April 2023

Research articles

1. 1. Cancer Biology
   2. Computational and Systems Biology

   Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

   Jonathan Rodriguez, Abdon Iniguez ... Richard A Van Etten

   A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Condensation of LINE-1 is critical for retrotransposition

   Srinjoy Sil, Sarah Keegan ... Liam J Holt

   The LINE-1 retrotransposon protein, ORF1p, forms a condensate on RNA that is essential for retrotransposition, and may explain cis-preference through a co-translational assembly mechanism.
3. 1. Developmental Biology
   2. Evolutionary Biology

   Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control

   Sílvia Chafino, Panagiotis Giannios ... Xavier Franch-Marro

   Stage identity and developmental progression in insects is controlled by sequential expression of temporal-specific transcription factors.
4. 1. Ecology
   2. Evolutionary Biology

   Spatiotemporal ecological chaos enables gradual evolutionary diversification without niches or tradeoffs

   Aditya Mahadevan, Michael T Pearce, Daniel S Fisher

   Evolution of multiple closely related strains with host-pathogen-like interactions but only one niche and no tradeoffs, can give rise to a spatiotemporally chaotic ecological state that continually diversifies even with generalist mutations that slow the evolution.
5. 1. Computational and Systems Biology
   2. Developmental Biology

   Patterning precision under non-linear morphogen decay and molecular noise

   Jan Andreas Adelmann, Roman Vetter, Dagmar Iber

   Statistical analysis of morphogen gradients indicates that non-linear morphogen decay does not lead to significantly increased patterning precision, and in fact, the opposite is observed far from the source.
6. 1. Neuroscience

   NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

   Ruolin Zhang, Weibing Mao ... Zhiqiang Dong

   The combination of NSCs with NSC-derived exosomes ameliorated the injury of brain tissue including cerebral infarction, neuronal death, and glial scarring, and promoted the recovery of motor function.
7. 1. Ecology
   2. Evolutionary Biology

   Thermal phenotypic plasticity of pre- and post-copulatory male harm buffers sexual conflict in wild Drosophila melanogaster

   Claudia Londoño-Nieto, Roberto García-Roa ... Pau Carazo

   Natural temperature variation across an optimal reproductive range for wild flies (Drosophila melanogaster) modulates the impact of sexual conflict on female fitness via asymmetric effects on pre- and post-copulatory male harm mechanisms.
8. 1. Neuroscience

   Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex

   Lindsay Collins, John Francis ... David A McCormick

   Cortical cholinergic and noradrenergic signaling contains a strong low-frequency component that is distributed across the mouse cortex and is related to the behavioral state of the animal.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Molecular basis of ligand-dependent Nurr1-RXRα activation

   Xiaoyu Yu, Jinsai Shang, Douglas J Kojetin

   Transcriptional activation of the orphan nuclear receptor Nurr1 by ligands targeting its heterodimer partner retinoid X receptor alpha (RXRα) occurs through a nonclassical pharmacological mechanism involving ligand-binding domain protein-protein interaction inhibition.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2

    Laura M Nocka, Timothy J Eisen ... John Kuriyan

    The adaptor protein Grb2 is able to enhance the activity of the cytoplasmic tyrosine kinase Btk through a novel mechanism, revealing a new role for Grb2 in B-cell signaling.
11. 1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

    Hanghang Liu, Akane Wada ... Clifford J Rosen

    Loss or PTH1R-mediated repression of Zfp467 results in a pathway that increases Pth1r transcription via NFκB1 and thus cellular responsiveness to PTH/PTHrP, ultimately leading to enhanced bone formation.
12. 1. Neuroscience

    cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

    Xin-Tai Wang, Lin Zhou ... Ying Shen

    Mouse models with specific presynaptic knockout demonstrate that Rim1α is subjected to threonine phosphorylation by a novel EPAC-PKCε module, which is essential to presynaptic transmitter release, required for the induction of presynaptic LTP, and critical for motor learning.
13. 1. Epidemiology and Global Health
    2. Evolutionary Biology

    Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020

    Romain Coppée, François Blanquart ... Antoine Bridier-Nahmias

    By producing one hundred SARS-CoV-2 phylogenetic trees for different geographical and time scales, the maximum likelihood-based phylodynamic method implemented here enabled to robustly describe SARS-CoV-2 geographic spread through France, Europe, and worldwide in 2020.
14. 1. Immunology and Inflammation

    Macrophages regulate gastrointestinal motility through complement component 1q

    Mihir Pendse, Haley De Selle ... Lora V Hooper

    Gut macrophages produce complement component C1q, which modulates neurogenic activity of gut peristalsis and is thus a key regulator of gastrointestinal motility.
15. 1. Neuroscience

    The normalization model predicts responses in the human visual cortex during object-based attention

    Narges Doostani, Gholam-Ali Hossein-Zadeh, Maryam Vaziri-Pashkam

    A normalization model is shown to predict responses to multiple objects across changes in the attentional state in the visual cortex, providing evidence for the role of normalization as a fundamental operation in the human brain.
16. 1. Medicine
    2. Physics of Living Systems

    Comparable in vivo joint kinematics between self-reported stable and unstable knees after TKA can be explained by muscular adaptation strategies: A retrospective observational study

    Longfeng Rao, Nils Horn ... Pascal Schütz

    Muscle synergies are able to identify muscular adaptation that results from feelings of joint instability, whereas tibiofemoral kinematics are sensitive for detecting acute instability events during functional activities.
17. 1. Epidemiology and Global Health

