December 2024

Cover articles

    1. Immunology and Inflammation

    Recruiting neutrophils

    Matteo Napoli, Roland Immler ... Monika Pruenster
    1. Genetics and Genomics

    Growth factor signaling

    Thomas E Forman, Marcin P Sajek ... Katherine A Fantauzzo
    1. Evolutionary Biology

    Making the most of plant DNA

    Dario Galanti, Jun Hee Jung ... Oliver Bossdorf
    1. Stem Cells and Regenerative Medicine

    Bone repair in aged mice

    Joshua Reeves, Pierre Tournier ... Shukry J Habib

Highlights controls:

Research articles

    1. Cell Biology
    2. Genetics and Genomics

    DNA replication in primary hepatocytes without the six-subunit ORC

    Róża K Przanowska, Yuechuan Chen ... Anindya Dutta
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Screening Envelope Genes Across Primate Genomes Reveals Evolution and Diversity Patterns of Endogenous Retroviruses

    Saili Chabukswar, Nicole Grandi ... Enzo Tramontano
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    Leonid Peshkin, Enrico Maria Daldello ... Catherine Jessus
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Medicine

    JAK inhibition decreases the autoimmune burden in Down syndrome

    Angela L Rachubinski, Elizabeth Wallace ... Joaquín M Espinosa
    Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in individuals with Down syndrome.
    1. Immunology and Inflammation

    Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

    Miki Kume, Hanako Koguchi-Yoshioka ... Rei Watanabe
    Downregulation of Sema4A in keratinocytes induces psoriatic non-lesional features, with its signaling cascades potentially triggering psoriasis and serving as targets for treatment and prevention.
    1. Structural Biology and Molecular Biophysics

    The known unknowns of the Hsp90 chaperone

    Laura-Marie Silbermann, Benjamin Vermeer ... Katarzyna Tych
    An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The fate of pyruvate dictates cell growth by modulating cellular redox potential

    Ashish G Toshniwal, Geanette Lam ... Jared Rutter
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth

    Flavie Coquel, Sing-Zong Ho ... Philippe Pasero
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Neuroscience

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Flamingo participates in multiple models of cell competition

    Pablo Sanchez Bosch, Bomsoo Cho, Jeffrey D Axelrod
    In Drosophila, the planar cell polarity protein Flamingo is required by winners to maintain their status during cell competition in multiple models as they compete to occupy excessive territory within wildtype tissues.
    1. Immunology and Inflammation

    TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

    Nincy Debeuf, Sahine Lameire ... Bart N Lambrecht
    Rationalized selection of responsive TCR clones by single-cell analysis to aid in the generation of novel TCR transgenic animals.
    1. Neuroscience

    Aberrant auditory prediction patterns robustly characterize tinnitus

    Lisa Reisinger, Gianpaolo Demarchi ... Nathan Weisz
    Alterations of auditory prediction patterns were robustly found in tinnitus using two independent samples.
    1. Immunology and Inflammation
    2. Medicine

    NK cell exhaustion in Wilson’s disease revealed by single-cell RNA sequencing predicts the prognosis of cholecystitis

    Yong Jin, Jiayu Xing ... Qingsheng Yu
    Metabolic abnormalities in hepatocytes cause the alteration of transcriptional profile and function of immune cells in the tissue microenvironment.
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle

    Chiara Tomasini, Celine Cuche ... Francesca Di Nunzio
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells

    Mate Sumegi, Gaspar Olah ... Zoltan Nusser
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty

    Gaqi Tu, Peiying Wen ... Kaori Takehara-Nishiuchi
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Neural adaptation to the eye’s optics through phase compensation

    Antoine Barbot, John T Pirog ... Geunyoung Yoon
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Axonal injury signaling is restrained by a spared synaptic branch

    Laura J Smithson, Juliana Zang ... Catherine A Collins
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Female Moths Incorporate Plant Acoustic Emissions into Their Oviposition Decision-Making Process

    Rya Seltzer, Guy Zer Eshel ... Yossi Yovel
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist

    Diana M Karosas, Leslie Gonzales ... Kenneth S Henry
    Not revised
    Reviewed Preprint v1
    1. Epidemiology and Global Health

    A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass Index

    Zhu Liduzi Jiesisibieke, Io Ieong Chan ... C Mary Schooling
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of adapting pathogens and host immunity

    Pierre Barrat-Charlaix, Richard A Neher
    Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
    1. Structural Biology and Molecular Biophysics

    N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

    Chuchu Wang, Chunyu Zhao ... Cong Liu
    NMR and clustering results show that N-terminal acetylation of α-syn enhances its binding to the neutral phospholipid lysophosphatidylcholine, thereby promoting its function of clustering synaptic vesicles.
    1. Cancer Biology

    Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

    Yiwei Huang, Gujie Wu ... Cheng Zhan
    Chemotherapy remodels lung adenocarcinoma’s tumor microenvironment by driving metabolic reprogramming and shifting immune cell functions to modulate tumor progression and immune responses.
    1. Biochemistry and Chemical Biology

    Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

    Yingjie Sun, Changheng Li ... Youngnam N Jin
    Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, successfully identifying SEPHS2 and VPS37C as targets for dasatinib and hydroxychloroquine, respectively.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

    Raji E Joseph, Thomas E Wales ... Amy H Andreotti
    The clinically approved BTK kinase active site inhibitors alter the conformational equilibrium of full-length BTK in distinct and unexpected ways.
    1. Cancer Biology
    2. Cell Biology

    TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

    Maojin Tian, Le Yang ... Peiqing Zhao
    The TIPE/PKM2/HIF-1α signaling pathway plays a crucial role in enhancing cancer stem cell properties by facilitating glycolysis, thereby presenting a promising therapeutic target for melanoma intervention.
    1. Genetics and Genomics

