September 2023

Attribution: Illustration © 2023 by Mike Costelloe is licensed under CC BY-NC-ND 4.0.

Cover articles

    1. Ecology
    2. Genetics and Genomics

    Baboons through the ages

    Franziska Grathwol, Christian Roos ... Gisela H Kopp
    1. Cell Biology
    2. Physics of Living Systems

    Water influx helps cells migrate

    Tamas L Nagy, Evelyn Strickland, Orion D. Weiner
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Keeping organelles in place

    Joseph L Basalla, Claudia A Mak ... Anthony G Vecchiarelli

Highlights controls:

Research articles

    1. Neuroscience
    2. Computational and Systems Biology

    Active Dendrites Enable Robust Spiking Computations Despite Timing Jitter

    Thomas SJ Burger, Michael E Rule, Timothy O’Leary
    1. Cancer Biology

    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

    Elena Farmaki, Aritro Nath ... Andrea H Bild
    Experimental and clinical models identify an effective add-on therapy for drug resistant estrogen receptor positive advanced breast cancer.
    1. Plant Biology

    Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis

    Alicia Kairouani, Dominique Pontier ... Thierry Lagrange
    Musashi-mediated post-transcriptional mechanisms regulate glucuronoxylan modification and secondary cell wall formation in the supportive fibre cells of stem in plants.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

    Vikrant K Bhosle, Chunxiang Sun ... Lisa A Robinson
    SLIT2, a prototypic neuro-repellent, spatiotemporally coordinates host defense against Staphylococcus aureus infection by priming neutrophils and stimulating release of reactive oxygen species and secondary and tertiary granules, potently enhancing bactericidal actions of neutrophils.
    1. Computational and Systems Biology
    2. Neuroscience

    Dissecting the chain of information processing and its interplay with neurochemicals and fluid intelligence across development

    George Zacharopoulos, Francesco Sella ... Roi Cohen Kadosh
    A novel integrative biological and psychological mechanistic explanation links cognitive processes and neurotransmitters across human development and establishes their involvement in intelligent behavior.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

    Elliott L Paine, Jack J Skalicky ... Wesley I Sundquist
    Biochemical, structural, imaging, and functional studies reveal how the ESCRT-III protein IST1 recruits the CAPN7 cysteine protease to midbodies, where its proteolytic activity is required for efficient abscission and NoCut checkpoint arrest.
    1. Physics of Living Systems

    The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid

    Celine Bellegarda, Guillaume Zavard ... Claire Wyart
    Experimental manipulations and a mechanical model of the fiber reveal that the Reissner fiber is under heterogenous tension in vivo, and interacts with the motile cilia of diverse cells contacting the cerebrospinal fluid.
    1. Neuroscience

    Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    The pre-Bötzinger complex, known as the kernel for the breathing generation, consists of separate subpopulations of neurons that project to specific nuclei to coordinate respiratory rhythmicity with different physiological behaviors, such as nasofacial activity.
    1. Neuroscience

    Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency

    Eleonora Parrotta, Patric Bach ... Francesca Ferri
    1. Immunology and Inflammation

    Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

    Sabelo Hadebe, Anca Flavia Savulescu ... Frank Brombacher
    1. Cell Biology
    2. Immunology and Inflammation

    Arpin deficiency increases actomyosin contractility and vascular permeability

    Armando Montoya-García, Idaira M. Guerrero-Fonseca ... Michael Schnoor
    1. Neuroscience

    Goal-directed vocal planning in a songbird

    Anja T. Zai, Anna E. Stepien ... Richard H.R. Hahnloser
    1. Developmental Biology
    2. Evolutionary Biology

    Hierarchical morphogenesis of swallowtail butterfly wing scale nanostructures

    Kwi Shan Seah, Vinodkumar Saranathan
    Structured illumination microscopy reveals that the hierarchical development of complex honeycomb-like nanostructures within the lumen of some swallowtail butterfly wing scales proceeds via a novel reorganization of disintegrating F-actin bundles.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Multiomics analyses reveal dynamic bioenergetic pathways and functional remodeling of the heart during intermittent fasting

    Thiruma V Arumugam, Asfa Alli-Shaik ... Jayantha Gunaratne
    Intermittent fasting orchestrates molecular shifts, yielding cardiovascular improvements, revealing novel cardioprotective mechanisms, and suggesting innovative pharmacological strategies for cardiovascular disease prevention and treatment.
    1. Evolutionary Biology

    Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

    Hironori Funabiki, Isabel E Wassing ... Thomas Carroll
    Coevolution analysis suggests that a DNA methylation-related role for the nucleosome remodeling ATPase HELLS and its activator CDCA7 was broadly inherited from the last eukaryotic common ancestor.
    1. Biochemistry and Chemical Biology
    2. Epidemiology and Global Health

    Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study

    Takashi Sasaki, Yoshinori Nishimoto ... Yasumichi Arai
    Circulating high-molecular-weight (cHMW) adiponectin levels increased with age until centenarians, and the contribution of known major factors associated with cHMW adiponectin levels including BMI varied with age, suggesting that its physiological significance also varies with age in the oldest old.
    1. Neuroscience

    An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

    Niraja Ramesh, Marc Escher ... Stephan J Sigrist
    An antagonism between Spinophilin and Syd-1 converge on presynaptic actin to control presynaptic plasticity and memory consolidation in the Drosophila mushroom body.
    1. Ecology
    2. Genetics and Genomics

    Adulis and the transshipment of baboons during classical antiquity

    Franziska Grathwol, Christian Roos ... Gisela H Kopp
    The first sequenced mitogenome of a mummified non-human primate connects an Egyptian baboon dated to ca. 800–540 BCE to modern baboon populations in Eritrea, Ethiopia, and eastern Sudan, providing evidence for Egyptian–Adulite trade centuries earlier than current archaeological evidence.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Vibrio cholerae’s ToxRS bile sensing system

    Nina Gubensäk, Theo Sagmeister ... Tea Pavkov-Keller
    The sensory regulatory system of the cholera causative involves the detection of bile acids by direct interaction with the inner membrane protein complex formed by ToxR and ToxS, thereby inducing concentration-dependent structural changes.
    1. Neuroscience

    Astrocytes gate long-term potentiation in hippocampal interneurons

    Weida Shen, Yejiao Tang ... Ling-Hui Zeng
    1. Neuroscience

    Why the brown ghost chirps at night

    Livio Oboti, Federico Pedraja ... Rüdiger Krahe
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth

    Francesca G Tomasi, Satoshi Kimura ... Matthew K Waldor
    Surveying Mycobacterium tuberculosis tRNA modification leads to identification of a modification promoting Mtb pathogenesis.
    1. Cancer Biology
    2. Computational and Systems Biology

    High-content microscopy reveals a morphological signature of bortezomib resistance

    Megan E Kelley, Adi Y Berman ... Gregory P Way
    Morphological profiling of untreated HCT116 cells using Cell Painting reveals a signature of bortezomib resistance, providing a proof-of-concept for the unbiased analysis of drug resistance.
    1. Cell Biology
    2. Neuroscience

    Translational regulation enhances distinction of cell types in the nervous system

    Toshiharu Ichinose, Shu Kondo ... Hiromu Tanimoto
    1. Neuroscience

    Different rules for binocular combination of luminance flicker in cortical and subcortical pathways

    Federico G Segala, Aurelio Bruno ... Daniel H Baker
    Binocular combination of luminance signals exhibits strong interocular suppression in pathways governing the pupil response, and weak interocular suppression in cortical pathways subserving perception.
    1. Developmental Biology
    2. Neuroscience

    The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes

    Xiong Yang, Rong Wan ... Ke Tang
    Two intrinsic factors converge to govern the differentiation and integration of distinct characteristics of the hippocampus in mice.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene expression mapping of the neuroectoderm across phyla – conservation and divergence of early brain anlagen between insects and vertebrates

    Nico Posnien, Vera S Hunnekuhl, Gregor Bucher
    Hypotheses on brain homologies between insects and vertebrates are tested by comparing gene expression patterns from flies and beetles with those from vertebrates at early neuroectoderm stages.
    1. Neuroscience

    Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection

    Hao Li, Xin Jin
    Experimental data and computational simulations reveal a new functional model, that is 'Triple-control' for the basal ganglia pathways in action selection.
    1. Plant Biology

    Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

    Pieter J Wolters, Doret Wouters ... Vivianne GAA Vleeshouwers
    Chemical modifications of steroidal glycoalkaloids of potato can cause strong resistance against the necrotrophic early blight fungus as well as the Colorado potato beetle.
    1. Neuroscience

    Long-timescale anti-directional rotation in Drosophila optomotor behavior

    Omer Mano, Minseung Choi ... Damon A Clark
    When walking flies are shown bright, high-contrast rotating visual stimuli, they begin to turn in the direction opposite the rotation, showing that optomotor turning behavior contains rich, stimulus-dependent dynamics.
    1. Neuroscience

    Optogenetic induction of appetitive and aversive taste memories in Drosophila

    Meghan Jelen, Pierre-Yves Musso ... Michael D Gordon
    Closed-loop pairing of taste stimuli with optogenetic activation of neurons encoding either reward or punishment reveals that flies can form both appetitive and aversive taste memories that impact their future behavioral responses to tastes.
    1. Genetics and Genomics

