October 2023

Cover articles

    1. Cell Biology

    Localization and lysosomes

    Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry

Highlights controls:

Research articles

    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular tuning of sea anemone stinging

    Lily S He, Yujia Qi ... Nicholas W Bellono
    Sea anemones use adapted ion channels to control stinging behavior.
    1. Structural Biology and Molecular Biophysics

    Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP

    Adel Hussein, Shujie Fan ... David L Stokes
    Cryo-EM, Molecular Dynamics, and in vitro binding assays are combined to elucidate a new occluded conformation associated with zinc binding and energy coupling with the proton motive force.
    1. Cell Biology

    Replisome loading reduces chromatin motion independent of DNA synthesis

    Maruthi Kumar Pabba, Christian Ritter ... M Cristina Cardoso
    Live cell tracking of labeled DNA reveals that replisome loading rather than DNA synthesis decreases the chromatin motion during S-phase in human cells.
    1. Neuroscience

    Homeostatic control of deep sleep and molecular correlates of sleep pressure in Drosophila

    Budhaditya Chowdhury, Lakshman Abhilash ... Orie Shafer
    Controlling for the effects of mechanical stimulation during sleep deprivation reveals substantial multi-cycle sleep rebound in Drosophila and reveals serotonin as a potential sleep substance in the fly brain.
    1. Cell Biology

    Human receptive endometrial organoid for deciphering the implantation window

    Yu Zhang, Rusong Zhao ... Han Zhao
    1. Cancer Biology
    2. Developmental Biology

    The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis

    Nydia Tejeda-Munoz, Yagmur Azbazdar ... Edward M De Robertis
    The archetypal tumor promoter PMA, which promotes cancer without mutating the DNA, increases Wnt signaling by activating macropinocytosis and membrane trafficking in Xenopus embryos and tumor cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

    Jinyang Wang, Yaxin Wen ... Qinxi Li
    Acetate concentration, which is significantly increased in association with energy stresses such as those that occur with diabetes or starvation, is emerging as a novel 'ketone body' with potential as a parameter for evaluating the progression of energy stress.
    1. Immunology and Inflammation

    CCR1 mediates Müller cell activation and photoreceptor cell death in macular and retinal degeneration

    Sarah Elbaz-Hayoun, Batya Rinsky ... Itay Chowers
    A novel therapy for a common blinding retinal disease uses an innovative CCR1 blocking-based strategy.
    1. Evolutionary Biology

    Colour polymorphism associated with a gene duplication in male wood tiger moths

    Melanie N Brien, Anna Orteu ... Johanna Mappes
    A complex colour polymorphism which links colour with behavioural and life-history traits is associated with a single gene duplication in male wood tiger moths.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the CBC-ALYREF complex

    Bradley P. Clarke, Alexia E. Angelos ... Yi Ren
    1. Neuroscience

    A spatial threshold for astrocyte calcium surge

    Justin Lines, Andres Baraibar ... Alfonso Araque
    1. Evolutionary Biology

    Evolutionary consequences of nascent multicellular life cycles

    Jennifer T Pentz, Kathryn MacGillivray ... William C Ratcliff
    Clonal development, but not aggregation, promotes the transition of Darwinian individuality from cells to groups, emphasizing the fundamental role of initial multicellular life cycles in the evolution of multicellularity.
    1. Ecology

    Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’

    Blanca Jimeno, Simon Verhulst
    Glucocorticoids are assumed to reflect 'stress,' but they increase proportionally to the increase in metabolic rate induced by stressors, leading us to propose that glucocorticoids reflect metabolic rate, not stress.
    1. Cancer Biology
    2. Medicine

    Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

    He Liu, Meisuo Liu ... Yongliang Yang
    Deep reinforcement model and experimental evaluations identified a small-molecule CRM1 inhibitor that can selectively ablate extranodal NK/T cell lymphoma cells.
    1. Neuroscience

    Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses

    Diego Candia-Rivera, Federico Raimondo ... Jacobo D Sitt
    Brain-heart interactions under the processing of auditory irregularities could help to distinguish whether a patient is in a vegetative state or in a minimally conscious state.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

    Vanessa Dumeaux, Samira Massahi ... Michael T Hallett
    Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

    Aarya Venkat, Grace Watterson ... Natarajan Kannan
    Isoform-specific variations in doublecortin-like kinases offer a new framework for understanding kinome-wide modulation of protein stability and catalytic activity.
    1. Genetics and Genomics
    2. Medicine

    Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study

    Lan Jiang, Ge Liu ... Qiping Feng
    A common genetic variant in Black patients increases the risk of renal disease, which increases the risk of sepsis, but there is no direct association between the variant and sepsis.
    1. Neuroscience

    Quantifying decision-making in dynamic, continuously evolving environments

    Maria Ruesseler, Lilian Aline Weber ... Laurence Tudor Hunt
    Human behaviour in a continuous decision making task adapts to the overall statistics of the sensory environment, and these adaptations are also reflected in changes in neural responses to incoming sensory evidence.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

    Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
    Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
    1. Immunology and Inflammation

    Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

    Eva Morgun, Jennifer Zhu ... Chyung-Ru Wang
    The bicontinuous nanospheres platform enables dual encapsulation and in vivo activation of lipid and protein antigen-specific T cells, resulting in enduring lipid depots for sustained immune responses.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study

    Tom G Richardson, Genevieve M Leyden, George Davey Smith
    Leveraging time-varying and tissue-dependent genetic instruments into Mendelian randomization studies may help develop insight over more conventional applications.
    1. Developmental Biology

    Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
    Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
    1. Cancer Biology

    A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

    Qiaomu Tian, Peng Zhang ... Anita S Chong
    CK21 emerges as a compelling candidate for pancreatic cancer treatment, and its capacity to target the NF-κB pathway, induce mitochondrial-mediated apoptosis, and do so with minimal toxicity is a significant stride in the quest for improved therapies.
    1. Cell Biology
    2. Immunology and Inflammation

    Stimulation-induced cytokine polyfunctionality as a dynamic concept

    Kevin Portmann, Aline Linder, Klaus Eyer
    1. Developmental Biology

    A scalable and tunable platform for functional interrogation of peptide hormones in fish

    Eitan Moses, Roman Franek, Itamar Harel
    A novel in vivo strategy for reversible, multiplexed control of circulating hormone expression levels, achieved by combining genome-editing and intramuscular electroporation of fluorescently tagged hormones in the naturally short-lived turquoise killifish.
    1. Developmental Biology

    The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila

    Leonard Drees, Susi Schneider ... Matthias Behr
    Genetic analyses reveal the importance of dynamic protein processing at the apical cell membrane in response to forces damaging cell membranes during tube expansion in tubular organs.
    1. Evolutionary Biology

    A toxin-antidote selfish element increases fitness of its host

    Lijiang Long, Wen Xu ... Patrick T McGrath
    A toxin-antidote element, identified for its role as a selfish genetic element that spreads through a population by killing certain offspring, also plays a beneficial role to the host.
    1. Cell Biology

    Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

    Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry
    Rab12 was identified as a key modulator of LRRK2-dependent Rab phosphorylation that mediates the recruitment of LRRK2 to lysosomes in response to damage.
    1. Cell Biology

    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

    Herschel S Dhekne, Francesca Tonelli ... Suzanne R Pfeffer
    Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.
    1. Cell Biology

    Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

    Jun Yang, Shitian Zou ... Xiaochun Bai
    1. Neuroscience

    Modulation of input sensitivity and output gain by retinal amacrine cells

    Neda Nategh, Mihai Manu, Stephen A. Baccus
    1. Immunology and Inflammation

    H2-O deficiency promotes regulatory T cell differentiation and CD4 hyperactivity

    Robin A. Welsh, Nianbin Song ... Scheherazade Sadegh-Nasseri
    1. Structural Biology and Molecular Biophysics

    Water and chloride as allosteric inhibitors in WNK kinase osmosensing

    Liliana R. Teixeira, Radha Akella ... Elizabeth J. Goldsmith
    1. Neuroscience

    Integrating Gaze, image analysis, and body tracking: Foothold selection during locomotion

    Karl Muller, Dan Panfili ... Mary Hayhoe
    1. Neuroscience

    Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    Adam Glaser, Jayaram Chandrashekar ... Karel Svoboda
    1. Developmental Biology
    2. Neuroscience

    Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2

    Yunjeong Lee, In Seo Yeo ... Mi-Ryoung Song
    Isl2 orchestrates specific hindlimb motor pool arrangement, guaranteeing accurate motor control and sensorimotor circuit functionality.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

    David J Torres, Paulus Mrass ... Judy L Cannon
    The analysis of T cell movement in multiple tissues (lymph node, villi, and lung under two different inflammatory conditions) sheds new light on how T cells navigate different tissue environments to improve immunity and search processes.
    1. Developmental Biology

