems

    β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

    Jennifer K Briggs, Anne Gresch ... Richard KP Benninger

    The functional network of β-cells in the pancreatic islet, which has been used to identify important subpopulations of β-cells implicated in diabetes progression, is indicative of intrinsic dynamics rather than structural communication, implying islet robustness.
20. 1. Neuroscience

    Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance

    Yi-Yun Ho, Qiuwei Yang ... Melissa R. Warden
21. 1. Neuroscience

    Jointly looking to the past and the future in visual working memory

    Baiwei Liu, Zampeta-Sofia Alexopoulou, Freek van Ede
22. 1. Neuroscience

    Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a GABAergic circuitry

    Lixia Chen, Danya Tian ... Luoying Zhang
23. 1. Genetics and Genomics

    Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing

    Thomas J. O’Brien, Ida L. Barlow ... André E.X. Brown
24. 1. Neuroscience

    Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions

    Jason R. Klug, Xunyi Yan ... Xin Jin
25. 1. Neuroscience

    The role of GABA in semantic memory and its neuroplasticity

    Stephen Williams, Matthew Lambon Ralph, JeYoung Jung
26. 1. Evolutionary Biology

    Multiple origins of cephalic sutures in trilobites and their relatives

    Kun-sheng Du, Jin Guo ... Ai-lin Chen
27. 1. Neuroscience

    Prothoracicotropic hormone controls female sexual receptivity through the function of ecdysone in pC1 neurons of Drosophila

    Jing Li, Chao Ning ... Chuan Zhou
28. 1. Neuroscience

    Early parafoveal semantic integration in natural reading

    Yali Pan, Steven Frisson ... Ole Jensen
29. 1. Neuroscience

    Boosting of neural circuit chaos at the onset of collective oscillations

    Agostina Palmigiano, Rainer Engelken, Fred Wolf
30. 1. Ecology
    2. Evolutionary Biology

    Longer mandible or nose? Co-evolution of feeding organs in early elephantiforms

    Chunxiao Li, Tao Deng ... Shi-Qi Wang
31. 1. Biochemistry and Chemical Biology
    2. Neuroscience

    Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism

    Bernd K. Gilsbach, Franz Y. Ho ... Christian Johannes Gloeckner
32. 1. Neuroscience
    2. Computational and Systems Biology

    Deciphering the Genetic Code of Neuronal Type Connectivity: A Bilinear Modeling Approach

    Mu Qiao
33. 1. Neuroscience

    Reactivation strength during cued recall is modulated by graph distance within cognitive maps

    Simon Kern, Juliane Nagel ... Gordon B. Feld
34. 1. Neuroscience

    A novel method for estimating properties of attentional oscillators reveals an age-related decline in flexibility

    Ece Kaya, Sonja A. Kotz, Molly J. Henry
35. 1. Immunology and Inflammation

    Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis

    Takeru Kondo, Annie Gleason ... Ichiro Nishimura

    A previously unrecognized subpopulation of fibroblasts that immediately responded to stimuli from mouse periodontitis models and activated the Toll-like receptor signaling and chemokine expression to guide oral barrier immunity and gingival inflammation was revealed by mouse gingival single-cell transcriptomic atlas.
36. 1. Cell Biology
    2. Developmental Biology

    Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle

    Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.
37. 1. Medicine

    Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction

    Erika Zodda, Olga Tura-Ceide ... Marta Cascante

    Acute myocardial infarction patient-derived endothelial cells display a strong mitochondrial proton coupling with excess ROS production, enhanced glutamine metabolism and a carbon source switch from glucose to glutamine.
38. 1. Neuroscience

    Circular and unified analysis in network neuroscience

    Mika Rubinov

    Circular analyses of knowledge are a common, serious, but often manageable problem in systems and network neuroscience.
39. 1. Cell Biology

    Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion

    Jean De Seze, Maud Bongaerts ... Mathieu Coppey
40. 1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

    Bronwyn A Lucas, Benjamin A Himes, Nikolaus Grigorieff

    2D template matching enables a streamlined single-particle cryogenic electron microscopy workflow that can be used to discover new high-resolution structural features in molecules and complexes, such as bound ligands and drugs.
41. 1. Cell Biology
    2. Immunology and Inflammation

    Regulation of pDC fate determination by histone deacetylase 3

    Yijun Zhang, Tao Wu ... Li Wu

    HDAC3 regulates the development of pDCs and maintenance of homeostasis of hematopoietic progenitors with dendritic cell (DC) differentiation potential, mechanistically by repressing cDC1 associated genes in a deacetylase-dependent manner.
42. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Microstructural differences in the osteochondral unit of terrestrial and aquatic mammals

    Irina AD Mancini, Riccardo Levato ... Jos Malda

    Analysis of the osteochondral unit of aquatic mammals reveals a distinctly different tissue structure, lacking the arcade-like collagen fiber organization, a calcified cartilage layer and a dense subchondral bone plate, typically seen in osteochondral tissue of terrestrial mammals.
43. 1. Ecology
    2. Plant Biology

    Unprecedented yet gradual nature of first millennium CE intercontinental crop plant dispersal revealed in ancient Negev desert refuse

    Daniel Fuks, Yoel Melamed ... Ehud Weiss

    New archaeobotanical data from Negev Highland rubbish middens demonstrate that crop diversity in the Southern Levant expanded more during the first millennium CE than in any earlier period, yet with minimal consequences for consumption and production patterns.
44. 1. Neuroscience

    Theory of systems memory consolidation via recall-gated plasticity

    Jack Lindsey, Ashok Litwin-Kumar
45. 1. Structural Biology and Molecular Biophysics

    Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

    Gabriel Ernesto Jara, Francesco Pontiggia ... Dorothee Kern
46. 1. Biochemistry and Chemical Biology