    A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

    Fan Zhang, Annie Lee ... Hong Xu
    A genetic screen and combined bioinformatic analyses revealed multiple novel transcription factors and their hierarchical organization in coordinating mitochondrial biogenesis.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
    1. Neuroscience

    Learning enhances behaviorally relevant representations in apical dendrites

    Sam E Benezra, Kripa B Patel ... Randy M Bruno
    Reinforcement learning produces long-lasting realignment of layer 1 apical dendrite tuft responses to behaviorally relevant task dimensions, both rewarded and unrewarded.
    1. Neuroscience

    Three-dimensional single-cell transcriptome imaging of thick tissues

    Rongxin Fang, Aaron Halpern ... Xiaowei Zhuang
    By integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH), deep learning, optical sectioning, and protocol optimization, thick-tissue 3D MERFISH allows volumetric single-cell transcriptome imaging of thick-tissue samples, broadening the scope of applications of spatial genomics.
    1. Ecology
    2. Evolutionary Biology

    Passive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses

    Rebecca D Tarvin, Jeffrey L Coleman ... Richard W Fitch
    The detection of low quantities of alkaloids in putatively nontoxic species of poison frogs sheds light on early evolutionary stages of chemical defense in animals.
    1. Cancer Biology

    Oncogenic and teratogenic effects of p53Y217C, a mouse model of the human hotspot mutant p53Y220C

    Sara Jaber, Eliana Eldawra ... Franck Toledo
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Neuroscience

    Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function

    Caleb CS Calhoun, Mary ES Capps ... Summer B Thyme
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Cancer Biology

    Monitoring of Cell-free Human Papillomavirus DNA in Metastatic or Recurrent Cervical Cancer: Clinical Significance and Treatment Implications

    Zhuomin Yin, Tao Feng ... Hanmei Lou
    Not revised
    Reviewed Preprint v1
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

    Li Tian, Zirui Liu ... Zhaolong Li
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

    Shengsheng Zhao, Ji Lin ... Weijian Sun
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells

    David Oestreicher, Shashank Chepurwar ... Tina Pangrsic
    Analysis of Cabp1/2 double knockout phyenotype and rescue by viral delivery of Cabp2 identifies the interplay between two CaBPs to promote sustained synaptic transmission at the inner hair cell synapses.
    1. Cancer Biology

    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

    Fan Sun, Pengrong Yan ... Zhaoxia Qu
    The novel PDLIM2 nanomedicine enhances chemoimmunotherapy for complete cure of lung cancer.
    1. Genetics and Genomics

    Accurate predictions of SARS-CoV-2 infectivity from comprehensive analysis

    Jongkeun Park, WonJong Choi ... Dongwan Hong
    Big data analysis, protein structure prediction, and artificial intelligence are integrated to predict novel and highly transmissible SARS-CoV-2 variants.
    1. Immunology and Inflammation

    Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis

    Jian Liu, YuYing Jiang ... ZhiQiang Yin
    Gasdermin D-mediated neutrophil pyroptosis plays an important role in driving inflammation in psoriasis, which unravels new pathogenesis of psoriasis and provides new insights into psoriasis treatment by targeting neutrophil pyroptosis.
    1. Cell Biology

    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

    Zewei Zhao, Longyun Hu ... Zhonghan Yang
    ADGRA3 signaling promotes adipose thermogenesis via Gs-PKA-CREB, suggesting hesperetin and ADGRA3 overexpression as obesity therapies.
    1. Neuroscience

    The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

    Lian Hollander-Cohen, Omer Cohen ... Berta Levavi-Sivan
    Genetic loss-of-function approaches and functional calcium imaging reveal cholecystokinin as the primary regulator of follicle-stimulating hormone in zebrafish, redefining our understanding of gonadotropin regulation in vertebrates.
    1. Neuroscience

    Bridging the gap between presynaptic hair cell function and neural sound encoding

    Lina María Jaime Tobón, Tobias Moser
    Synaptic diversity in the ear's inner hair cells significantly empowers sound encoding to enable our processing of sounds across a broad range of intensities.
    1. Neuroscience

    A multisite validation of brain white matter pathways of resilience to chronic back pain

    Mina Mišić, Noah Lee ... Herta Flor
    The structural integrity of the right superior longitudinal fasciculus was identified as a neuroimaging predictor of chronic back pain, with potential for clinical translation.
    1. Evolutionary Biology

    Horizontally transferred cell-free chromatin particles function as autonomous “predatory” genomes and vehicles for transposable elements within host cells

    Soumita Banerjee, Soniya Shende ... Indraneel Mittra
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Naa10 regulates hippocampal neurite outgrowth via Btbd3 N-α-acetylation-mediated actin dynamics

    Chien-Te Chou, Ming-Lun Kang ... Li-Jung Juan
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism

    Priyojit Das, Rebeca San Martin ... Rachel Patton McCord
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Unique longitudinal contributions of sulcal interruptions to reading acquisition in children

    Florence Bouhali, Jessica Dubois ... Kevin S Weiner
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Prefoldin 5 is a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicity

    Anjali Bisht, Srikanth Pippadpally ... Vimlesh Kumar
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression

    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

    Ashwin Govindan, Nicholas K Conrad
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Different serotonergic neurons regulate appetite for sucrose and hunger for proteins

    Katharina Dorn, Magdalena Gompert ... Henrike Scholz
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Differential destinations, dynamics, and functions of high- and low-order features in the feedback signal during object processing

    Wenhao Hou, Sheng He, Jiedong Zhang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The emergence of visual category representations in infants’ brains

