June 2023

Research articles

1. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

   Jessica Gray, Von Vergel L Torres ... Ian R Henderson
2. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   A back-door insight into the modulation of Src kinase activity by the polyamine spermidine

   Sofia Rossini, Marco Gargaro ... Giada Mondanelli

   A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.
3. 1. Neuroscience

   Rapid, automated, and experimenter-free touchscreen testing reveals reciprocal interactions between cognitive flexibility and activity-based anorexia in female rats

   Kaixin Huang, Laura K Milton ... Claire J Foldi

   An automated touchscreen cognitive testing system for rats reduces the length of training required to learn tasks, making it possible to assess cognitive profiles in adolescent animals to more appropriately capture cognitive deficits in adolescent pathologies, such as anorexia nervosa.
4. 1. Genetics and Genomics

   Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation

   Michael T Kimble, Matthew J Johnson ... Lorraine S Symington

   The long-range resection machinery is dispensable for homologous recombination between closely linked repeats but is necessary for DNA damage checkpoint activation which is associated with interchromosomal recombination.
5. 1. Microbiology and Infectious Disease

   Bacterial DNA on the skin surface overrepresents the viable skin microbiome

   Ellen M Acosta, Katherine A Little ... Zemer Gitai

   The bacterial DNA on the surface of human and mouse skin is primarily from dead bacteria while viable skin microbiome bacteria mostly colonize subsurface skin structures like hair follicles.
6. 1. Neuroscience

   A stable, distributed code for cue value in mouse cortex during reward learning

   David J Ottenheimer, Madelyn M Hjort ... Garret D Stuber

   Individual neurons in a surprising number of frontal cortical regions encode the value of reward-predicting olfactory cues across distinct stimulus sets and experimental sessions.
7. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   DnaJC7 specifically regulates tau seeding

   Valerie Ann Perez, David W Sanders ... Marc I Diamond

   Knockout of the J domain protein DnaJC7 reduces tau aggregate clearance and increases intracellular tau seeding for recombinant and human brain-derived tau seed sources.
8. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

   Roberta Cacioppo, Hesna Begum Akman ... Catherine Lindon

   Post-transcriptional regulation of Aurora Kinase A (AURKA) through alternative polyadenylation of its mRNA determines miRNA influence and is a feature of cell cycle-specific AURKA expression whose impairment leads to acquisition of cancer phenotypes.
9. 1. Epidemiology and Global Health
   2. Medicine

   Pan-Canadian survey on the impact of the COVID-19 pandemic on cervical cancer screening and management: cross-sectional survey of healthcare professionals

   Mariam El-Zein, Rami Ali ... Survey Study Group

   Decline in cervical cancer screening and challenges faced by healthcare professionals and patients when the pandemic was declared emphasize the importance of implementing human papillomavirus (HPV) primary screening, HPV self-sampling, and telemedicine to continue cervical cancer screening and care.
10. 1. Neuroscience

    Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

    Christian Thome, Jan Maximilian Janssen ... Maren Engelhardt
11. 1. Medicine

    Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

    Yohei Nitta, Jiro Osaka ... Atsushi Sugie
12. 1. Neuroscience

    Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates

    Sebastien Bouret, Emmanuel Paradis ... Cécile Garcia
13. 1. Developmental Biology

    Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity

    Guillem Torcal Garcia, Elisabeth Kowenz-Leutz ... Thomas Graf

    A mutation in the lineage-determining regulator C/EBPα that increases the factor’s affinity for its partner PU.1 dramatically accelerates the velocity of B cell to macrophage transdifferentiation.
14. 1. Neuroscience

    Pupil size reflects activation of subcortical ascending arousal system nuclei during rest

    Beth Lloyd, Lycia D de Voogd ... Sander Nieuwenhuis

    Pupil size during rest reflects activation of a network of subcortical ascending arousal system nuclei.
15. 1. Cell Biology

    Competition between myosin II and β_H-spectrin regulates cytoskeletal tension

    Consuelo Ibar, Krishna Chinthalapudi ... Kenneth D Irvine

    Insight into the activity of β-heavy spectrin is provided by the discovery that it can compete with myosin for association with F-actin, which provides explanations for its influences on Hippo signaling and morphogenesis.
16. 1. Neuroscience

    Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development

    Ellen J Guss, Yulia Akbergenova ... J Troy Littleton

    Loss of the extracellular matrix protein Perlecan leads to disruption of the neural lamella surrounding nerve bundles in Drosophila, resulting in axonal breakage and synaptic retraction of neuromuscular junctions.
17. 1. Computational and Systems Biology

    How honey bees make fast and accurate decisions

    HaDi MaBouDi, James AR Marshall ... Andrew B Barron

    A fast and accurate decision-making strategy observed in bees, and reproduced in a neurally-grounded model, suggests a robust, risk-averse decision strategy suitable for when sampling and errors are both costly.
18. 1. Epidemiology and Global Health

    The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study

    Victoria P Mak, Kami White ... Loic Le Marchand

    During the COVID-19 pandemic, cancer-related screening and healthcare practices varied (by age, race/ethnicity, education, and comorbidities), and considering these differences in high-risk individuals' monitoring is important as undiagnosed cases or poor prognosis may increase due to delayed screening/treatment.
19. 1. Neuroscience

    Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

    Guangfang Liu, Xin Zhou ... Haijing Niu
20. 1. Neuroscience

    Ketamine’s rapid antidepressant effects are mediated by Ca²⁺-permeable AMPA receptors

