May 2024

Research articles

1. 1. Physics of Living Systems

   Unlocking the secrets of kangaroo locomotor energetics: Postural adaptations underpin increased tendon stress in hopping kangaroos

   Lauren H. Thornton, Taylor J.M. Dick ... Christofer J. Clemente
2. 1. Medicine
   2. Microbiology and Infectious Disease

   Neuroinfectiology of an atypical anthrax-causing pathogen in wild chimpanzees

   Tobias Gräßle, Carsten Jäger ... Markus Morawski
3. 1. Cancer Biology

   Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

   Honglei Zhang, Chao Liu ... Gaofeng Li
4. 1. Developmental Biology

   SMAD4 promotes somatic-germline contact during murine oocyte growth

   Sofia Granados-Aparici, Qin Yang, Hugh J Clarke

   Depletion of the TGFβ signal-transducer, SMAD4, in granulosa cells of growing follicles reduces the number of filopodia, termed transzonal projections, that stably attach to and mediate communication with the oocyte.
5. 1. Neuroscience

   Genetically defined nucleus incertus neurons differ in connectivity and function

   Emma D Spikol, Ji Cheng ... Marnie E Halpern

   Transgenic zebrafish generated by targeted genomic integration distinguish neuronal subtypes in the nucleus incertus that differ in their connections and functional properties.
6. 1. Neuroscience

   Visual working memories are abstractions of percepts

   Ziyi Duan, Clayton E Curtis

   Working memory representations are not hard copies of sensory information, even in early visual cortex, but can be recoded into more abstract and goal-directed formats aligned to behavioral goals.
7. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Bacterial vampirism mediated through taxis to serum

   Siena J Glenn, Zealon Gentry-Lear ... Arden Baylink

   Enteric bacteria associated with bloodstream infections are attracted to human serum through L-serine and the chemoreceptor Tsr, and in an enterohemorrhagic lesion model use chemotaxis to invade damaged vasculature.
8. 1. Microbiology and Infectious Disease

   Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

   Xufeng Xie, Xi Chen ... Yongguo Cao

   Gut dysbiosis is involved in severe leptospirosis that is related to translocated microbiota-derived lipopolysaccharide.
9. 1. Cell Biology
   2. Genetics and Genomics

   Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

   Jiali Chen, Qinghe Zeng ... Hongting Jin

   Alterations of DNA methylation were associated with articular cartilage degeneration in hemophilic arthropathy, and aberrant methylation and expression of TNXB promote blood-induced chondrocyte apoptosis by regulating AKT activation.
10. 1. Neuroscience

    High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

    Li A. Zhang, Peichao Li, Edward M. Callaway
11. 1. Computational and Systems Biology

    Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

    Dylan C. Sarver, Muzna Saqib ... G. William Wong
12. 1. Cell Biology
    2. Neuroscience

    Rab11 suppresses neuronal stress signaling by localizing Dual leucine zipper kinase to axon terminals for protein turnover

    Seungmi Kim, Yaw Quagraine ... Jung Hwan Kim
13. 1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model for Parkinson’s disease

    Desirée Böck, Maria Wilhelm ... Gerald Schwank
14. 1. Neuroscience

    Whole-brain neural substrates of behavioral variability in the larval zebrafish

    Jason Manley, Alipasha Vaziri
15. 1. Neuroscience

    Convolutional networks can model the functional modulation of MEG responses during reading

    Marijn van Vliet, Oona Rinkinen ... Riitta Salmelin
16. 1. Ecology

    The larva and adult of Helicoverpa armigera use differential gustatory receptors to sense sucrose

    Shuai-Shuai Zhang, Pei-Chao Wang ... Chen-Zhu Wang

    The sweet taste receptors in the cotton bollworm (Helicoverpa armigera) are evolved to adapt towards the larval and adult foods with different types and amounts of sugar.
17. 1. Plant Biology

    H1 restricts euchromatin-associated methylation pathways from heterochromatic encroachment

    C Jake Harris, Zhenhui Zhong ... Steven E Jacobsen

    The efficient deployment of RdDM for transposon silencing is hierarchically controlled by the linker histone H1.
18. 1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

    Kejia Zhang, Patrick Eldin ... Dragony Fu

    SARS-CoV-2 infection reduces the intracellular levels of a human tRNA modification enzyme and alters host tRNA modification profiles.
19. 1. Computational and Systems Biology
    2. Neuroscience

    Theoretical principles explain the structure of the insect head direction circuit

    Pau Vilimelis Aceituno, Dominic Dall'Osto, Ioannis Pisokas

    Three theoretical principles explain the neural activity observed in the head direction circuit of insects, the connectivity pattern underlying the circuit, and how the ubiquitous eight-column circuit structure emerged from evolutionary processes.
20. 1. Neuroscience

    Neurexins control the strength and precise timing of glycinergic inhibition in the auditory brainstem

    He-Hai Jiang, Ruoxuan Xu ... Fujun Luo

    Neurexins are essential for shaping the functional properties of glycinergic synapse in the auditory brainstem, further attesting their universal role as critical presynaptic organizers in all major fast chemical synapses.
21. 1. Developmental Biology
    2. Genetics and Genomics

    Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

    Ruby Oberin, Sigrid Petautschnig ... Patrick S Western

    Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.
22. 1. Plant Biology

    Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)

    Shijia Lin, Yiwen Zhang ... Zhaoliang Zhang
23. 1. Cell Biology
    2. Neuroscience

    Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to GDNF secretion

    Lu Yang, Zijin Lin ... Li Liu
24. 1. Structural Biology and Molecular Biophysics

    Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

    Parveen Goyal, KanagaVijayan Dhanabalan ... Subramanian Ramaswamy
25. 1. Structural Biology and Molecular Biophysics

    Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications

    Rasa Giniūnaitė, Rahul Sharma ... Daiva Petkevičiūtė-Gerlach
26. 1. Physics of Living Systems

    Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

    Till M. Muenker, Bart E. Vos, Timo Betz
27. 1. Developmental Biology

    Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

    Fengzhu Xiong, Andrea R. Tentner ... Sean G. Megason
28. 1. Cell Biology

    Circular RNA HMGCS1 sponges miR-4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

    Ming Zhang, Guangyi Du ... Wei Chen
29. 1. Immunology and Inflammation

    The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

    Yalan Jiang, Pingping He ... Xiaoou Shan
30. 1. Computational and Systems Biology

    Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regions

    Apiwat Sangphukieo, Pitiporn Noisagul ... Parunya Chaiyawat
31. 1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
32. 1. Evolutionary Biology

    Artificial selection for microbial collective composition can succeed or fail depending on the initial and target values

    Juhee Lee, Wenying Shou, Hye Jin Park
33. 1. Medicine
    2. Neuroscience

    Neural mechanism of rebooting the unconsciousness caused by midazolam

    LeYuan Gu, WeiHui Shao ... HongHai Zhang
34. 1. Biochemistry and Chemical Biology

    Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C

    Alexander S Baier, Nathan Gioacchini ... Craig L Peterson

    Nucleosome recognition by the SWR1C chromatin remodeling enzyme requires both nucleosomal acidic patches.
35. 1. Neuroscience