    Xiaoqian Yan, Sarah Shi Tung ... Kalanit Grill-Spector
    Scalp electroencephalography combined with a frequency tagging method reveals that distinct responses to daily categories emerge at different ages in infants.
    1. Neuroscience

    Frequency-specific cortico-subcortical interaction in continuous speaking and listening

    Omid Abbasi, Nadine Steingräber ... Joachim Gross
    Distinct frequency-based interactions between cortical and subcortical regions highlight the cerebellum’s crucial role in speech production and perception.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

    Paolo Petazzi, Telma Ventura ... Antonella Fidanza
    A novel tool is used to assess gene function in vitro by targeted endogenous transcriptional activation to unveil novel players in development and disease.
    1. Microbiology and Infectious Disease

    Virus adaptation to heparan sulfate comes with capsid stability tradeoff

    Han Kang Tee, Simon Crouzet ... Caroline Tapparel
    1. Computational and Systems Biology
    2. Medicine

    Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

    Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez
    Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
    1. Cell Biology

    Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

    John Yong, Jacqueline E Villalta ... Calvin H Jan
    Genome-wide CRISPRi screens and proteome profiling of lysosomes link lipid dysregulation to ESCRT disruption and proteostasis defect.
    1. Cell Biology
    2. Medicine

    Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway

    Yongli Qin, Jumpei Shirakawa ... Baohong Zhao
    Malat1 is a key skeletal regulator, unveiling how lncRNAs integrate cellular crosstalk and molecular networks to regulate bone remodeling and regeneration, establishing a novel paradigm in tissue homeostasis and repair.
    1. Developmental Biology

    The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo

    Natsuko Emura, Florence DM Wavreil ... Mamiko Yajima
    Activator of G-protein signaling C-terminus serves as a variable element to induce asymmetric cell division, facilitating developmental diversity among species.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

    Desiree Böck, Maria Wilhelm ... Gerald Schwank
    Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
    1. Cell Biology

    Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

    Jarno Mäkelä, Alexandros Papagiannakis ... Christine Jacobs-Wagner
    Genome dilution limits cell growth by modulating the activities, rather than the concentrations, of RNA polymerases and ribosomes, and is accompanied by changes in proteome composition.
    1. Developmental Biology

    Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development

    Pénélope Tignard, Karen Pottin ... Marie Anne Breau
    Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfactory axons.
    1. Ecology

    Vasopressin 1a receptor antagonist disrupts male-male affiliative relationships formed by triadic cohabitation in large-billed crows

    Akiko Seguchi, Ei-Ichi Izawa
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    A fat-2(wa17) suppressor screen in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

    Delaney Kaper, Uroš Radović ... Marc Pilon
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

    Yevheniia Ishchenko, Amanda T Jeng ... Anthony J Koleske
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Neuroprotective role of Hippo signaling by microtubule stability control in C. elegans

    Hanee Lee, Junsu Kang ... Junho Lee
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Developmental Biology

    Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes

    Dylan A Valencia, Angela N Koeberlein ... Margot E Quinlan
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

    Pavla Nedbalova, Nikola Kaislerova ... Tomas Dolezal
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The emergence and evolution of gene expression in genome regions replete with regulatory motifs

    Timothy Fuqua, Yiqiao Sun, Andreas Wagner
    Mutagenizing sequences enriched with promoter motifs creates gene expression de novo, and helps to understand promoter logic, regulatory evolution, and the birth of de novo genes.
    1. Structural Biology and Molecular Biophysics

    Streamlining segmentation of cryo-electron tomography datasets with Ais

    Mart GF Last, Leoni Abendstein ... Thomas H Sharp
    The software package Ais simplifies automated segmentation in cryo-electron tomography, enabling users to segment, detect particles, and visualize data in a streamlined and accessible workflow.
    1. Cell Biology
    2. Neuroscience

    A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit

    Jun Sun, Francisca Rojo-Cortes ... Alicia Hidalgo
    A novel molecular mechanism linking a neurotrophin with a Toll-family and kinase-less Trk-like receptors provides a direct link from molecules to structural circuit plasticity and modification of behaviour.
    1. Computational and Systems Biology

    Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

    Dylan C Sarver, Muzna Saqib ... G William Wong
    Mitochondrial respiration atlas reveals functional signatures of aging across diverse tissues and organ systems.
    1. Medicine
    2. Microbiology and Infectious Disease

    The effect of combining antibiotics on resistance: A systematic review and meta-analysis

    Berit Siedentop, Viacheslav N Kachalov ... Sebastian Bonhoeffer
    A systematic review shows no evidence of harm or benefit of antibiotic combinations on resistance evolution as clinical data lack statistical power to draw definitive conclusions, highlighting a knowledge gap.
    1. Cell Biology

    Inclusive, exclusive and hierarchical atlas of NFATc1+/PDGFR-α+ cells in dental and periodontal mesenchyme

    Xue Yang, Chuyi Han ... Fanyuan Yu
    The inclusive, exclusive, and hierarchical atlas of NFATc1+/PDGFR-α+ cells in dental and periodontal mesenchyme is described.
    1. Structural Biology and Molecular Biophysics

    CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples

    Johannes Elferich, Lingli Kong ... Nikolaus Grigorieff
    CTFFIND5 estimates the thickness and tilt of cryogenic electron microscopy samples directly from the power spectrum of a single exposure.
    1. Neuroscience

    A neuronal least-action principle for real-time learning in cortical circuits

    Walter Senn, Dominik Dold ... Mihai A Petrovici
    A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
    1. Cell Biology

    Vesiculation pathways in clathrin-mediated endocytosis

    Xinran Wang, Julien Berro, Rui Ma
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Does slow oscillation-spindle coupling contribute to sleep-dependent memory consolidation? A Bayesian meta-analysis