    A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue

    Brennan J Wadsworth, Marina Leiwe ... Randall S Johnson
47. 1. Neuroscience

    Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

    Ann-Kathrin Joechner, Michael A Hahn ... Markus Werkle-Bergner

    Across four samples of children, adolescents, and young adults, age-related higher similarity of dominant, development-specific fast sleep spindles and adult-like fast sleep spindles is uniquely related to stronger and more precise slow oscillation-sleep spindle coupling.
48. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes

    Baira Godneeva, Maria Ninova ... Alexei Aravin

    Bonus, the Drosophila TIF1 factor, functions as a repressor of tissue-specific genes in the germline, emphasizing an important function of SUMOylation in transcriptional regulation.
49. 1. Physics of Living Systems

    Catalytic growth in a shared enzyme pool ensures robust control of centrosome size

    Deb Sankar Banerjee, Shiladitya Banerjee
50. 1. Cancer Biology

    BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

    Paul Huchedé, Swann Meyer ... Marie Castets
51. 1. Cancer Biology

    GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

    Qingyao Shang, Fei Ren ... Xin Wang
52. 1. Ecology

    Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

    Yang Gao, Shao-Cong Su ... Shun-Fan Wu
53. 1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
54. 1. Neuroscience

    A neurocomputational account of the link between social perception and social action

    Lisa M. Bas, Ian D. Roberts ... Anita Tusche
55. 1. Biochemistry and Chemical Biology
    2. Plant Biology

    Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling

    Henning Mühlenbeck, Yuko Tsutsui ... Cyril Zipfel
56. 1. Neuroscience

    Cross-movie prediction of individualized functional topography

    Guo Jiahui, Ma Feilong ... M Ida Gobbini

    A computational approach based on connectivity hyperalignment can estimate individualized functional topography with high fidelity across movie contents, scanners, protocols, and languages.
57. 1. Epidemiology and Global Health

    Sleep regularity and mortality: a prospective analysis in the UK Biobank

    Lachlan Cribb, Ramon Sha ... Matthew P Pase

    Irregular sleep-wake patterns are associated with higher mortality risk, including mortality due to cancer and cardiovascular disease.
58. 1. Microbiology and Infectious Disease
    2. Plant Biology

    Soil-borne fungi alter the apoplastic purinergic signaling in plants by deregulating the homeostasis of extracellular ATP and its metabolite adenosine

    Christopher Kesten, Valentin Leitner ... Clara Sanchez-Rodriguez

    Biochemical and in vivo physiology imaging reveal that plant pathogens actively imbalance the apoplastic eAdo/eATP levels as a virulence mechanism.
59. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

    Riham Ayoubi, Joel Ryan ... Carl Laflamme

    Open science and consensus antibody validation protocols can identify high-quality, renewable antibodies for the ~50% of the human proteome currently covered, enabling robust and reproducible biomedical research.
60. 1. Medicine

    Eleven strategies for making reproducible research and open science training the norm at research institutions

    Friederike E Kohrs, Susann Auer ... Tracey L Weissgerber

    Researchers and administrators can integrate reproducible research and open science practices into daily practice at their research institutions by adapting research assessment criteria and program requirements, offering training, and building communities.
61. 1. Genetics and Genomics

    Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

    Irina Lazar-Contes, Deepak K. Tanwar ... Isabelle M. Mansuy
62. 1. Chromosomes and Gene Expression

    Ethanol stress induces transient restructuring of the yeast genome yet stable formation of Hsf1 transcriptional condensates

    Linda S. Rubio, Suman Mohajan, David S. Gross
63. 1. Genetics and Genomics

    Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

    Xiuling Cao, Xiang Wu ... Beidong Liu
64. 1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

    Rajdeep Banerjee, Thomas J. Meyer ... David D. Roberts
65. 1. Cancer Biology

    Replication of “null results” – Absence of evidence or evidence of absence?

    Samuel Pawel, Rachel Heyard ... Leonhard Held
66. 1. Cell Biology

    TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

    Jessica Y. Chotiner, N. Adrian Leu ... P. Jeremy Wang
67. 1. Neuroscience

    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival

    Jongkyun Kang, Guodong Huang ... Jie Shen
68. 1. Developmental Biology

    Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

    Yongfeng Luo, Ke Cao ... Wei Shi
69. 1. Evolutionary Biology

    Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics

    John S Favate, Kyle S Skalenko ... Premal Shah

    Metabolomic analysis shows how genome-wide changes in gene expression propagate to and affect the metabolomes of an organism during adaptation.
70. 1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels

    Jinping Lu, Ingo Dreyer ... Rainer Hedrich

    Polymorphic residues of a vacuolar Ca²⁺ sensor site in TPC1 channels differ between species of Brassicacea and Fabaceae and lead to distinct TPC1 gating behavior.
71. 1. Cell Biology
    2. Neuroscience

    ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims

    Tylor R Lewis, Mustafa S Makia ... Muna I Naash

    The photoreceptor tetraspanin protein ROM1 contributes to the formation of light-sensitive 'disc' membranes, but it can be functionally replaced by an excess of its homologous binding partner PRPH2.
72. 1. Developmental Biology

    Overburdened ferroptotic stress impairs tooth morphogenesis

    Haisheng Wang, Xiaofeng Wang ... Ling Ye

    The accumulation of ferroptotic stress during tooth development has a critical effect on its morphogenesis.
73. 1. Microbiology and Infectious Disease

    Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

    Qibin Geng, Yushun Wan ... Fang Li

    Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
74. 1. Neuroscience

    ACC neural ensemble dynamics are structured by strategy prevalence

    Mikhail Proskurin, Maxim Manakov, Alla Karpova

    Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
75. 1. Computational and Systems Biology

    Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease

    Ricardo Omar Ramirez Flores, Jan David Lanzer ... Julio Saez-Rodriguez

    A computational framework allows the unsupervised analysis of samples from single cell data across conditions, inference of multicellular programs associated with disease, and meta-analysis of independent patient cohorts.
76. 1. Cell Biology
    2. Developmental Biology

    The exocyst complex controls multiple events in the pathway of regulated exocytosis

    Sofía Suárez Freire, Sebastián Pérez-Pandolfo ... Mariana Melani
77. 1. Neuroscience

    ThermoMaze: A behavioral paradigm for readout of immobility-related brain events

    Mihály Vöröslakos, Yunchang Zhang ... György Buzsáki
78. 1. Cell Biology

    Exonuclease Xrn1 regulates TORC1 signaling in response to SAM availability

    Madeline M. McGinnis, Benjamin M. Sutter ... Benjamin P. Tu
79. 1. Evolutionary Biology

    Not so local: the population genetics of convergent adaptation in maize and teosinte

    Silas Tittes, Anne Lorant ... Jeffrey Ross-Ibarra
80. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

    Andrew P. Latham, Longchen Zhu ... Bin Zhang
81. 1. Chromosomes and Gene Expression

    Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

    Léonard Colin, Celine Reyes ... Sylvie Tournier

    Telomeric proteins Taz1 or Mit1 specifically regulate telomere association of condensin which is essential for sister-telomere disjunction in mitosis by restraining telomere association of cohesin.
82. 1. Developmental Biology

    Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

    Laura Celotto, Fabian Rost ... Michael Brand

    Single-cell transcriptome analysis of the regenerating retina in adult zebrafish reveals molecular control steps during Müller glia stem cell activation, progressive differentiation, and neural regeneration.
83. 1. Neuroscience

    Functional ultrasound imaging of stroke in awake rats

    Clément Brunner, Gabriel Montaldo, Alan Urban

    Functional ultrasound imaging was used to monitor brain hemodynamics and sensory-evoked thalamocortical functions in awake rats pre- and post-stroke, advancing our understanding toward new therapeutic developments.
84. 1. Cancer Biology
    2. Computational and Systems Biology

    Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records

    Jessica Xin Hjaltelin, Sif Ingibergsdóttir Novitski ... Søren Brunak

    A comprehensive comparison of the two types of pancreatic cancer symptom trajectories can in combination leverage a fuller potential of large health data and ultimately aid the detection of early risk factors for pancreatic cancer.
85. 1. Neuroscience

    Against cortical reorganisation

    Tamar R Makin, John W Krakauer

    A critical re-evaluation of some of the quintessential examples given as evidence for cortical reorganisation argues that, contrary to the prevalent view, any opportunities for functional change in cortical organisation are incremental and constrained by the underlying structural ‘blueprint'.
86. 1. Neuroscience

    The shared and unique neural correlates of personal semantic, general semantic, and episodic memory

    Annick FN Tanguay, Daniela J Palombo ... Louis Renoult

    Four types of declarative memory rely on different weightings of similar component processes, according to fMRI and subjective ratings.
87. 1. Developmental Biology

    Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

    Merve Bilgic, Quan Wu ... Fumio Matsuzaki

    Single-cell transcriptome analyses during cortical brain development in ferrets and its comparison with public human datasets reveal that there are common progenitors and lineages among gyrencephalic mammalian brain development.
88. 1. Cell Biology
    2. Microbiology and Infectious Disease

    Rapid cloning-free mutagenesis of new SARS-CoV-2 variants using a novel reverse genetics platform

    Enja Tatjana Kipfer, David Hauser ... Thomas Klimkait

    CLEVER enables the rapid manipulation and direct rescue of plus-strand RNA viruses with the shortest hands-on time to study viral variants of concern.
89. 1. Plant Biology

    Characterization of tryptophan oxidation affecting D1 degradation by FtsH in the photosystem II quality control of chloroplasts

    Yusuke Kato, Hiroshi Kuroda ... Wataru Sakamoto

    Oxidative modification of Tryptophan residues in the reaction center protein D1 may be a key to drive the Photosystem II repair, likely enhancing accessibility of FtsH protease to D1.
90. 1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Indole produced during dysbiosis mediates host–microorganism chemical communication

    Rui-Qiu Yang, Yong-Hong Chen ... Cheng-Gang Zou

    In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
91. 1. Medicine
    2. Neuroscience

    Interrogating basal ganglia circuit function in Parkinson’s disease and dystonia

    S Sumarac, KA Spencer ... L Milosevic
92. 1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum

    Z Chahine, M Gupta ... KG Le Roch
93. 1. Biochemistry and Chemical Biology

    Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2

    Kehan Chen, Lie Wang ... Gang Wu

    Six-transmembrane epithelial antigen of the prostate isoform 1 (STEAP1) can establish a physiologically relevant electron transfer chain and STEAP2 can transfer electrons via a diffusible FAD mechanism.
94. 1. Cell Biology

    Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

    Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu

    In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
95. 1. Neuroscience

    Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

    Sina B Kirchhofer, Victor Jun Yu Lim ... Moritz Bünemann

    The molecular pattern underlying the interactions of opioids with their receptor determines whether membrane depolarization increases or decreases their response or even convert antagonists to agonists.
96. 1. Neuroscience

    Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

    Samantha K. Millard, Alan K.I. Chiang ... David A. Seminowicz
97. 1. Neuroscience

    Novel Cyclic Homogeneous Oscillation Detection Method for High Accuracy and Specific Characterization of Neural Dynamics

    Hohyun Cho, Markus Adamek ... Peter Brunner
98. 1. Biochemistry and Chemical Biology

    Recognition of the Nucleotide-Dependent Feature Facilitates the Microtubule End-Binding of MCAK