    Anastasiya Zaytseva, Evelina Bouckova ... Seonil Kim

    Ketamine induces the expression of Ca²⁺-permeable AMPA receptors to enhance synaptic glutamatergic and Ca²⁺ activity in neurons to cause rapid antidepressant effects.
21. 1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A billion years arms-race between viruses, virophages, and eukaryotes

    Jose Gabriel Nino Barreat, Aris Katzourakis

    Phylogenetic analyses of the four core virion proteins support a new evolutionary model for the origin of the main groups of eukaryotic viruses in the kingdom Bamfordvirae.
22. 1. Neuroscience

    Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice

    Leslie D Claar, Irene Rembado ... Christof Koch

    Activating deeper layers of the cortex using cortical electrical stimulation triggers the activation of thalamic nuclei through trans-synaptic signaling, which can result in a range of complex responses that can be detected using EEG signals.
23. 1. Developmental Biology

    A MSTN^Del273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia via MEK-ERK-FOSL1 axis

    Ming-Ming Chen, Yue Zhao ... Zheng-Xing Lian
24. 1. Cell Biology
    2. Chromosomes and Gene Expression

    High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope

    Swati Tyagi, Juliana S. Capitanio ... Martin W. Hetzer
25. 1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    TCR-pMHC complex formation triggers CD3 dynamics

    Floris J. van Eerden, Aalaa Alrahman Sherif ... Daron M. Standley
26. 1. Neuroscience

    Prior information enhances tactile representation in primary somatosensory cortex

    Pegah Kassraian, Finn Rabe ... Nicole Wenderoth
27. 1. Neuroscience

    Astrocytic Neuroligins Are Not Required for Synapse Formation or a Normal Astrocyte Cytoarchitecture

    Samantha R. Golf, Justin H. Trotter ... Thomas C. Südhof
28. 1. Neuroscience

    MotorNet: a Python toolbox for controlling differentiable biomechanical effectors with artificial neural networks

    Olivier Codol, Jonathan A. Michaels ... Paul L. Gribble
29. 1. Neuroscience

    Rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning

    Krzysztof H. Olszyński, Rafał Polowy ... Robert K. Filipkowski
30. 1. Structural Biology and Molecular Biophysics

    Mechanistic insights into robust cardiac I_Ks potassium channel activation by aromatic polyunsaturated fatty acid analogues

    Briana M Bohannon, Jessica J Jowais ... H Peter Larsson

    Changing substituents on the aromatic rings of polyunsaturated fatty acid analogues tailors their activation effect on the I_Ks channel and thus their therapeutic potential for long QT syndrome.
31. 1. Computational and Systems Biology
    2. Ecology

    Spatial structure favors microbial coexistence except when slower mediator diffusion weakens interactions

    Alexander Lobanov, Samantha Dyckman ... Babak Momeni

    Investigating microbial communities in a spatial environment in silico suggests that spatial structure promotes higher coexistence by allowing spatial self-organization, but can hinder coexistence by weakening interactions mediated through diffusible metabolites.
32. 1. Cancer Biology

    Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

    Wayne Croft, Hayden Pearce ... Paul Moss

    Profiling spatially defined fibroblasts in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment identifies high levels of podoplanin and hypoxia in tumor-proximal fibroblasts associated with bad prognosis, whilst inflammatory markers define more distal fibroblast regions and associate with better outcomes.
33. 1. Neuroscience

    Targeted memory reactivation in human REM sleep elicits detectable reactivation

    Mahmoud EA Abdellahi, Anne CM Koopman ... Penelope A Lewis

    Sound cues that were associated with memories during wake elicit memory reactivations when replayed to human participants during rapid eye movement sleep, those memory reactivations are identifiable by machine learning models that directly relate electroencephalography patterns of wake and sleep.
34. 1. Structural Biology and Molecular Biophysics

    Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

    David N Tippett, Colum Breen ... Raimund Dutzler

    The structural and functional characterization of SLC26A6 provides greater understanding of coupled versus uncoupled transport processes for the SLC26 transporter family.
35. 1. Microbiology and Infectious Disease

    A unique cell division protein critical for the assembly of the bacterial divisome

    Xiao Chu, Lidong Wang ... Zhaoqing Luo
36. 1. Neuroscience

    GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation

    Carlos Gonzalez-Islas, Zahraa Sabra ... Peter Wenner
37. 1. Biochemistry and Chemical Biology

    Nuclear bodies protect phase separated proteins from degradation in stressed proteome

    Kwan Ho Jung, Jiarui Sun ... Xin Zhang
38. 1. Neuroscience

    Distinct hippocampal and cortical contributions in the representation of hierarchies

    Robert Scholz, Arno Villringer, Mauricio J.D. Martins
39. 1. Genetics and Genomics
    2. Cancer Biology

    Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

    Robbin A. Nameki, Heidi Chang ... Kate Lawrenson
40. 1. Immunology and Inflammation

    Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

    Takuma Asahi, Shinya Abe ... Koichi Ikuta

    Interleukin 15-producing microenvironments in the fetal and adult liver foster a type 1 innate lymphoid cell lineage with intrinsic cytotoxicity mediated through cytotoxic granules that are expressed under their steady state, unlike conventional natural killer cells with stimulation-dependent cytotoxicity.
41. 1. Neuroscience

    Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

    Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell

    RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
42. 1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

    Lina Sagert, Christian Winter ... Robert Tampé

    The endoplasmic reticulum (ER) folding sensor UGGT1 essentially cooperates with the peptide editor TAPBPR to provide quality control of MHC I molecules in the antigen presentation pathway.
43. 1. Cell Biology
    2. Developmental Biology