    Thea Ng, Eunsol Noh, Rebecca MC Spencer
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Exploiting functional regions in the viral RNA genome as druggable entities

    Dehua Luo, Yingge Zheng ... Dengguo Wei
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Mechanism of expanded DNA recognition in xCas9

    Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Inferring illness causes recruits the animacy semantic network

    Miriam Hauptman, Marina Bedny
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Computational and Systems Biology

    Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

    Hadel Al Asafen, Natalie M Clark ... Gregory T Reeves
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Enzymatic protein fusions with 100% product yield

    Adrian CD Fuchs
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects

    Chien-Hui Lo, Siyu Chen ... Yang Sun
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The Hungry Lens: Hunger Shifts Attention and Attribute Weighting in Dietary Choice

    Jennifer March, Sebastian Gluth
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

    Josse Poppinga, Nolan J Barrett ... Jan RT van Weering
    SNX4 influences synaptic vesicle recruitment at the active zone, linking endosomal sorting to docked vesicle density and modulating neurotransmission efficiency during sustained activity.
    1. Evolutionary Biology

    Discarded sequencing reads uncover natural variation in pest resistance in Thlaspi arvense

    Dario Galanti, Jun Hee Jung ... Oliver Bossdorf
    Aphid and mildew read counts leftover from the sequencing of greenhouse plants correlated with the environment of origin of the plants, and allowed the mapping of pathogen resistance genes.
    1. Neuroscience

    Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

    Mengqiao Cui, Xiaoyuan Pan ... Jun-Li Cao
    RNA-Seq analysis and molecular biological approaches reveal a novel mechanism and provide a promising preventive and therapeutic molecular target for vulnerability to chronic pain-related memory impairment.
    1. Cell Biology
    2. Genetics and Genomics

    Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

    Showkat Ahmad Dar, Sulochan Malla ... Manolis Maragkakis
    Cellular stress induces RNA decay that depends on stress granule assembly and is mediated by XRN1, independent of poly(A) tail and 5' cap removal.
    1. Biochemistry and Chemical Biology

    Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism

    Bernd K Gilsbach, Franz Y Ho ... Christian Johannes Gloeckner
    The Parkinson’s protein Leucine-Rich Repeat Kinase 2 contains a GTPase as well as kinase domain and modulates its intrinsic GTPase activity by autophosphorylation of the P-loop residue threonine 1343.
    1. Immunology and Inflammation

    Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

    Matteo Napoli, Roland Immler ... Monika Pruenster
    Cytosolic S100A8/A9 enhances Ca2+ availability at LFA-1 adhesion sites, facilitating neutrophil recruitment and extravasation by supporting proper integrin signaling and cytoskeletal rearrangement.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation

    Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko
    N‑terminus of MSL1 protein, involved in dosage compensation in Drosophila, is required for the interaction with non-coding roX2 RNA and the assembly of the complex on the male X chromosome.
    1. Developmental Biology
    2. Physics of Living Systems

    The geometric basis of epithelial convergent extension

    Fridtjof Brauns, Nikolas H Claussen ... Boris I Shraiman
    Active and passive contributions to cell shape change and rearrangements can be distinguished from observed cell geometry, revealing the self-organization mechanisms underlying internally-driven epithelial convergent extension.
    1. Computational and Systems Biology

    Statistical analysis supports pervasive RNA subcellular localization and alternative 3' UTR regulation

    Rob Bierman, Jui M Dave ... Julia Salzman
    Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.
    1. Physics of Living Systems

    Mapping spatial patterns to energetic benefits in groups of flow-coupled swimmers

    Sina Heydari, Haotian Hang, Eva Kanso
    Fish swimming in groups can either conserve or expend energy during collective movement, depending on their spatial position within the school.
    1. Cancer Biology
    2. Cell Biology

    Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    Zijing Wang, Bihan Xia ... Jilin Yang
    The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
    1. Neuroscience

    NeuroSCAN: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks

    Noelle L Koonce, Sarah E Emerson ... Daniel Colón-Ramos
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

    Atsushi Matsumoto, Akihito Inoko ... Junichi Ikenouchi
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Protective effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Dissociable dynamic effects of expectation during statistical learning

    Hannah H McDermott, Federico De Martino ... Ryszard Auksztulewicz
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    High-throughput unsupervised quantification of patterns in the natural behavior of marmosets

    William Menegas, Erin Corbett ... Guoping Feng
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Dissociable after-effects of prosocial acts: Effort is costly for others but valued for self

    Ya Zheng, Rumeng Tang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Mother-child dyadic interactions shape children’s social brain and theory of mind

    Lei Li, Jinming Xiao ... Xujun Duan
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Tachykinin1-expressing neurons in the parasubthalamic nucleus control active avoidance learning

    Ruining Hu, Nannan Wu ... Rongfeng K Hu
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Circadian control of a sex-specific behaviour in Drosophila

    Sabrina Riva, M Fernanda Ceriani ... D Lorena Franco
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

    Dipasree Hajra, Raju S Rajmani ... Dipshikha Chakravortty
    SIRT1 and SIRT3-mediated immunometabolic shift governs intracellular Salmonella proliferation both in vitro and in vivo and dissemination in mice, thereby influencing the infection outcomes.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations

    Lucia Csepregi, Kenneth Hoehn ... Sai T Reddy
    Systems analysis of antibody repertoires reveals that strong humoral responses lead to extensive B-cell overlap across multiple lymphoid organs, indicating physiological axes of B-cell migration and a direct correlation with antigen specificity.
    1. Stem Cells and Regenerative Medicine

    Rejuvenating aged osteoprogenitors for bone repair

    Joshua Reeves, Pierre Tournier ... Shukry J Habib
    Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.
    1. Evolutionary Biology