    Wei Chen, Yin-Long Song ... Xin Liang
99. 1. Biochemistry and Chemical Biology

    Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress

    Marwa O. Mikati, Petra Erdmann-Gilmore ... Ream Al-Hasani
100. 1. Structural Biology and Molecular Biophysics
     2. Chromosomes and Gene Expression

     Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging

     Liza Dahal, Thomas GW Graham ... Xavier Darzacq
101. 1. Neuroscience

     Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast-signaling and slow-plastic synapses

     Satyajit Mahapatra, Tomoyuki Takahashi
102. 1. Epidemiology and Global Health

     Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar

     Sean V. Connelly, Nicholas F. Brazeau ... Jeffrey A. Bailey
103. 1. Cell Biology
     2. Developmental Biology

     Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans

     Shashwat Mishra, Mohamed Dabaja ... Joy Alcedo

     On different bacterial diets, which also serve as different environments for Caenorhabditis elegans, specific sensory neurons and insulin-like peptides integrate food-derived signals to modulate oocyte biology, and hence reproduction.
104. 1. Chromosomes and Gene Expression

     What AlphaFold tells us about cohesin’s retention on and release from chromosomes

     Kim A Nasmyth, Byung-Gil Lee ... Jan Löwe

     Structural predictions using AlphaFold suggest a mechanism by which Wapl mediates cohesin's dissociation from chromatin, a process whose downregulation is essential for VDJ recombination and diverse protocadherin gene expression.
105. 1. Neuroscience

     Single-cell RNAseq analysis of spinal locomotor circuitry in larval zebrafish

     Jimmy J Kelly, Hua Wen, Paul Brehm

     Single-cell transcriptomics of larval zebrafish spinal cord reveal ion channels and exocytotic machinery that enhance transmitter release in neuronal types shown to mediate high-speed swimming and escape behavior.
106. 1. Neuroscience

     Judging the difficulty of perceptual decisions

     Anne Löffler, Ariel Zylberberg ... Daniel M Wolpert

     Deciding which of two perceptual decisions is more difficult involves sequential sampling processes that terminate when the difference in accumulated evidence for each decision exceeds a threshold.
107. 1. Cancer Biology

     Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

     Gehad Youssef, Luke Gammon ... Adrian Biddle

     Cancer stem cells that have undergone EMT are identified in the region surrounding metastatic human oral tumours in a retrospective cohort study, and these are predictive of metastatic outcome in an image-based machine learning approach.
108. 1. Computational and Systems Biology
     2. Neuroscience

     Neuroimaging and behavioral evidence that violent video games exert no negative effect on human empathy for pain and emotional reactivity to violence

     Lukas Leopold Lengersdorff, Isabella C Wagner ... Claus Lamm

     After playing violent video games for 7 hr over the course of 2 weeks, human male participants show neither signs of decreased empathy for the pain of another person nor of decreased responsivity to violent images.
109. 1. Medicine

     Evaluating Study Design Rigor in Preclinical Cardiovascular Research: A Replication Study

     Isaiah C. Jimenez, Gabrielle C. Montenegro ... Adrienne Mueller
110. 1. Medicine
     2. Cancer Biology

     Development and Assessment of a Sustainable PhD Internship Program Supporting Diverse Biomedical Career Outcomes

     Patrick D. Brandt, Dawayne Whittington ... Rebekah L. Layton
111. 1. Genetics and Genomics
     2. Cancer Biology

     Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

     Joakim Karlsson, Vasu R. Sah ... Jonas A. Nilsson
112. 1. Microbiology and Infectious Disease

     A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin

     Maneesh Kumar Singh, Victoria A. Bonnell ... Célia R. S. Garcia
113. 1. Medicine

     A single-cell atlas depicting the cellular and molecular features in human anterior cruciate ligamental degeneration: A single cell combined spatial transcriptomics study

     Runze Yang, Tianhao Xu ... Weili Fu

     Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.
114. 1. Neuroscience

     Dynamics and maintenance of categorical responses in primary auditory cortex during task engagement

     Rupesh K Chillale, Shihab Shamma ... Yves Boubenec

     Primary auditory cortex shows population-level correlates of sound categorization, with categorical patterns emerging during sound presentation and task engagement leading to asymmetrical representation of stimuli, indicating an early involvement in stimulus categorization.
115. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

     Angel D′Oliviera, Xuhang Dai ... Jeffrey S. Mugridge
116. 1. Ecology
     2. Evolutionary Biology

     miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis

     Songdou Zhang, Jianying Li ... Xiaoxia Liu

     The first comprehensive study on the regulation mechanism of miR-252 and temperature receptor CcTRPM on insect seasonal polyphenism will also conducive to designing a new method for pest control.
117. 1. Neuroscience

     Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain

     Nahian Shahmat Chowdhury, Alan KI Chiang ... Siobhan M Schabrun

     Combined TMS-EEG can be used to further elucidate the mechanisms for pain perception and to discover biomarkers for the development of chronic pain.
118. 1. Cancer Biology
     2. Medicine

     Tissue-derived exosome proteomics identifies promising diagnostic biomarkers for esophageal cancer

     Dingyu Rao, Hua Lu ... Zhixian Tang

     Exosomal CD54 can be used as an effective biomarker for esophageal squamous cell carcinoma and CD54 promotes the proliferation and migration of tumor cells in vitro.
119. 1. Neuroscience

     DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

     Ernie Yulyaningsih, Jung H. Suh ... Pascal E. Sanchez
120. 1. Neuroscience

     Neural substrates of cold nociception in Drosophila larva

     Atit A. Patel, Albert Cardona, Daniel N. Cox
121. 1. Neuroscience

     Post-Mating Inhibition of Female Sexual Drive via Heterogeneous Neuronal Ensembles in the Medial Preoptic Area