    Differential modification of the C-terminal tails of different α-tubulins and their importance for microtubule function in vivo

    Mengjing Bao, Ruth E Dörig ... Beat Suter

    Specific glutamylation of some α-tubulin isotypes affects kinesin-1 localization and transport processes that depend on it, but their absence can speed up transport, possibly explaining why some large cells express α-tubulin isotypes that are not glutamylated.
44. 1. Stem Cells and Regenerative Medicine

    Comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'

    Anne Sustar, John C Tuthill

    We are writing to comment on the article by Abrams et al., 2021 about appendage regeneration in jellyfish, fruit flies, and mice.
45. 1. Evolutionary Biology
    2. Stem Cells and Regenerative Medicine

    Response to comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'

    Yutian Li, Anish A Sarma ... Lea Goentoro

    We are writing to respond to the comment by Sustar and Tuthill, 2023 on our article about appendage regeneration in jellyfish, fruit flies, and mice (Abrams et al., 2021).
46. 1. Genetics and Genomics
    2. Immunology and Inflammation

    A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation

    Elma El Khouri, Farah Diab ... Irina Giurgea

    Enhanced proteasomal degradation of TNFAIP3 proteins carrying missense variations is one of the pathophysiological mechanisms underlying HA20.
47. 1. Structural Biology and Molecular Biophysics

    Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels

    Ahmad Elbahnsi, John Cowgill ... Lucie Delemotte

    The HCN1 channel gates thanks to a coupling mechanism involving the reorganization of the interfaces between the voltage-sensor domains and pore helices, subtly shifting the balance between hydrophobic and hydrophilic interactions in a 'domino effect'.
48. 1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

    Joshua R Heyza, Mariia Mikhova ... Jens C Schmidt

    Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.
49. 1. Medicine

    Epidemiological characteristics and prevalence rates of research reproducibility across disciplines: A scoping review of articles published in 2018-2019

    Kelly D Cobey, Christophe A Fehlmann ... David Moher

    Definitions of reproducibility vary considerably across disciplines and overall rates of reproducibility are low irrespective of the definition used.
50. 1. Immunology and Inflammation

    Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

    Carlos Castrillon, Lea Simoni ... Michael C Carroll

    In an autoimmune environment B cells mature from spontaneous germinal centers into transcriptomically and phenotypically diverse memory and antibody-secreting cells but maintaining shared clonal and potential self-reactive specificities which has important implications for pathogenic cell targeted depletion.
51. 1. Genetics and Genomics

    Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations

    M Elise Lauterbur, Maria Izabel A Cavassim ... Ilan Gronau

    Stdpopsim, a framework for generating realistic chromosome-scale simulations, is expanded to facilitate simulations for non-model species, resulting in insights into how such simulations should be designed.
52. 1. Computational and Systems Biology
    2. Cancer Biology

    Is tumor mutational burden predictive of response to immunotherapy?

    Carino Gurjao, Dina Tsukrov ... Leonid A. Mirny
53. 1. Genetics and Genomics

    Sibling Similarity Can Reveal Key Insights Into Genetic Architecture

    Tade Souaiaia, Hei Man Wu ... Paul O’Reilly
54. 1. Genetics and Genomics
    2. Immunology and Inflammation

    Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

    Alexandru-Ioan Voda, Kristina Correa ... Luke Jostins-Dean
55. 1. Epidemiology and Global Health
    2. Neuroscience

    Impact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study

    Laurenz Lammer, Frauke Beyer ... A Veronica Witte

    Analyses of longitudinal neuroimaging data highlight the importance of social contact for brain health.
56. 1. Plant Biology

    Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

    Yaron Caspi, Chrysoula K Pantazopoulou ... Kaisa Kajala

    Recent findings about the possible intercellular signalling role of glutamate, GABA, and melatonin might help to establish hypotheses concerning the evolutionary factors that caused intercellular organisms to use specific molecules in intercellular signalling.
57. 1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

    Jean-Philippe Defour, Emilie Leroy ... Stefan N Constantinescu

    Structural and functional analyses reveal the general mechanism of activation of the thrombopoietin receptor and unravel the critical role of W515.
58. 1. Microbiology and Infectious Disease

    Genome editing of an African elite rice variety confers resistance against endemic and emerging Xanthomonas oryzae pv. oryzae strains

    Van Schepler-Luu, Coline Sciallano ... Wolf B Frommer

    Discovery of a rapidly spreading outbreak of bacterial blight in Tanzania caused by a Xanthomonas strain that originates from Asia and editing of Komboka rice lines resistant to the newly introduced strains and to other Asian and African strains.
59. 1. Neuroscience

    α₁-Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca²⁺ channel Ca_V1.2 activity and long-term potentiation in rodents

    Kwun Nok Mimi Man, Peter Bartels ... Johannes W Hell

    The α₁-adrenergic receptor augments the activity of the L-type Ca²⁺ channel Ca_V1.2 through PKC and the tyrosine kinases Pyk2 and Src and thereby synaptic plasticity.
60. 1. Genetics and Genomics
    2. Neuroscience

    Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

    Maria I Lazaro-Pena, Adam B Cornwell ... Andrew V Samuelson

    The transcriptional cofactor HPK-1 (homeodomain-interacting protein kinase) functions as a key regulator of multiple proteostatic stress responses, each originating from discrete neuronal subtypes within the Caenorhabditis elegans nervous system to preserve neuronal health and maintain organismal proteostasis during normal aging.
61. 1. Developmental Biology
    2. Genetics and Genomics