    The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans

    Bhoomi Madhu, Mohammed Farhan Lakdawala, Tina L Gumienny
    The C. elegans canonical DBL1/TGFβ signaling pathway is not only regulated in response to bacterial challenges, but also appropriately tailors behaviors and molecular immune responses to bacterial challenges, and animals lacking DBL1 respond to specific bacteria as more harmful.
    1. Neuroscience

    Contributions of associative and non-associative learning to the dynamics of defensive ethograms

    Quan-Son Eric Le, Daniel Hereford ... Jonathan P. Fadok
    1. Neuroscience
    2. Ecology

    Exploring natural odour landscapes: A case study with implications for human-biting insects

    Jessica L. Zung, Sumer M. Kotb, Carolyn S. McBride
    1. Cell Biology
    2. Physics of Living Systems

    A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

    Xarxa Quiroga, Nikhil Walani ... Pere Roca-Cusachs
    Cell stretch release generates plasma membrane (PM) evaginations of ≈100 nm, triggering a local event of actin polymerization that flattens and recovers PM shape.
    1. Cell Biology

    CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

    Bo Wang, Zheyong Liang ... Peijun Liu
    The apical polarity protein CRB3 is crucial for regulating vesicle trafficking in γ-tubulin ring complex assembly during ciliogenesis and cilium-related Hedgehog and Wnt signaling pathways in tumorigenesis.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture

    Jiyu Xin, Yang Shi ... Xiaoling Xu
    Investigations of the reaction center (RC)-light harvesting (LH) complex from an ancient chlorosome-less anoxygenic phototroph Roseiflexus castenholzii reveal the structural basis by which carotenoids assembly regulates the architecture and quinone exchange of bacterial RC-LH complex.
    1. Epidemiology and Global Health

    The importance of patient-partnered research in addressing long COVID: Takeaways for biomedical research study design from the RECOVER Initiative’s Mechanistic Pathways taskforce

    C Kim, Benjamin Chen ... RECOVER Mechanistic Pathways Task Force
    Collaborative and mutually beneficial patient-provider-researcher relationships are crucial in achieving success in understanding and treating long COVID.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    PerTurboID, a targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria-causing parasites

    Heledd Davies, Hugo Belda ... Moritz Treeck
    A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.
    1. Evolutionary Biology
    2. Neuroscience

    Diversity and evolution of cerebellar folding in mammals

    Katja Heuer, Nicolas Traut ... Roberto Toro
    A computational neuroanatomy analysis of cerebellar and cerebral folding in 56 mammalian species reveals groups of highly variable 'diverse' phenotypes, and strongly conserved 'stable' phenotypes, providing new insights into the diversity, evolution, and influence of cortical folding on brain organisation.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

    Rebecca EK Mandt, Madeline R Luth ... Amanda K Lukens
    The mutational flexibility of the antimalarial target dihydroorotate dehydrogenase thwarts the use of collateral sensitivity as a strategy to suppress the evolution of resistance.
    1. Cell Biology

    PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

    Shuxian Li, Lingbing Li ... Xietong Wang
    Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.
    1. Developmental Biology

    An atypical basement membrane forms a midline barrier in left-right asymmetric gut development

    Cora Demler, John Coates Lawlor ... Natasza Kurpios
    1. Neuroscience

    Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

    Amanda J González Segarra, Gina Pontes ... Kristin Scott
    A peptidergic network translates internal nutrient abundance cues into the coordinated regulation of sugar and water ingestion.
    1. Neuroscience

    Dynamic top-down biasing implements rapid adaptive changes to individual movements

    Lucas Y Tian, Timothy L Warren ... Michael S Brainard
    Multi-area recordings reveal how communication between two songbird brain areas conveys a top-down bias that adaptively modifies ongoing singing to support context-specific vocal learning.
    1. Cancer Biology
    2. Genetics and Genomics

    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

    Ann-Kathrin Herzfeldt, Marta Puig Gamez ... Lee Kim Swee
    Loss of membrane-bound ICAM-1, overexpression of soluble ICAM-1 or ILKAP activity in tumor cells induce resistance to antigen-specific cytotoxic T-cell-mediated killing independently from regulating antigen presentation, PD-L1 expression, IFN-γ, or TNF-α responsiveness.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

    Arturo Torres Ortiz, Michelle Kendall ... Louis Grandjean
    The use of within-host pathogen genomic sequence data can be used to improve phylogenetic and transmission estimates.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