    New soft tissue data of pterosaur tail vane reveals sophisticated, dynamic tensioning usage and expands its evolutionary origins

    Natalia Jagielska, Thomas G Kaye ... Michael Pittman
    Laser-stimulated fluorescence (LSF) imaging of early pterosaurs uncovers new soft tissue data of tail vane that reveals sophisticated, dynamic tensioning usage and expands its evolutionary origins.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens

    Vera Vollenweider, Karoline Rehm ... Rolf Kümmerli
    Iron-chelating pyoverdines from environmental Pseudomonas spp. show promising antibacterial activity against key human pathogens through the induction of iron starvation, while associated toxicity for host systems remains low.
    1. Neuroscience

    Drosulfakinin signaling encodes early-life memory for adaptive social plasticity

    Jiwon Jeong, Kujin Kwon ... Chunghun Lim
    1. Cancer Biology

    A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer

    Bruno Bockorny, Lakshmi Muthuswamy ... Senthil K Muthuswamy
    Proteomic profiling of extracellular vesicle proteins from patients with benign and malignant pancreatic diseases offers a valuable resource for identifying biomarkers for pancreatic cancer detection.
    1. Structural Biology and Molecular Biophysics

    An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein

    Sneha Menon, Subinoy Adhikari, Jagannath Mondal
    Interaction of small molecule expands the conformational ensemble of alpha synuclein.
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics of a nicotinic receptor neurotransmitter site

    Mrityunjay Singh, Dinesh C Indurthi ... Shailendra Asthana
    MD-simulations reveal low- to high-affinity conformational shift of orthosteric site in the nicotinic acetylcholine receptor, offering insight into agonist roles in activation dynamics, and highlighting the utility of agonist efficiency.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

    Lan Yao, Wanwan Zhang ... Kuntong Jia
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Change point estimation by the mouse medial frontal cortex during probabilistic reward learning

    Cayla E Murphy, Hongli Wang ... Huriye Atilgan
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Harnessing AlphaFold to reveal hERG channel conformational state secrets

    Khoa Ngo, Pei-Chi Yang ... Igor Vorobyov
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Non-linear transcriptional responses to gradual modulation of transcription factor dosage

    Júlia Domingo, Mariia Minaeva ... Tuuli Lappalainen
    Not revised
    Reviewed Preprint v1
    1. Evolutionary Biology

    Recombination shapes the diversification of the wtf meiotic drivers

    Yan Wang, Hao Xu ... Guan-Zhu Han
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity

    Xiaodan Yan, Hebin Liao ... Yingying Pu
    RiboD-PETRI, a cost-effective, equipment-free plate-based scRNA-seq technique that integrates a unique bacterial rRNA depletion protocol, significantly enhancing mRNA detection rate and revealing within-population heterogeneity, offering valuable insights for research applications.
    1. Structural Biology and Molecular Biophysics

    Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

    Aivaras Vaškevičius, Denis Baronas ... Daumantas Matulis
    A series of compounds were synthesized and demonstrated to form a specific covalent bond with His64 of CAIX, an anticancer target, a strategy applicable to any drug design project.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Control of 3′ splice site selection by the yeast splicing factor Fyv6

    Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
    The Saccharomyces cerevisiae spliceosome component Fyv6 contributes to precursor messenger RNA splicing by promoting use of branch site distal 3' splice sites and interacting with key factors involved in exon ligation.
    1. Genetics and Genomics
    2. Neuroscience

    Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

    Thomas P Spargo, Lachlan Gilchrist ... Alfredo Iacoangeli
    Pleiotropic loci that play a role in multiple neuropsychiatric diseases exist, but many of them might contribute to each disease via a distinct mechanism.
    1. Neuroscience

    Restoring vestibular function during natural self-motion: Progress and challenges

    Kantapon Pum Wiboonsaksakul, Olivia ME Leavitt Brown, Kathleen E Cullen
    Fully incorporating our current understanding of vestibular neurophysiology into prosthesis design and clinical application will be integral to the development of the next generation of vestibular prostheses.
    1. Cancer Biology
    2. Evolutionary Biology

    Characterization of cancer-driving nucleotides (CDNs) across genes, cancer types, and patients

    Lingjie Zhang, Tong Deng ... Hai-Jun Wen
    Analyses of discovered cancer-driving nucleotides (CDNs) reveal their evolutionary, biochemical, and therapeutic characteristics that are often shared among multiple cancer types.
    1. Cancer Biology
    2. Evolutionary Biology

    The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)

    Lingjie Zhang, Tong Deng ... Chung-I Wu
    A mathematical model shows that mutations that recur even modestly among cancer patients are cancer driving nucleotides that can be exhaustively identified to serve as targets of cancer therapy.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

    Arkadiy K Golov, Alexey A Gavrilov ... Sergey V Razin
    A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.
    1. Cell Biology
    2. Medicine

    Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

    Judith Hüttemeister, Franziska Rudolph ... Michael Gotthardt
    Titin’s regulated integration and mobility after cell fusion support syncytium formation in culture, while limited diffusion in vivo highlights a key challenge for developing effective cell-based therapies for skeletal muscle diseases.
    1. Neuroscience

    Midbrain encodes sound detection behavior without auditory cortex

    Tai-Ying Lee, Yves Weissenberger ... Johannes C Dahmen
    Behavior is a major determinant of the activity of auditory midbrain neurons and can shape their responses independently of input from the auditory cortex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    Glucocorticoids desensitize hypothalamic CRH neurons to norepinephrine and somatic stress activation via rapid nitrosylation-dependent regulation of α1 adrenoreceptor trafficking

    Grant L Weiss, Laura M Harrison ... Jeffrey Tasker
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Q-Learning to navigate turbulence without a map

    Marco Rando, Martin James ... Agnese Seminara
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

