November 2023

Cover articles

    1. Cell Biology
    2. Developmental Biology

    Cylicins and male fertility

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    1. Neuroscience

    Memory and multiple sclerosis

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Accidental virulence

    Luke I Ekdahl, Juliana A Salcedo ... Helen A Murphy

Highlights controls:

Research articles

    1. Cell Biology
    2. Immunology and Inflammation

    WASP facilitates tumor mechanosensitivity in T lymphocytes

    Srishti Mandal, Mariane Melo ... Sudha Kumari
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

    Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosome-specific maturation of the epigenome in the Drosophila male germline

    James T Anderson, Steven Henikoff, Kami Ahmad
    Chromatin profiling of Drosophila testes reveals activation of the transcriptional program of the germline, widespread changes in RNA polymerase progression, and the absence of chromosomal regulation across the X chromosome.
    1. Neuroscience

    Human attention during goal-directed reading comprehension relies on task optimization

    Jiajie Zou, Yuran Zhang ... Nai Ding
    When reading natural passages with or without a question in mind, the time reading each word is explained by deep neural networks optimized for information-retrieval or word prediction tasks, respectively.
    1. Microbiology and Infectious Disease
    2. Epidemiology and Global Health

    The inter-continental population dynamics of Neisseria gonorrhoeae

    Magnus N Osnes, Ola B Brynildsrud ... Vegard Eldholm
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Cell chirality reversal through tilted balance between polymerization of radial fibers and clockwise-swirling of transverse arcs

    Hoi Kwan Kwong, Miu Ling Lam ... Ting-Hsuan Chen
    Revised
    Reviewed Preprint v2
    1. Ecology
    2. Evolutionary Biology

    Sensory collectives in natural systems

    Hannah J Williams, Vivek H Sridhar ... Amanda D Melin
    A synthetic, prospective article considers how the fields of sensory ecology and collective behaviour can combine when considering animal collective movements and interactions, and how these fields can inspire each other to advance understanding of animal behaviour, adaptation and evolution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A

    Daniel Muñoz-Reyes, Levi J McClelland ... Maria Jose Sanchez-Barrena
    Biochemical, biophysical, and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

    Jennifer K Briggs, Anne Gresch ... Richard KP Benninger
    The functional network of β-cells in the pancreatic islet, which has been used to identify important subpopulations of β-cells implicated in diabetes progression, is indicative of intrinsic dynamics rather than structural communication, implying islet robustness.
    1. Neuroscience

    Eelbrain, a Python toolkit for time-continuous analysis with temporal response functions

    Christian Brodbeck, Proloy Das ... Jonathan Z Simon
    Brain activity is modelled as a function of stimuli that evolve continuously in time, in experimental designs without repeated trials.
    1. Medicine

    Resistance exercise protects mice from protein-induced fat accretion

    Michaela E Trautman, Leah N Braucher ... Dudley W Lamming
    A high-protein diet promotes unfavorable metabolic effects in mice, but resistance exercise training protects from some of these effects while promoting muscle hypertrophy and increased strength.
    1. Neuroscience

    Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells

    Louise Schenberg, Aïda Palou ... Mathieu Beraneck
    Ototoxic transient loss of inner ear inputs leads to suboptimal visuo-vestibular integration despite visual substitution and demonstrates the fundamental role of type I hair cells in the vestibulo-ocular reflexes.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

    Abdoulie O Touray, Rishi Rajesh ... Igor Cestari
    Nuclear phosphoinositide signaling controls telomeric gene repression and activation essential for switching expression of surface antigen genes and thus antigenic variation.
    1. Neuroscience

    Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a GABAergic circuitry

    Lixia Chen, Danya Tian ... Luoying Zhang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions

    Jason R. Klug, Xunyi Yan ... Xin Jin
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Boosting of neural circuit chaos at the onset of collective oscillations

    Agostina Palmigiano, Rainer Engelken, Fred Wolf
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The role of GABA in semantic memory and its neuroplasticity

    Stephen Williams, Matthew Lambon Ralph, JeYoung Jung
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Infralimbic parvalbumin neural activity facilitates cued threat avoidance

    Yi-Yun Ho, Qiuwei Yang ... Melissa R Warden
    Revised
    Reviewed Preprint v2
    1. Genetics and Genomics

    Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing

    Thomas J O’Brien, Ida L Barlow ... André EX Brown
    Revised
    Reviewed Preprint v3
    1. Medicine

    Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction

    Erika Zodda, Olga Tura-Ceide ... Marta Cascante
    Acute myocardial infarction patient-derived endothelial cells display a strong mitochondrial proton coupling with excess ROS production, enhanced glutamine metabolism and a carbon source switch from glucose to glutamine.
    1. Neuroscience

    Circular and unified analysis in network neuroscience

    Mika Rubinov
    Circular analyses of knowledge are a common, serious, but often manageable problem in systems and network neuroscience.
    1. Immunology and Inflammation

    Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis

    Takeru Kondo, Annie Gleason ... Ichiro Nishimura
    A previously unrecognized subpopulation of fibroblasts that immediately responded to stimuli from mouse periodontitis models and activated the Toll-like receptor signaling and chemokine expression to guide oral barrier immunity and gingival inflammation was revealed by mouse gingival single-cell transcriptomic atlas.
    1. Cell Biology
    2. Developmental Biology

    Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.
    1. Cell Biology

    Control of cell retraction and protrusion with a single protein

    Jean De Seze, Maud Bongaerts ... Mathieu Coppey
    Revised
    Reviewed Preprint v2
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Microstructural differences in the osteochondral unit of terrestrial and aquatic mammals

    Irina AD Mancini, Riccardo Levato ... Jos Malda
    Analysis of the osteochondral unit of aquatic mammals reveals a distinctly different tissue structure, lacking the arcade-like collagen fiber organization, a calcified cartilage layer and a dense subchondral bone plate, typically seen in osteochondral tissue of terrestrial mammals.
    1. Cell Biology
    2. Immunology and Inflammation

    Regulation of pDC fate determination by histone deacetylase 3

    Yijun Zhang, Tao Wu ... Li Wu
    HDAC3 regulates the development of pDCs and maintenance of homeostasis of hematopoietic progenitors with dendritic cell (DC) differentiation potential, mechanistically by repressing cDC1 associated genes in a deacetylase-dependent manner.
    1. Ecology
    2. Plant Biology

    Unprecedented yet gradual nature of first millennium CE intercontinental crop plant dispersal revealed in ancient Negev desert refuse

    Daniel Fuks, Yoel Melamed ... Ehud Weiss
    New archaeobotanical data from Negev Highland rubbish middens demonstrate that crop diversity in the Southern Levant expanded more during the first millennium CE than in any earlier period, yet with minimal consequences for consumption and production patterns.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

    Bronwyn A Lucas, Benjamin A Himes, Nikolaus Grigorieff
    2D template matching enables a streamlined single-particle cryogenic electron microscopy workflow that can be used to discover new high-resolution structural features in molecules and complexes, such as bound ligands and drugs.
    1. Structural Biology and Molecular Biophysics

    Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

    Gabriel Ernesto Jara, Francesco Pontiggia ... Dorothee Kern
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

    Ann-Kathrin Joechner, Michael A Hahn ... Markus Werkle-Bergner
    Across four samples of children, adolescents, and young adults, age-related higher similarity of dominant, development-specific fast sleep spindles and adult-like fast sleep spindles is uniquely related to stronger and more precise slow oscillation-sleep spindle coupling.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes

    Baira Godneeva, Maria Ninova ... Alexei Aravin
    Bonus, the Drosophila TIF1 factor, functions as a repressor of tissue-specific genes in the germline, emphasizing an important function of SUMOylation in transcriptional regulation.
    1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

    Qingyao Shang, Fei Ren ... Xin Wang
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Catalytic growth in a shared enzyme pool ensures robust control of centrosome size

    Deb Sankar Banerjee, Shiladitya Banerjee
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

    Yang Gao, Shao-Cong Su ... Shun-Fan Wu
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A neurocomputational account of the link between social perception and social action

    Lisa M. Bas, Ian D. Roberts ... Anita Tusche
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Cross-movie prediction of individualized functional topography

    Guo Jiahui, Ma Feilong ... M Ida Gobbini
    A computational approach based on connectivity hyperalignment can estimate individualized functional topography with high fidelity across movie contents, scanners, protocols, and languages.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Soil-borne fungi alter the apoplastic purinergic signaling in plants by deregulating the homeostasis of extracellular ATP and its metabolite adenosine

    Christopher Kesten, Valentin Leitner ... Clara Sanchez-Rodriguez
    Biochemical and in vivo physiology imaging reveal that plant pathogens actively imbalance the apoplastic eAdo/eATP levels as a virulence mechanism.
    1. Medicine

    Eleven strategies for making reproducible research and open science training the norm at research institutions

    Friederike E Kohrs, Susann Auer ... Tracey L Weissgerber
    Researchers and administrators can integrate reproducible research and open science practices into daily practice at their research institutions by adapting research assessment criteria and program requirements, offering training, and building communities.
    1. Epidemiology and Global Health

    Sleep regularity and mortality: a prospective analysis in the UK Biobank

    Lachlan Cribb, Ramon Sha ... Matthew P Pase
    Irregular sleep-wake patterns are associated with higher mortality risk, including mortality due to cancer and cardiovascular disease.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

    Riham Ayoubi, Joel Ryan ... Carl Laflamme
    Open science and consensus antibody validation protocols can identify high-quality, renewable antibodies for the ~50% of the human proteome currently covered, enabling robust and reproducible biomedical research.
    1. Genetics and Genomics

    Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

    Irina Lazar-Contes, Rodrigo G Arzate-Mejia ... Isabelle M Mansuy
    Revised
    Reviewed Preprint v2
    1. Genetics and Genomics

    Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

    Xiuling Cao, Xiang Wu ... Beidong Liu
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    ACC neural ensemble dynamics are structured by strategy prevalence

    Mikhail Proskurin, Maxim Manakov, Alla Karpova
    Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
    1. Computational and Systems Biology

    Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease

    Ricardo Omar Ramirez Flores, Jan David Lanzer ... Julio Saez-Rodriguez
    A computational framework allows the unsupervised analysis of samples from single cell data across conditions, inference of multicellular programs associated with disease, and meta-analysis of independent patient cohorts.
    1. Microbiology and Infectious Disease

    Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

    Qibin Geng, Yushun Wan ... Fang Li
    Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels

    Jinping Lu, Ingo Dreyer ... Rainer Hedrich
    Polymorphic residues of a vacuolar Ca2+ sensor site in TPC1 channels differ between species of Brassicacea and Fabaceae and lead to distinct TPC1 gating behavior.
    1. Evolutionary Biology

    Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics

    John S Favate, Kyle S Skalenko ... Premal Shah
    Metabolomic analysis shows how genome-wide changes in gene expression propagate to and affect the metabolomes of an organism during adaptation.
    1. Developmental Biology

    Overburdened ferroptotic stress impairs tooth morphogenesis

    Haisheng Wang, Xiaofeng Wang ... Ling Ye
    The accumulation of ferroptotic stress during tooth development has a critical effect on its morphogenesis.
    1. Cell Biology
    2. Neuroscience

    ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims

    Tylor R Lewis, Mustafa S Makia ... Muna I Naash
    The photoreceptor tetraspanin protein ROM1 contributes to the formation of light-sensitive 'disc' membranes, but it can be functionally replaced by an excess of its homologous binding partner PRPH2.
    1. Evolutionary Biology

    Not so local: the population genetics of convergent adaptation in maize and teosinte

    Silas Tittes, Anne Lorant ... Jeffrey Ross-Ibarra
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Exonuclease Xrn1 regulates TORC1 signaling in response to SAM availability

    Madeline M. McGinnis, Benjamin M. Sutter ... Benjamin P. Tu
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    ThermoMaze: A behavioral paradigm for readout of immobility-related brain events

    Mihály Vöröslakos, Yunchang Zhang ... György Buzsáki
    Revised
    Reviewed Preprint v2
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

    Andrew P. Latham, Longchen Zhu ... Bin Zhang
    Revised
    Reviewed Preprint v3
    1. Neuroscience

    The shared and unique neural correlates of personal semantic, general semantic, and episodic memory

    Annick FN Tanguay, Daniela J Palombo ... Louis Renoult
    Four types of declarative memory rely on different weightings of similar component processes, according to fMRI and subjective ratings.
    1. Neuroscience

    Against cortical reorganisation

    Tamar R Makin, John W Krakauer
    A critical re-evaluation of some of the quintessential examples given as evidence for cortical reorganisation argues that, contrary to the prevalent view, any opportunities for functional change in cortical organisation are incremental and constrained by the underlying structural ‘blueprint'.
    1. Cancer Biology
    2. Computational and Systems Biology

    Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records

    Jessica Xin Hjaltelin, Sif Ingibergsdóttir Novitski ... Søren Brunak
    A comprehensive comparison of the two types of pancreatic cancer symptom trajectories can in combination leverage a fuller potential of large health data and ultimately aid the detection of early risk factors for pancreatic cancer.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Indole produced during dysbiosis mediates host–microorganism chemical communication

    Rui-Qiu Yang, Yong-Hong Chen ... Cheng-Gang Zou
    In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
    1. Developmental Biology

    Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

    Merve Bilgic, Quan Wu ... Fumio Matsuzaki
    Single-cell transcriptome analyses during cortical brain development in ferrets and its comparison with public human datasets reveal that there are common progenitors and lineages among gyrencephalic mammalian brain development.
    1. Developmental Biology

    Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

    Laura Celotto, Fabian Rost ... Michael Brand
    Single-cell transcriptome analysis of the regenerating retina in adult zebrafish reveals molecular control steps during Müller glia stem cell activation, progressive differentiation, and neural regeneration.
    1. Plant Biology

    Characterization of tryptophan oxidation affecting D1 degradation by FtsH in the photosystem II quality control of chloroplasts

    Yusuke Kato, Hiroshi Kuroda ... Wataru Sakamoto
    Oxidative modification of Tryptophan residues in the reaction center protein D1 may be a key to drive the Photosystem II repair, likely enhancing accessibility of FtsH protease to D1.
    1. Neuroscience