    Reactivation strength during cued recall is modulated by graph distance within cognitive maps

    Simon Kern, Juliane Nagel ... Gordon B Feld

    Items retrieved from cognitive maps are reactivated simultaneously or sequentially depending on the performance, where in the first case the reactivation strength reflects the distance within the map.
36. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

    Léa Torcq, Sara Majello ... Anne A Schmidt

    Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.
37. 1. Neuroscience

    Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

    Evan D Vickers, David A McCormick

    Procedures were developed to perform mesoscale 2-photon Ca²⁺ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
38. 1. Cancer Biology
    2. Cell Biology

    mitoBK_Ca is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming

    Helmut Bischof, Selina Maier ... Robert Lukowski

    A novel role of the mitochondrial BK_Ca channel involves the metabolic reprogramming of breast cancer cells, facilitating their unrestricted proliferation and O₂-independence, which is also of potential clinical relevance.
39. 1. Neuroscience

    Brain representations of motion and position in the double-drift illusion

    Noah J Steinberg, Zvi N Roth ... Elisha Merriam

    The 'double-drift' illusion involves integration of retinal and non-retinal signals in the human visual cortex, providing evidence for a perceptual representation that incorporates extraretinal information.
40. 1. Immunology and Inflammation

    Downregulation of Semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

    Miki Kume, Hanako Koguchi-Yoshioka ... Rei Watanabe
41. 1. Neuroscience

    Stable sequential dynamics in prefrontal cortex represents subjective estimation of time

    Yiting Li, Wenqu Yin ... Baoming Li
42. 1. Microbiology and Infectious Disease

    Aeromonas hydrophila CobQ is a new type of NAD⁺- and Zn²⁺-independent protein lysine deacetylase in prokaryotes

    Yuqian Wang, Guibin Wang ... Xiangmin Lin
43. 1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

    Eva Herdering, Tristan Reif-Trauttmansdorff ... Ruth A. Schmitz
44. 1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning

    Ruihan Dong, Rongrong Liu ... Cheng Zhu
45. 1. Chromosomes and Gene Expression

    Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways

    Daphne R Knudsen-Palmer, Pravrutha Raman ... Antony M Jose
46. 1. Structural Biology and Molecular Biophysics

    PPI-hotspot^ID: A Method for Detecting Protein-Protein Interaction Hot Spots from the Free Protein Structure

    Yao Chi Chen, Karen Sargsyan ... Carmay Lim
47. 1. Genetics and Genomics
    2. Medicine

    Biallelic pathogenic variants in DNAH3 cause male infertility in humans and mice

    Xiang Wang, Gan Shen ... Ying Shen
48. 1. Computational and Systems Biology

    Analysis of science journalism reveals gender and regional disparities in coverage

    Natalie R Davidson, Casey S Greene

    Those quoted and mentioned in stories in Nature News mostly have names associated with men and are much less likely to have names associated with East Asia.
49. 1. Microbiology and Infectious Disease

    The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

    João Paulo Portela Catani, Anouk Smet ... Thorsten U Vogel

    N2 neuraminidases from human H3N2 viruses from 2009 until 2017 can be subdivided into four antigenic groups, with amino acid substitutions near the catalytic site more likely impacting neuraminidase inhibition.
50. 1. Medicine

    Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

    Wei Chen, Yun Lu ... Yi-Ping Li

    Low expression of Cbfb may be the cause of osteoarthritis, and local admission of Cbfb may rescue and protect against osteoarthritis through decreasing Wnt/β-catenin signaling, and increasing Hippo/Yap signaling and Tgfβ/Smad2/3 signaling in osteoarthritis articular cartilage.
51. 1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

    Timothy A Bates, Mila Trank-Greene ... Fikadu G Tafesse

    ESAT-6, a virulence factor of Mycobacterium tuberculosis, dimerizes at neutral pH and transitions to oligomers under acidic pH similar to that of lysosome, helping the bacterium evade host defense mechanisms.
52. 1. Developmental Biology

    An important role for triglyceride in regulating spermatogenesis

    Charlotte F Chao, Yanina-Yasmin Pesch ... Elizabeth Rideout

    Triglyceride plays an important role in regulating sperm development.
53. 1. Cancer Biology
    2. Immunology and Inflammation

    Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

    Brandon H Hayes, Mai Wang ... Dennis E Discher

    Chromosomal instability induced in solid tumors can combine with macrophages that are made highly phagocytic to thereby initiate elimination of and immunity against poorly immunogenic tumors in immunocompetent mice.
54. 1. Neuroscience

    Distinct neural bases of subcomponents of the attentional blink

    Swagata Halder, Deepak Velgapuni Raya, Devarajan Sridharan
55. 1. Cell Biology

    Amoeboid cells undergo durotaxis with soft end polarized NMIIA

    Chenlu Kang, Pengcheng Chen ... Congying Wu
56. 1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

    S. P. Maher, M. A. Bakowski ... D. E. Kyle
57. 1. Cell Biology

    Dysregulated Ca²⁺ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s syndrome

    Kai-Ting Huang, Larry E. Wagner ... David I. Yule
58. 1. Cell Biology
    2. Genetics and Genomics

    Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity

    Jisun So, Olivia Strobel ... Hyun Cheol Roh
59. 1. Developmental Biology

    Flamingo participates in multiple models of cell competition

    Pablo Sanchez Bosch, Bomsoo Cho, Jeffrey D. Axelrod
60. 1. Ecology

    Fine-scale tracking reveals visual field use for predator detection and escape in collective foraging of pigeon flocks

    Mathilde Delacoux, Fumihiro Kano
61. 1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum: A containment strategy for toxic intermediates

    Samantha J Ziegler, Brandon C Knott ... Yannick J Bomble
62. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Spotless, a reproducible pipeline for benchmarking cell type deconvolution in spatial transcriptomics

    Chananchida Sang-aram, Robin Browaeys ... Yvan Saeys

    Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.
63. 1. Genetics and Genomics
    2. Neuroscience

    Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes

    Donghui Yan, Bowen Hu ... Qiongshi Lu

    BADGERS, as a new powerful method for conducting polygenic score-based biobank-wide association scans, identified 48 significant associations for AD and 41 significant associations for a variety of AD endophenotypes.
64. 1. Cancer Biology

    Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

    Keene L Abbott, Ahmed Ali ... Matthew G Vander Heiden

    Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.
65. 1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

    Bing Liang Alvin Chew, AN Qi Ngoh ... Dahai Luo

    Molecular architecture of the secreted NS1 dimer from dengue virus infection in complex with a high density lipoprotein particle.
66. 1. Microbiology and Infectious Disease

    A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

    Swagata Bose, Satya Ranjan Sahu ... Narottam Acharya

    A detailed characterizations of EDTA-treated Candida albicans cells both in vitro and pre-clinical models led to discovery of a potential live whole-cell vaccine against fungal infections.
67. 1. Neuroscience

    Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

    Jewoo Seo, Seung Ha Kim ... Sang Jeong Kim
68. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

    Axelle Amen, Randy Yoo ... Matthijs M. Jore
69. 1. Neuroscience

    Value construction through sequential sampling explains serial dependencies in decision making