    Poor air quality is associated with impaired visual cognition in the first two years of life: A longitudinal investigation

    John P Spencer, Samuel H Forbes ... Aarti Kumar

    Infants exposed to poorer air quality showed lower visual working memory at 6 and 9 months and slower visual processing speed from 6 to 21 months, suggesting interventions to improve air quality could improve cognition early in development.
18. 1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the endothelin-1-ET_B-G_i complex

    Fumiya K Sano, Hiroaki Akasaka ... Osamu Nureki

    The cryo-EM structure of ET_B-G_i complex, obtained using the Fusion-G system, provides insights into the distinct activation mechanism and G-protein promiscuity of ET_B, aiding in the design of ET_B agonists for therapeutic applications.
19. 1. Cancer Biology
    2. Immunology and Inflammation

    Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles

    Jason T George, Herbert Levine

    Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.
20. 1. Cell Biology
    2. Developmental Biology

    Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner

    Melina Hußmann, Dörte Schulte ... Stefan Schulte-Merker

    Tie1 is a binding partner for Svep1 in zebrafish and humans, and both genes (but not Tie2) are required during zebrafish lymphangiogenesis especially for the facial lymphatics, which in part develop independent of Vegfc.
21. 1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

    Pramod K Jangir, Lois Ogunlana ... Craig R MacLean

    Resistance genes that spread as a result of the use of an antimicrobial peptide (colistin) in agriculture (MCR) protect bacteria against key components of human and animal immune systems.
22. 1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    CHD-associated enhancers shape human cardiomyocyte lineage commitment

    Daniel A Armendariz, Sean C Goetsch ... Gary C Hon

    Single-cell screens during human cardiomyocyte (CM) differentiation reveal that perturbation of congenital heart defect-linked enhancers/genes causes deficient CM differentiation.
23. 1. Ecology
    2. Evolutionary Biology

    A toxin-mediated policing system in Bacillus optimizes division of labor via penalizing cheater-like nonproducers

    Rong Huang, Jiahui Shao ... Ruifu Zhang

    A policing system in Bacillus velezensis coordinated extracellular matrix production and autotoxin synthesis/self-immunity to penalize cheater-like nonproducers in biofilm community, which enhances the population stability and ecological fitness under stress conditions and in the rhizosphere.
24. 1. Medicine

    The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

    Karla J Suchacki, Benjamin J Thomas ... William P Cawthorn

    The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.
25. 1. Chromosomes and Gene Expression
    2. Developmental Biology

    The single-cell chromatin accessibility landscape in mouse perinatal testis development

    Hoi Ching Suen, Shitao Rao ... Jinyue Liao

    Single-cell chromatin accessibility analysis reveals the intricate regulatory landscape of mouse testicular development, uncovering novel cell subpopulations and transcription factors, and offering valuable insights into the molecular mechanisms driving germ cell and somatic cell maturation.
26. 1. Cell Biology

    Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

    Ines Hernandez-Perez, Javier Rubio ... María Isabel Geli

    Kazrin, a protein widely expressed in vertebrates whose depletion causes defects in cell adhesion and migration, is recruited to early endosomes and promotes dynein/dynactin-dependent traffic of endocytosed cargo to the recycling endosomes.
27. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function

    Tal Ben Yaakov, Tanya Wasserman ... Yonatan Savir

    The ovarian immune system ages while coping with the two main challenges of the aging ovary before menopause, the inflammatory stimulations due to repeated cycles and the increasing need for clearance of accumulating atretic follicles.
28. 1. Neuroscience

    The nematode worm C. elegans chooses between bacterial foods as if maximizing economic utility

    Abraham Katzen, Hui-Kuan Chung ... Shawn R Lockery

    A worm with a nervous system of only 302 neurons satisfies the necessary and sufficient conditions for value-based decision making.
29. 1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitotic chromosomes scale to nuclear-cytoplasmic ratio and cell size in Xenopus

    Coral Y Zhou, Bastiaan Dekker ... Rebecca Heald

    A combination of in vivo and in vitro approaches using Xenopus eggs and embryos reveals how dimensions of mitotic chromosomes scale with decreasing cell size and increasing nuclear-cytoplasmic ratio during early embryogenesis.
30. 1. Genetics and Genomics

    A genetic and linguistic analysis of the admixture histories of the islands of Cabo Verde

    Romain Laurent, Zachary A Szpiech ... Paul Verdu

    The complex histories of social relationships between enslaved and non-enslaved communities and their descendants during and after the Trans-Atlantic Slave-Trade shaped the detailed genetic and linguistic histories of admixture of the islands of Cabo Verde.
31. 1. Neuroscience

    Rapid cell type-specific nascent proteome labeling in Drosophila

    Stefanny Villalobos-Cantor, Ruth M Barrett ... Ian Martin

    Newly-synthesized protein can be labeled with cellular specificity in Drosophila brain using the puromycin analog PhAc-OPP coupled to expression of the unblocking enzyme PGA in a tissue or cell type of interest.
32. 1. Chromosomes and Gene Expression

    Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics

    Vijyendra Ramesh, Fang Liu ... Anne E West

    Bidirectional regulation of the chromatin modification H3K27me3 orchestrates programs of gene expression that underlie postmitotic stages of neuronal maturation.
33. 1. Developmental Biology
    2. Immunology and Inflammation

    Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

    Amy E Spens, Nicholas A Sutliff ... Stephen J Tapscott

    The developmental transcription factor DUX4 interacts with STAT1 and broadly suppresses expression of IFNγ-stimulated genes.
34. 1. Neuroscience

    TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration

    Victoria L Czech, Lauren C O'Connor ... Alexandra B Byrne

    TIR-1 regulates both repair and destruction on either side of an injury axon.
35. 1. Neuroscience

    TMS-evoked responses are driven by recurrent large-scale network dynamics

    Davide Momi, Zheng Wang, John D Griffiths

    Whole-brain computational modelling, incorporating novel ML-based parameter estimation techniques, reveals how transcranial magnetic stimulation-evoked brain responses are driven at earlier timepoints by local echoes of the external stimulus, and at later timepoints by large-scale network reverberation across the connectome.
36. 1. Ecology
    2. Evolutionary Biology

    Complex plumages spur rapid color diversification in kingfishers (Aves: Alcedinidae)

    Chad M Eliason, Jenna M McCullough ... Michael J Andersen

    Treating color patterns in a geometric morphometrics framework reveals rapid rates of color evolution that are explained by a combination of intrinsic organismal features (color variation among patches) and geography within a cosmopolitan radiation of birds.
37. 1. Cell Biology
    2. Developmental Biology

    Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

    Martina Rossi, Carlos Anerillas ... Myriam Gorospe

    The levels of the cytokine BAFF increase across senescence paradigms, in turn triggering a secretory phenotype in some senescent cells and activating p53 in other senescent cells.
38. 1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly

    Martin H Berryer, Gizem Rizki ... Lindy E Barrett

    An automated synaptic phenotyping platform combined with small molecule screening reveals modulators of human neuron synapse formation.
39. 1. Neuroscience

    A task-general connectivity model reveals variation in convergence of cortical inputs to functional regions of the cerebellum

    Maedbh King, Ladan Shahshahani ... Jörn Diedrichsen

    Models of cortico-cerebellar connectivity are quantified using task-based fMRI, and demonstrate that convergent rather than sparse inputs best characterize cortico-cerebellar connectivity, namely, cerebellar areas linked to cognition receive the highest convergence of cortical inputs.
40. 1. Neuroscience

    In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis

    Maxime Donadieu, Nathanael J Lee ... Daniel S Reich

    Spontaneous remyelination is a common phenomenon in the marmoset experimental autoimmune encephalomyelitis model, reliably detected using in vivo magnetic resonance imaging, rendering this an indispensable model to further investigate the pathobiology of remyelination in multiple sclerosis.
41. 1. Genetics and Genomics

    Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation

    Jing Hu, Bingna Zhou ... Mei Li

    Impaired bone microstructure and bone strength are prominent characteristics of rats with hemizygous E10-16del mutation in PLS3, and treatment with alendronate or teriparatide can improve bone mineral density and bone microstructure of this novel rat model with PLS3-related early-onset osteoporosis.
42. 1. Neuroscience

    Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement

    Elijah A Petter, Isabella P Fallon ... Henry H Yin

    Mice can learn to press a lever persistently for activation of a dopaminergic projection from the locus coeruleus to the hippocampal dentate gyrus.
43. 1. Neuroscience

    Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

    Ruben van den Bosch, Frank H Hezemans ... Roshan Cools

    The absence of generally assumed strong correlations between striatal dopamine synthesis capacity and simple indices of working memory capacity, trait impulsivity, and spontaneous eye-blink rate warrants caution for using these traits as proxy measures to replace direct striatal dopamine assessments.
44. 1. Cell Biology
    2. Genetics and Genomics

    The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

    Xiao-Lan Liu, Yulin Yang ... Xiao Liu

    The nutrient-sensing GCN2 signaling pathway is required for robust circadian rhythm by recruiting the histone acetyltransferase GCN5 to establish a proper chromatin state at the circadian clock gene promoter under amino acid starvation in Neurospora.
45. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell transcriptomics of a dynamic cell behavior in murine airways

    Sheldon JJ Kwok, Daniel T Montoro ... Vladimir Vinarsky

    Live imaging of cells in an intact murine tissue combined with single-cell sequencing reveals a unique transcriptional signature of an observed cellular behavior.
46. 1. Cell Biology
    2. Developmental Biology

    DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice

    Yi Tian Yap, Wei Li ... Zhibing Zhang

    Axonemal dynein light intermediate polypeptide 1 is required for sperm formation and male fertility through association with MEIG1/PACRG complex in the manchette, involvement in a cargo transport system, intraflagellar transport, and sperm individualization.
47. 1. Epidemiology and Global Health

    Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations

    Katharine Sherratt, Hugo Gruson ... Sebastian Funk

    A large collaborative project combined many different researchers' forecasts of COVID-19 across Europe, making predictions used in policy more reliable.
48. 1. Cell Biology

    Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation

    Eline Lemerle, Jeanne Lainé ... Stéphane Vassilopoulos

    Caveolae and Bin1 form tubulation platforms.
49. 1. Genetics and Genomics

    Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in Drosophila cells

    Baolong Xia, Raghuvir Viswanatha ... Norbert Perrimon

    A novel genome-wide transcriptional activation screening in Drosophila cells revealed the activation of InR-Akt-mTOR pathway by cholesterol in plasma membrane to confer resistance to Rapamycin.
50. 1. Cell Biology
    2. Neuroscience