    Sevim Kahraman, Kimitaka Shibue ... Rohit N Kulkarni
    Live human pancreatic α-cells can be purified effectively using zinc-based reaction probe diacetylated Zinpyr1 and cultured as pseudoislets without losing their viability and function.
    1. Cell Biology
    2. Physics of Living Systems

    Neutrophils actively swell to potentiate rapid migration

    Tamas L Nagy, Evelyn Strickland, Orion D. Weiner
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

    Valentin Chabert, Geun-Don Kim ... Andreas Mayer
    Analysis of inositol pyrophosphate dynamics upon inorganic phosphate (Pi) starvation identifies 1,5-IP8 as the inositol pyrophosphate isomer signaling Pi sufficiency to the SPX domain of Pho81 that controls the transcriptional Pi starvation program.
    1. Chromosomes and Gene Expression

    Single molecule analysis of CENP-A chromatin by high-speed atomic force microscopy

    Daniël P Melters, Keir C Neuman ... Yamini Dalal
    A novel analytical workflow to quantitatively track motions of thousands of nucleosomes within chromatin fibers by high-speed atomic force microscopy.
    1. Medicine

    An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo

    Luyang Cao, Lixiang Ma ... Jingsong Xu
    Neutrophils are the predominant phagocytes that clear dead liver cells under normal physiological conditions.
    1. Cell Biology
    2. Neuroscience

    Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

    Elisabeth Jongsma, Anita Goyala ... Collin Yvès Ewald
    A novel Caenorhabditis elegans model that secretes human amyloid beta forms aggregates in the extracellular matrix, which are removed by activation of extracellular matrix dynamics.
    1. Genetics and Genomics
    2. Neuroscience

    Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

    Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri ... Pankaj Kapahi
    Advanced glycation end-products (compounds which make the food appetizing and aromatic) intricately modulate organism’s homeostatic and hedonistic signaling pathways thereby inducing preferential consumption of excess nutrients offering preliminary insights into overconsumption of modern-day processed food.
    1. Medicine

    SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury

    Xiaoyan Yang, Hsiang-Chun Chang ... Hossein Ardehali
    SIRT2 has detrimental effects in the heart and plays a role in cardiac response to injury and the progression of cardiac hypertrophy, and targeting SIRT2 may provide a novel avenue for the treatment of cardiac hypertrophy and ischemic disease.
    1. Neuroscience

    Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit

    Kei Jokura, Nobuo Ueda ... Gáspár Jékely
    1. Neuroscience

    Dual-color optical activation and suppression of neurons with high temporal precision

    Noëmie Mermet-Joret, Andrea Moreno ... Sadegh Nabavi
    1. Neuroscience

    A cortical information bottleneck during decision-making

    Michael Kleinman, Tian Wang ... Jonathan C. Kao
    1. Immunology and Inflammation

    Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART

    Oscar Blanch-Lombarte, Dan Ouchi ... Julia G Prado
    PLWH over a decade of ART showed a significant reshaping of the function and expression of inhibitory receptors across the CD8+ T cell landscape, ultimately leading to a decrease of CD107a TIGIT HIV-1-specific CD8+ T cells recovered by TIGIT blockade.
    1. Developmental Biology
    2. Neuroscience

    Lmx1a is a master regulator of the cortical hem

    Igor Y Iskusnykh, Nikolai Fattakhov ... Victor V Chizhikov
    LIM-homeodomain transcription factor Lmx1a co-regulates multiple developmental processes in the cortical hem, a major signaling center necessary for hippocampus formation in the mammalian brain.
    1. Microbiology and Infectious Disease

    Evolution of a functionally intact but antigenically distinct DENV fusion loop

    Rita M Meganck, Deanna Zhu ... Longping V Tse
    Operating as a serum profiling tool for dengue infection and vaccination, the D2-FLM variant, which is insensitive to antibody-dependent enhancement-prone fusion loop antibodies, also offers potential for a safer dengue virus vaccine.
    1. Cell Biology

    Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells

    Yueyang Wang, Lee D Troughton ... Qing Deng
    Mfn2 depletion upregulates cytosolic Ca2+ in mouse fibroblast cells, leading to RhoA and nonmuscle myosin II overactivation and a prominent peripheral actin band structure, which is dependent on the contractile force on the cell–substrate interface.
    1. Neuroscience

    Towards a Neurometric-based Construct Validity of Trust

    Pin-Hao A. Chen, Dominic Fareri ... Luke J. Chang
    1. Evolutionary Biology
    2. Neuroscience

    Broca’s area, variation and taxic diversity in early Homo from Koobi Fora (Kenya)