    Functional ultrasound imaging of stroke in awake rats

    Clément Brunner, Gabriel Montaldo, Alan Urban
    Functional ultrasound imaging was used to monitor brain hemodynamics and sensory-evoked thalamocortical functions in awake rats pre- and post-stroke, advancing our understanding toward new therapeutic developments.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Rapid cloning-free mutagenesis of new SARS-CoV-2 variants using a novel reverse genetics platform

    Enja Tatjana Kipfer, David Hauser ... Thomas Klimkait
    CLEVER enables the rapid manipulation and direct rescue of plus-strand RNA viruses with the shortest hands-on time to study viral variants of concern.
    1. Chromosomes and Gene Expression

    Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

    Léonard Colin, Celine Reyes ... Sylvie Tournier
    Telomeric proteins Taz1 or Mit1 specifically regulate telomere association of condensin which is essential for sister-telomere disjunction in mitosis by restraining telomere association of cohesin.
    1. Neuroscience

    Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

    Sina B Kirchhofer, Victor Jun Yu Lim ... Moritz Bünemann
    The molecular pattern underlying the interactions of opioids with their receptor determines whether membrane depolarization increases or decreases their response or even convert antagonists to agonists.
    1. Cell Biology

    Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

    Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu
    In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
    1. Biochemistry and Chemical Biology

    Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2

    Kehan Chen, Lie Wang ... Gang Wu
    Six-transmembrane epithelial antigen of the prostate isoform 1 (STEAP1) can establish a physiologically relevant electron transfer chain and STEAP2 can transfer electrons via a diffusible FAD mechanism.
    1. Biochemistry and Chemical Biology

    Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress

    Marwa O. Mikati, Petra Erdmann-Gilmore ... Ream Al-Hasani
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

    Samantha K. Millard, Alan K.I. Chiang ... David A. Seminowicz
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Recognition of the Nucleotide-Dependent Feature Facilitates the Microtubule End-Binding of MCAK

    Wei Chen, Yin-Long Song ... Xin Liang
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging

    Liza Dahal, Thomas GW Graham ... Xavier Darzacq
    Revised
    Reviewed Preprint v2
    1. Cancer Biology

    Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

    Gehad Youssef, Luke Gammon ... Adrian Biddle
    Cancer stem cells that have undergone EMT are identified in the region surrounding metastatic human oral tumours in a retrospective cohort study, and these are predictive of metastatic outcome in an image-based machine learning approach.
    1. Cell Biology
    2. Developmental Biology

    Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans

    Shashwat Mishra, Mohamed Dabaja ... Joy Alcedo
    On different bacterial diets, which also serve as different environments for Caenorhabditis elegans, specific sensory neurons and insulin-like peptides integrate food-derived signals to modulate oocyte biology, and hence reproduction.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuroimaging and behavioral evidence that violent video games exert no negative effect on human empathy for pain and emotional reactivity to violence

    Lukas Leopold Lengersdorff, Isabella C Wagner ... Claus Lamm
    After playing violent video games for 7 hr over the course of 2 weeks, human male participants show neither signs of decreased empathy for the pain of another person nor of decreased responsivity to violent images.
    1. Chromosomes and Gene Expression

    What AlphaFold tells us about cohesin’s retention on and release from chromosomes

    Kim A Nasmyth, Byung-Gil Lee ... Jan Löwe
    Structural predictions using AlphaFold suggest a mechanism by which Wapl mediates cohesin's dissociation from chromatin, a process whose downregulation is essential for VDJ recombination and diverse protocadherin gene expression.
    1. Neuroscience

    Judging the difficulty of perceptual decisions

    Anne Löffler, Ariel Zylberberg ... Daniel M Wolpert
    Deciding which of two perceptual decisions is more difficult involves sequential sampling processes that terminate when the difference in accumulated evidence for each decision exceeds a threshold.
    1. Neuroscience

    Single-cell RNAseq analysis of spinal locomotor circuitry in larval zebrafish

    Jimmy J Kelly, Hua Wen, Paul Brehm
    Single-cell transcriptomics of larval zebrafish spinal cord reveal ion channels and exocytotic machinery that enhance transmitter release in neuronal types shown to mediate high-speed swimming and escape behavior.
    1. Medicine

    Evaluating Study Design Rigor in Preclinical Cardiovascular Research: A Replication Study

    Isaiah C. Jimenez, Gabrielle C. Montenegro ... Adrienne Mueller
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Cancer Biology

    Development and Assessment of a Sustainable PhD Internship Program Supporting Diverse Biomedical Career Outcomes

    Patrick D Brandt, Dawayne Whittington ... Rebekah L Layton
    Revised
    Reviewed Preprint v2
    1. Medicine

    A single-cell atlas depicting the cellular and molecular features in human anterior cruciate ligamental degeneration: A single cell combined spatial transcriptomics study

    Runze Yang, Tianhao Xu ... Weili Fu
    Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.
    1. Neuroscience

    Dynamics and maintenance of categorical responses in primary auditory cortex during task engagement