    Nelson V Simwela, Eleni Jaecklein ... David G Russell
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Attention modulates human visual responses to objects by tuning sharpening

    Narges Doostani, Gholam-Ali Hossein-Zadeh ... Maryam Vaziri-Pashkam
    Attentional modulation is affected by target-distractor similarity, indicating tuning sharpening as the underlying mechanism for response enhancement during object-based attention.
    1. Neuroscience

    Identification of an early subset of cerebellar nuclei neurons in mice

    Maryam Rahimi-Balaei, Shayan Amiri ... Hassan Marzban
    A distinct subset of cerebellar nuclei neurons originates from a previously unrecognized germinal zone within the cerebellar primordium, independent of Atoh1 influence, highlighting new cellular origins in cerebellar development.
    1. Neuroscience

    Contributions of associative and non-associative learning to the dynamics of defensive ethograms

    Quan-Son Eric Le, Daniel Hereford ... Jonathan P Fadok
    Associative and non-associative learning mechanisms summate to produce robust and complex conditioned behavior profiles, opening new avenues to in-depth investigations of defensive responses and threat evaluation.
    1. Cell Biology
    2. Neuroscience

    A spatial threshold for astrocyte calcium surge

    Justin Lines, Andres Baraibar ... Alfonso Araque
    In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integration of time and space.
    1. Ecology
    2. Neuroscience

    Unsupervised discovery of family specific vocal usage in the Mongolian gerbil

    Ralph E Peterson, Aman Choudhri ... Dan H Sanes
    Gerbils exhibit stable, family-specific vocal dialects over weeks, suggesting vocal communication may play a key role in representing kinship in natural social groups.
    1. Neuroscience

    Microstructural asymmetries of the planum temporale predict functional lateralization of auditory-language processing

    Peipei Qin, Qiuhui Bi ... Gaolang Gong
    The important role of structural asymmetry in the functional lateralization of the same brain area provides a crucial insight into the neurobiological fundament for human brain's functional lateralization.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

    Eyal Paz, Sahil Jain ... Abdussalam Azem
    TIM23 core deficiency specifically impacts the oxidative phosphorylation and the mitochondrial ribosome complexes and, unexpectedly, leads to reduction of plasma membrane voltage-dependent potassium channels in neurons.
    1. Neuroscience

    Homeostatic synaptic normalization optimizes learning in network models of neural population codes

    Jonathan Mayzel, Elad Schneidman
    An accurate and efficient biologically plausible statistical model of the spiking activity of neural populations shows computational benefits of homeostatic synaptic scaling in learning large neural population codes.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution

    Felix Lankester, Tito J Kibona ... Sarah Cleaveland
    Livestock abortion surveillance can capture valuable information on important livestock pathogens, including those that are zoonotic and with epidemic potential, revealing importance of timely collection of diagnostic samples for attribution.
    1. Neuroscience

    Distinct release properties of glutamate/GABA co-transmission serve as a frequency-dependent filtering of supramammillary inputs

    Himawari Hirai, Kohtarou Konno ... Yuki Hashimotodani
    Co-release of the functionally opposing fast neurotransmitters, glutamate and GABA, from distinct synaptic vesicles within the same supramammillary synaptic terminal modulates dentate granule cell firing in a frequency-dependent manner.
    1. Cell Biology
    2. Medicine

    Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice

    Shuo He, Lei Huang ... Jinlong He
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Evolutionary Biology

    An evolutionarily conserved Hox-Gbx segmentation code in the rice coral Montipora capitata

    Shuonan He, Emma Rangel-Huerta ... Matthew C Gibson
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    UBR-1 deficiency leads to ivermectin resistance in C. elegans

    Yi Li, Long Gong ... Shangbang Gao
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Physics of Living Systems

    Imaging of brain electric field networks

    Lawrence R Frank, Vitaly L Galinsky ... Antigona Martinez
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland

    Gabriel Magno de Freitas Almeida, Miika Leppänen ... Lotta-Riina Sundberg
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Social Experience Shapes Fighting Strategies for Reproductive Success

    Can Gao, Mingze Ma ... Yufeng Pan
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    The Role of ATP Synthase Subunit e (ATP5I) in Mediating the Metabolic and Antiproliferative Effects of Biguanides

    Guillaume Lefrançois, Emilie Lavallée ... Gerardo Ferbeyre
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18 clamp loader bound to PCNA

    Giuseppina R Briola, Muhammad Tehseen ... Alfredo De Biasio
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Prefrontal working memory signal primarily controls phase-coded information within extrastriate cortex

    Mohsen Parto-Dezfouli, Isabel Vanegas ... Behrad Noudoost
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling

    Benjamin Le Gac, Marine Tournissac ... Bruno Cauli
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Not revised
    Reviewed Preprint v1
    1. Stem Cells and Regenerative Medicine

    Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical trial

    Shiyu Zhang, Min Zhou ... Wei Zuo
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Correlated spontaneous activity sets up multi-sensory integration in the developing higher-order cortex

    JaeAnn M Dwulet, Nawal Zabouri ... Julijana Gjorgjieva
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Control of pili synthesis and putrescine homeostasis in Escherichia coli

    Iti Mehta, Jacob Hogins ... Larry Reitzer
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

    Eleonore Schiltz, Martijn Broux ... Sebastian Haesler
    Not revised
    Reviewed Preprint v1
    1. Physics of Living Systems

    Physical constraints and biological regulations underlie universal osmoresponses

    Yiyang Ye, Qirun Wang, Jie Lin
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

    Zhiwei Huang, Songhao Luo ... Jiajun Zhang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Progressive neural engagement within the IFG-pMTG circuit as gesture and speech entropy and MI advances