    Regulation of different phases of AMPA receptor intracellular transport by 4.1N and SAP97

    Caroline Bonnet, Justine Charpentier ... Françoise Coussen

    Biochemistry, videomicroscopy, and immunocytochemistry reveal differential roles of GluA1/4.1N and GluA1/SAP97 interactions on GluA1 intracellular transport and exocytosis in basal transmission and during cLTP in cultured hippocampal neurons.
51. 1. Epidemiology and Global Health

    Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome

    Ricardo Cortez Cardoso Penha, Karl Smith-Byrne ... James D Mckay

    A novel Mendelian randomisation framework unravels one gene expression component, correlated with proliferation and genome stability-related features, associated with telomere length in lung adenocarcinoma tumours, which provides insights into how telomere length influences the genetic basis of lung cancer aetiology.
52. 1. Developmental Biology

    Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction

    Mingkun Wang, Belle Yanyu Lin ... Jonathan T Butcher

    Local coordination between shear and hydrostatic stress regulates valve shape and size.
53. 1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

    Rafael Soares Godoy, Nicholas D Cober ... Duncan J Stewart

    Single-cell transcriptomic analysis reveals novel regenerative endothelial cell populations that mediate remarkably rapid and complete microvascular repair in a novel model of acute lung injury induced by endothelial cell ablation.
54. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes

    James M Pemberton, Dang Nguyen ... David W Andrews

    A second anti-apoptotic protein binding site in PUMA confers resistance to BH3 mimetic drugs and binds the protein to membranes.
55. 1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith

    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
56. 1. Neuroscience

    Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate

    Adam R Almeida, Wendy B Macklin

    Oligodendrocytes iteratively wrap and unwrap the same domain of an axon multiple times during development, which likely impacts myelin sheath stabilization.
57. 1. Structural Biology and Molecular Biophysics

    Structural and functional properties of a plant NRAMP-related aluminum transporter

    Karthik Ramanadane, Márton Liziczai ... Cristina Manatschal

    The structure of an NRAMP-related Al³⁺ transporter illustrates the evolution of a branch of a conserved protein family of metal ion transporters in plants to combat Al³⁺ toxicity in acidic soil.
58. 1. Neuroscience

    Functional cell types in the mouse superior colliculus

    Ya-tang Li, Markus Meister

    Neurons in the mouse superior colliculus comprise about 20 types based on their responses to visual stimuli, and neurons of the same type tend to cluster together.
59. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

    Owen Leddy, Forest M White, Bryan D Bryson

    Human macrophages infected with Mycobacterium tuberculosis present peptides derived from substrates of type VII secretion systems on MHC class I via a pathway dependent on the ESX-1 secretion system and independent of antigen processing by the proteasome and cathepsins.
60. 1. Cell Biology

    Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

    Jonas R Knudsen, Kaspar W Persson ... Thomas Elbenhardt Jensen

    Microtubule-dependent movement of the glucose transporter GLUT4 is important for insulin-stimulated muscle glucose uptake, involves the motor protein KIF5B, and is impaired in muscle from diet-induced obese mice.
61. 1. Neuroscience

    Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

    Janani Parameswaran, Nancy Zhang ... Jie Jiang

    C9ORF72 antisense repeat expanded RNAs activate PKR/eIF2α dependent integrated stress response and cause neuronal toxicity independent of DPR proteins.
62. 1. Computational and Systems Biology
    2. Developmental Biology

    Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

    William Duncan Martinson, Rebecca McLennan ... Philip K Maini

    Data-driven mathematical modeling suggests that leading neural crest cells in a moving stream can robustly communicate with trailing cells by remodeling their extracellular matrix, thereby enabling long-distance collective migration.
63. 1. Genetics and Genomics

    Sparse dimensionality reduction approaches in Mendelian randomisation with highly correlated exposures

    Vasileios Karageorgiou, Dipender Gill ... Verena Zuber

    Applied and computational results show how dimensionality reduction approaches can help in grouping correlated genetic variant-exposure associations and improve causal inference in the Mendelian randomisation framework.
64. 1. Cancer Biology
    2. Cell Biology

    Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

    Julieta Martino, Sebastián Omar Siri ... Vanesa Gottifredi

    Replication stress-indepedent synthetic lethality can be triggered in BRCA2-deficient cells by exploiting M phase defects.
65. 1. Ecology

    Echolocating bats prefer a high risk-high gain foraging strategy to increase prey profitability

    Laura Stidsholt, Antoniya Hubancheva ... Peter T Madsen

    Greater mouse-eared bats prefer to hunt large ground insects despite high failure rates, but switch to smaller, easily caught flying insects in response to environmental changes.
66. 1. Physics of Living Systems

    Mechanical basis and topological routes to cell elimination

    Siavash Monfared, Guruswami Ravichandran ... Amin Doostmohammadi

    Using self-organization, cells can collectively leverage defects in nematic and hexatic orders to localize mechanical stresses and remove an unwanted cell with their preferred path to achieve this explored here by independently tuning cell–cell and cell–substrate adhesion strengths.
67. 1. Cell Biology

    PIMT is a novel and potent suppressor of endothelial activation

    Chen Zhang, Zhi-Fu Guo ... Jianxin Sun

    Protein repairing enzyme PIMT maintains vascular endothelium in a quiescent state, thus preventing the development of inflammatory vascular diseases.
68. 1. Cell Biology
    2. Plant Biology