    Rupesh K Chillale, Shihab Shamma ... Yves Boubenec
    Primary auditory cortex shows population-level correlates of sound categorization, with categorical patterns emerging during sound presentation and task engagement leading to asymmetrical representation of stimuli, indicating an early involvement in stimulus categorization.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

    Angel D’Oliviera, Xuhang Dai ... Jeffrey S Mugridge
    Revised
    Reviewed Preprint v2
    1. Cancer Biology
    2. Medicine

    Tissue-derived exosome proteomics identifies promising diagnostic biomarkers for esophageal cancer

    Dingyu Rao, Hua Lu ... Zhixian Tang
    Exosomal CD54 can be used as an effective biomarker for esophageal squamous cell carcinoma and CD54 promotes the proliferation and migration of tumor cells in vitro.
    1. Ecology
    2. Evolutionary Biology

    miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis

    Songdou Zhang, Jianying Li ... Xiaoxia Liu
    The first comprehensive study on the regulation mechanism of miR-252 and temperature receptor CcTRPM on insect seasonal polyphenism will also conducive to designing a new method for pest control.
    1. Neuroscience

    Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain

    Nahian Shahmat Chowdhury, Alan KI Chiang ... Siobhan M Schabrun
    Combined TMS-EEG can be used to further elucidate the mechanisms for pain perception and to discover biomarkers for the development of chronic pain.
    1. Neuroscience

    Post-Mating Inhibition of Female Sexual Drive via Heterogeneous Neuronal Ensembles in the Medial Preoptic Area

    Kentaro K Ishii, Koichi Hashikawa ... Garret D. Stuber
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction

    Brandon Rawson, Mariam Ordyan ... Douglas E. Smith
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Four Individually Identified Paired Dopamine Neurons Signal Taste Punishment in Larval Drosophila

    Denise Weber, Katrin Vogt ... Andreas S. Thum
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A. Patel, Albert Cardona, Daniel N. Cox
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Separating the control of moving and holding in post-stroke arm paresis

    Alkis M Hadjiosif, Kahori Kita ... John W Krakauer
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens

    Yi He, Yanhua H Huang ... Yan Dong
    Two distinct projections from the basolateral amygdala to nucleus accumbens differentially contribute to cue- versus reward-mediated behavioral reinforcement.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems genetics approaches for understanding complex traits with relevance for human disease

    Hooman Allayee, Charles R Farber ... Aldons J Lusis
    Systems genetics is a powerful approach that links DNA variation to complex clinical and physiological traits through the integration of intermediate phenotypes, such as RNA, protein, and metabolite levels.
    1. Neuroscience

    Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis

    Mastura Akter, Mahadi Hasan ... Ying Li
    Astrocytic Gi pathway activation in the anterior cingulate cortex impairs schema memory and neuronal mitochondrial biogenesis, which can be rescued by exogenous L-lactate administration directly into the area.
    1. Neuroscience

    Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

    Yumeya Yamamori, Oliver J Robinson, Jonathan P Roiser
    A computational and translational approach to measuring anxiety-related behaviour was validated in two large independent samples, presenting opportunities for cross-species anxiety research and potential implications for anxiolytic drug development.
    1. Neuroscience

    Mesotrode allows chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

    Dongsheng Xiao, Yuhao Yan, Timothy H Murphy
    Low-profile tetrodes that are compatible with wide-field imaging provide the opportunity to evaluate the relationship between spiking neurons and broad networks.
    1. Structural Biology and Molecular Biophysics

    Mechanism of substrate binding and transport in BASS transporters

    Patrick Becker, Fiona Naughton ... Alexander D Cameron
    The putative substrate pantoate binds to a sodium-coupled secondary transporter of the bile acid sodium symporter family, with sodium-dependent binding and conformational changes consistent with an elevator mechanism of transport.
    1. Genetics and Genomics
    2. Neuroscience

    Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

    Yiqiao Zheng, Chi Sun ... Shiming Chen
    The integrated analysis of multi-omics and functional evidence both in vitro and in knock-in mouse models reveal novel gain-of-function pathogenic mechanisms of dominant CRX HD missense mutations.
    1. Stem Cells and Regenerative Medicine

    Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

    Lampros Mavrommatis, Hyun-Woo Jeong ... Holm Zaehres
    Skeletal muscle organoids differentiated from human pluripotent stem cells offer a system for investigating myogenesis and satellite cell development with translational potential for muscular dystrophy modeling and therapy development.
    1. Immunology and Inflammation

    MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production

    Conan J O O’Brien, Giorgio Ratti ... Ana I Domingos
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Computational and Systems Biology

    Diversity in Notch ligand-receptor signaling interactions

    Rachael Kuintzle, Leah A Santat, Michael B Elowitz
    Revised
    Reviewed Preprint v2
    1. Computational and Systems Biology