    Wanying Zhao, Zhouyi Li ... Yi Du
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana C Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

    Shek Man Chim, Kristen Howell ... Regeneron Genetics Center
    Loss of the Zinc transporter SLC39A5 protects from obesity-driven hyperglycemia and liver pathology.
    1. Developmental Biology
    2. Neuroscience

    Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier

    Jayanarayanan Sadanandan, Sithara Thomas ... Peeyush Kumar T
    Histone deacetylase 2 (HDAC2) and polycomb repressive complex 2 (PRC2) control endothelial gene expression for BBB development and prevented Wnt/β-catenin target genes from being expressed in adult CNS ECs.
    1. Cell Biology
    2. Physics of Living Systems

    Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum

    Pyae Hein Htet, Edward Avezov, Eric Lauga
    The viscous hydraulics of contracting endoplasmic reticulum networks challenge common solute transport theories, suggesting the contraction of peripheral sheets as a plausible driving mechanism.
    1. Cell Biology
    2. Developmental Biology

    Ciliary length regulation by intraflagellar transport in zebrafish

    Yi Sun, Zhe Chen ... Chengtian Zhao
    The speed of intraflagellar transport, influenced by particle size, shows a positive correlation with ciliary length in zebrafish.
    1. Cell Biology

    Amoeboid cells undergo durotaxis with soft end polarized NMIIA

    Chenlu Kang, Pengcheng Chen ... Congying Wu
    T cells, neutrophils, and protista Dictyostelium undergo amoeboid durotaxis which involves soft end polarized NMIIA.
    1. Developmental Biology

    CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility

    Bingbing Wu, Chenghong Long ... Chao Liu
    CCDC113 is a key structural hub for sperm axoneme and head-tail coupling apparatus (HTCA) stability, with defects leading to male infertility through disruption of sperm flagellar and HTCA integrity.
    1. Developmental Biology

    Cell-autonomous timing drives the vertebrate segmentation clock’s wave pattern

    Laurel A Rohde, Arianne Bercowsky-Rama ... Andrew C Oates
    A noisy cell-intrinsic timer provides positional information for the segmentation clock, modulated by extrinsic factors such as FGF.
    1. Computational and Systems Biology
    2. Neuroscience

    Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

    Jian Qiu, Margaritis Voliotis ... Martin J Kelly
    Kiss1ARH neurons transition from synchronous to burst firing under preovulatory levels of E2, causing a shift from peptidergic to glutamatergic transmission that drives the GnRH surge through enhanced glutamate neurotransmission.
    1. Neuroscience

    Single-cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes

    GVS Devakinandan, Mark Terasaki, Adish Dani
    Developmental specialization of vomeronasal sensory neurons involves selective upregulation of endoplasmic reticulum genes in a subset of neurons along with a hypertrophic gyroid membrane architecture.
    1. Developmental Biology
    2. Neuroscience

    A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome

    Xingsen Zhao, Qihang Sun ... Xuekun Li
    Studies with mice and brain organoids models reveals that dysregulation of GTF2IRD1-TTR-ERK pathway significantly contributes to neuronal deficits of Williams syndrome.
    1. Medicine
    2. Neuroscience

    Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

    Chi Zhang, Qian Huang ... Yun Guan
    The naturally occurring biologics, FLO and HC-HA/PTX3, derived from human birth tissues, may be developed as a much-needed non-opioid therapy for post-surgical pain treatment, leveraging robust neuronal mechanisms.
    1. Developmental Biology
    2. Genetics and Genomics

    Caspar specifies primordial germ cell count and identity in Drosophila melanogaster

    Subhradip Das, Sushmitha Hegde ... Girish S Ratnaparkhi
    During Drosophila primordial germ cells (PGCs) specification, the centrosome and germplasm are subject to regulation, during the maternal zygotic transition, by Caspar/TER94-dependent degradative pathways that influence PGC determinants.
    1. Cell Biology
    2. Neuroscience

    Projection neurons are necessary for the maintenance of the mouse olfactory circuit

    Luis Sánchez-Guardado, Peyman Razavi ... Carlos Lois
    Ablation of olfactory projection neurons in adult mice triggers sprouting of the apical dendrite of remaining neurons towards multiple nearby glomeruli and disrupts the odor map.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

    Amy Tresenrider, Marcus Hooper ... Thomas A Reh
    An in vitro chemical screen with single-cell sequencing output leads to the identification of Metformin as an in vivo enhancer of Muller glia to neuron reprogramming in mice.
    1. Evolutionary Biology

    A systematic review and meta-analysis of eyespot anti-predator mechanisms

    Ayumi Mizuno, Malgorzata Lagisz ... Shinichi Nakagawa
    The efficacy of eyespots in deterring avian predators is more due to their conspicuousness rather than their resemblance to eyes.
    1. Medicine

    Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies

    Sami Fawaz, Severine Marti ... Thierry Couffinhal
    If CHIP and mLOY do not significantly contribute to inflammation, atherosclerosis or myocardial infarction risk independently, CHIP may increase the risk of MI in men who do not carry mLOY.
    1. Developmental Biology

    Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus

    Mohamed El Amri, Abhay Pandit, Gerhard Schlosser
    Marcks and Marcks-like 1 proteins are required for normal neurite formation and proliferation of neuro-glial progenitors during development and regeneration of the Xenopus spinal cord implicating these proteins as critical new factors for spinal cord development and regeneration.
    1. Evolutionary Biology

    The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

    Xuankun Li, Adriana E Marvaldi ... Duane D McKenna
    The evolutionary trajectory of phytophagous weevils reveals how ancient host plant shifts and continental drift influenced the development of diverse insect-plant interactions through time.
    1. Neuroscience