    Ariel Zylberberg, Akram Bakkour ... Michael N Shadlen
70. 1. Neuroscience

    A Connectome of the Male Drosophila Ventral Nerve Cord

    Shin-ya Takemura, Kenneth J Hayworth ... Stuart Berg
71. 1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis

    Eva Pyrihová, Martin S King ... Edmund RS Kunji

    Stramenopiles are unusual, because the pay-off phase of glycolysis occurs in mitochondria rather than the cytosol and the identified mitochondrial carrier links the two parts by transporting glycolytic intermediates.
72. 1. Biochemistry and Chemical Biology

    Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309

    Zheng Ruan, Junuk Lee ... Wei Lü

    A comprehensive analysis questioned the prevailing views of Src-mediated hPANX1 phosphorylation at Tyr199 and Tyr309.
73. 1. Plant Biology

    Natural genetic variation underlying the negative effect of elevated CO₂ on ionome composition in Arabidopsis thaliana

    Oceane Cassan, Lea-Lou Pimpare ... Antoine Martin

    Plants show a high level of genetic diversity in their response to elevated CO₂, suggesting the presence of genetic mechanisms that will allow them to adapt to this environmental change.
74. 1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

    Samuel C Griffiths, Jia Tan ... Hsin-Yi Henry Ho

    Structure-function analysis of the ROR2 cysteine-rich domain reveals a new mechanism of WNT5A reception at the cell surface and provides new insights into the pathogenic mechanisms of Robinow syndrome-driving ROR2 mutations.
75. 1. Computational and Systems Biology
    2. Cancer Biology

    Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

    Khanh N. Dinh, Monika K. Kurpas, Marek Kimmel
76. 1. Developmental Biology
    2. Immunology and Inflammation

    Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

    Tobias Weinberger, Messerer Denise ... Christian Schulz

    In cardiac ischemia/reperfusion injury, resident macrophages orchestrate the immune response and positively influence postinfarct remodeling, whereas recruited macrophages determine infarct size.
77. 1. Cell Biology
    2. Developmental Biology

    Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

    Corey D Holman, Alexander P Sakers ... Patrick Seale

    Single-cell expression profiling and genetic lineage analysis show that aging impairs adipocyte differentiation from precursor cells and blocks the thermogenic activation of adipocytes during cold exposure.
78. 1. Neuroscience

    Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain

    Ya-Hui Lin, Li-Wen Wang ... Li-An Chu

    A new approach uses heat-induced antigen retrieval to enable tissue clearing, multiple-round immunostaining, and expansion microscopy for volumetric imaging of centimeter-scale clinical formalin-fixed paraffin-embedded specimens.
79. 1. Developmental Biology

    Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K. Alexander, Karina F. Rodriguez ... Humphrey Hung-Chang Yao
80. 1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
81. 1. Microbiology and Infectious Disease

    A packaging signal-binding protein regulates the assembly checkpoint of integrative filamentous phages

    Ting-Yu Yeh, Michael C. Feehley ... Gregory P. Contreras
82. 1. Cell Biology
    2. Immunology and Inflammation

    ^UFMTrack: Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

    Mykhailo Vladymyrov, Luca Marchetti ... Britta Engelhardt
83. 1. Developmental Biology

    Contribution of the epididymis beyond fertilization: relevance of CRISP1 and CRISP3 for sperm DNA integrity and early embryo development

    Sulzyk Valeria, Curci Ludmila ... Patricia S Cuasnicu
84. 1. Neuroscience

    Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles

    Yevgenia Rosenblum, Mahdad Jafarzadeh Esfahani ... Martin Dresler
85. 1. Neuroscience

    Olfactory ensheathing cells are hybrid glial cells that promote neural repair

    Patricia E. Phelps, Sung Min Ha ... Xia Yang
86. 1. Evolutionary Biology

    Alasemenia, the earliest ovule with three wings and without cupule

    Deming Wang, Jiangnan Yang ... Pu Huang
87. 1. Evolutionary Biology

    Extant cartilaginous fishes share trabecular and areolar mineralization patterns, but not tesserae, and evidence for a paedomorphic chimaera skeleton

    Oghenevwogaga J. Atake, Fidji Berio ... B. Frank Eames
88. 1. Physics of Living Systems

    Mapping Spatial Patterns to Energetic Benefits in Groups of Flow-coupled Swimmers

    Sina Heydari, Haotian Hang, Eva Kanso
89. 1. Cell Biology

    Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

    Tongtong Ma, Ruimin Ren ... Heng Wang

    Efficient myogenic and lipogenic transdifferentiation of chicken fibroblasts in 3D culture produces meat with precisely controlled levels of intramuscular fat and extracellular matrix.
90. 1. Immunology and Inflammation

    Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2

    Tong Feng, Qi Zhang ... Qiao-Feng Wu

    Serum exosomal sequencing combined with cell and animal experiments indicate that miRNA-199b-5p is a novel miRNA associated with osteoarthritis (OA) and can modulate the onset and progression of the disease.
91. 1. Microbiology and Infectious Disease

    Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics

    Tomoko Kubori, Kohei Arasaki ... Hiroki Nagai

    Interplay between multiple Legionella pneumophila effector proteins lead to spatial and temporal regulation of the host Rab10 localization to the bacterial vacuole by controlling noncanonical ubiquitin modifications.
92. 1. Neuroscience

    A fear conditioned cue orchestrates a suite of behaviors in rats

    Amanda Chu, Nicholas T Gordon ... Michael A McDannald

    Comprehensive behavioral ethograms reveal a fear conditioned cue to elicit a temporally organized suite of behaviors spanning freezing, locomotion, rearing, and jumping.
93. 1. Genetics and Genomics
    2. Medicine

    Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis

    Lianlei Wang, Sen Zhao ... Nan Wu
94. 1. Cell Biology

    Clearance of protein aggregates during cell division

    Shoukang Du, Yuhan Wang ... Ting Gang Chew
95. 1. Developmental Biology
    2. Medicine

    The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

    Rion Brattig Correia, Joana M. Almeida ... Paulo Navarro-Costa
96. 1. Cell Biology
    2. Developmental Biology

    Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

    Dilara N. Anbarci, Jennifer McKey ... Blanche Capel
97. 1. Neuroscience

    Coupling of saccade plans to endogenous attention during urgent choices

    Allison T Goldstein, Terrence R Stanford, Emilio Salinas
98. 1. Medicine

    Time to Eat - A Personalized Circadian Eating Schedule Leads to Weight Loss Without Calorie Restriction: A Randomized Controlled Trial

    Isabell Wilming, Jana Tuschewski ... Dominic Landgraf
99. 1. Cell Biology

    Engineered Migrasomes: A Robust, Thermally Stable Vaccination Platform

    Dongju Wang, Haifang Wang ... Zhihua Liu
100. 1. Microbiology and Infectious Disease
     2. Computational and Systems Biology

     Benchmarking reveals superiority of deep learning variant callers on bacterial nanopore sequence data

     Michael B. Hall, Ryan R. Wick ... Lachlan J. M. Coin
101. 1. Immunology and Inflammation
     2. Cancer Biology