    Spinal neural tube formation and regression in human embryos

    Chloe Santos, Ailish Murray ... Andrew J. Copp
    1. Structural Biology and Molecular Biophysics

    A cryo-ET study of ciliary rootlet organization

    Chris van Hoorn, Andrew P. Carter
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence

    Wei-Sheng Sun, Lena Lassinantti ... Ronnie P-A Berntsson
    The enterococcal adhesin PrgB consists of four immunoglobulin-like domains that support the proper function of its polymer adhesin domain.
    1. Developmental Biology

    C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy

    Hui Zhang, Chan Li ... Baohua Ma
    In vitro and in vivo data show that C-natriuretic peptide is significant for increasing mitochondrial bioenergetics by cAMP-PKA pathway and improving cytoplasmic and nuclear maturation of maternally aged oocyte.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments

    Vivian Chen, Milo S Johnson ... Gavin Sherlock
    Pleiotropy of adaptive clones isolated from diverse experimental environment.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

    Christopher T Boughter, Martin Meier-Schellersheim
    A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
    1. Neuroscience

    MicroRNA-218 instructs proper assembly of hippocampal networks

    Seth R Taylor, Mariko Kobayashi ... Giordano Lippi
    MicroRNA-218 is required in both excitatory and inhibitory neurons of the developing hippocampus to regulate intrinsic and network excitability.
    1. Developmental Biology
    2. Plant Biology

    The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation

    Elmehdi Bahafid, Imke Bradtmöller ... Rüdiger GW Simon
    Mutant and gene expression analyses shows that phytohormones and mobile transcription factors interact to coordinate organ formation with stem cell maintenance in the plant shoot meristem.
    1. Developmental Biology

    Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

    Akihiro Miura, Hemanta Sarmah ... Munemasa Mori
    The Foxa2 lineage-based organ generative strategy allows us to establish a unique paradigm for the simultaneous generation of functional whole lungs and thymus, which can be applied to future transplantation therapy.
    1. Neuroscience

    Two human brain systems micro-structurally associated with obesity

    Manfred G Kitzbichler, Daniel Martins ... Neil A Harrison
    Revealing two distinct brain systems linked to obesity, this research illuminates the intricate relationship between obesity, brain microstructure and genetics with potential implications for treatment and prevention.
    1. Computational and Systems Biology

    Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

    Xiaoxu Li, Jean-David Morel ... Johan Auwerx
    A strategy combining large mouse and human genetic data sheds light on dietary and genetic drivers of gut inflammation.
    1. Neuroscience
    2. Physics of Living Systems

    Mechanical vibration patterns elicit behavioral transitions and habituation in crawling Drosophila larvae

    Alexander Berne, Tom Zhang ... Mason Klein
    Habituation to mechanical vibration of crawling Drosophila larvae exhibits distinct time constants that characterize desensitization, re-sensitization, and further adaptation to repeated stimulus patterns.
    1. Cell Biology

    β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

    Carole Daly, Akim Abdul Guseinov ... Bianca Plouffe
    The vasopressin type 2 receptor promotes dual Gαs and Gαq/11 signaling at early endosomes in β-arrestin-dependent and -independent manners.
    1. Cell Biology
    2. Medicine

    Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes

    Jana Riegger, Rolf E Brenner
    Disruption of the intracellular vimentin network upon cellular stress results in enhanced cell surface vimentin on human osteoarthritic chondrocytes and might represent a novel membrane-associated marker of stress-induced premature senescence.
    1. Neuroscience

    Motor actions are spatially organized in motor and dorsal premotor cortex

    Nicholas G Chehade, Omar A Gharbawie
    The spatial dimension of neural activity is an organizing feature of the neural code that controls motor actions.
    1. Computational and Systems Biology

    Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins

    Yingnan Zhang, Kelly Zhang ... Natalia A Trayanova
    A novel computational approach integrates personal genetics into personalized whole heart digital twins to predict ventricular arrhythmia circuits for patients with arrhythmogenic right ventricular cardiomyopathy.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    SIRT-1 is required for release of enveloped enteroviruses

    Alagie Jassey, James Logue ... William T Jackson
    Enterovirus D68, a pathogen associated with a rare child paralysis disease, depends on the cellular protein SIRT-1 for release of virus, indicating that SIRT-1 may be an important therapeutic target.
    1. Neuroscience