     Kentaro K Ishii, Koichi Hashikawa ... Garret D. Stuber
122. 1. Structural Biology and Molecular Biophysics
     2. Physics of Living Systems

     Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction

     Brandon Rawson, Mariam Ordyan ... Douglas E. Smith
123. 1. Neuroscience

     Separating the control of moving and holding still in post-stroke arm paresis

     Alkis M. Hadjiosif, Kahori Kita ... John W. Krakauer
124. 1. Neuroscience

     Four Individually Identified Paired Dopamine Neurons Signal Taste Punishment in Larval Drosophila

     Denise Weber, Katrin Vogt ... Andreas S. Thum
125. 1. Neuroscience

     Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury

     S Bolívar, E Sanz ... E Udina
126. 1. Medicine

     Senescence of endplate osteoclasts induces sensory innervation and spinal pain

     Dayu Pan, Kheiria Gamal Benkato ... Xu Cao
127. 1. Neuroscience

     Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis

     Mastura Akter, Mahadi Hasan ... Ying Li

     Astrocytic G_i pathway activation in the anterior cingulate cortex impairs schema memory and neuronal mitochondrial biogenesis, which can be rescued by exogenous L-lactate administration directly into the area.
128. 1. Computational and Systems Biology
     2. Genetics and Genomics

     Systems genetics approaches for understanding complex traits with relevance for human disease

     Hooman Allayee, Charles R Farber ... Aldons J Lusis

     Systems genetics is a powerful approach that links DNA variation to complex clinical and physiological traits through the integration of intermediate phenotypes, such as RNA, protein, and metabolite levels.
129. 1. Stem Cells and Regenerative Medicine

     Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

     Lampros Mavrommatis, Hyun-Woo Jeong ... Holm Zaehres

     Skeletal muscle organoids differentiated from human pluripotent stem cells offer a system for investigating myogenesis and satellite cell development with translational potential for muscular dystrophy modeling and therapy development.
130. 1. Neuroscience

     Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

     Yumeya Yamamori, Oliver J Robinson, Jonathan P Roiser

     A computational and translational approach to measuring anxiety-related behaviour was validated in two large independent samples, presenting opportunities for cross-species anxiety research and potential implications for anxiolytic drug development.
131. 1. Structural Biology and Molecular Biophysics

     Mechanism of substrate binding and transport in BASS transporters

     Patrick Becker, Fiona Naughton ... Alexander D Cameron

     The putative substrate pantoate binds to a sodium-coupled secondary transporter of the bile acid sodium symporter family, with sodium-dependent binding and conformational changes consistent with an elevator mechanism of transport.
132. 1. Genetics and Genomics
     2. Neuroscience

     Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

     Yiqiao Zheng, Chi Sun ... Shiming Chen

     The integrated analysis of multi-omics and functional evidence both in vitro and in knock-in mouse models reveal novel gain-of-function pathogenic mechanisms of dominant CRX HD missense mutations.
133. 1. Neuroscience

     Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens

     Yi He, Yanhua H Huang ... Yan Dong

     Two distinct projections from the basolateral amygdala to nucleus accumbens differentially contribute to cue- versus reward-mediated behavioral reinforcement.
134. 1. Neuroscience

     Mesotrode allows chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

     Dongsheng Xiao, Yuhao Yan, Timothy H Murphy

     Low-profile tetrodes that are compatible with wide-field imaging provide the opportunity to evaluate the relationship between spiking neurons and broad networks.
135. 1. Developmental Biology
     2. Computational and Systems Biology

     Diversity in Notch ligand-receptor signaling interactions

     Rachael Kuintzle, Leah A. Santat, Michael B. Elowitz
136. 1. Developmental Biology

     Laminin γ1-dependent basement membranes are instrumental to ensure proper olfactory placode shape, position and boundary with the brain, as well as olfactory axon development

     P Tignard, K Pottin ... MA Breau
137. 1. Biochemistry and Chemical Biology

     A robust method for measuring aminoacylation through tRNA-Seq

     Kristian Davidsen, Lucas B Sullivan
138. 1. Immunology and Inflammation

     MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production

     Conan J O O’Brien, Giorgio Ratti ... Ana I Domingos
139. 1. Biochemistry and Chemical Biology

     Structure and evolution of Alanine/Serine Decarboxylases and the engineering of theanine production

     Hao Wang, Biying Zhu ... Zhaoliang Zhang
140. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

     Kejia Zhang, Patrick Eldin ... Dragony Fu
141. 1. Cancer Biology
     2. Cell Biology

     Treatment with tumor-treating fields (TTFields) suppresses intercellular tunneling nanotube formation in vitro and upregulates immuno-oncologic biomarkers in vivo in malignant mesothelioma

     Akshat Sarkari, Sophie Korenfeld ... Emil Lou

     Cancer-directed treatment using Tumor-Treating Fields spatially modulates the tumor microenvironment at the cellular and molecular levels, decreasing nanotube-based cellular networks of communication while creating a microenvironment more susceptible to immunotherapeutic strategies.
142. 1. Ecology

     Delayed postglacial colonization of Betula in Iceland and the circum North Atlantic

     David J Harning, Samuel Sacco ... Gifford H Miller

     Following the last deglaciation in the North Atlantic, DNA evidence shows Betulaceae colonization was consistently delayed compared to Salicaceae, which may serve as an analog for modern global warming.
143. 1. Computational and Systems Biology

     Identification of a carbohydrate recognition motif of purinergic receptors

     Lifen Zhao, Fangyu Wei ... Xi Cheng

     Computational models and mutagenesis study reveal a conserved carbohydrate recognition motif of two therapeutically important purinergic receptors to help understand the carbohydrate regulation of G-protein coupled receptors.
144. 1. Neuroscience

     Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

     Sehrish Javed, Ya-Ting Chang ... Wei-Hsiang Huang

     RAI1 regulates molecular signalling and intrinsic excitability of hypothalamic brain-derived neurotrophic factor neurons important for energy homeostasis.
145. 1. Cancer Biology

     Molecular portraits of colorectal cancer morphological regions

     Eva Budinská, Martina Hrivňáková ... Vlad Popovici

     Tumor morphological patterns are linked to distinct transcriptional profiles and may indicate the need for a multi-site tumor sampling in gene expression-based studies.
146. 1. Neuroscience

     Evaluation of surface-based hippocampal registration using ground-truth subfield definitions

     Jordan DeKraker, Nicola Palomero-Gallagher ... Alan C Evans

     Surface-based registration of the folded or unfolded human hippocampus achieves subfield alignment to within approximately 0.5 mm.
147. 1. Physics of Living Systems

     Cyclic muscle contractions reinforce the acto-myosin motors and mediate the full elongation of C. elegans embryo

     Anna Dai, Martine Ben Amar
148. 1. Developmental Biology

     scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities

     Yong-Il Kim, Rebecca O'Rourke, Charles G Sagerström

     Combined single nucleus RNAseq and ATACseq enabled the first molecular resolution of all hindbrain rhombomeres, the derivation of a unique gene regulatory network for each rhombomere, and the identification of gene expression changes as rhombomeres form from early progenitor pools.
149. 1. Neuroscience

     Neural interactions in the human frontal cortex dissociate reward and punishment learning

     Etienne Combrisson, Ruggero Basanisi ... Andrea Brovelli
150. 1. Neuroscience

     Distractor effects in decision making depends on individual’s style of integrating choice attributes

     Jing Jun Wong, Alessandro Bongioanni ... Bolton K H Chau
151. 1. Neuroscience

     Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

     Louis Richevaux, Dongkyun Lim ... Desdemona Fricker
152. 1. Neuroscience

     Reconfigurations of cortical manifold structure during reward-based motor learning

     Qasem Nick, Daniel J. Gale ... Jason Gallivan
153. 1. Neuroscience

     Modulation of alpha oscillations by attention is predicted by hemispheric asymmetry of subcortical regions

     Tara Ghafari, Cecilia Mazzetti ... Ole Jensen
154. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Allosteric regulation of kinase activity in living cells

     Shivani Sujay Godbole, Nikolay V Dokholyan

     Protein kinase dysregulation, implicated in various diseases via cell signaling pathways, can be therapeutically and experimentally managed through allosteric modulation, facilitated by a dynamic network of interactions, with computational techniques enabling precise control in live systems.
155. 1. Cell Biology

     Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability

     Ke Lu, Ming Zhang ... Di Chen

     Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.
156. 1. Microbiology and Infectious Disease
     2. Computational and Systems Biology

     Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction

     Saugat Poudel, Jason Hyun ... Bernhard O. Palsson
157. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

     Angela Papalamprou, Victoria Yu ... Dmitriy Sheyn
158. 1. Neuroscience

     Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer

     Robert A Phillips, Ethan Wan ... Jeremy J Day

     Identification of activity-dependent transcriptional changes in striatal neurons reveals a conserved functional enhancer for prodynorphin.
159. 1. Microbiology and Infectious Disease

     Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

     Weiwei Sun, Yelizaveta Rassadkina ... Mathias Lichterfeld

     Genome-intact HIV-1 proviruses were detected in autopsy samples from the brain of ART-treated persons living with HIV, indicating that the virus can persist in the central nervous system.
160. 1. Neuroscience

     A mechanistic insight into sources of error of visual working memory in multiple sclerosis

     Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei

     Imprecision in decoding information and swap error, that is, mistakenly reporting a non-target feature, contributes to working memory deficit in the multiple sclerosis population.
161. 1. Computational and Systems Biology
     2. Neuroscience

     A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

     Hannah Jones, Jenny A Willis ... Giorgio F Gilestro

     Coccinella, an open-source framework, combines real-time tracking on microcomputers with statistical learning, optimising behaviour analysis in Drosophila melanogaster while surpassing other advanced systems in throughput and performance.
162. 1. Neuroscience

     Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes

     Ely Contreras, Jacob D Bhoi ... Tiffany M Schmidt

     Melanopsin phototransduction targets distinct complements of transduction channels across intrinsically photosensitive retinal ganglion cell subtypes and does not require hyperpolarization-activated cyclic nucleotide-gated channels.
163. 1. Cell Biology
     2. Medicine

     Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

     Tengteng Huang, Xiaoling Chen ... Zhiqing Huang
164. 1. Immunology and Inflammation

     Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

     Kentarou Waki, Hideki Tani ... Nobuyuki Kurosawa
165. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation

     Thi Thom Mac, Teddy Fauquier ... Thierry Brue
166. 1. Medicine
     2. Cancer Biology

     Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China

     Wenhui Zhang, Yan Wang ... Zhuan Liao
167. 1. Genetics and Genomics
     2. Evolutionary Biology

     Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

     Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
168. 1. Medicine
     2. Cancer Biology

     The impact of colectomy and chemotherapy on risk of type 2 diabetes onset in patients with colorectal cancer: Nationwide cohort study in Denmark

     Caroline Elisabeth Krag, Maria Saur Svane ... Tinne Laurberg
169. 1. Medicine

     PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

     Teruhiko Yoshida, Khun Zaw Latt ... Jeffrey B. Kopp
170. 1. Ecology

     The larva and adult of Helicoverpa armigera use differential gustatory receptors to sense sugars

     Shuai-Shuai Zhang, Pei-Chao Wang ... Chen-Zhu Wang
171. 1. Computational and Systems Biology
     2. Ecology

     100 years of anthropogenic impact causes changes in freshwater functional biodiversity