    Identification of a carbohydrate recognition motif of purinergic receptors

    Lifen Zhao, Fangyu Wei ... Xi Cheng
    Computational models and mutagenesis study reveal a conserved carbohydrate recognition motif of two therapeutically important purinergic receptors to help understand the carbohydrate regulation of G-protein coupled receptors.
    1. Cancer Biology
    2. Cell Biology

    Treatment with tumor-treating fields (TTFields) suppresses intercellular tunneling nanotube formation in vitro and upregulates immuno-oncologic biomarkers in vivo in malignant mesothelioma

    Akshat Sarkari, Sophie Korenfeld ... Emil Lou
    Cancer-directed treatment using Tumor-Treating Fields spatially modulates the tumor microenvironment at the cellular and molecular levels, decreasing nanotube-based cellular networks of communication while creating a microenvironment more susceptible to immunotherapeutic strategies.
    1. Neuroscience

    Evaluation of surface-based hippocampal registration using ground-truth subfield definitions

    Jordan DeKraker, Nicola Palomero-Gallagher ... Alan C Evans
    Surface-based registration of the folded or unfolded human hippocampus achieves subfield alignment to within approximately 0.5 mm.
    1. Cancer Biology

    Molecular portraits of colorectal cancer morphological regions

    Eva Budinská, Martina Hrivňáková ... Vlad Popovici
    Tumor morphological patterns are linked to distinct transcriptional profiles and may indicate the need for a multi-site tumor sampling in gene expression-based studies.
    1. Ecology

    Delayed postglacial colonization of Betula in Iceland and the circum North Atlantic

    David J Harning, Samuel Sacco ... Gifford H Miller
    Following the last deglaciation in the North Atlantic, DNA evidence shows Betulaceae colonization was consistently delayed compared to Salicaceae, which may serve as an analog for modern global warming.
    1. Neuroscience

    Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

    Sehrish Javed, Ya-Ting Chang ... Wei-Hsiang Huang
    RAI1 regulates molecular signalling and intrinsic excitability of hypothalamic brain-derived neurotrophic factor neurons important for energy homeostasis.
    1. Developmental Biology

    scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities

    Yong-Il Kim, Rebecca O'Rourke, Charles G Sagerström
    Combined single nucleus RNAseq and ATACseq enabled the first molecular resolution of all hindbrain rhombomeres, the derivation of a unique gene regulatory network for each rhombomere, and the identification of gene expression changes as rhombomeres form from early progenitor pools.
    1. Neuroscience

    Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

    Louis Richevaux, Dongkyun Lim ... Desdemona Fricker
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability

    Ke Lu, Ming Zhang ... Di Chen
    Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric regulation of kinase activity in living cells

    Shivani Sujay Godbole, Nikolay V Dokholyan
    Protein kinase dysregulation, implicated in various diseases via cell signaling pathways, can be therapeutically and experimentally managed through allosteric modulation, facilitated by a dynamic network of interactions, with computational techniques enabling precise control in live systems.
    1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction

    Saugat Poudel, Jason Hyun ... Bernhard O Palsson
    Revised
    Reviewed Preprint v2
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

    Angela Papalamprou, Victoria Yu ... Dmitriy Sheyn
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes

    Ely Contreras, Jacob D Bhoi ... Tiffany M Schmidt
    Melanopsin phototransduction targets distinct complements of transduction channels across intrinsically photosensitive retinal ganglion cell subtypes and does not require hyperpolarization-activated cyclic nucleotide-gated channels.
    1. Neuroscience

    A mechanistic insight into sources of error of visual working memory in multiple sclerosis

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    Imprecision in decoding information and swap error, that is, mistakenly reporting a non-target feature, contributes to working memory deficit in the multiple sclerosis population.
    1. Microbiology and Infectious Disease

    Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

    Weiwei Sun, Yelizaveta Rassadkina ... Mathias Lichterfeld
    Genome-intact HIV-1 proviruses were detected in autopsy samples from the brain of ART-treated persons living with HIV, indicating that the virus can persist in the central nervous system.
    1. Computational and Systems Biology
    2. Neuroscience

    A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

    Hannah Jones, Jenny A Willis ... Giorgio F Gilestro
    Coccinella, an open-source framework, combines real-time tracking on microcomputers with statistical learning, optimising behaviour analysis in Drosophila melanogaster while surpassing other advanced systems in throughput and performance.
    1. Neuroscience

    Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer

    Robert A Phillips, Ethan Wan ... Jeremy J Day
    Identification of activity-dependent transcriptional changes in striatal neurons reveals a conserved functional enhancer for prodynorphin.
    1. Medicine
    2. Cancer Biology

    Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China

    Wenhui Zhang, Yan Wang ... Zhuan Liao
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation

    Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

    Kentarou Waki, Hideki Tani ... Nobuyuki Kurosawa
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Evolutionary Biology