     An Evaluation of the Tumor Microenvironment through CALR, IL1R1, IFNB1, and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients

     Lilong Liu, Zhenghao Liu ... Zheng Liu
102. 1. Neuroscience

     A ventral hippocampal-lateral septum pathway regulates social novelty preference

     Maha Rashid, Sarah Thomas ... Malavika Murugan
103. 1. Genetics and Genomics
     2. Microbiology and Infectious Disease

     Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

     Jason E Stajich, Brian Lovett ... Carolyn Elya

     Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
104. 1. Evolutionary Biology
     2. Genetics and Genomics

     Epistasis facilitates functional evolution in an ancient transcription factor

     Brian PH Metzger, Yeonwoo Park ... Joseph W Thornton

     A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.
105. 1. Microbiology and Infectious Disease

     Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

     Cenk Celik, Stella Tue Ting Lee ... Guillaume Thibault

     Enterococcus faecalis infection elicits a cellular response marked by novel bacterial-host interactions, revealing insights into immune evasion mechanisms in chronic wound infections.
106. 1. Neuroscience

     Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices

     Yanqi Liu, Pol Bech ... Carl C.H. Petersen
107. 1. Cell Biology
     2. Microbiology and Infectious Disease

     Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

     Hsiao-Fen Han, Shao-Fu Nien ... Yi-Chun Wu
108. 1. Neuroscience

     Cortical beta oscillations map to shared brain networks modulated by dopamine

     Meera Chikermane, Liz Weerdmeester ... Wolf-Julian Neumann
109. 1. Neuroscience

     Visual to default network pathways: A double dissociation between semantic and spatial cognition

     Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
110. 1. Neuroscience

     Frequency-specific cortico-subcortical interaction in continuous speaking and listening

     Omid Abbasi, Nadine Steingräber ... Joachim Gross
111. 1. Neuroscience

     Inverted encoding of neural responses to audiovisual stimuli reveals super-additive multisensory enhancement

     Zak Buhmann, Amanda K. Robinson ... Reuben Rideaux
112. 1. Neuroscience

     Effort Drives Saccade Selection

     Damian Koevoet, Laura Van Zantwijk ... Christoph Strauch
113. 1. Neuroscience

     GABA-ergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex

     Yuan Gao, Yong-Chun Cai ... Xue Mei Song
114. 1. Cell Biology

     PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

     Gang Liu, Yunxuan Hou ... Xiumei Jiang

     HSCB could be activated by PI3K signaling to facilitate FOG1 nuclear translocation to promote human erythropoiesis and megakaryopoiesis, highlighting an important, previously unrecognized iron–sulfur cluster delivery independent function of HSCB.
115. 1. Neuroscience

     FMRP regulates postnatal neuronal migration via MAP1B

     Salima Messaoudi, Ada Allam ... Isabelle Caille

     A novel neurodevelopmental role for FMRP in collaboration with MAP1B, jointly orchestrating neuronal migration by influencing the microtubular cytoskeleton.
116. 1. Developmental Biology

     Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone

     Yan-Xue Li, Xin-Le Kang ... Xiao-Fan Zhao
117. 1. Developmental Biology

     Cytoneme-mediated intercellular signaling in keratinocytes essential for epidermal remodeling

     Yi Wang, Qingan He ... Dae Seok Eom
118. 1. Physics of Living Systems

     The younger flagellum sets the beat for Chlamydomonas reinhardtii

     Da Wei, Greta Quaranta ... Daniel SW Tam

     External hydrodynamic forcing on each flagellum of Chlamydomonas reinhardtii reveals a leader-follower relation between the two flagella in the synchronous beating.
119. 1. Biochemistry and Chemical Biology
     2. Cell Biology

     Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

     Christopher TA Lewis, Elise G Melhedegaard ... Julien Ochala

     During hibernation, animals remodel the structure of their relaxed muscle via a protein called myosin and this enables vast temperature changes.
120. 1. Epidemiology and Global Health

     Misstatements, misperceptions, and mistakes in controlling for covariates in observational research

     Xiaoxin Yu, Roger S Zoh ... David B Allison

     This quick reference guide for researchers addresses common misconceptions in the use of covariates in observational research and offers tips for preventing misstatements and mistakes.
121. 1. Ecology
     2. Epidemiology and Global Health

     Landscape drives zoonotic malaria prevalence in non-human primates

     Emilia Johnson, Reuben Sunil Kumar Sharma ... Kimberly Fornace

     Regional meta-analysis enriches our understanding of zoonotic malaria in primate reservoirs in areas of Southeast Asia experiencing deforestation, with wider ecological implications for human disease risk in fragmented landscapes.
122. 1. Stem Cells and Regenerative Medicine

     Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

     Jing-Ping Wang, Chun-Hao Hung ... C-K James Shen

     The anti-cancer or lifespan extension properties of a novel genetically engineered hematopoietic blood system could be transferred horizontally in mice, which suggests a new direction of biomedical research for anti-aging/antidisease.
123. 1. Genetics and Genomics
     2. Microbiology and Infectious Disease

     MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions

     Yongjin Liu, Sandra LaBonte ... Paul D. Straight
124. 1. Chromosomes and Gene Expression
     2. Physics of Living Systems

     An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli

     Irina Kalita, Ira Alexandra Iosub ... Meriem El Karoui
125. 1. Immunology and Inflammation

     Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

     Alessandra M Araujo, Joseph D Dekker ... Haley O Tucker
126. 1. Biochemistry and Chemical Biology
     2. Neuroscience

     Deciphering the chemical language of inbred and wild mouse conspecific scents

     Maximilian Nagel, Marco Niestroj ... Marc Spehr

     Parallel chemical and physiological profiling of conspecific chemosensory communication in mice identifies both common and unique strategies for vomeronasal signaling of sex and strain.
127. 1. Developmental Biology

     FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis

     Meng-Hao Pan, Kun-Huan Zhang ... Shao-Chen Sun

     FMNL2 associates with Formin2 and Arp2/3 complex for actin assembly, which further regulates spindle migration and INF2/Cofilin-related organelle dynamics during mammalian oocyte maturation.
128. 1. Neuroscience

     Functional diversity of dopamine axons in prefrontal cortex during classical conditioning

     Kenta Abe, Yuki Kambe ... Tatsuo Sato

     Two-photon calcium imaging revealed that many mesocortical dopamine axons show enhanced selectivity for aversive cue processing during classical conditioning.
129. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

     Claudia D Consalvo, Adedeji M Aderounmu ... Brenda L Bass

     Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.
130. 1. Neuroscience

     Jointly looking to the past and the future in visual working memory

     Baiwei Liu, Zampeta-Sofia Alexopoulou, Freek van Ede

     When memorising dynamic visual objects, the brain codes for both the past and the anticipated future object location and co-activates both codes when selecting memories for guiding behaviour.
131. 1. Cell Biology

     Mecp2 fine-tunes quiescence exit by targeting nuclear receptors

     Jun Yang, Shitian Zou ... Xiaochun Bai

     Mecp2 expression is cell cycle-dependent and negatively regulates quiescence exit.
132. 1. Cancer Biology