     Niamh Eastwood, Jiarui Zhou ... Luisa Orsini

     High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
172. 1. Cell Biology
     2. Microbiology and Infectious Disease

     Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

     Alex W Chan, Malgorzata Broncel ... Sebastian Lourido

     Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.
173. 1. Stem Cells and Regenerative Medicine

     An in vitro model for vitamin A transport across the human blood–brain barrier

     Chandler B Est, Regina M Murphy

     A human stem cell-derived in vitro model provided novel insights into the mechanisms of retinoid accumulation in, and permeation across, the blood–brain barrier.
174. 1. Chromosomes and Gene Expression

     ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes

     Danielle J Owen, Elisa Aguilar-Martinez ... Andrew D Sharrocks

     The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.
175. 1. Chromosomes and Gene Expression
     2. Developmental Biology

     Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos

     Sahla Syed, Yifei Duan, Bomyi Lim

     TF-DNA binding regulates spatial and temporal gene expression and drives robust pattern formation by modulating transcriptional kinetics via cooperative interactions among weak TF binding sites and tuning bursting rates by reducing the time spent in the ON state.
176. 1. Genetics and Genomics

     Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

     Denis Dacheux, Guillaume Martinez ... Charles Coutton

     Bi-allelic mutations in ZMYND12, encoding a novel axonemal protein interacting with TTC29 and DNAH1, cause male infertility and flagellum defects in human and Trypanosoma.
177. 1. Microbiology and Infectious Disease

     Genetic validation of PfFKBP35 as an antimalarial drug target

     Basil T Thommen, Jerzy M Dziekan ... Nicolas MB Brancucci

     Knocking out the FK506-binding protein in Plasmodium falciparum (PfFKBP35) affects ribosome homeostasis and results in a delayed death-like phenotype that is independent of the mode of action of FK506.
178. 1. Neuroscience

     Loss of finger control complexity and intrusion of flexor biases are dissociable in finger individuation impairment after stroke

     Jing Xu, Timothy Ma ... John Krakauer
179. 1. Microbiology and Infectious Disease
     2. Structural Biology and Molecular Biophysics

     Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

     René L Bærentsen, Stine V Nielsen ... Ditlev E Brodersen

     Structural analysis of the HipBST toxin–antitoxin system from E. coli shows how a toxin kinase has been split into two proteins and encodes its own inhibitor.
180. 1. Evolutionary Biology

     Genetic and karyotype divergence between parents affect clonality and sterility in hybrids

     Anatolie Marta, Tomáš Tichopád ... Karel Janko

     Crosses of loaches with various genetic and karyptype divergence cause different reproductive outcomes in hybrids, ranging from sexual reproduction to sterility, inviability, and clonality among females.
181. 1. Medicine

     Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study

     Yajing Chi, Mu Su ... Huihui Li

     ctDNA predict prognosis and treatment response of mTNBC patients more sensitively than traditional tumor markers, which implies ctDNA may be valuable for individualized treatment decision-making and paves the way for a non-invasive real-time clinical management strategy in patients with mTNBC.
182. 1. Cell Biology
     2. Medicine

     Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

     Thao DV Le, Dianxin Liu ... Julio E Ayala

     The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
183. 1. Medicine

     GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases

     Gaoran Ge, Qianping Guo ... Dechun Geng

     A new role is identified for GLI1 in modulating the inflammatory response of macrophages and the overaction of osteoclasts in collagen-induced arthritis by collaboratively regulating DNMT1 and DNMT3a.
184. 1. Chromosomes and Gene Expression
     2. Computational and Systems Biology

     Large-scale analysis of the integration of enhancer-enhancer signals by promoters

     Miguel Martinez-Ara, Federico Comoglio, Bas van Steensel
185. 1. Microbiology and Infectious Disease
     2. Physics of Living Systems

     Long-Distance Electron Transport in Multicellular Freshwater Cable Bacteria

     Tingting Yang, Marko S. Chavez ... Mohamed Y. El-Naggar
186. 1. Structural Biology and Molecular Biophysics
     2. Microbiology and Infectious Disease

     Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

     Bing Liang Alvin Chew, An Qi Ngoh ... Dahai Luo
187. 1. Biochemistry and Chemical Biology
     2. Cancer Biology

     The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

     Vineeth Vengayil, Shreyas Niphadkar ... Sunil Laxman
188. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

     Léa Torcq, Sara Majello ... Anne A. Schmidt
189. 1. Neuroscience

     ChatGPT identifies gender disparities in scientific peer review

     Jeroen PH Verharen

     Generative artificial intelligence, such as OpenAI’s ChatGPT, can be used to analyze scientific texts with specialized constructions, including peer review reports.
190. 1. Cell Biology

     Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

     Abigail C Neininger-Castro, James B Hayes ... Dylan Tyler Burnette

     Software is introduced for the rapid and comprehensive quantification of sarcomere-containing myofibrils and their precursors in cardiac myocytes, aiding in the advancement of cardiovascular cell biology investigations.
191. 1. Structural Biology and Molecular Biophysics

     Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

     Tej Kandola, Shriram Venkatesan ... Randal Halfmann

     The disease-associated aggregation of polyglutamine begins in a single molecule with a specific structure.
192. 1. Neuroscience

     History information emerges in the cortex during learning

     Odeya Marmor, Yael Pollak ... Ariel Gilad

     As mice learn a sensory discrimination task, information from the previous trial emerges during the current trial period in several task-related cortical areas, just before and during the sensation period.
193. 1. Neuroscience

     Awake responses suggest inefficient dense coding in the mouse retina

     Tom Boissonnet, Matteo Tripodi, Hiroki Asari

     Retinal visual response properties in awake mice are similar to those under anesthesia or ex vivo, but not exactly the same, so knowledge of retinal function cannot be simply translated from ex vivo to in vivo.
194. 1. Developmental Biology