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos

    Sahla Syed, Yifei Duan, Bomyi Lim
    TF-DNA binding regulates spatial and temporal gene expression and drives robust pattern formation by modulating transcriptional kinetics via cooperative interactions among weak TF binding sites and tuning bursting rates by reducing the time spent in the ON state.
    1. Computational and Systems Biology
    2. Ecology

    100 years of anthropogenic impact causes changes in freshwater functional biodiversity

    Niamh Eastwood, Jiarui Zhou ... Luisa Orsini
    High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
    1. Stem Cells and Regenerative Medicine

    An in vitro model for vitamin A transport across the human blood–brain barrier

    Chandler B Est, Regina M Murphy
    A human stem cell-derived in vitro model provided novel insights into the mechanisms of retinoid accumulation in, and permeation across, the blood–brain barrier.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

    Alex W Chan, Malgorzata Broncel ... Sebastian Lourido
    Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.
    1. Genetics and Genomics

    Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

    Denis Dacheux, Guillaume Martinez ... Charles Coutton
    Bi-allelic mutations in ZMYND12, encoding a novel axonemal protein interacting with TTC29 and DNAH1, cause male infertility and flagellum defects in human and Trypanosoma.
    1. Microbiology and Infectious Disease

    Genetic validation of PfFKBP35 as an antimalarial drug target

    Basil T Thommen, Jerzy M Dziekan ... Nicolas MB Brancucci
    Knocking out the FK506-binding protein in Plasmodium falciparum (PfFKBP35) affects ribosome homeostasis and results in a delayed death-like phenotype that is independent of the mode of action of FK506.
    1. Chromosomes and Gene Expression

    ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes

    Danielle J Owen, Elisa Aguilar-Martinez ... Andrew D Sharrocks
    The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.
    1. Neuroscience

    Loss of finger control complexity and intrusion of flexor biases are dissociable in finger individuation impairment after stroke

    Jing Xu, Timothy Ma ... John Krakauer
    Not revised
    Reviewed Preprint v1
    1. Medicine

    GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases

    Gaoran Ge, Qianping Guo ... Dechun Geng
    A new role is identified for GLI1 in modulating the inflammatory response of macrophages and the overaction of osteoclasts in collagen-induced arthritis by collaboratively regulating DNMT1 and DNMT3a.
    1. Cell Biology
    2. Medicine

    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

    Thao DV Le, Dianxin Liu ... Julio E Ayala
    The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
    1. Medicine

    Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study

    Yajing Chi, Mu Su ... Huihui Li
    ctDNA predict prognosis and treatment response of mTNBC patients more sensitively than traditional tumor markers, which implies ctDNA may be valuable for individualized treatment decision-making and paves the way for a non-invasive real-time clinical management strategy in patients with mTNBC.
    1. Evolutionary Biology

    Genetic and karyotype divergence between parents affect clonality and sterility in hybrids

    Anatolie Marta, Tomáš Tichopád ... Karel Janko
    Crosses of loaches with various genetic and karyptype divergence cause different reproductive outcomes in hybrids, ranging from sexual reproduction to sterility, inviability, and clonality among females.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

    René L Bærentsen, Stine V Nielsen ... Ditlev E Brodersen
    Structural analysis of the HipBST toxin–antitoxin system from E. coli shows how a toxin kinase has been split into two proteins and encodes its own inhibitor.
    1. Genetics and Genomics
    2. Neuroscience

    Genomic stability of self-inactivating rabies

    Ernesto Ciabatti, Ana González-Rueda ... Marco Tripodi
    SiR does not revert to wild type when produced in high-TEVp cell lines, is non-toxic in vivo, maintains transsynaptic spreading capabilities and revertant mutations do not accumulate during in vivo experiments.
    1. Developmental Biology

    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

    Rabina Shrestha, Tess McCann ... Joshua Bloomekatz
    Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
    1. Neuroscience

    History information emerges in the cortex during learning

    Odeya Marmor, Yael Pollak ... Ariel Gilad
    As mice learn a sensory discrimination task, information from the previous trial emerges during the current trial period in several task-related cortical areas, just before and during the sensation period.
    1. Neuroscience

    Awake responses suggest inefficient dense coding in the mouse retina

    Tom Boissonnet, Matteo Tripodi, Hiroki Asari
    Retinal visual response properties in awake mice are similar to those under anesthesia or ex vivo, but not exactly the same, so knowledge of retinal function cannot be simply translated from ex vivo to in vivo.
    1. Cell Biology

    Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

    Abigail C Neininger-Castro, James B Hayes ... Dylan Tyler Burnette
    Software is introduced for the rapid and comprehensive quantification of sarcomere-containing myofibrils and their precursors in cardiac myocytes, aiding in the advancement of cardiovascular cell biology investigations.
    1. Structural Biology and Molecular Biophysics

    Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

    Tej Kandola, Shriram Venkatesan ... Randal Halfmann
    The disease-associated aggregation of polyglutamine begins in a single molecule with a specific structure.
    1. Neuroscience