    The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts

    Han Nim Lee, Jenu Varghese Chacko ... Marisa S Otegui

    Photodamaged chloroplasts are targeted for vacuolar degradation through microautophagy by the NBR1 autophagy receptor without the participation of the canonical autophagy machinery.
69. 1. Neuroscience

    Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

    Milena Rmus, Mingjian He ... Matthew R Nassar

    Apparent age-related differences in learning are best accounted for by rapid decay of information in working memory, which is associated with levels of prefrontal glutamate.
70. 1. Cell Biology
    2. Microbiology and Infectious Disease

    A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum

    Lyudmil Raykov, Manon Mottet ... Thierry Soldati

    The Dictyostelium discoideum TRAF6 homolog TrafE coordinates the autophagy and ESCRT membrane repair machineries and works in the major cell-autonomous restriction pathway to control Mycobacterium marinum intracellular infection.
71. 1. Plant Biology

    Domestication and lowland adaptation of coastal preceramic maize from Paredones, Peru

    Miguel Vallebueno-Estrada, Guillermo G Hernández-Robles ... Rafael Montiel

    Ancient maize (~6700-5000 BP) from Paredones, Peru, originated in Mesoamerica, suffered a rapid domestication process, and fast coastal migration to Peru, involving adaptation to both Mesoamerican and South American lowlands with no relevant introgression from teosinte mexicana.
72. 1. Computational and Systems Biology
    2. Ecology

    Emergent regulation of ant foraging frequency through a computationally inexpensive forager movement rule

    Lior Baltiansky, Guy Frankel, Ofer Feinerman

    Rather than complex decisions, it is the motion of individuals that allows for collective foraging regulation in ant colonies.
73. 1. Evolutionary Biology

    The evolution and structure of snake venom phosphodiesterase (svPDE) highlight its importance in venom actions

    Cheng-Tsung Pan, Chien-Chu Lin ... Wen-Guey Wu

    Snake venom phosphodiesterase (svPDE), one of the critical venom components, is co-opted from the ancestral ENPP3 gene that makes membrane-anchored ENPP3 into secretory svPDE by using an alternative 5' exon.
74. 1. Cell Biology

    BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes

    Samuel JP Taylor, Laura Bel Borja ... Federico Pelisch

    PLK-1 regulates multiple steps during oocyte meiosis I and is recruited to meiotic chromosomes through a dual mechanism involving BUB-1 and CENP-C.
75. 1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

    Adedeji M Aderounmu, P Joseph Aruscavage ... Brenda L Bass

    Ancient animal Dicer used its helicase domain to couple the detection of foreign double-stranded RNA to efficient ATP hydrolysis and antiviral defense, but this function declined before the advent of deuterostomes and vertebrates.
76. 1. Neuroscience

    Spike-phase coupling patterns reveal laminar identity in primate cortex

    Zachary W Davis, Nicholas M Dotson ... John H Reynolds

    By examining the relationship between spike timing and the phase of the LFP across cortical layers, researchers can use a stereotyped phase-coupling pattern as a diagnostic marker for electrode depth when other methods of electrode placement are ambiguous.
77. 1. Neuroscience

    Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes

    Sophie Aimon, Karen Y Cheng ... Ilona C Grunwald Kadow

    Major neuron classes are activated when the fly walks, whether it chooses or is forced to do so.
78. 1. Medicine
    2. Neuroscience

    Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex

    Irene Cumplido-Mayoral, Marina García-Prat ... OASIS study

    Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.
79. 1. Neuroscience

    Ventral striatum dopamine release encodes unique properties of visual stimuli in mice

    L Sofia Gonzalez, Austen A Fisher ... J Elliott Robinson

    Dopamine release in the nucleus accumbens in mice encodes the rate and magnitude of rapid environmental luminance changes rather than visual stimulus novelty or threat intensity.
80. 1. Neuroscience

    Striatal ensemble activity in an innate naturalistic behavior

    Samuel Minkowicz, Mychaela Alexandria Mathews ... Yevgenia Kozorovitskiy
81. 1. Microbiology and Infectious Disease

    Integration host factor regulates colonization factors in the bee gut symbiont Frischella perrara

    Konstantin Schmidt, Gonçalo Santos-Matos ... Philipp Engel

    Genes for adhesion, interbacterial competition, and secondary metabolite production are important colonization factors of the honey bee gut symbiont Frischella perrara and are regulated by the conserved histone-like DNA-binding protein integration host factor.
82. 1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

    Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa

    Zebrafish genetics and sperm cryo-electron tomography reveal a novel function of Calaxin as a docking complex component stabilizing the outer arm dynein onto the ciliary doublet microtubule.
83. 1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Statistical modeling based on structured surveys of Australian native possum excreta harboring Mycobacterium ulcerans predicts Buruli ulcer occurrence in humans

    Koen Vandelannoote, Andrew H Buultjens ... Timothy P Stinear

    The systematic field testing of excreta from Australian native possums for the bacterial pathogen Mycobacterium ulcerans can be used to build statistical models that predict the regions in southeast Australia where humans will subsequently get Buruli ulcer.
84. 1. Immunology and Inflammation
    2. Neuroscience

    MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi

    Oligodendroglia express major histocompatibility complex (MHC) pathways in response to inflammation and MHC reporter mice allow for the investigation of MHC molecule expressing cells in vivo.
85. 1. Cancer Biology
    2. Cell Biology