    Biallelic variants in MAD2L1BP (p31^comet) cause female infertility characterized by oocyte maturation arrest

    Lingli Huang, Wenqing Li ... Jianqiang Bao

    Biallelic MAD2L1BP variants contribute to oocyte metaphase I arrest in women with primary infertility and p31^comet is required for human oocyte maturation.
62. 1. Medicine

    Development and biophysical characterization of a humanized FSH–blocking monoclonal antibody therapeutic formulated at an ultra-high concentration

    Satish Rojekar, Anusha R Pallapati ... Mone Zaidi

    MS-Hu6 biotherapeutic formulation for the treatment of osteoporosis, obesity, and Alzheimer's disease.
63. 1. Neuroscience

    Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

    James M Roe, Didac Vidal-Pineiro ... René Westerhausen

    Brain asymmetry in cortical surface area shows lifespan stability from early childhood to old age and is more underpinned by genetic differences, whereas asymmetry in cortical thickness grows through childhood and adolescence and is minimally explained by genetics.
64. 1. Neuroscience

    Brain structure and function link to variation in biobehavioral dimensions across the psychopathological continuum

    Jasper van Oort, Alberto Llera ... Philip FP van Eijndhoven

    The multimodal linked independent component analysis promotes a more integrative understanding of transdiagnostic mechanisms of psychopathology.
65. 1. Cell Biology

    An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo

    Peter H Lee, Michael Anaya ... Kai Zinn

    The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.
66. 1. Biochemistry and Chemical Biology

    Ribozyme activity modulates the physical properties of RNA–peptide coacervates

    Kristian Kyle Le Vay, Elia Salibi ... Hannes Mutschler

    The physical properties of model coacervate protocells are modulated by the activity of an RNA ligase ribozyme, which confers resistance to growth, surface wetting, and material exchange, establishing a link between RNA sequence and protocell phenotype.
67. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation

    Yonathan Tamrat Aberra, Lijiang Ma ... Mete Civelek
68. 1. Genetics and Genomics
    2. Neuroscience

    Behavioral dissection of hunger states in Drosophila

    Kristina J Weaver, Sonakshi Raju ... Scott D Pletcher

    Drosophila experience two hunger states, one driven by need and the other by pleasure, which arise from unique neural substrates.
69. 1. Microbiology and Infectious Disease
    2. Neuroscience

    Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

    Jie Wang, Amir Rattner, Jeremy Nathans

    A model of early postnatal bacterial meningitis in the mouse demonstrates the transcriptome responses of each of the major meningeal cell types and should prove useful in dissecting the pathophysiology of bacterial meningitis in human infants.
70. 1. Microbiology and Infectious Disease

    Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution

    Clair R Henthorn, Paul M Airs ... Mostafa Zamanian

    A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.
71. 1. Biochemistry and Chemical Biology

    Phase separation-mediated actin bundling by the postsynaptic density condensates

    Xudong Chen, Bowen Jia ... Mingjie Zhang

    Biochemical and cell biology studies reveal that postsynaptic density condensates of neuronal synapses and actin cytoskeletons can directly communicate with each other in a phase separation-dependent manner.
72. 1. Neuroscience

    Flexible specificity of memory in Drosophila depends on a comparison between choices

    Mehrab N Modi, Adithya E Rajagopalan ... Glenn C Turner

    Flies can optimally recall a memory with high specificity by comparing options close in time, or default to generalization when they cannot.
73. 1. Neuroscience

    Differentiation and Integration of Competing Memories: A Neural Network Model

    Victoria J. H. Ritvo, Alex Nguyen ... Kenneth A. Norman
74. 1. Neuroscience

    Male rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict

    Sandeep S Dhawan, Carl Pinter ... Rutsuko Ito

    Optogenetics was used to reveal a novel role for the perirhinal cortex in regulating approach-avoidance behaviors under object-based motivational conflict.
75. 1. Cell Biology
    2. Medicine

    Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis

    Jiurong Liang, Guanling Huang ... Dianhua Jiang

    The synergy between aging and injury impairs alveolar progenitor functions leading to progressive lung fibrosis.
76. 1. Neuroscience

    Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms

    Jordan T Bateman, Erica S Levitt

    Opioids have distributed effects on the brainstem circuitry that controls breathing, including presynaptic and postsynaptic receptor-mediated inhibition of an excitatory circuit from the dorsolateral pons to the ventrolateral medulla.
77. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Low-level repressive histone marks fine-tune gene transcription in neural stem cells

    Arjun Rajan, Lucas Anhezini ... Cheng-Yu Lee

    Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.
78. 1. Neuroscience

    Nested circuits mediate the decision to vocalize

    Shuyun Xiao, Valerie Michael, Richard Mooney

    The decision to vocalize depends on neural circuits that balance the rewards of potential social affiliation with the risks of advertising.
79. 1. Structural Biology and Molecular Biophysics

    Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

    Thomas-O Peulen, Carola S Hengstenberg ... Christian Herrmann

    Multimodal spectroscopy (smFRET, EPR, SAXS, and SANS) and integrative structural modeling reveal large-scale domain rearrangements in human guanylate binding protein 1 (hGBP1) that are driving forces for the formation of oligomers that enable its biological function in innate immune defense.
80. 1. Stem Cells and Regenerative Medicine

    Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis

    Corentin Bernou, Marc-André Mouthon ... François D. Boussin
81. 1. Neuroscience

    A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury

    Tingting Li, Wenwen Shi ... Yong Q. Zhang
82. 1. Medicine
    2. Immunology and Inflammation