     The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

     Rabina Shrestha, Tess McCann ... Joshua Bloomekatz

     Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
195. 1. Genetics and Genomics
     2. Neuroscience

     Genomic stability of self-inactivating rabies

     Ernesto Ciabatti, Ana González-Rueda ... Marco Tripodi

     SiR does not revert to wild type when produced in high-TEVp cell lines, is non-toxic in vivo, maintains transsynaptic spreading capabilities and revertant mutations do not accumulate during in vivo experiments.
196. 1. Neuroscience

     Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

     Linda H Kim, Adam Lognon ... Patrick J. Whelan
197. 1. Neuroscience

     The magnitude and time course of pre-saccadic foveal prediction depend on the conspicuity of the saccade target

     Lisa M. Kroell, Martin Rolfs
198. 1. Neuroscience
     2. Computational and Systems Biology

     Robust, fast and accurate mapping of diffusional mean kurtosis

     Megan E. Farquhar, Qianqian Yang, Viktor Vegh
199. 1. Neuroscience

     Using synchronized brain rhythms to bias memory-guided decisions

     J. J. Stout, A. E. George ... A. L. Griffin
200. 1. Neuroscience

     Non-Hebbian plasticity transforms transient experiences into lasting memories

     Islam Faress, Valentina Khalil ... Sadegh Nabavi
201. 1. Cell Biology
     2. Neuroscience

     Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity

     Lizbeth de la Cruz, Derek Bui ... Oscar Vivas
202. 1. Immunology and Inflammation

     De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

     Jaemoon Koh, Yeon Duk Woo ... Doo Hyun Chung

     The development and functionalities of invariant natural-killer T cells are dependent upon their cell-intrinsic ACC1-mediated de novo fatty acid synthesis, which greatly affect outcomes of allergic asthma.
203. 1. Cancer Biology
     2. Epidemiology and Global Health

     Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study

     Xiaohao Ruan, Da Huang ... Rong Na

     A certain type of primary cancer may cause another second primary cancer which would be of clinical importance to make a personalized screening plan for certain primary cancer patients.
204. 1. Evolutionary Biology
     2. Microbiology and Infectious Disease

     Selection on plastic adherence leads to hyper-multicellular strains and incidental virulence in the budding yeast

     Luke I Ekdahl, Juliana A Salcedo ... Helen A Murphy

     Yeast that were evolved to adhere to plastic surfaces for a few hundred generations became hyper-adherent and more virulent.
205. 1. Neuroscience

     Foveated metamers of the early visual system

     William F. Broderick, Gizem Rufo ... Eero P. Simoncelli
206. 1. Neuroscience

     Deficiency of Orexin Receptor Type 1 in Dopaminergic Neurons Increases Novelty-Induced Locomotion and Exploration

     Xing Xiao, Gagik Yeghiazaryan ... A. Christine Hausen
207. 1. Neuroscience

     Menopause, Brain Anatomy, Cognition and Alzheimer’s Disease

     Manuela Costantino, Grace Pigeau ... M. Mallar Chakravarty
208. 1. Neuroscience
     2. Stem Cells and Regenerative Medicine

     Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination

     Amber R. Philp, Carolina R. Reyes ... Francisco J. Rivera
209. 1. Cell Biology

     Lymphatic muscle cells are the innate pacemaker cells regulating mouse lymphatic collecting vessel contractions

     S.D. Zawieja, G.A. Pea ... M.J. Davis
210. 1. Neuroscience

     Auditory cortical error signals retune during songbird courtship

     Caleb Jones, Jesse H. Goldberg
211. 1. Cell Biology
     2. Cancer Biology

     Bestrophin-4 relays Hes4 and interacts with Twist1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

     Zijing Wang, Bihan Xia ... Jinlin Yang
212. 1. Neuroscience

     DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment

     Ran-Der Hwang, Yu-Ning Lu ... Jiou Wang
213. 1. Immunology and Inflammation

     RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia

     Xiaozhuo Yu, Wen Zhou ... Yanhong Ji
214. 1. Neuroscience

     Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

     Niki Anthoney, Lucy Tainton-Heap ... Bruno van Swinderen

     Different methods for inducing sleep in Drosophila flies may be promoting distinct sleep stages with different functions when brain activity and gene expression are compared.
215. 1. Cell Biology
     2. Structural Biology and Molecular Biophysics

     Autoinhibited kinesin-1 adopts a hierarchical folding pattern

     Zhenyu Tan, Yang Yue ... Michael A Cianfrocco

     Modular folding of kinesin-1 motor proteins enables a fully autoinhibited state.
216. 1. Neuroscience

     Mega-scale movie-fields in the mouse visuo-hippocampal network

     Chinmay Purandare, Mayank Mehta

     Neurons in the mouse hippocampus, known as place cells, surprisingly show movie-fields, where they reliably encode distinct segments of a black-and-white, silent movie, even without any task demand or rewards.
217. 1. Developmental Biology

     A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

     Antonietta Franco, Jiajia Li ... Gerald W Dorn

     A rare human mitofusin (MFN) 2 mutation that uniquely impaired Parkin-mediated mitophagy evoked developmental heart disease and increased myocardial sensitivity to doxorubicin in mice, differentiating it from mitophagy-competent MFN2 mutations that cause neuropathy and implicating mitophagy in clinical cardiomyopathy.
218. 1. Structural Biology and Molecular Biophysics

     Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

     Xiaomei Sun, Yuxin Ye ... Min Yao

     A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
219. 1. Neuroscience

     Brain-imaging evidence for compression of binary sound sequences in human memory

     Fosca Al Roumi, Samuel Planton ... Stanislas Dehaene

     Humans memorize structured sound sequences using a language-of-thought compression algorithm.