     Overcoming the nutritional immunity by engineering iron-scavenging bacteria for cancer therapy

     Sin-Wei Huang, See-Khai Lim ... Kurt Yun Mou

     Bacterial therapy can be impeded by nutrition deprivation in the tumor microenvironment, and enhancing bacteria resistance to iron sequestration enhances its antitumoral activity for therapeutic purposes.
133. 1. Neuroscience

     Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'

     James Taniguchi, Riccardo Melani ... Nicolas X Tritsch

     We are writing to comment on the article by Mohebi et al., 2023: we show that blue light alters the fluorescent properties of a genetically-encoded dopamine sensor in a manner that may be misconstrued as phasic dopamine release.
134. 1. Cell Biology
     2. Neuroscience

     Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging

     Laxmi Rathor, Shayla Curry ... Sung Min Han
135. 1. Neuroscience

     Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning

     Xiang Mou, Daoyun Ji
136. 1. Genetics and Genomics

     A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

     Fan Zhang, Annie Lee ... Hong Xu
137. 1. Neuroscience

     Anti-drift pose tracker (ADPT): A transformer-based network for robust animal pose estimation cross-species

     Guoling Tang, Yaning Han ... Pengfei Wei
138. 1. Structural Biology and Molecular Biophysics

     Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

     Giuseppe Deganutti, Ludovico Pipitò ... Christopher A. Reynolds
139. 1. Developmental Biology
     2. Genetics and Genomics

     Astrogliosis And Neuroinflammation Underlie Scoliosis Upon Cilia Dysfunction

     Morgane Djebar, Isabelle Anselme ... Christine Vesque
140. 1. Ecology
     2. Physics of Living Systems

     Evidence of social learning across symbolic cultural barriers in sperm whales

     Antonio Leitao, Maxime Lucas ... Giovanni Petri
141. 1. Computational and Systems Biology

     Phantasus, a web application for visual and interactive gene expression analysis

     Maksim Kleverov, Daria Zenkova ... Alexey A Sergushichev

     Phantasus democratizes gene expression analysis, offering intuitive and interactive tools that streamline the exploration and analysis of user-provided data and over 96,000 public datasets.
142. 1. Computational and Systems Biology

     Phantasus, a web-application for visual and interactive gene expression analysis

     Maksim Kleverov, Daria Zenkova ... Alexey A Sergushichev
143. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

     Damien M Rasmussen, Manny M Semonis ... Nicholas M Levinson

     A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.
144. 1. Evolutionary Biology

     CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues

     Raphael Aguillon, Mieka Rinsky ... Oren Levy

     Disruption of the Clock gene in the cnidarian Nematostella vectensis revealed its essential role in circadian rhythm maintenance and uncovered a compensatory light-response pathway, advancing our comprehension of circadian regulation in non-bilaterian animals.
145. 1. Neuroscience

     Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury

     Sara Bolívar, Elisenda Sanz ... Esther Udina

     In reporter mice, subtypes of peripheral neurons show different regenerative capabilities after nerve injury and activate common pathways but also specific ones, indicating a different intrinsic growth response among them.
146. 1. Genetics and Genomics
     2. Neuroscience

     Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

     Jiro Yoshino, Sonali S. Mali ... Jay Z. Parrish
147. 1. Cell Biology

     Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells

     Amélie-Rose Boudjema, Rémi Balagué ... Alice Meunier
148. 1. Stem Cells and Regenerative Medicine

     Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

     Sujeethkumar Prithiviraj, Alejandro Garcia Garcia ... Paul E Bourgine
149. 1. Biochemistry and Chemical Biology
     2. Developmental Biology

     Non-autonomous cell redox-pairs dictate niche homeostasis in multi-lineage stem populations

     Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
150. 1. Cancer Biology

     Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

     Kyle Spinler, Michael Hamilton ... Tannishtha Reya
151. 1. Chromosomes and Gene Expression
     2. Medicine

     LncRNA-Snhg3 Aggravates Hepatic Steatosis by Regulating PPARγ via SND1/H3K27me3

     Xianghong Xie, Mingyue Gao ... Xiaojun Liu
152. 1. Genetics and Genomics
     2. Microbiology and Infectious Disease

     A single-cell atlas of the miracidium larva of the human blood fluke Schistosoma mansoni: cell types, developmental pathways and tissue architecture

     Teresa Attenborough, Kate A Rawlinson ... Matthew Berriman
153. 1. Chromosomes and Gene Expression
     2. Immunology and Inflammation

     Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

     Matthew C Pahl, Prabhat Sharma ... Andrew D Wells
154. 1. Cancer Biology

     Inhibition of ULK1/2 and KRAS^G12C controls tumor growth in preclinical models of lung cancer

     Phaedra C Ghazi, Kayla T O’Toole ... Martin McMahon
155. 1. Microbiology and Infectious Disease

     Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level

     Hina Khan, Partha Paul ... Dibyendu Sarkar

     In a stress-specific manner, Mycobacterium tuberculosis PhoP regulates Rv0805 phosphodiesterase expression to control cAMP level and contributes to intracellular survival of the bacilli.
156. 1. Neuroscience

     Inferring control objectives in a virtual balancing task in humans and monkeys

     Mohsen Sadeghi, Reza Sharif Razavian ... Dagmar Sternad

     A virtual balancing task with parallel experiments on human and non-human primates revealed a spectrum of behaviors (classified by a computational model into position, velocity, or mixed control strategy) that can serve as basis for analyzing neural population dynamics.
157. 1. Cancer Biology
     2. Cell Biology

     mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3^IBTK-mediated ubiquitination of eIF4A1 in cancer cells

     Dongyue Jiao, Huiru Sun ... Kun Gao

     Overexpression of inhibitor of Bruton's tyrosine kinase contributes to the process of tumorigenesis by amplifying translation, represents a promising target for anti-cancer therapies.
158. 1. Cancer Biology

     Replication of null results: Absence of evidence or evidence of absence?

     Samuel Pawel, Rachel Heyard ... Leonhard Held

     Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.
159. 1. Neuroscience

     Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle

     Yiyi Chen, Laimdota Zizmare ... Christoph Trautwein

     Targeted manipulations on organotypic cultures show that the retina switches between at least four different metabolic pathways, each with different yields and kinetics, to dynamically adapt to momentaneous energy needs.
160. 1. Computational and Systems Biology
     2. Evolutionary Biology

     CoCoNuTs are a diverse subclass of Type IV restriction systems predicted to target RNA

     Ryan T Bell, Harutyun Sahakyan ... Eugene V Koonin

     Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.
161. 1. Immunology and Inflammation
     2. Microbiology and Infectious Disease

     Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

     Suman Kundu, Advait Shetty, Maria Gomes-Solecki
162. 1. Structural Biology and Molecular Biophysics
     2. Genetics and Genomics

     The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

     Nasim Saadat, Rhys N. Colson ... Peter R. Boag
163. 1. Neuroscience

     Dynamic reinforcement learning reveals time-dependent shifts in strategy during reward learning

     Sarah Jo C Venditto, Kevin J Miller ... Nathaniel D Daw
164. 1. Cell Biology

     Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

     Jarno Mäkelä, Alexandros Papagiannakis ... Christine Jacobs-Wagner
165. 1. Computational and Systems Biology
     2. Physics of Living Systems