    Anti-inflammatory therapy with nebulised dornase alfa for severe COVID-19 pneumonia

    Joanna C. Porter, Jamie Inshaw ... Venizelos Papayannopoulos
83. 1. Developmental Biology

    Three-dimensional imaging of vascular development in the mouse epididymis

    Christelle Damon-Soubeyrand, Antonino Bongiovanni ... Joelle Henry-Berger

    The lymphatic and blood network of the mouse epididymis in adulthood and during postnatal ontogeny has been analyzed in detail.
84. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

    Silvia N Kariuki, Alexander W Macharia ... Thomas N Williams

    Strongly protective effect conferred by the Dantu blood group variant against early, non-clinical, Plasmodium falciparum malaria infections in vivo.
85. 1. Evolutionary Biology

    Femora from an exceptionally large population of coeval ornithomimosaurs yield evidence of sexual dimorphism in extinct theropod dinosaurs

    Romain Pintore, Raphaël Cornette ... Ronan Allain

    Consistent bimodal variations in the femoral morphology of various modern amniotes and a remarkably large herd of coeval fossil non-avian theropods evidences sexual dimorphism in dinosaurs.
86. 1. Genetics and Genomics
    2. Neuroscience

    Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons

    Kai Li, Yuma Tsukasa ... Tadao Usui

    Belly roll, Bero, an Ly6/α-neurotoxin family protein, is identified as a critical modulator of peptidergic interneurons in Drosophila melanogaster, shedding light on genetic regulations of nociceptive escape behaviors and providing a potential target for future studies on pain perception.
87. 1. Immunology and Inflammation

    Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

    Marianna Santopaolo, Michaela Gregorova ... Laura Rivino

    Prolonged CD4⁺ and CD8⁺ T-cell activation and long COVID symptoms at 3 months post hospitlization independently associate with severe COVID-19, and ongoing T-cell activation does not affect the generation and maintenance of memory T-cell and antibody responses to SARS-CoV-2.
88. 1. Ecology

    Flying squirrels use a mortise-tenon structure to fix nuts on understory twigs

    Han Xu, Lian Xia ... Suqin Fang

    Two flying squirrel species chewed grooves into Cyclobalanopsis nuts, and used them to pressure-fit nuts tightly in crotches formed by small twigs on understory plants, in a way similar to a mortise-tenon joint used in architecture and carpentry.
89. 1. Neuroscience

    A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila

    Izumi Oikawa, Shu Kondo ... Ken Honjo

    Descending inhibition of nociception from the brain has been identified in Drosophila larvae, for the first time in non-mammalian organisms.
90. 1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Structure of the photosynthetic Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase SBPase from the model microalga Chlamydomonas reinhardtii

    Théo Le Moigne, Martina Santoni ... Julien Henri
91. 1. Developmental Biology
    2. Ecology

    Microplastics are present in women’s and cows’ follicular fluid and polystyrene microplastics compromise bovine oocyte function in vitro

    Nicole Grechi, Roksan Franko ... Marcia de A. M. M. Ferraz
92. 1. Neuroscience

    The cation channel mechanisms of subthreshold inward depolarizing currents in the VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

    Jing Wang, Min Su ... Hailin Zhang
93. 1. Plant Biology

    A dual function of the IDA peptide in regulating cell separation and modulating plant immunity at the molecular level

    Vilde Olsson Lalun, Maike Breiden ... Melinka A. Butenko
94. 1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

    Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard

    Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
95. 1. Evolutionary Biology
    2. Genetics and Genomics

    Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates

    Adele Francis Xu, Rut Molinuevo ... Maria Barna

    Ribosomal proteins Rps27 (eS27) and Rps27l (eS27L) are an ancient pair of duplicated genes that encode functionally interchangeable proteins, yet have been evolutionarily retained because both copies are necessary to achieve protein expression across cell types.
96. 1. Epidemiology and Global Health

    Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data

    Margarita Pons-Salort, Ben Lambert ... Nicholas C Grassly

    Serocatalytic models applied to seroprevalence data from England reveal an increase in Enterovirus D68 transmission that occurred before 2011.
97. 1. Cell Biology
    2. Neuroscience

    Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain

    Elizabeth L Wagner, Jun-Sub Im ... Jung-Bum Shin

    A novel mechanism for F-actin repair is involved in the maintenance of sensory hair cells and hearing function.
98. 1. Developmental Biology
    2. Microbiology and Infectious Disease

    Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

    Théodore Grenier, Jessika Consuegra ... François Leulier

    Bacterial ribosomal and transfer RNAs are symbiotic clues sensed by host general control nonderepressible 2 to support Drosophila systemic growth.
99. 1. Evolutionary Biology

    Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population

    Khai C Ang, Victor A Canfield ... Keith C Cheng

    Analysis of 458 Kalinago provides new insights into the population's genetic structure, the contribution of Native American ancestry to skin pigmentation, and the identification of a coding variant in OCA2 with an estimated –8 melanin units effect size.
100. 1. Plant Biology

     Plant Arbovirus Mobilizes a Vector Salivary Protein to Initiate Plant Infection

     Jing Zhao, Jie Yang ... Lili Zhang
101. 1. Neuroscience

     Hippocampal remapping induced by new behavior is mediated by spatial context

     Samuel J. Levy, Michael E. Hasselmo
102. 1. Neuroscience

     Pharyngeal Mechanosensory Neurons Control Food Swallow in Drosophila melanogaster