    Amélie Beaudet, Edwin de Jager
    A computer-assisted revision of a unique fossil from Kenya supports the hypothesis that the modern features of our brain emerged recently in the human evolutionary history.
    1. Neuroscience

    Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement

    Yoshinori Aso, Daichi Yamada ... Toshihide Hige
    A cluster of neurons that integrates inhibitory and excitatory synaptic inputs from the mushroom body output neurons of the appetitive and aversive memory compartments, respectively, triggers upwind steering, mediating memory-driven olfactory navigation behaviors.
    1. Cell Biology

    BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

    Zhiwang Zhang, Qichao Liao ... Lei Zhou
    Gene function studies confirmed that the BATF-PD1 axis and BATF-IL27 axis are regulatory factor for lipid accumulation in hepatocytes and adipocytes.
    1. Computational and Systems Biology
    2. Neuroscience

    Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning

    Huu Hoang, Shinichiro Tsutsumi ... Keisuke Toyama
    Dimensions for reinforcement learning reduced by dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP

    Maria Körner, Susanne R Meyer ... Alexander Buchberger
    The previously uncharacterized, evolutionarily conserved FAM104 proteins VCF1/2 stimulate the nuclear import of p97/VCP, with their absence causing reduced nuclear p97/VCP levels, slow growth, and hypersensitivity to pharmacological inhibition of p97/VCP.
    1. Plant Biology

    Interdependence of a kinase and its cognate substrate plasma membrane nanoscale dynamics underlies Arabidopsis response to viral infection

    Marie-Dominique Jolivet, Anne-Flore Deroubaix ... Véronique Germain
    1. Biochemistry and Chemical Biology

    A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

    Magnus Chan, Harutyun Sahakyan ... David Fedida
    Characterization of an extra-membrane site in IKs formed by KCNQ1 S1, Pore and S6 domains and the near extracellular region of KCNE1, which forms a binding pocket for channel activators.
    1. Ecology

    Engineering multifunctional rhizosphere probiotics using consortia of Bacillus amyloliquefaciens transposon insertion mutants

    Jingxuan Li, Chunlan Yang ... Zhong Wei
    Increasing the intra-species phenotypic diversity of a plant-beneficial bacterium effectively improves probiotic consortium functioning and plant growth promotion in agricultural systems.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pH-sensitive switch activates virulence in Salmonella

    Dasvit Shetty, Linda J Kenney
    A single conserved residue – histidine 12 – confers pH-sensitive DNA binding to the Salmonella Typhimurium SPI-2 transcriptional regulator SsrB, thereby regulating Salmonella virulence.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis

    John F Ouyang, Kunal Mishra ... Jacques Behmoaras
    A meta-analysis of single-cell data reveals an advanced and conserved polarisation state of SPP1+ macrophages in multiple human fibrotic tissues.
    1. Developmental Biology

    Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways

    Ana Sofia Pinheiro, Vasilios Tsarouhas ... Christos Samakovlis
    During tracheal morphogenesis, the scavenger receptor Emp senses and responds to luminal cargo levels by initiating apical membrane endocytosis along the longitudinal tube axis to restrict airway elongation.
    1. Epidemiology and Global Health

    Prediction of diabetic kidney disease risk using machine learning models: A population-based cohort study of Asian adults

    Charumathi Sabanayagam, Feng He ... Ching Yu Cheng
    Integrating machine learning (ML) models with selected features improved the prediction accuracy of diabetic kidney disease compared to traditional logistic regression models using established features, revealing potential new markers and supporting the use of ML techniques in epidemiological studies.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Deep Batch Active Learning for Drug Discovery

    Michael Bailey, Saeed Moayedpour ... Sven Jager
    1. Ecology
    2. Plant Biology

    An ecological network approach for detecting and validating influential organisms for rice growth

    Masayuki Ushio, Hiroki Saito ... Atsushi J Nagano
    By leveraging quantitative environmental DNA metabarcoding and ecological network analysis, influential organisms in rice fields are identified, thereby revealing potential avenues for environmentally friendly agricultural practices.
    1. Computational and Systems Biology

    A hierarchical model for external electrical control of an insect, accounting for inter-individual variation of muscle force properties

    Dai Owaki, Volker Dürr, Josef Schmitz
    A near-linear relationship between electrical stimulus duration and resultant joint torque in stick insects has been unveiled, enhancing control strategies in biohybrid robotics.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1

    Juan Xiang, Chaoyang Fan ... Pei Xu
    An inducible two-component CRISPR-based platform that rapidly repositions HSV-1 genomes to the nuclear edge unveils intranuclear space heterogeneity for the incoming viral genomes and dynamic stages of the host-virus interplay during early infection.
    1. Ecology
    2. Epidemiology and Global Health