    Neural correlates of individual odor preference in Drosophila

    Matthew A. Churgin, Danylo O. Lavrentovich ... Benjamin de Bivort
    1. Cell Biology

    Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation

    Saori Shinoda, Yuji Sakai ... Noboru Mizushima
    1. Neuroscience

    Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

    Marco Leibinger, Charlotte Zeitler ... Dietmar Fischer
    Systemic treatment with di-methyl-amino-parthenolide facilitates CNS axon regeneration and functional recovery by reducing the induction of microtubule detyrosination by established regenerative therapies.
    1. Cancer Biology
    2. Cell Biology

    Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

    Kota Kaneko, Yan Liang ... Gen-Sheng Feng
    A new type of mRNAs-loaded CD133+ vesicles, named intercellsome, mediate cell-cell communications to compensate intracellular proliferative signal deficit, representing a previously unrecognized mechanism of cell proliferation under stress.
    1. Ecology

    Drivers of species knowledge across the tree of life

    Stefano Mammola, Martino Adamo ... Ricardo A Correia
    Different species-level characteristics and sociocultural factors influence scientific and societal interest in biodiversity, with important implications for species-level conservation and dissemination.
    1. Neuroscience

    Intuitive movement-based prosthesis control enables arm amputees to reach naturally in virtual reality

    Effie Segas, Sébastien Mick ... Aymar de Rugy
    A novel trans-humeral prosthesis control method based on artificial intelligence, and the proof of its effectiveness in virtual reality as well as on a robotic platform.
    1. Developmental Biology
    2. Genetics and Genomics

    Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis

    Jun Hu, Zhe Zhang ... Chao Liu
    Germline extrachromosomal circular DNAs are mainly formed by microhomology-mediated ligation of nucleosome-protected fragments and barely contribute to de novo genomic deletions at meiotic recombination hotspots.
    1. Developmental Biology
    2. Genetics and Genomics

    DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility

    Emilie Dujardin, Marjolaine André ... Maëlle Pannetier
    The absence of DMRT1 induces a male-to-female sex reversal in XY rabbits and complete infertility in both sexes.
    1. Epidemiology and Global Health

    Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study

    Gayathri Nagaraj, Shaveta Vinayak ... Dimpy P Shah
    Sociodemographic (age, race/ethnicity) and clinical (Eastern Cooperative Oncology Group performance status, pre-existing comorbidities, and active and progressing cancer) risk factors were associated with worse COVID-19 outcomes in patients with breast cancer.
    1. Evolutionary Biology

    Evolutionary adaptation to juvenile malnutrition impacts adult metabolism and impairs adult fitness in Drosophila

    Berra Erkosar, Cindy Dupuis ... Tadeusz J Kawecki
    Juvenile and adult metabolism are constrained from evolving independently from each other even in a species that lacks developmental continuity between juvenile and adult organs.
    1. Neuroscience

    Omissions of Threat Trigger Subjective Relief and Reward Prediction Error-Like Signaling in the Human Reward System

    Anne L. Willems, Lukas Van Oudenhove, Bram Vervliet
    1. Neuroscience

    Auditory cortex anatomy reflects multilingual phonological experience

    Olga Kepinska, Josue Dalboni da Rocha ... Narly Golestani
    1. Neuroscience

    Pinpoint: trajectory planning for multi-probe electrophysiology and injections in an interactive web-based 3D environment

    Daniel Birman, Kenneth J. Yang ... Nicholas A. Steinmetz
    1. Neuroscience

    How Absence Seizures Impair Sensory Perception: Insights from Awake fMRI and Simulation Studies in Rats

    Petteri Stenroos, Isabelle Guillemain ... Emmanuel L. Barbier
    1. Neuroscience

    Pynapple, a toolbox for data analysis in neuroscience

    Guillaume Viejo, Daniel Levenstein ... Adrien Peyrache
    Pynapple advances data analysis in systems neuroscience with a versatile, open-source framework that uses common objects to handle diverse data streams, ensuring reliable and reproducible analysis while maintaining long-term backward compatibility.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    σ28-dependent small RNA regulation of flagella biosynthesis

    Sahar Melamed, Aixia Zhang ... Gisela Storz
    σ28-Dependent sRNAs fine-tune flagella synthesis, with one sRNA connecting synthesis with metabolism and two sRNAs with opposing effects connecting synthesis with ribosomal protein production through unique binding within coding sequences.
    1. Biochemistry and Chemical Biology