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam

    ERK3 controls actin cytoskeleton.
86. 1. Evolutionary Biology
    2. Genetics and Genomics

    On the limits of fitting complex models of population history to f-statistics

    Robert Maier, Pavel Flegontov ... David Reich

    Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
87. 1. Structural Biology and Molecular Biophysics

    Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus

    Bochuan Teng, Joshua P Kaplan ... Emily R Liman

    Members of the OTOP family of proton-selective ion channels, which includes the sour receptor OTOP1, are differentially sensitive to activation by zinc, which interacts with residues on tm 5-6 and 11-12 linkers that form part of the channel gating apparatus.
88. 1. Neuroscience

    Differential ripple propagation along the hippocampal longitudinal axis

    Roberto De Filippo, Dietmar Schmitz

    Ripple origination point shapes neural activity dynamics across the different hippocampal subfields.
89. 1. Cell Biology

    PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence

    Michael Xiao, Chia-Hua Wu ... Chintan K Kikani

    Stem cell heterogeneity is progressively built in proliferating population by the action of mitochondrial glutamine metabolism that opposes the cell cycle-linked self-renewal network to generate differentiation-competent progenitors.
90. 1. Neuroscience
    2. Physics of Living Systems

    Exploring the role of the outer subventricular zone during cortical folding through a physics-based model

    Mohammad Saeed Zarzor, Ingmar Blumcke, Silvia Budday

    Continuum mechanics-based computational modeling provides insights into the interplay between cell proliferation in different zones of the developing human brain and the evolving cortical folding patterns.
91. 1. Neuroscience

    Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity

    Yong Han, Yang He ... Qi Wu

    A GABAergic neural circuit from AgRP to the dorsomedial hypothalamic nucleus regulates leptin-mediated feeding and energy balance through α3-GABAA signaling, which could provide a new therapeutic avenue for obesity.
92. 1. Developmental Biology
    2. Neuroscience

    Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish

    Sol Pose-Méndez, Paul Schramm ... Reinhard W Köster

    Purkinje cell-specific ablation demonstrates regeneration of these neurons and functional recovery of the cerebellum during both larval and adult zebrafish.
93. 1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Rapid geographical source attribution of Salmonella enterica serovar Enteritidis genomes using hierarchical machine learning

    Sion C Bayliss, Rebecca K Locke ... Lauren A Cowley

    Application of hierarchical machine learning to the geographical source attribution of Salmonella enteritidis indicates high utility for the rapid translation of raw pathogen genome sequencing data into accurate and actionable information for disease management in public health.
94. 1. Genetics and Genomics

    Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization

    Mark Gormley, Tom Dudding ... Caroline Bull

    Mendelian randomization suggests the possibility that the observational effects of obesity and related metabolic traits in head and neck cancer risk are overestimated.
95. 1. Microbiology and Infectious Disease

    Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus

    Lea Antje Adolf, Angelika Müller-Jochim ... Simon Heilbronner

    Staphylococcal heme acquisition needs a highly structured cell envelope, the membrane transporter accumulates in membrane domains most likely to allow concerted passage of heme from the cell wall-funnel to the membrane.
96. 1. Neuroscience

    Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM

    Ian Coombs, Cécile Bats ... Mark Farrant

    Intracellular NASPM, unlike the widely used spermine, fully blocks outward currents through calcium-permeable AMPA-type glutamate receptors, enabling an improved functional readout for this physiologically important receptor subtype in neurons.
97. 1. Immunology and Inflammation
    2. Medicine

    Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

    Sanne Hiddingh, Aridaman Pandit ... Jonas JW Kuiper

    CX3CR1-positive dendritic cells are altered in patients with non-infectious uveitis.
98. 1. Microbiology and Infectious Disease

    Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth

    Nikos Nikolopoulos, Renata C Matos ... François Leulier

    D-alanylated lipoteichoic acids support Drosophila juvenile growth.
99. 1. Neuroscience

    Retinal microvascular and neuronal pathologies probed in vivo by adaptive optical two-photon fluorescence microscopy

    Qinrong Zhang, Yuhan Yang ... Na Ji

    A properly designed two-photon fluorescence microscope allows high-resolution visualization of neurons and capillaries in healthy and diseased mouse retinas in vivo, while to visualize subcellular structures, adaptive optics is required to correct the eye-induced optical aberrations.
100. 1. Neuroscience

     Firing patterns of ventral hippocampal neurons predict the exploration of anxiogenic locations

     Hugo Malagon-Vina, Stéphane Ciocchi, Thomas Klausberger

     A novel behavioural paradigm reveals how neurons in the ventral hippocampus dynamically adapt their firing activity after the introduction of an anxiogenic location.
101. 1. Developmental Biology

     Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis

     Zhao-Bo Luo, Shengzhong Han ... Jin-Dan Kang

     Gut microbiota reshaped by myostatin gene variation has a positive effect on skeletal muscle growth by activating GPR43 through valeric acid, as a metabolite of gut microbiota.
102. 1. Ecology

     Ocean acidification increases susceptibility to sub-zero air temperatures in ecosystem engineers and limits poleward range shifts

     Jakob Thyrring, Colin D Macleod ... Christopher DG Harley

     A novel experiment shows that ocean acidification decreases freeze tolerance in blue mussels, which may limit their ability to redistribute poleward in response to climate warming.
103. 1. Cell Biology
     2. Neuroscience

     Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2

     Sang Hwa Kim, Kye D Nichols ... Randal S Tibbetts

     Axon guidance genes are conserved regulators of neurodegeneration in Drosophila melanogaster and human inducible motor neuron models of UBQLN2-associated amyotrophic lateral sclerosis.
104. 1. Structural Biology and Molecular Biophysics

     Transmembrane protein CD69 acts as an S1PR1 agonist

     Hongwen Chen, Yu Qin ... Xiaochun Li

     Cryo-EM in combination with biochemistry, flow cytometry and fluorescence microscopy reveals the activation of S1PR1 by CD69, a type II membrane protein, in cis to induce receptor internalization and thereby disrupt cellular responsiveness to S1P gradients.
105. 1. Neuroscience

     A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice

     Georgia Balsevich, Gavin N Petrie ... Matthew N Hill

     A genetic knock-in mouse model reveals that the endocrine state governs the effect of the common fatty acid amide hydrolase C385A variant on body weight through a hypothalamic-mediated mechanism.
106. 1. Physics of Living Systems

     Generating active T1 transitions through mechanochemical feedback

     Rastko Sknepnek, Ilyas Djafer-Cherif ... Silke Henkes

     Directed mechanical stresses can trigger active T1 events that lead to tissue elongation perpendicular to the main direction of tissue stress.
107. 1. Computational and Systems Biology
     2. Medicine

     Local generation and efficient evaluation of numerous drug combinations in a single sample

     Vlad Elgart, Joseph Loscalzo

     Engineered local heterogeneity in drug concentration is used as a tool to encode drug treatment regimens and to predict the macroscopic cellular response to drug perturbations.
108. 1. Structural Biology and Molecular Biophysics

     High-resolution structures with bound Mn²⁺ and Cd²⁺ map the metal import pathway in an Nramp transporter

     Shamayeeta Ray, Samuel P Berry ... Rachelle Gaudet

     Structures of a transition metal transporter spanning the entire Mn²⁺ transport cycle reveal distinct coordination geometries and dynamic polar networks that enable Mn²⁺ import, and a Cd²⁺-bound structure helps explain how Cd²⁺ behaves differently as a substrate.
109. 1. Neuroscience

     The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement

     Kara K Cover, Abby G Lieberman ... Brian N Mathur

     Neural circuit monitoring and manipulation reveal that neurons of the rostral intralaminar nuclei of the thalamus projecting to the dorsal striatum activate at movement initiation and reward to reinforce actions.
110. 1. Epidemiology and Global Health

     Weakening of the cognition and height association from 1957 to 2018: Findings from four British birth cohort studies

     David Bann, Liam Wright ... Vanessa Moulton

     The link between height and cognitive assessment scores substantially weakened from 1957 to 2018.
111. 1. Epidemiology and Global Health

     A modelled evaluation of the impact of COVID-19 on breast, bowel, and cervical cancer screening programmes in Australia

     Carolyn Nickson, Megan A Smith ... Karen Canfell

     Modelled estimates for changes in cancer incidence, staging, and demand on health services are presented for a range of potential COVID-related disruptions to national population screening programmes for breast, cervical, and colorectal cancer, indicating markedly different impacts for each programme.
112. 1. Evolutionary Biology
     2. Microbiology and Infectious Disease

     Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

     Samantha DM Arras, Nellie Sibaeva ... Anthony M Poole

     An Escherichia coli line lacking deoxyribonucleotide synthesis has been created and subjected to experimental evolution, revealing that endosymbionts and pathogens that lack ribonucleotide reduction avoid loss of deoxyribonucleotides to central metabolism by disruption of the salvage pathway.
113. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish

     William Tyler Frantz, Sharanya Iyengar ... Craig J Ceol

     Zebrafish pigment cell progenitors are a heterogeneous class of adult tissue-resident cells which reiterate developmental signaling during melanocyte regeneration.
114. 1. Epidemiology and Global Health
     2. Microbiology and Infectious Disease

     Increased public health threat of avian-origin H3N2 influenza virus caused by its evolution in dogs

     Mingyue Chen, Yanli Lyu ... Yipeng Sun

     During adaptation in dogs, H3N2 canine influenza viruses (CIVs) became to recognize human-like SAα2,6-Gal receptor, increased replication ability in human cells, acquired a 100% transmission rate via respiratory droplet in ferret model, and human population lacked immunity to H3N2 CIVs.
115. 1. Epidemiology and Global Health

     The effect of weight loss following 18 months of lifestyle intervention on brain age assessed with resting-state functional connectivity

     Gidon Levakov, Alon Kaplan ... Iris Shai

     Assessing predicted fMRI-based functional brain age before and after a lifestyle intervention suggests that weight loss, improved liver biomarkers, decreased liver fat, and visceral and deep subcutaneous adipose tissues correlate with attenuated brain aging.
116. 1. Ecology
     2. Evolutionary Biology

     Sensory conflict disrupts circadian rhythms in the sea anemone Nematostella vectensis

     Cory A Berger, Ann M Tarrant

     Misalignment between light and temperature cycles leads to disrupted circadian behavior and a substantially altered rhythmic transcriptome.
117. 1. Biochemistry and Chemical Biology

     Rapid, DNA-induced interface swapping by DNA gyrase

     Thomas Germe, Natassja G. Bush ... Anthony Maxwell
118. 1. Computational and Systems Biology
     2. Epidemiology and Global Health