     Light-driven synchronization of optogenetic clocks

     Maria Cristina Cannarsa, Filippo Liguori ... Roberto Di Leonardo
166. 1. Immunology and Inflammation

     SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

     Somen K Mistri, Brianna M Hilton ... Jonathan E Boyson
167. 1. Medicine
     2. Neuroscience

     Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

     Yunlu Xue, Yimin Zhou, Constance L Cepko

     Multiple alleles of Txnip, which can interact with several different proteins, including Hsp90AB1, were tested for their ability to prolong the survival of cone photoreceptors in diseases leading to blindness.
168. 1. Neuroscience

     Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses

     Juan Jose Rodriguez Gotor, Kashif Mahfooz ... John F Wesseling

     Reevaluation of reserve synaptic vesicle pools supports a new model of presynaptic function.
169. 1. Chromosomes and Gene Expression
     2. Developmental Biology

     Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

     F Javier DeHaro-Arbona, Charalambos Roussos ... Sarah Bray

     Live imaging of the Notch co-activator Mastermind reveals that it promotes the formation of a dynamic transcription hub in Notch ON nuclei, conferring probabilistic transcription and providing a template for signal memory.
170. 1. Evolutionary Biology
     2. Neuroscience

     Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems

     Daniel Thiel, Luis Alfonso Yañez Guerra ... Gáspár Jékely

     The identification of 31 neuropeptide GPCRs in the sea anemone Nematostella vectensis provides a rich resource to study peptidergic signaling in cnidarians and suggests that cnidarian and bilaterian peptidergic systems diversified independent from each other from a few ancestral systems.
171. 1. Neuroscience

     Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO₂ chemoreflex in rats

     Silvia Cardani, Tara A Janes ... Silvia Pagliardini

     Knockdown of PHOX2B in the chemosensitive area of the retrotrapezoid nucleus of adult rats reduces CO₂ responses and the expression of the proton sensors TASK2 and GPR4.
172. 1. Developmental Biology

     Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation

     Rieko Asai, Vivek N Prakash ... Takashi Mikawa

     At the onset of gastrulation, primitive streak morphogenesis that requires mitosis along the embryo midline, persists even with a disrupted bilateral cell flow.
173. 1. Neuroscience

     Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan

     Kristin Nordin, Robin Pedersen ... Alireza Salami
174. 1. Cell Biology

     Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states

     Revathi Balasubramanian, Krishnakumar Kizhatil ... Simon W.M. John
175. 1. Neuroscience

     The decoding of extensive samples of motor units in human muscles reveals the rate coding of entire motoneuron pools

     Simon Avrillon, François Hug ... Dario Farina
176. 1. Neuroscience

     Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex

     Claire Meissner-Bernard, Friedemann Zenke, Rainer W. Friedrich
177. 1. Neuroscience

     Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder

     Sophie Leclercq, Hany Ahmed ... Nathalie M. Delzenne
178. 1. Neuroscience

     Shortcutting from self-motion signals: quantifying trajectories and active sensing in an open maze

     Jiayun Xu, Mauricio Girardi-Schappo ... Leonard Maler
179. 1. Evolutionary Biology

     Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

     Jacob D. Bowman, Neide Silva ... Vincent J. Lynch
180. 1. Immunology and Inflammation
     2. Computational and Systems Biology

     Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

     Jan Stuchly, David Novak ... Tomas Kalina
181. 1. Cancer Biology

     Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

     Yiwei Huang, Lin Cheng ... Shanye Yin
182. 1. Chromosomes and Gene Expression

     Connecting Chromatin Structures to Gene Regulation Using Dynamic Polymer Simulations

     Yi Fu, Finnegan Clark ... Timothee Lionnet
183. 1. Genetics and Genomics
     2. Computational and Systems Biology

     Sequence characteristics and an accurate model of abundant hyperactive loci in the human genome

     Sanjarbek Hudaiberdiev, Ivan Ovcharenko
184. 1. Neuroscience

     Axon arrival times and physical occupancy establish visual projection neuron integration on developing dendrites in the Drosophila optic glomeruli

     Brennan W. McFarland, HyoJong Jang ... Catherine R. von Reyn
185. 1. Immunology and Inflammation

     Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

     Ziyu Wen, Pingchao Li ... Caijun Sun
186. 1. Genetics and Genomics

     Genetic Stability of Mycobacterium smegmatis under the Stress of First-Line Antitubercular Agents: Assessing Mutagenic Potential

     Dániel Molnár, Éva Viola Surányi ... Judit Tóth
187. 1. Cancer Biology
     2. Evolutionary Biology

     High-density sampling reveals volume growth in human tumours

     Arman Angaji, Michel Owusu ... Johannes Berg
188. 1. Structural Biology and Molecular Biophysics
     2. Neuroscience

     Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

     Balázs István Tóth, Bahar Bazeli ... Thomas Voets
189. 1. Developmental Biology

     Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

     Emily Delgouffe, Samuel Madureira Silva ... Ellen Goossens
190. 1. Neuroscience

     Action sequence learning, habits, and automaticity in obsessive-compulsive disorder

     Paula Banca, Maria Herrojo Ruiz ... Trevor W Robbins

     Habit-based theories of obsessive-compulsive disorder are further elucidated by employing mobile phone motor sequence training, for which patients exhibited equivalent automatization, but enhanced value for the trained sequence, potentially ameliorating symptoms.
191. 1. Cell Biology

     Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile

     Yoko Nakai-Futatsugi, Jianshi Jin ... Masayo Takahashi

     Pigmentation that confers protective function of RPE is not underlaid by a specific gene expression profile, reviled by microscopic imaging together with single-cell RNA sequencing.
192. 1. Computational and Systems Biology

     Improved clinical data imputation via classical and quantum determinantal point processes

     Skander Kazdaghli, Iordanis Kerenidis ... Philip Teare

     A new data imputation method that can be implemented quantumly allows for better and more reliable classifications.
193. 1. Neuroscience
     2. Stem Cells and Regenerative Medicine

     SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA

     Pascal Forcella, Niklas Ifflander ... Verdon Taylor

     Extensive analysis shows that the RNA-binding protein SAFB binds to Drosha in hippocampal stem cells and controls oligodendrocyte fate commitment through post-transcriptional regulation of NFIB expression.
194. 1. Immunology and Inflammation

     Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

     Phillip A Erice, Xinyan Huang ... Antony Rodriguez

     Mirlet7 functions as a molecular brake of CD8⁺IL17a⁺ T cells (Tc17) inflammation and chronic obstructive pulmonary disease via direct regulation RAR-related orphan receptor gamma t (RORγt).
195. 1. Neuroscience

     Task dependent coarticulation of movement sequences

     Hari Teja Kalidindi, Frederic Crevecoeur
196. 1. Neuroscience
     2. Computational and Systems Biology

     Testing the state-dependent model of subsecond time perception against experimental evidence

     Pirathitha Ravichandran-Schmidt, Joachim Hass
197. 1. Plant Biology

     Improving rice drought tolerance through host-mediated microbiome selection

     Alex Styer, Dean Pettinga ... Devin Coleman-Derr
198. 1. Microbiology and Infectious Disease