     Jierui Qin, Tingting Yang ... Wei Zhang
103. 1. Genetics and Genomics
     2. Microbiology and Infectious Disease

     A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

     Abderrahman Hachani, Stefano G Giulieri ... Timothy P Stinear

     Staphylococcus aureus switches from innocuous coloniser to invasive human pathogen, the bacterial population can accumulate pathoadaptive mutations that reduce bacterial toxicity whilst allowing persistence within infected cells, potentially leading to severe human infections.
104. 1. Biochemistry and Chemical Biology
     2. Cell Biology

     Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

     Wenxin Zhang, Taki Nishimura ... Sharon A Tooze

     cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.
105. 1. Computational and Systems Biology
     2. Neuroscience

     High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

     George A Spirou, Matthew Kersting ... Paul B Manis

     Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.
106. 1. Chromosomes and Gene Expression
     2. Neuroscience

     Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

     Bradley M Colquitt, Kelly Li ... Michael S Brainard

     Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.
107. 1. Cell Biology

     Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions

     Florian Geisler, Sanne Remmelzwaal ... Rudolf E Leube

     Aberrant cytoskeletal intermediate filament networks in the C. elegans intestine are associated with hyperphosphorylated intermediate filament proteins and impact not only intestinal cell structure but have also detrimental consequences for organismal well-being.
108. 1. Neuroscience

     The impact of task context on predicting finger movements in a brain-machine interface

     Matthew J Mender, Samuel R Nason-Tomaszewski ... Cynthia A Chestek

     Task changes, like increased force production or altered posture, decrease the accuracy of brain-machine interfaces predicting intended finger movements, however, understanding how neural activity changes with the altered biomechanics of the task may provide insights for generalizable decoder development.
109. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

     Francisco X Galdos, Carissa Lee ... Sean M Wu

     TBX5 lineage tracing and high resolution single cell transcriptomics uncover the predominance of first heart field development during human-induced pluripotent stem cell cardiac differentiation.
110. 1. Stem Cells and Regenerative Medicine

     Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

     Claudia Dominici, Oscar D Villarreal ... Stéphane Richard

     Inhibition of type I PRMTs increases the proliferation capabilities of MuSCs with altered cellular metabolism, while maintaining their stem-like properties such as self-renewal and engraftment potential.
111. 1. Neuroscience

     The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity

     Rebecca Jordan, Georg B Keller

     A brain-wide neuromodulatory system enables rapid cortical plasticity to occur by signaling sensorimotor prediction errors across wide regions of the cerebral cortex.
112. 1. Genetics and Genomics
     2. Evolutionary Biology

     Somatic mutation rates scale with time not growth rate in long-lived tropical trees

     Akiko Satake, Ryosuke Imai ... Masahiro Kasahara
113. 1. Biochemistry and Chemical Biology

     High-throughput Automated Muropeptide Analysis (HAMA) Reveals Peptidoglycan Composition of Gut Microbial Cell Walls

     Ya-Chen Hsu, Pin-Rui Su ... Cheng-Chih Hsu
114. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

     Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
115. 1. Immunology and Inflammation

     Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in ESRD

     Hee Young Kim, Dong Hyun Kim ... Won-Woo Lee
116. 1. Developmental Biology
     2. Neuroscience

     Establishing And Maintaining The Blood-Brain Barrier: Epigenetic And Signaling Determinants

     Jayanarayanan Sadanandan, Sithara Thomas ... T Peeyush Kumar
117. 1. Immunology and Inflammation
     2. Cancer Biology

     Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

     Brandon H. Hayes, Mai Wang ... Dennis E. Discher
118. 1. Genetics and Genomics

     Mec1-independent activation of the Rad53 checkpoint kinase revealed by quantitative analysis of protein localization dynamics

     Brandon Ho, Ethan J Sanford ... Grant W Brown

     Retrograde signaling activates the Rad53 checkpoint kinase independently of the canonical DNA replication stress response.
119. 1. Ecology
     2. Evolutionary Biology

     Metabolic consequences of various fruit-based diets in a generalist insect species

     Laure Olazcuaga, Raymonde Baltenweck ... Julien Foucaud

     Metabolomic analyses indicate that diet generalism may stem from a neutral metabolic response to different chemistries, rather than from an accumulation of specific adaptations.
120. 1. Evolutionary Biology
     2. Genetics and Genomics

     Endoparasitoid lifestyle promotes endogenization and domestication of dsDNA viruses

     Benjamin Guinet, David Lepetit ... Julien Varaldi

     The propensity to endogenize and domesticate dsDNA viruses depends on lifestyle in Hymenoptera.
121. 1. Neuroscience

     Changing the incentive structure of social media platforms to halt the spread of misinformation

     Laura K Globig, Nora Holtz, Tali Sharot

     Offering users reaction buttons that convey reliability (e.g., ‘trust’, ‘distrust’) increases discernment and significantly reduces the spread of misinformation on a social media platform.
122. 1. Medicine

     The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

     Amy Louise Ball, Carol E Jolly ... Amy E Chadwick

     HepG2 transmitochondrial cybrids of haplogroup J genome had increased sensitivity to aspects of mitochondrial dysfunction induced by tolcapone and 2-hydroxyflutamide, compared to haplogroup H, thus cybrids provide a practical system to investigate the consequences of mitochondrial genome on drug-induced hepatotoxicity.
123. 1. Developmental Biology
     2. Neuroscience

     Glial-dependent clustering of voltage-gated ion channels in Drosophila precedes myelin formation