    Mosquito community composition shapes virus prevalence patterns along anthropogenic disturbance gradients

    Kyra Hermanns, Marco Marklewitz ... Sandra Junglen
    Analysis of naturally infected mosquitoes shows that ecosystem disturbance can lead to a turnover in host community composition and that more individuals of a single species are a key driver of virus emergence.
    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J. Fothergill ... Gene W. Yeo
    1. Neuroscience

    Attention Modulates Human Visual Responses to Objects by Tuning Sharpening

    Narges Doostani, Gholam-Ali Hossein-Zadeh ... Maryam Vaziri-Pashkam
    1. Neuroscience

    Neurofeedback training can modulate task-relevant memory replay in rats

    Anna K. Gillespie, Daniela A. Astudillo Maya ... Loren M. Frank
    1. Cell Biology

    Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

    Marta Bicka, Corbin Black ... Dorota Wloga
    1. Neuroscience

    Spectrally and temporally resolved estimation of neural signal diversity

    Pedro A.M. Mediano, Fernando E. Rosas ... Daniel Bor
    1. Neuroscience

    Robust Optogenetic Inhibition with Red-light-sensitive Anion-conducting Channelrhodopsins

    Johannes Oppermann, Andrey Rozenberg ... Peter Hegemann
    1. Neuroscience

    Cortical Plasticity is associated with Blood-Brain-Barrier Modulation

    Evyatar Swissa, Uri Monsonego ... Alon Friedman
    1. Developmental Biology
    2. Neuroscience

    Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

    Agnik Dasgupta, Caleb C. Reagor ... A. J. Hudspeth
    1. Neuroscience

    Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss

    Yaoxuan Wang, Mengda Jiang ... Hao Wu
    Innovative MRI mapping of the auditory pathway reveals that peripheral auditory structure significantly impacts the development of the central auditory-language network in children with profound sensorineural hearing loss, emphasizing the need for early speech input and tailored interventions.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

    Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
    An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

    Tao Zhang, Liyang Wan ... Hongbin Lu
    Single-cell RNA sequencing to delineate the comprehensive postnatal RC enthesis growth from as early as postnatal day 1 to postnatal day 56.
    1. Immunology and Inflammation
    2. Neuroscience

    Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus

    René Lemcke, Christine Egebjerg ... Birgitte R Kornum
    Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.
    1. Cell Biology
    2. Computational and Systems Biology

    Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

    Breanne Sparta, Nont Kosaisawe ... John G Albeck
    Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of cellular metabolism.
    1. Neuroscience

    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming

    Jie Yang, Ruijun Tang ... Liming Wang
    Exposure to high-sugar diet in Drosophila resulted in the suppression of sweet sensitivity and feeding behavior in the offspring via altered epigenetic modifications on the histone, highlighting sustained impact of ancestral experience on the physiology and health of offspring.
    1. Epidemiology and Global Health

    A rapid review of COVID-19’s global impact on breast cancer screening participation rates and volumes from January to December 2020

    Reagan Lee, Wei Xu ... Jonine Figueroa
    A reduction in breast screening participation volume during COVID-19 that differed by region and healthcare setting was observed in a rapid review of 26 studies globally, suggesting monitoring of screening access by disadvantaged groups to reduce disparities.
    1. Neuroscience

    Bayesian analysis of phase data in EEG and MEG

    Sydney Dimmock, Cian O'Donnell, Conor Houghton
    A Bayesian model of phase angles illustrates a novel approach to the analysis of phase coherence in frequency-tagged experiments.
    1. Biochemistry and Chemical Biology

    Human Lantern Ribozymes: Smallest Known Self-cleaving Ribozymes

    Yaoqi Zhou, Zhe Zhang ... Jian Zhan
    1. Developmental Biology
    2. Genetics and Genomics

    Fat body-specific reduction of CTPS alleviates HFD-induced obesity

    Jingnan Liu, Yuanbing Zhang ... Ji-Long Liu
    Genetic interaction and biochemical analyses have unveiled the crucial involvement of CTPS in the regulation of adipocyte growth, lipid metabolism, and metabolic adaptation in Drosophila, achieved through activating the PI3K-Akt-SREBP pathway.
    1. Cell Biology
    2. Neuroscience

    Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

    Aygul Subkhangulova, Miguel A Gonzalez-Lozano ... Matthijs Verhage
    SNARE protein tomosyn differentially affects two main secretory pathways in mammalian neurons.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy

    Haoyan Huang, Meng Qian ... Zongjin Li
    Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.
    1. Developmental Biology

    Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

    Pankaj Sahai-Hernandez, Claire Pouget ... David Traver
    A rare population of endothelial cells emerges from a bipotent muscle progenitor population in the paraxial mesoderm and provides niche support to induce hematopoietic stem cells.
    1. Developmental Biology

    Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin

    Andrew J Aman, Lauren M Saunders ... David M Parichy
    Single-cell transcriptomics enables functional dissection of signaling interactions that drive morphogenesis of complex organ systems.
    1. Neuroscience

    Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo

    Carolin Gehr, Jeremie Sibille, Jens Kremkow
    Excitatory and inhibitory neurons in the mouse superior colliculus receive comparably strong inputs from retinal ganglion cells, in contrast to the thalamocortical system.
    1. Computational and Systems Biology

    A transfer-learning approach to predict antigen immunogenicity and T-cell receptor specificity

    Barbara Bravi, Andrea Di Gioacchino ... Rémi Monasson
    An interpretable machine learning approach can recapitulate the molecular features associated to immune protein-protein binding and leverage them for the prediction of immune response specificity.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Influenza virus transcription and progeny production are poorly correlated in single cells

    David J Bacsik, Bernadeta Dadonaite ... Jesse D Bloom
    Quantification of both viral transcription and progeny production from single influenza-infected cells shows that the cells that produce the most viral RNA often do not produce the most virions.
    1. Genetics and Genomics
    2. Neuroscience

    Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons

    Yoshifumi Sonobe, Soojin Lee ... Paschalis Kratsios
    Mutational analysis in cell-based models of C9ORF72 ALS/FTD identifies canonical translation initiation codons (AUG) on the antisense CCCCGG transcript as initiation sites for synthesis of neurotoxic dipeptide repeat proteins.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

    Yanqiu Li, Feifei Wang ... Aimin Peng
    The initiation of DNA damage checkpoint recovery involves ATM-mediated E3 ubiquitin ligase E6AP phosphorylation which disrupts E6AP-MASTL association and leads to MASTL protein accumulation and cell cycle resumption.
    1. Medicine

    Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

    Hong Zheng, Qianjin Li ... Cheng-Kui Qu
    The balanced utilization of energy sources, namely carbohydrates and fats, by mitochondria, is critically important for the long-term maintenance of both skeletal muscle and heart health.
    1. Computational and Systems Biology
    2. Neuroscience

    Task-dependent optimal representations for cerebellar learning

    Marjorie Xie, Samuel P Muscinelli ... Ashok Litwin-Kumar
    Classical theoretical approaches to studying the cerebellar cortex are generalized to a broader set of learning tasks, revealing that the optimal value for the sparsity of granule cell activity is task-dependent.
    1. Medicine

    Gender differences in submission behavior exacerbate publication disparities in elite journals

    Isabel Basson, Chaoqun Ni ... Vincent Larivière
    1. Cell Biology

    Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen

    Rachel Sharninghausen, Jiwon Hwang ... Ryan D. Baldridge
    1. Neuroscience

    Memory at your fingertips: how viscoelasticity affects tactile neuron signaling

    Hannes P. Saal, Ingvars Birznieks, Roland S. Johansson
    1. Evolutionary Biology

    Evidence for adolescent length growth spurts in bonobos and other primates highlights the importance of scaling laws

    Andreas Berghaenel, Jeroen MG Stevens ... Verena Behringer
    Scaling laws reveal the presence of adolescent growth spurts in bonobos and potentially in other non-human primates, challenging the notion of these spurts as a uniquely human trait and emphasizing the need to consider scaling laws when interpreting growth patterns.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of human RPA70N association with DNA damage response proteins

    Yeyao Wu, Wangmi Fu ... Chun Zhou
    Structural characterization of human RPA70N association with a series of DNA damage response proteins reveals versatile protein interaction mechanisms that help to recruit DNA repair proteins to the damage site quickly and efficiently.
    1. Neuroscience

    Manganese-enhanced magnetic resonance imaging reveals light-induced brain asymmetry in embryo

    Elena Lorenzi, Stefano Tambalo ... Angelo Bifone
    The protocol reported can open the way to investigation of the effects of a variety of sensory stimulations on brain activity in embryo.
    1. Cancer Biology
    2. Computational and Systems Biology

    Spatial transformation of multi-omics data unlocks novel insights into cancer biology

    Mateo Sokač, Asbjørn Kjær ... Nicolai J Birkbak
    GENIUS provides a deep learning framework for multi-omics integration that transforms data into spatial images, using integrated gradients to reveal novel and critical cancer gene association.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    FOXP2 confers oncogenic effects in prostate cancer