    An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

    Tim Aguirre, Gillian L Dornan ... Dorothea Fiedler
    A subtle mutation in the ATP-binding site of inositol hexakisphosphate kinases increases their conformational flexibility and thereby makes them susceptible to isozyme-selective, allosteric inhibition.
    1. Neuroscience

    A class-specific effect of dysmyelination on the excitability of hippocampal interneurons

    Delphine Pinatel, Edouard Pearlstein ... Catherine Faivre-Sarrailh
    Dysmyelination of GABAergic hippocampal interneurons causes mislocalization of axonal ionic channels and disturbs their intrinsic physiological properties, suggesting that it may contribute to cognitive deficits observed in multiple sclerosis patients.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Myristoyl’s dual role in allosterically regulating and localizing Abl kinase

    Svenja de Buhr, Frauke Gräter
    The cellular membrane competes with Abl for myristoyl binding to stabilize the preactivated state and enhance allosteric activation.
    1. Neuroscience

    Hierarchical temporal prediction captures motion processing along the visual pathway

    Yosef Singer, Luke Taylor ... Nicol S Harper
    Neural network modeling shows that hierarchical application of the simple computational principle of predicting future sensory input from its past can capture features of visual motion processing from the retina to the visual cortex.
    1. Neuroscience

    Flexible coding of time or distance in hippocampal cells

    Shai Abramson, Benjamin J Kraus ... Genela Morris
    The hippocampus demonstrates flexible coding during memory encoding, prioritizing either distance or time information based on the specific requirements of the experiment.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19

    The COVID Tissue Atlas Consortium, Alejandro A Granados ... Bruce Wang
    A conserved transcriptional signature in macrophages and endothelial cells occurs in multiple organs in response to COVID-19 and suggests potential molecular interactions between the two cell types.
    1. Neuroscience

    Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

    Surjeet Mastwal, Xinjian Li ... Kuan Hong Wang
    Frontal cortical circuit alterations and cognitive deficits identified in mouse genetic models are reversed by chemogenetic or optogenetic stimulation of the mesocortical dopamine circuit in an adolescent period.
    1. Cell Biology
    2. Neuroscience

    Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency

    Léa Broca-Brisson, Rania Harati ... Aloïse Mabondzo
    Proteomic analysis of brain organoids from creatine transporter deficiency (CTD) patients enhance the understanding of CTD offering potential therapeutic targets and a robust foundation for continued research in the field.
    1. Developmental Biology

    Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

    Liang-Yu Pang, Steven DeLuca ... Allan C Spradling
    Chromatin changes downstream from Drosophila germline stem cells and fertilized zygotes alter how transposable element activity and gene expression are controlled to facilitate differentiation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    A modelled analysis of the impact of COVID-19-related disruptions to HPV vaccination

    Louiza S Velentzis, Megan A Smith ... Karen Canfell
    Results from this modelled analysis indicate that short-term delays in HPV vaccination of adolescents are unlikely to have substantial long-term effects on HPV-related cancers, provided catch-up of missed vaccine doses can be implemented.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence

    Zachary Baker, Molly Przeworski, Guy Sella
    Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.
    1. Neuroscience

    Direct observation of the neural computations underlying a single decision

    Natalie A Steinemann, Gabriel M Stine ... Michael N Shadlen
    1. Biochemistry and Chemical Biology

    Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes

    Michele Brischigliaro, Alfredo Cabrera-Orefice ... Erika Fernández-Vizarra
    Inducing the formation of mitochondrial respiratory chain supercomplexes in Drosophila melanogaster, where they are normally absent, does not have any noticeable impact in the function of the respiratory chain.
    1. Neuroscience

    Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

    Marija Markicevic, Oliver Sturman ... Nicole Wenderoth
    The structural characteristics of a circuit and its hierarchical dimensions are shown to influence regional time-series dynamics after targeted cellular-level manipulations.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Theoretical analysis reveals a role for RAF conformational autoinhibition in paradoxical activation

    Gaurav Mendiratta, Edward Stites
    Mathematical modeling shows how RAF inhibitors can actually activate RAF kinases by stabilizing RAF proteins in the conformation capable of dimerization.
    1. Cancer Biology

    Mutant SF3B1 promotes malignancy in PDAC

    Patrik Simmler, Eleonora I Ioannidi ... Gerald Schwank
    SF3B1-K700E, a gene mutaiton found recurrently mutated in pancreatic cancer, increases malignancy in an autochthonous mouse model of pancreatic cancer and induces resistance against TGF-β-induced apoptosis in vitro by missplicing of MAP3K7.
    1. Microbiology and Infectious Disease

    Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

    Nikol Kadeřábková, R. Christopher D. Furniss ... Despoina A.I. Mavridou
    1. Computational and Systems Biology

    A three filament mechanistic model of musculotendon force and impedance

    Matthew Millard, David W. Franklin, Walter Herzog
    1. Structural Biology and Molecular Biophysics

    Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop

    Jian Wu, Nisha A. Jonniya ... Susan S. Taylor
    1. Cancer Biology
    2. Genetics and Genomics

    Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

    Van Thien Chi Nguyen, Trong Hieu Nguyen ... Le Son Tran
    SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.
    1. Cell Biology
    2. Neuroscience

    RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

    Julie C Necarsulmer, Jeremy M Simon ... Todd J Cohen
    Impairing TDP-43 RNA-binding capacity through a single acetylation-mimic mutation alters TDP-43 function and recapitulates biochemical, molecular, and behavioral features of sporadic TDP-43 proteinopathies, thus providing opportunities for new research into pathogenic mechanisms and therapeutic interventions.
    1. Biochemistry and Chemical Biology

    GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes

    Jayashree Jena, Luis Miguel García-Peña ... Renata O Pereira
    Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.
    1. Neuroscience

    An observational treatment study of metacognition in anxious-depression

    Celine Ann Fox, Chi Tak Lee ... Claire M Gillan
    Improvement in levels of anxious-depression corresponds with increased confidence in performance among individuals receiving mental health treatment within a large longitudinal dataset.
    1. Developmental Biology
    2. Neuroscience

    Using multi-modal neuroimaging to characterise social brain specialisation in infants

    Maheen Siddiqui, Paola Pinti ... Emily JH Jones
    The coupling between neural oscillatory activity, haemodynamics, and metabolism is localised to the temporo-parietal region in response to social stimuli, providing evidence of the importance of investigating the energetic basis of brain functional specialisation.
    1. Neuroscience

    Competing neural representations of choice shape evidence accumulation in humans

    Krista Bond, Javier Rasero ... Timothy Verstynen
    Interactions between cortical and subcortical circuits in the mammalian brain flexibly control the flow of information streams that drive decisions by shifting the balance of power both within and between action representations.
    1. Biochemistry and Chemical Biology

    On the role of nucleotides and lipids in the polymerization of the actin homolog MreB from a Gram-positive bacterium

    Wei Mao, Lars D Renner ... Rut Carballido-Lopez
    First 3D-structure and first observation of organized protofilaments of MreB from a Gram-positive bacterium, suggesting a model where ATP drives the formation of dynamic pairs of MreB protofilaments on a lipid surface.
    1. Neuroscience

    Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

    Matthew H. Davenport, Ha Na Choe ... Erich D. Jarvis
    1. Neuroscience

    Neural spiking signatures predict behavioral phenotypes of cerebellar movement disorders

    Meike E. van der Heijden, Amanda M. Brown ... Roy V. Sillitoe
    1. Neuroscience

    Simple decoding of behavior from a complicated neural manifold

    Sean M. Perkins, John P. Cunningham ... Mark M. Churchland
    1. Neuroscience

    On the computational principles underlying human exploration

    Lior Fox, Ohad Dan, Yonatan Loewenstein
    1. Neuroscience

    Representational drift as a result of implicit regularization

    Aviv Ratzon, Dori Derdikman, Omri Barak
    1. Ecology

    Wandering albatrosses exert high take-off effort only when both wind and waves are gentle

    Leo Uesaka, Yusuke Goto ... Kentaro Q Sakamoto
    Wind and ocean wave conditions experienced by albatrosses were estimated using an animal-borne recorder and revealed that take-off was easier under higher wave conditions.
    1. Computational and Systems Biology

    Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models

    Ben Vezina, Stephen C Watts ... Kelly L Wyres
    Bactabolize is a pipeline for rapid and scalable production of accurate bacterial strain-specific metabolic models and growth phenotype predictions.
    1. Genetics and Genomics
    2. Neuroscience

    Tyramine and its Amtyr1 receptor modulate attention in honey bees (Apis mellifera)

    Joseph S Latshaw, Reece E Mazade ... Brian Smith
    Genetic variation in a biogenic amines receptor underlies a means of gain control for nonassociative learning and hence an important form of attention that is the basis for tradeoffs in foraging in a social collective.
    1. Neuroscience