     Bias in nutrition-health associations is not eliminated by excluding extreme reporters in empirical or simulation studies

     Nao Yamamoto, Keisuke Ejima ... Andrew W Brown

     Elimination of extreme reporters using Goldberg cutoffs does not always produce unbiased estimates of associations between nutrition intakes and health outcomes.
119. 1. Cell Biology
     2. Developmental Biology

     AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis

     Carlos P Descovich, Kendall J Lough ... Scott E Williams

     A proper balance of planar and perpendicular balances is critical to establishing proper epidermal architecture and is mediated by the opposing activities of LGN and its enigmatic paralog AGS3.
120. 1. Neuroscience

     Prefrontal PV interneurons facilitate attention and are linked to attentional dysfunction in a mouse model of absence epilepsy

     Brielle Ferguson, Cameron Glick, John R Huguenard

     Targeting reductions in prefrontal PV interneuron activity and gamma power during cue presentation can rescue attention impairments in a mouse model of absence epilepsy.
121. 1. Cell Biology
     2. Stem Cells and Regenerative Medicine

     Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

     John Se Kit Yuen Jr, Michael K Saad ... David L Kaplan

     A simple way to create larger volumes of fat tissue for food purposes may be to grow individual fat cells and mechanically combine them together (rather than directly growing the full tissue).
122. 1. Evolutionary Biology

     Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis

     Sana Naderi, Peter E Chen ... B Jesse Shapiro

     Several different mutations in the SARS-CoV-2 genome have occurred more times than expected by chance in either mink or deer infections, suggesting species-specific viral adaptations to these animals.
123. 1. Neuroscience

     Columnar neurons support saccadic bar tracking in Drosophila

     Giovanni Frighetto, Mark A Frye

     Flies have two parallel visual pathways with specialized physiological properties to compensate for perturbations in their flight course and to saccade toward objects.
124. 1. Neuroscience

     GABA_BR silencing of nerve terminals

     Daniel C Cook, Timothy A Ryan

     Single bouton measurements of calcium influx shows that activating GABA_B receptors at nerve terminals can lead to complete inhibition of calcium entry when one is operating at the physiological setpoint of extracellular calcium concentration.
125. 1. Epidemiology and Global Health

     Disentangling the rhythms of human activity in the built environment for airborne transmission risk: An analysis of large-scale mobility data

     Zachary Susswein, Eva C Rest, Shweta Bansal

     Fine-grain mobility data empirically quantify the propensity for human mixing to be indoors across the US and improve understanding of the relationship between the physical environment and infection risk in light of global change.
126. 1. Microbiology and Infectious Disease
     2. Structural Biology and Molecular Biophysics

     Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

     Amit Kumar, Oscar Vadas ... Stephen Matthews

     The glideosome-associated connector protein transitions between open and closed states, and this regulates its assembly and function during apicomplexan parasite motility.
127. 1. Microbiology and Infectious Disease
     2. Physics of Living Systems

     Defining basic rules for hardening influenza A virus liquid condensates

     Temitope Akhigbe Etibor, Silvia Vale-Costa ... Maria-João Amorim

     Thermodynamic, kinetic, and dynamic analyses as well as solubility proteome profiling reveal that influenza A virus liquid inclusions may be selectively hardened with promising antiviral activity.
128. 1. Epidemiology and Global Health

     An umbrella review of systematic reviews on the impact of the COVID-19 pandemic on cancer prevention and management, and patient needs

     Taulant Muka, Joshua JX Li ... John PA Ioannidis

     A diverse and substantial impact of the COVID-19 pandemic on cancer care is observed, including delays in treatment, screening, and diagnosis, as well as on the psychosocial welling of patients with cancer.
129. 1. Cell Biology

     Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy

     Wei Li, Xinqi Lou ... Shigang Qiao

     Cardiac intercellular communication plays a critical role in diabetic myocardial fibrosis and specific targeting of Hrc^hi fibroblasts may be a potential therapeutic target for diabetic cardiomyopathy.
130. 1. Neuroscience

     Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

     Eleftheria Koropouli, Qiang Wang ... Alex L Kolodkin

     Posttranslational protein palmitoylation and palmitoyl acyltransferase-substrate specificity emerge as a novel mechanism specifying the functional identity of neuronal substrates during the development of the central nervous system.
131. 1. Microbiology and Infectious Disease

     A frameshift in Yersinia pestis rcsD alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

     Xiao-Peng Guo, Hai-Qin Yan ... Yi-Cheng Sun

     Pseudogenization of rcsD alters canonical Rcs phosphorelay signalling and marks a significant adaptive evolutionary step in the emergence of ubiquitous extant branches of Yersinia pestis that can maintain stable plague outbreaks.
132. 1. Developmental Biology
     2. Neuroscience

     Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain

     Siân Wilson, Maximilian Pietsch ... Tomoki Arichi

     Using fetal magnetic resonance imaging (MRI), maturational changes in tissue microstructure can be derived using diffusion MRI which provide new insight into the fundamental neurobiological transitions occurring within the emerging thalamocortical white matter pathways.
133. 1. Cell Biology
     2. Chromosomes and Gene Expression

     Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading

     Hayley Porter, Yang Li ... Suzana Hadjur

     STAG proteins function independently of core cohesin at R-loops to facilitate cohesin loading.