    ChatGPT identifies gender disparities in scientific peer review

    Jeroen PH Verharen
    Generative artificial intelligence, such as OpenAI’s ChatGPT, can be used to analyze scientific texts with specialized constructions, including peer review reports.
    1. Neuroscience

    Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

    Linda H Kim, Adam Lognon ... Patrick J. Whelan
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The magnitude and time course of pre-saccadic foveal prediction depend on the conspicuity of the saccade target

    Lisa M. Kroell, Martin Rolfs
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology
    2. Epidemiology and Global Health

    Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study

    Xiaohao Ruan, Da Huang ... Rong Na
    A certain type of primary cancer may cause another second primary cancer which would be of clinical importance to make a personalized screening plan for certain primary cancer patients.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Selection on plastic adherence leads to hyper-multicellular strains and incidental virulence in the budding yeast

    Luke I Ekdahl, Juliana A Salcedo ... Helen A Murphy
    Yeast that were evolved to adhere to plastic surfaces for a few hundred generations became hyper-adherent and more virulent.
    1. Immunology and Inflammation

    De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

    Jaemoon Koh, Yeon Duk Woo ... Doo Hyun Chung
    The development and functionalities of invariant natural-killer T cells are dependent upon their cell-intrinsic ACC1-mediated de novo fatty acid synthesis, which greatly affect outcomes of allergic asthma.
    1. Neuroscience

    Deficiency of Orexin Receptor Type 1 in Dopaminergic Neurons Increases Novelty-Induced Locomotion and Exploration

    Xing Xiao, Gagik Yeghiazaryan ... A Christine Hausen
    Revised
    Reviewed Preprint v2
    1. Neuroscience

    Auditory cortical error signals retune during songbird courtship

    Caleb Jones, Jesse H. Goldberg
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Foveated metamers of the early visual system

    William F. Broderick, Gizem Rufo ... Eero P. Simoncelli
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Menopause, Brain Anatomy, Cognition and Alzheimer’s Disease

    Manuela Costantino, Grace Pigeau ... M. Mallar Chakravarty
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Revised
    Reviewed Preprint v2
    1. Developmental Biology

    A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

    Antonietta Franco, Jiajia Li ... Gerald W Dorn
    A rare human mitofusin (MFN) 2 mutation that uniquely impaired Parkin-mediated mitophagy evoked developmental heart disease and increased myocardial sensitivity to doxorubicin in mice, differentiating it from mitophagy-competent MFN2 mutations that cause neuropathy and implicating mitophagy in clinical cardiomyopathy.
    1. Neuroscience

    Brain-imaging evidence for compression of binary sound sequences in human memory

    Fosca Al Roumi, Samuel Planton ... Stanislas Dehaene
    Humans memorize structured sound sequences using a language-of-thought compression algorithm.
    1. Neuroscience

    Mega-scale movie-fields in the mouse visuo-hippocampal network

    Chinmay Purandare, Mayank Mehta
    Neurons in the mouse hippocampus, known as place cells, surprisingly show movie-fields, where they reliably encode distinct segments of a black-and-white, silent movie, even without any task demand or rewards.
    1. Structural Biology and Molecular Biophysics

    Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

    Xiaomei Sun, Yuxin Ye ... Min Yao
    A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
    1. Neuroscience

    Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

    Niki Anthoney, Lucy Tainton-Heap ... Bruno van Swinderen
    Different methods for inducing sleep in Drosophila flies may be promoting distinct sleep stages with different functions when brain activity and gene expression are compared.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibited kinesin-1 adopts a hierarchical folding pattern

    Zhenyu Tan, Yang Yue ... Michael A Cianfrocco
    Modular folding of kinesin-1 motor proteins enables a fully autoinhibited state.

Magazine

    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Transcription: A hub of activity

    Virginia L Pimmett, Mounia Lagha
    1. Cell Biology

    Trans-Golgi Network: Sorting secretory proteins

    Anup Parchure, Julia von Blume

  3. Meta-Research: The changing career paths of PhDs and postdocs trained at EMBL

    Junyan Lu, Britta Velten ... Rachel Coulthard-Graf
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Antibody Specificity: A strong case for third-party testing

    Fridtjof Lund-Johansen
    1. Neuroscience

    Anesthesia: Putting early sensory neurons to sleep

    Julia Fadjukov, Gregory Schwartz
    1. Evolutionary Biology
    2. Neuroscience

    Cerebellum: Folding into shape

    Héloïse de Vareilles
    1. Medicine

    Cardiology: A new strategy for cardiac protection

    Esmaa Bouhamida, Hina W Chaudhry
    1. Evolutionary Biology

    Genetics: A colourful duplication

    Violaine Llaurens
    1. Epidemiology and Global Health
    2. Medicine

    Science Forum: Best practices to promote rigor and reproducibility in the era of sex-inclusive research

    Janet W Rich-Edwards, Donna L Maney