    Theta cycle dynamics of spatial representations in the lateral septum

    Katarzyna Bzymek, Fabian Kloosterman
    1. Neuroscience

    Transformation of value signaling in a striatopallidal circuit

    Donghyung Lee, Lillian Liu, Cory M. Root
    1. Microbiology and Infectious Disease

    Stumpy forms are the predominant transmissible forms of Trypanosoma brucei

    Jean Marc Tsagmo Ngoune, Parul Sharma ... Brice Rotureau
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S. Thum
    1. Microbiology and Infectious Disease

    The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

    João Paulo Portela Catani, Anouk Smet ... Thorsten U. Vogel
    1. Ecology
    2. Evolutionary Biology

    Response to comment on 'Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs'

    Longhui Zhao, Wouter Halfwerk, Jianguo Cui
    We are writing to respond to the comment by Anderson et al., 2023 on our article about limb movements in male little torrent frogs (Zhao et al., 2022).
    1. Ecology
    2. Evolutionary Biology

    Comment on 'Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs'

    Nigel K Anderson, Doris Preininger, Matthew J Fuxjager
    We are writing to comment on the article by Zhao et al., 2023 about limb movements in male little torrent frogs.
    1. Cancer Biology

    Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

    Weirong Kang, Yibo Fan ... Zhizhan Gu
    1. Physics of Living Systems

    Quantifying gliding forces of filamentous cyanobacteria by self-buckling

    Maximilian Kurjahn, Antaran Deka ... Stefan Karpitschka
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Diminishing neuronal acidification by channelrhodopsins with low proton conduction

    Rebecca Frank Hayward, F Phil Brooks III ... Adam E Cohen
    Many channelrhodopsins acidify cells, but two new ones do not.
    1. Cell Biology

    Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI

    Alexander Kapustin, Sofia Serena Tsakali ... Catherine M Shanahan
    1. Stem Cells and Regenerative Medicine

    Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

    Fanny-Meï Cloarec-Ung, Jamie Beaulieu ... David JHF Knapp
    1. Structural Biology and Molecular Biophysics

    Allosteric inhibition of the T cell receptor by a designed membrane ligand

    Yujie Ye, Shumpei Morita ... Francisco N Barrera
    A designer peptide inhibits the T cell receptor through allosteric binding to the transmembrane region.
    1. Neuroscience

    Thalamic regulation of ocular dominance plasticity in adult visual cortex

    Yi Qin, Mehran Ahmadlou ... Christiaan N Levelt
    Inhibitory innervation in the dorsolateral geniculate nucleus is crucial for adult thalamic and cortical ocular dominance plasticity, highlighting potential thalamic involvement in conditions like amblyopia and learning disabilities.
    1. Structural Biology and Molecular Biophysics

    Absence of electron-transfer-associated changes in the time-dependent X-ray free-electron laser structures of the photosynthetic reaction center

    Gai Nishikawa, Yu Sugo ... Hiroshi Ishikita
    Revisiting limitations in time-resolved X-ray free-electron laser structures of the bacterial photosynthetic reaction center uncovers their irrelevance to proposed structural changes in electron transfer dynamics.
    1. Microbiology and Infectious Disease

    Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

    Abhishek Jamwal, Cristina F Constantin ... Matthew K Higgins
    The most effective growth-neutralising antibodies which target the PfRH5 protein from a malaria parasite function by preventing the parasite from binding to basigin-containing membrane protein complexes on human erythrocytes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteostasis is differentially modulated by inhibition of translation initiation or elongation

    Khalyd J Clay, Yongzhi Yang ... Michael Petrascheck
    Carefully controlling the level of protein synthesis reduction and mode of translation inhibitor action reveal different and sometimes opposing phenotypic effects following proteostasis stress, wherein protection via initiation inhibition specifically depends on heat shock factor 1.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans

    Cori K Cahoon, Colette M Richter ... Diana E Libuda
    Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.
    1. Neuroscience

    Facial expression is a distinctive behavioural marker of pain processing in the brain

    Marie-Eve Picard, Miriam Kunz ... Pierre Rainville
    1. Neuroscience

    Statistical learning shapes pain perception and prediction independently of external cues

    Jakub Onysk, Nicholas Gregory ... Flavia Mancini
    1. Neuroscience

    Increasing adult neurogenesis protects mice from epilepsy

    Swati Jain, John J. LaFrancois ... Helen E. Scharfman
    1. Cell Biology
    2. Cancer Biology

    SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

    Linda Zhang, Joanne I. Hsu ... Margaret A. Goodell
    1. Neuroscience

    A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences

    Yuk-Hoi Yiu, Christian Leibold
    A spiking neural network model explains how hippocampal theta sequences in two-dimensional arenas can arise from a combination of sensory-motor inputs, short-term synaptic plasticity, and intrinsic connectivity.
    1. Neuroscience

    Optogenetic activation of visual thalamus generates artificial visual percepts

    Jing Wang, Hamid Azimi ... Gregor Rainer
    The visual thalamus is a promising target for neural prosthetic intervention aimed at the restoration of visual function.
    1. Neuroscience

    Glutamatergic Supramammillary Nucleus Neurons Respond to Threatening Stressors and Promote Active Coping

    Abraham Escobedo, Salli-Ann Holloway ... Aaron J. Norris
    1. Ecology

    Higher social tolerance is associated with more complex facial behavior in macaques

    Alan V Rincon, Bridget M Waller ... Jérôme Micheletta
    Detailed quantification of macaque facial behavior reveals a positive link between social and communicative complexity, and helps us to better understand the evolution of animal communication.
    1. Cancer Biology

    Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

    Huan Fang, Wenlong Ren ... Ceshi Chen
    TNFAIP2 was found to interact with IQGAP1 and Integrin β4, which activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in triple-negative breast cancer.
    1. Cell Biology
    2. Genetics and Genomics

    Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

    Christopher H Emfinger, Lauren E Clark ... Alan D Attie
    Analysis of islet calcium oscillation responses will provide the field with a resource with which to determine the strain of interest for their specific islet biology questions.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Broad functional profiling of fission yeast proteins using phenomics and machine learning

    María Rodríguez-López, Nicola Bordin ... Jürg Bähler
    Large-scale screens and computational approaches reveal phenotypes for 3492 genes and gene-ontology predictions for 783 genes, including hitherto unstudied genes, which provides a potent platform to further dissect protein function.
    1. Developmental Biology
    2. Evolutionary Biology

    Hybridization led to a rewired pluripotency network in the allotetraploid Xenopus laevis

    Wesley A Phelps, Matthew D Hurton ... Miler T Lee
    Xenopus laevis arose from hybridization of two different frog species millions of years ago, leading to adaptation of the genetic networks controlling early embryonic development and stem cell induction to balance expression between the genes inherited from each ancestor.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K

    Matthew T Parker, Sebastian M Fica ... Gordon G Simpson
    A computational approach examines the roles of splicing factors and their association with evolutionary change in splicing.
    1. Neuroscience

    An image segmentation method based on the spatial correlation coefficient of Local Moran’s I

    Csaba Dávid, Kristóf Giber ... László Acsády
    1. Neuroscience

    Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

    Benjamin R. Kop, Yazan Shamli Oghli ... Lennart Verhagen
    1. Cell Biology
    2. Genetics and Genomics

    Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

    Sagen Flowers, Rushali Kothari ... Joel H Rothman
    Mitochondrial quality control in the germline is mediated by regulators of both programmed cell death and the aging program.
    1. Medicine

    Structural insights into the career path between pre- and postgraduate physician-scientist training programs

    Christopher S Williams, Emily J Gallagher ... Kyu Y Rhee
    Essential advice for trainees when evaluating postgraduate physician scientist training programs.
    1. Medicine

    Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

    Chandramohan Chitraju, Alexander W Fischer ... Robert V Farese Jr
    Inhibiting triglyceride storage in adipose tissue prevents obesity and improves metabolic health.
    1. Computational and Systems Biology
    2. Developmental Biology

    A comprehensive model of Drosophila epithelium reveals the role of embryo geometry and cell topology in mechanical responses

    Mohamad Ibrahim Cheikh, Joel Tchoufag ... Konstantin Doubrovinski
    Direct mechanical microcantilever-based measurements establish key material parameters describing mechanical response of the early Drosophila embryonic epithelium.
    1. Structural Biology and Molecular Biophysics

    Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

    Márton A Simon, Iordan Iordanov ... László Csanády
    Functional studies on CFTR anion channels harboring combinations of catalytic site mutations in the active ATPase site reveal the true stability of the prehydrolytic open-pore state as well as nucleotide-binding domain interface features that are unique to human CFTR.