     Hosts Manipulate Lifestyle Switch and Pathogenicity Heterogeneity of Opportunistic Pathogens in the Single-cell Resolution

     Ziguang Wang, Shuai Li ... Wei Liu
199. 1. Physics of Living Systems

     Cell-cycle and Age-Related Modulations in Mouse Chromosome Stiffness

     Ning Liu, Wenan Qiang ... Huanyu Qiao
200. 1. Evolutionary Biology

     mirror determines the far posterior domain in butterfly wings

     Martik Chatterjee, Xin Y. Yu ... Robert D. Reed
201. 1. Neuroscience

     Goal-directed motor actions drive acetylcholine dynamics in sensory cortex

     Jing Zou, Jan Willem de Gee ... Samuel Andrew Hires
202. 1. Neuroscience

     Spatially targeted inhibitory rhythms differentially affect neuronal integration

     Drew B. Headley, Benjamin Latimer ... Satish S. Nair
203. 1. Chromosomes and Gene Expression

     The role of RNA in the maintenance of chromatin domains as revealed by antibody-mediated proximity labelling coupled to mass spectrometry

     Rupam Choudhury, Anuroop Venkateswaran Venkatasubramani ... Axel Imhof

     Proximity biotinylation of the Drosophila centromere suggests a role of RNA helicases, centromeric transcripts, and centromeric R-loops for centromere function.
204. 1. Computational and Systems Biology

     Heritable epigenetic changes are constrained by the dynamics of regulatory architectures

     Antony M Jose

     A foundation for analyzing epigenetic changes within the context of regulatory architectures that enable heredity.
205. 1. Immunology and Inflammation

     Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

     Xiuyuan Lu, Hiroki Hayashi ... Sho Yamasaki

     Clonotypic tracing of SARS-CoV-2–responsive T cells reveals vaccination-induced dominant Tfh clonotypes, not pre-existing T cells, associated with sustained humoral response, and can serve as an index of antigen-specific antibody longevity.
206. 1. Cell Biology
     2. Neuroscience

     Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

     Josse Poppinga, Nolan J. Barret ... Jan R.T. van Weering
207. 1. Cell Biology

     Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

     Yunpo Zhao, Jianli Duan ... Zhe Han
208. 1. Neuroscience

     The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

     Lian Hollander Cohen, Omer Cohen ... Berta Levavi Sivan
209. 1. Neuroscience

     DIETS: a simple and sensitive assay to measure and control the intake of complex solid foods, like high-fat diets, in Drosophila

     Manikrao R. Thakare, Prerana Choudhary ... Gaurav Das
210. 1. Neuroscience
     2. Computational and Systems Biology

     Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

     Jian Qiu, Margaritis Voliotis ... Martin J. Kelly
211. 1. Neuroscience
     2. Computational and Systems Biology

     Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

     Jayati Gera, Marishia Agard ... Meet Zandawala
212. 1. Evolutionary Biology

     The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

     Xuankun Li, Adriana E. Marvaldi ... Duane D. McKenna
213. 1. Physics of Living Systems

     Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women

     Alex James, Franca Buelow ... Ann Brower
214. 1. Chromosomes and Gene Expression
     2. Cancer Biology

     Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

     Ashley L Cook, Surojit Sur ... Nicolas Wyhs
215. 1. Computational and Systems Biology
     2. Ecology

     Collaborative hunting in artificial agents with deep reinforcement learning

     Kazushi Tsutsui, Ryoya Tanaka ... Keisuke Fujii

     Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.
216. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

     Natalia E Ketaren, Fred D Mast ... John D Aitchison

     High-affinity nanobodies targeting the SARS-CoV-2 spike protein demonstrate sustained effectiveness against current and emerging variants, offering a promising avenue for treatment.
217. 1. Genetics and Genomics

     Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

     Mohammad Alfatah, Jolyn Jia Jia Lim ... Frank Eisenhaber

     Revealing YBR238C's involvement in the TORC1–mitochondria feedback loop deepens our understanding of aging biology, emphasizing the TOMITO concept as a crucial mechanism in cellular aging regulation.
218. 1. Neuroscience

     A stochastic world model on gravity for stability inference

     Taicheng Huang, Jia Liu

     Empirical experiments and computational modeling reveal a stochastic world model on gravity for stability inference that represents gravity’s vertical direction as a Gaussian distribution.
219. 1. Neuroscience

     Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

     Geoffroy Delamare, Yosif Zaki ... Claudia Clopath

     Internal neural variability can induce drift of memory ensembles through synaptic plasticity, allowing for encoding of temporal information.
220. 1. Biochemistry and Chemical Biology

     Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

     Benjamin R Duewell, Naomi E Wilson ... Scott D Hansen

     Single molecule reconstitution of PI3Kβ synergistic activation reveals mechanism for rapid PI(3,4,5)P₃ production during immune cell signaling.
221. 1. Structural Biology and Molecular Biophysics

     Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics

     Nicholas James Ose, Paul Campitelli ... Sefika Banu Ozkan

     Insights from integrating evolutionary predictions and protein dynamics unveil how specific mutations in the SARS-CoV-2 spike protein epistatically interact in order to influence spike protein interaction with human cells, potentially altering the virus's infectivity and immune evasion capabilities.
222. 1. Cell Biology
     2. Neuroscience

     Synapsin E-domain is essential for α-synuclein function

     Alexandra Stavsky, Leonardo A Parra-Rivas ... Daniel Gitler

     Alpha-synuclein binding to the synapsin E-domain is essential and sufficient for their cooperation in attenuating synaptic-vesicle trafficking and neurotransmission.
223. 1. Cancer Biology
     2. Cell Biology

     CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

     Savvas Nikolaou, Amelie Juin ... Laura M Machesky

     Macropinocytosis of the signalling receptor LPAR1, by an actin and CYRI-B-dependent mechanism, impacts on progression and spread of pancreatic cancer in a mouse model.
224. 1. Immunology and Inflammation

     Development of a new genotype–phenotype linked antibody screening system

     Takashi Watanabe, Hikaru Hata ... Hidehiro Fukuyama
225. 1. Neuroscience

     Laminar specificity and coverage of viral-mediated gene expression restricted to GABAergic interneurons and their parvalbumin subclass in marmoset primary visual cortex

     Frederick Federer, Justin Balsor ... Alessandra Angelucci
226. 1. Neuroscience

     The NeuroML ecosystem for standardized multi-scale modeling in neuroscience

     Ankur Sinha, Padraig Gleeson ... R. Angus Silver
227. 1. Evolutionary Biology

     Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D Geometric Morphometrics reveals wide-gauge posture as an exaptation for gigantism

     Adrian Paramo Blazquez, Pedro Mocho ... Francisco Ortega
228. 1. Neuroscience

     A dynamic neural resource model bridges sensory and working memory

     Ivan Tomić, Paul M Bays

     Psychophysical measurement and computational modeling show that sensory information cannot contribute directly to a cognitive judgment, but must first be integrated into resource-limited working memory.
229. 1. Genetics and Genomics
     2. Neuroscience

     Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

     Céline Petitgas, Laurent Seugnet ... Serge Birman

     Purine recycling deficiency triggers metabolic and neurological defects reminiscent of Lesch–Nyhan disease in Drosophila, paving the way for studying this disorder and carrying out drug screening in an invertebrate organism.
230. 1. Computational and Systems Biology
     2. Developmental Biology

     The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

     Arya Y Nakhe, Prasanna K Dadi ... David A Jacobson

     A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.
231. 1. Neuroscience

     Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making

     Mariann Oemisch, Hyojung Seo

     The NMDA receptor might preferentially mediate immediate experience/impact of events with negative over positive valence.
232. 1. Neuroscience

     Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex

     Hao Li, Jingyu Feng ... Jufang He

     CCK released from the neural projections from the rhinal cortex to the motor cortex modulates neural plasticity and facilitates motor skill learning.
233. 1. Medicine

     Comprehensive Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: A Thorough Analysis in prospective studies

     S Fawaz, S Marti ... T Couffinhal
234. 1. Cell Biology
     2. Genetics and Genomics

     The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2

     Adam D. Longhurst, Kyle Wang ... David P. Toczyski
235. 1. Neuroscience

     Semantic relatedness proactively benefits learning, memory, and interdependence across episodes

     Kelly A. Bennion, Jade Phong ... James W. Antony
236. 1. Chromosomes and Gene Expression

     Transcription Factor Condensates Mediate Clustering of MET Regulon and Enhancement in Gene Expression

     James Lee, Leman Simpson ... Lu Bai
237. 1. Medicine

     Characterisation and comparison of semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility

     Shahriar Mowla, Linda Farahani ... Channa N Jayasena
238. 1. Biochemistry and Chemical Biology
     2. Computational and Systems Biology

     The interplay between biomolecular assembly and phase separation

     Giacomo Bartolucci, Ivar S. Haugerud ... Christoph A. Weber
239. 1. Cell Biology
     2. Stem Cells and Regenerative Medicine

     Novel 3D Approach to Model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells

     Carola Maria Morell, Samantha Grace Tilson ... Ludovic Vallier
240. 1. Cell Biology

     Visualization of endogenous G proteins on endosomes and other organelles

     Wonjo Jang, Kanishka Senarath ... Nevin A. Lambert
241. 1. Structural Biology and Molecular Biophysics

     The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

     Marco van den Noort, Panagiotis Drougkas ... Bert Poolman

     Transient and weak interactions between the substrate-binding proteins of the ATP-binding cassette transporter OpuA can influence the transport efficiency.
242. 1. Cell Biology

     Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

     Rita De Gasperi, Laszlo Csernoch ... Christopher P Cardozo

     Genetic reduction of Numb or Numb/Nubl is linked to deterioration of the Septin cytoskeleton and suggests cytoskeletal abnormalities are the consequences of and contribute to age-related changes in skeletal muscle.
243. 1. Computational and Systems Biology

     Predicting metabolic modules in incomplete bacterial genomes with MetaPathPredict

     David Geller-McGrath, Kishori M Konwar ... Jason E McDermott

     MetaPathPredict is a novel bioinformatics tool that makes accurate predictions of KEGG module presence within highly incomplete bacterial genomes.
244. 1. Neuroscience

     Representational drift as a result of implicit regularization

     Aviv Ratzon, Dori Derdikman, Omri Barak

     Continuous noisy learning in neural networks leads to slow, directed qualitative changes in their internal representations, without affecting their quality.
245. 1. Neuroscience

     Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons and heterogeneity

     Andrew E. Worthy, JoAnna T. Anderson ... Francisco J. Alvarez
246. 1. Structural Biology and Molecular Biophysics

     CTFFIND5 provides improved insight into quality, tilt and thickness of TEM samples

     Johannes Elferich, Lingli Kong ... Nikolaus Grigorieff
247. 1. Structural Biology and Molecular Biophysics

     TMEM16 and TMEM63/OSCA proteins share a conserved potential to permeate ions and phospholipids

     Augustus J. Lowry, Pengfei Liang ... Yang Zhang
248. 1. Evolutionary Biology

     A direct experimental test of Ohno’s hypothesis

     Ljiljana Mihajlovic, Bharat Ravi Iyengar ... Yolanda Schaerli
249. 1. Cell Biology

     Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

     Xiaoning Gao, WuYan Guo ... Jun Kang
250. 1. Biochemistry and Chemical Biology
     2. Cell Biology

     Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling

     Senem Ntourmas, Martin Sachs ... Dominic B. Bernkopf
251. 1. Immunology and Inflammation

     CD81⁺ fibroblasts, a unique subpopulation with accelerated cellular senescence, exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

     Liangliang Fu, Chenghu Yin ... Haibin Xia
252. 1. Neuroscience

     Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

     Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
253. 1. Cell Biology

     The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the gut

     Yueliang Zhang, Yongjun Li ... Amita Sehgal
254. 1. Cell Biology

     JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

     Yunpo Zhao, Jianli Duan ... Zhe Han
255. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms

     Qian Wang, Jinxin Liu ... Qian Liu
256. 1. Developmental Biology

     Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

     Alexandra V. Bruter, Ekaterina A. Varlamova ... Victor V. Tatarskiy
257. 1. Microbiology and Infectious Disease
     2. Computational and Systems Biology

     An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks

     Gaetan De Waele, Gerben Menschaert, Willem Waegeman
258. 1. Neuroscience

     Implicit motor adaptation patterns in a redundant motor task manipulating a stick with both hands

     Toshiki Kobayashi, Daichi Nozaki
259. 1. Medicine
     2. Cancer Biology

     Metabolic heterogeneity of colorectal cancer as a prognostic factor: insights gained from fluorescence lifetime imaging

     Anastasia D Komarova, Snezhana D Sinyushkina ... Marina V Shirmanova
260. 1. Genetics and Genomics

     From sequence to molecules: Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

     Shaohua Gu, Yuanzhe Shao ... Zhiyuan Li
261. 1. Structural Biology and Molecular Biophysics

     Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

     Dipti Lenka, Shakti Dahe ... Atul Kumar
262. 1. Genetics and Genomics

     Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging

     Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M Karimi
263. 1. Cell Biology

     The actomyosin system is essential for the integrity of the endosomal system in bloodstream form Trypanosoma brucei

     Fabian Link, Sisco Jung ... Brooke Morriswood
264. 1. Computational and Systems Biology
     2. Evolutionary Biology

     Experimental evolution for the recovery of growth loss due to genome reduction

     Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying

     Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.
265. 1. Cell Biology

     BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

     Ruichen Yang, Hongshang Chu ... Baojie Li

     Uncovering a new function of BMP signaling and enhancing our comprehension of the pathogenesis of microtia.
266. 1. Genetics and Genomics

     Mono-methylated histones control PARP-1 in chromatin and transcription

     Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin

     Genome-wide PARP-1 binding analysis advances the understanding of molecular mechanisms governing gene regulation in response to developmental cues and environmental stressors.
267. 1. Medicine

     Fungal–bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

     Peigen Chen, Haicheng Chen ... Xing Yang

     Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.