    Xiaoquan Zhu, Chao Chen ... Yanyang Zhao
    FOXP2, encoding a forkhead-box transcription factor regarded as vital to proper development of human speech, was revealed to have an oncogenic potential and activate MET signaling in prostate cancer.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dissecting the phase separation and oligomerization activities of the carboxysome positioning protein McdB

    Joseph L Basalla, Claudia A Mak ... Anthony G Vecchiarelli
    Carbon-fixing organelles, called carboxysomes, link to their spatial organization system in the bacterial cell by a hexameric protein that forms pH-dependent condensates via a nuanced multidomain mechanism.
    1. Developmental Biology

    Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons

    Wei Liu, Rupendra Shrestha ... Ludovic Spaeth
    Organoids are useful in studying guidance cues for retinal ganglion cell (RGC) axon generation and regeneration, and the method of RGC isolation via CNTN2 facilitates investigating RGC-related retinal diseases such as glaucoma.
    1. Cell Biology
    2. Developmental Biology

    Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress

    Ukrae H Cho, Martin W Hetzer
    The nuclear pore complex is transiently proteolyzed during cell differentiation and the nuclear proteome experience dramatic change.
    1. Epidemiology and Global Health
    2. Medicine

    Examining the perceived impact of the COVID-19 pandemic on cervical cancer screening practices among clinicians practicing in Federally Qualified Health Centers: A mixed methods study

    Lindsay Fuzzell, Paige Lake ... Rebecca Perkins
    In late 2021 and early 2022, many clinicians in Federally Qualified Health Centers (FQHCs) reported reduced cervical cancer screening and reported that pandemic-related staffing shortages impacted screening and follow-up.
    1. Epidemiology and Global Health

    The role of migration networks in the development of Botswana’s generalized HIV epidemic

    Janet Song, Justin T Okano ... Sally Blower
    Complex migration networks can help explain the development of generalized HIV epidemics in sub-Saharan Africa.
    1. Chromosomes and Gene Expression

    A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

    R Samuel Herron, Alexander K Kunisky ... Hun-Way Hwang
    Genetics and biochemical analyses reveal an evolutionarily conserved mechanism to regulate gene isoform expression by mTORC1 and implicate possible gene isoform imbalance in cancer and neurological disorders with mTORC1 pathway dysregulation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A cell wall synthase accelerates plasma membrane partitioning in mycobacteria

    Takehiro Kado, Zarina Akbary ... M Sloan Siegrist
    A newly established reversible model of membrane departitioning and repartitioning in bacteria uncovers the role of a cell wall synthase in regulating membrane partitioning.
    1. Neuroscience

    Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells

    Robert Machold, Shlomo Dellal ... Bernardo Rudy
    Id2 GABAergic interneurons represent a fourth major group of local inhibitory neurons that includes neurogliaform cells, and these neurons can be targeted using intersectional genetics, revealing their distinctive connectivity and in vivo activity properties.
    1. Neuroscience

    Large depth differences between target and flankers can increase crowding: Evidence from a multi-depth plane display

    Samuel P Smithers, Yulong Shao ... Peter J Bex
    Visual crowding from clutter outside the limits of binocular fusion can still have a significant impact on object recognition and visual perception in the peripheral field.
    1. Neuroscience

    Precise Spatial Tuning of Visually Driven Alpha Oscillations in Human Visual Cortex

    Kenichi Yuasa, Iris I.A. Groen ... Jonathan Winawer
    1. Evolutionary Biology

    Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus

    E. Genzoni, T. Schwander, L. Keller
    1. Neuroscience
    2. Computational and Systems Biology

    Modeled grid cells aligned by a flexible attractor

    Sabrina Benas, Ximena Fernandez, Emilio Kropff
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling

    Miguel A Maria-Solano, Sun Choi
    Deciphering the dynamics of the allosteric communication and the formation of transient pockets along the activation pathway of G-protein-coupled receptors provides useful information for the design of allosteric modulators.
    1. Epidemiology and Global Health

    Examining the association of clinician characteristics with perceived changes in cervical cancer screening and colposcopy practice during the COVID-19 pandemic: a mixed methods assessment

    Lindsay Fuzzell, Naomi C Brownstein ... Rebecca B Perkins
    Reductions in cervical cancer screening and colposcopy among nearly half of surveyed clinicians more than a year into the COVID-19 pandemic raise concerns that inadequate screening and follow-up will lead to future increases in preventable cancers.

Magazine

    1. Evolutionary Biology

    Phenotypic Evolution: Predicting the future

    Greg M Walter, Katrina McGuigan
    1. Cancer Biology
    2. Cell Biology

    Cancer Survivorship: Protecting the heart

    Joshua M Inglis, Arduino A Mangoni