     Simone Rey, Henrike Ohm ... Christian Klämbt

     Evolution of saltatory conductance is mirrored in fly development where glia-dependent clustering of voltage-gated ion channels precedes myelination.
124. 1. Ecology

     Divergent functions of two clades of flavodoxin in diatoms mitigate oxidative stress and iron limitation

     Shiri Graff van Creveld, Sacha N Coesel ... E Virginia Armbrust

     Diatoms encode two forms of flavodoxin with divergent functions that mitigate the oxidative stress and iron requirements associated with life in contemporary oxygenated iron-poor oceans.
125. 1. Neuroscience

     Inconsistencies between human and macaque lesion data can be resolved with a stimulus-computable model of the ventral visual stream

     Tyler Bonnen, Mark AG Eldridge

     A 'stimulus-computable' modeling approach resolves apparent inconsistencies between human and monkey lesion data, implicating perirhinal cortex in visual object perception.
126. 1. Computational and Systems Biology
     2. Neuroscience

     Model discovery to link neural activity to behavioral tasks

     Jamie D Costabile, Kaarthik A Balakrishnan ... Martin Haesemeyer

     Model identification of neural encoding is an accessible system for the analysis of neural data that allows identifying and characterizing arbitrary relationships between neural activity and task-related variables such as behavior, stimuli, or internal states.
127. 1. Computational and Systems Biology
     2. Epidemiology and Global Health

     Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

     Oliver Robinson, ChungHo E Lau ... Martine Vrijheid

     Among European children, shorter telomere length and older DNA methylation age relative to chronological age were associated with poorer behaviors, while older age, as predicted by a novel immunometabolic clock relative to chronological age, was associated with greater cognitive maturity.
128. 1. Cell Biology

     Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

     Devon E. Mason, Megan Goeckel ... Joel D. Boerckel
129. 1. Cell Biology
     2. Neuroscience

     A rapid microglial metabolic response controls metabolism and improves memory

     Anne Drougard, Eric H Ma ... J. Andrew Pospisilik
130. 1. Stem Cells and Regenerative Medicine

     Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors

     Claudia Dell'Amico, Marilyn M Angulo Salavarria ... Marco Onorati

     Microcephaly-associated mutations disrupt microtubule-dependent WDR62 translocation from the Golgi complex to the mitotic spindle poles, impair mitotic progression, and alter neurogenic trajectories in patient induced Pluripotent Stem Cell-derived 2D and 3D models of human neurodevelopment.
131. 1. Cell Biology

     A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity

     Qin Zou, Rong Yuan ... Yanzhi Jiang

     The heterogeneity in molecule and function of three main cell types of smooth muscle cells, endothelial cells, and fibroblasts from both different anatomical sites of pig skin was comprehensively exposited.
132. 1. Computational and Systems Biology
     2. Genetics and Genomics

     Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

     Karthickeyan Chella Krishnan, Elie-Julien El Hachem ... Aldons J Lusis

     The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.
133. 1. Neuroscience

     Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation

     Ali Mohebi, Val L Collins, Joshua D Berke

     In awake behaving rats, cholinergic interneurons in the nucleus accumbens drive dopamine release via nicotinic receptors, boosting motivation to work.
134. 1. Genetics and Genomics

     Allele-specific gene-editing approach for vision loss restoration in RHO-associated retinitis pigmentosa

     Xiaozhen Liu, Jing Qiao ... Liping Yang

     The allele-specific gene-editing drug is expected to make RHO-T17M-associated retinitis pigmentosa therapy a reality.
135. 1. Cell Biology
     2. Neuroscience

     Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis

     Sotaro Ichinose, Yoshihiro Susuki ... Hirohide Iwasaki

     Teneurin-2, a synaptic organizer, localizes to microtubule-rich inhibitory synapses and recruits microtubules via interaction with end-binding proteins, and this mechanism enables GABA_A receptors exocytosis.
136. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

     Maura Greiser, Mariusz Karbowski ... Liron Boyman

     A novel signaling system in heart mitochondria in which the byproduct of energy metabolism, CO₂/bicarbonate, acts as the primary signal to tune mitochondrial ATP production while keeping energy supply in tight synchronization with energy consumption.
137. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance

     Virginia Folgado-Marco, Kristina Ames ... Nicholas E Baker

     The homozygous and heterozygous phenotypes of mouse Rps12 deletion are described, highlighting pancytopenia reflecting roles in hematopoiesis and erythropoiesis.
138. 1. Developmental Biology
     2. Genetics and Genomics

     Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

     Mahdi Moradi Marjaneh, Edwin P Kirk ... Richard P Harvey

     A high-resolution picture of genetic complexity and network perturbations underlying cardiac inter-atrial septal dysmorphology associated with patent foramen ovale, a common human congenital anomaly, using quantitative trait locus mapping, genome sequencing, and transcriptomics in a mouse model.
139. 1. Neuroscience

     Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

     Alyssa Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez

     The postinspiratory complex acts as an interface between the swallow pattern generator and the preBötzinger complex to coordinate swallow and breathing.
140. 1. Cell Biology

     Metabolic regulation of misfolded protein import into mitochondria

     Yuhao Wang, Linhao Ruan ... Rong Li
141. 1. Stem Cells and Regenerative Medicine

     Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

     Nurul Jannah Mohamed Nasir, Hans Heemskerk ... Lisa Tucker-Kellogg

     Myoglobin iron contributes to the formation and poor healing of muscle pressure injuries, that is, bedsores, and iron-chelation therapy can be administered after prolonged pressure to increase survival of the damaged tissue.
142. 1. Microbiology and Infectious Disease
     2. Immunology and Inflammation

     Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

     Sharon A McGrath-Morrow, Jarrett Venezia ... Alan L Scott

     A pre-clinical model of E. coli pneumonia reveals attenuated dynamics of MHCII-expressing mononuclear cells in neonatal lung associated with elevated susceptibility to bacterial pneumonia.
143. 1. Microbiology and Infectious Disease

     Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations

     Daan F van den Berg, Baltus A van der Steen ... Stan JJ Brouns

     A new perspective on the 50-year old mystery of why phages encode their own tRNAs.
144. 1. Genetics and Genomics

     Engineering of the endogenous HBD promoter increases HbA2

     Mandy Y Boontanrart, Elia Mächler ... Jacob E Corn

     Gene-editing to repair non-functional transcriptional elements in the endogenous promoter of δ-globin increases overall expression of adult hemoglobin 2 (HbA2), providing proof-of-concept for a therapeutic avenue to treat β-hemoglobinopathies.
145. 1. Chromosomes and Gene Expression
     2. Genetics and Genomics

     Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

     Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch

     The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.
146. 1. Stem Cells and Regenerative Medicine

     Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

     Yaeko Nakajima-Takagi, Motohiko Oshima ... Atsushi Iwama

     Polycomb repressive complex 1.1 restricts precocious myeloid differentiation of hematopoietic stem/progenitor cells and expansion of myeloid progenitors, thereby serving as a gatekeeper of emergency myelopoiesis and myeloid transformation.
147. 1. Cancer Biology

     Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

     Jiangfei Chen, Kunal Baxi ... Myron S Ignatius

     Zebrafish are an optimal model organism to study rare TP53 mutations whose functions are not readily understood.
148. 1. Immunology and Inflammation

     CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

     Yu Li, Pablo Guaman Tipan ... Lauren IR Ehrlich

     Two-photon microscopy, combined with chemotaxis assays, synchronized thymocyte selection studies, and flow cytometry analyses, reveal that CCR4 and CCR7 promote medullary entry and central tolerance of immature and mature post-positive selection thymocyte subsets, respectively, with distinct outcomes for central tolerance.
149. 1. Cancer Biology
     2. Computational and Systems Biology

     Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

     Xiangkun Wu, Hong Yan ... Li Liang

     Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
150. 1. Biochemistry and Chemical Biology

     Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

     Loïc Duffet, Elyse T Williams ... Tommaso Patriarchi

     A genetically encoded sensor and a photocaged peptide together enable precise investigation of human glucagon-like peptide-1 receptor activation with high spatiotemporal resolution.
151. 1. Plant Biology

     Adenylnucleotide-mediated binding of the PII-like protein SbtB contributes to controlling activity of the cyanobacterial bicarbonate transporter SbtA

     Britta Förster, Bratati Mukherjee ... G. Dean Price
152. 1. Ecology

     Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age

     J. Graham Ruby, Megan Smith, Rochelle Buffenstein
153. 1. Biochemistry and Chemical Biology
     2. Immunology and Inflammation

     The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

     Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco

     RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.
154. 1. Structural Biology and Molecular Biophysics

     Biological condensates form percolated networks with molecular motion properties distinctly different from dilute solutions

     Zeyu Shen, Bowen Jia ... Mingjie Zhang

     Molecules in the condensed phase of biological condensates convert between transiently confined states and mobile states by forming dynamic percolated networks.
155. 1. Cell Biology

     Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

     Emmeline Marchal-Duval, Méline Homps-Legrand ... Arnaud A Mailleux

     Inhibition of a single fibroblast-associated transcription factor, namely Paired-related Homeobox Protein 1 (PRRX1), is sufficient to dampen lung fibrogenesis.
156. 1. Cancer Biology

     MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

     Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe

     Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.
157. 1. Evolutionary Biology

     Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows

     Anthony V Signore, Phillip R Morrison ... Kevin L Campbell

     Resurrected Steller’s sea cow hemoglobin exhibits novel functional traits underlying their adaptation to the sub-Arctic.
158. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     Cell-free DNA as a potential biomarker of differentiation and toxicity in cardiac organoids

     Brian Silver, Kevin Gerrish, Erik Tokar

     Cardiac organoids have potential as a tool used for identifying cell-free DNA as biomarkers for toxicity and severity of exposure outcomes.
159. 1. Computational and Systems Biology
     2. Neuroscience

     Flexible control of representational dynamics in a disinhibition-based model of decision-making

     Bo Shen, Kenway Louie, Paul Glimcher

     Local disinhibition provides a biologically plausible mechanism for flexible top-down control of network states that integrates normalized value coding, winner-take-all choice, and persistent activity in a single circuit of decision-making.
160. 1. Cancer Biology

     The CD73 immune checkpoint promotes tumor cell metabolic fitness

     David Allard, Isabelle Cousineau ... John Stagg

     Targeting CD73 not only enhances anti-tumor immunity but also disrupts tumor cell metabolism and hinders poly ADP ribose polymerase (PARP) activity, thus unveiling novel opportunities for combination cancer treatments.
161. 1. Medicine
     2. Neuroscience

     Instantaneous antidepressant effect of lateral habenula deep brain stimulation in rats studied with functional MRI

     Gen Li, Binshi Bo ... Xiaojie Duan

     Electrical stimulation at the lateral habenula causes an instantaneous remission of depressive symptoms in two rat models, with more medial stimulation sites exhibiting greater antidepressant effects than more lateral stimulation sites, as revealed by functional MRI studies.