    Rab10 inactivation promotes AMPAR insertion and spine enlargement during long-term potentiation

    Jie Wang, Jun Nishiyama ... Ryohei Yasuda
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Neuroscience

    GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

    Dhanesh Sivadasan Bindu, Justin T Savage ... Cagla Eroglu
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

    Luke J Dillard, Gina M Calabrese ... Charles R Farber
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Beyond gradients: Factorized, geometric control of interference and generalization

    Daniel N Scott, Michael J Frank
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone

    Assmaa ElSheikh, Camden M Driggers ... Show-Ling Shyng
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Elucidating the Selection Mechanisms in Context-Dependent Computation through Low-Rank Neural Network Modeling

    Yiteng Zhang, Jianfeng Feng, Bin Min
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Genetics and Genomics

    Kinesin Autoinhibition Requires Elbow Phosphorylation

    Guanghan Chen, Zhengyang Guo ... Guangshuo Ou
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Minimal background noise enhances neural speech tracking: Evidence of stochastic resonance

    Björn Herrmann
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Associative plasticity of granule cell inputs to cerebellar Purkinje cells

    Rossella Conti, Céline Auger
    Associative plasticity of proximal and distal granule cell inputs to Purkinje cells enables time dependent association of information from local and distant receptive fields.
    1. Computational and Systems Biology

    Emergence of power-law distributions in protein-protein interaction networks through study bias

    David B Blumenthal, Marta Lucchetta ... Martin H Schaefer
    1. Neuroscience

    Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

    Bhanu Shrestha, Jiun Sang ... Youngseok Lee
    Uncovering pharyngeal sour taste receptors in Drosophila melanogaster reveals a novel mechanism for detecting ingested carboxylic acids, expanding understanding of how insects internally sense and respond to appetitive tastants.
    1. Ecology
    2. Microbiology and Infectious Disease

    Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

    Benedikt M Mortzfeld, Shakti K Bhattarai, Vanni Bucci
    12 new class IIb microcins have been structurally identified, phylogenetically assessed, and functionally tested for their antimicrobial activity, increasing the total number of these bacteriocins to 17.
    1. Cancer Biology
    2. Genetics and Genomics

    Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

    Yaroslav Kainov, Fursham Hamid, Eugene V Makeyev
    Somatic mutations frequently disrupt cleavage and polyadenylation signals in tumour suppressor genes in human cancers, likely contributing to tumour progression.
    1. Neuroscience

    Stable sequential dynamics in prefrontal cortex represents subjective estimation of time

    Yiting Li, Wenqu Yin ... Baoming Li
    Time-related sequential activities in prefrontal cortex exhibit stable coding over weeks, while representations of other variables are dynamic, suggesting that neural sequences are consisted of unique group of neurons.
    1. Developmental Biology

    Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification

    Imran S Khan, Christopher Molina ... Dean Sheppard
    Reduced lung myofibroblast proliferation is a unifying feature in multiple models of developmental emphysema and inhibition of myofibroblast proliferation is sufficient to cause this pathology.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

    Amanda Mixon Blackwell, Yasaman Jami-Alahmadi ... Paul A Sigala
    Plasmodium parasites have repurposed the heme oxygenase scaffold from its canonical heme-degrading function to fulfill an essential and adaptive role in gene expression within the apicoplast organelle.
    1. Cell Biology

    Hypersensitive intercellular responses of endometrial stromal cells drive invasion in Endometriosis

    Chun-Wei Chen, Jeffery B Chavez ... Bruce J Nicholson
    1. Neuroscience

    Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive effects

    Brian C Ruyle, Sarah Masud ... Jose A Moron
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A novel image segmentation method based on spatial autocorrelation identifies A-type potassium channel clusters in the thalamus

    Csaba Dávid, Kristóf Giber ... Laszlo Acsady
    The spatial autocorrelation method Local Moran’s I was used for image segmentation to delineate pixel clusters representing congruous objects with fuzzy borders, in this case potassium ion channel clusters.
    1. Cell Biology

    UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

    Satoshi Ninagawa, Masaki Matsuo ... Kazutoshi Mori
    The fate of glycoproteins in the endoplasmic reticulum whether they are directed toward folding or targeted to degradation depends on a tug of war between UGGT1 and EDEM family proteins.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

    Simei Go, Constantinos Demetriou ... Eric O Neill
    Tissue-resident natural killer cells are important mediators of CD8 T responses in human cancers and these cells can be harnessed to increase immunity against pancreatic ductal adenocarcinoma.
    1. Neuroscience

    Male rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning

    Krzysztof Hubert Olszyński, Rafał Polowy ... Robert Kuba Filipkowski
    When exposed to prolonged stressful stimulation, rats start to emit long, frequency-unmodulated 44-kHz ultrasonic vocalizations, usually within the 35–50 kHz range, along with, previously described, long and unmodulated 22-kHz ultrasonic vocalizations.
    1. Chromosomes and Gene Expression

    Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

    Felix Y Zhou, David P Waterman ... James E Haber
    Cell cycle arrest in response to a double-stranded break is initially maintained by the DNA damage checkpoint and later by the spindle assembly checkpoint.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Lipid discovery enabled by sequence statistics and machine learning

    Priya M Christensen, Jonathan Martin ... Kelli L Palmer
    A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.
    1. Neuroscience

    Value construction through sequential sampling explains serial dependencies in decision making

    Ariel Zylberberg, Akram Bakkour ... Michael N Shadlen
    The subjective value of choice options changes during deliberation, and accounting for these changes improves predictions of choices, response times, and BOLD fMRI activity.
    1. Neuroscience

    Semantic relatedness proactively benefits learning, memory, and interdependence across episodes

    Kelly A Bennion, Jade Phong ... James W Antony
    Increasing semantic relationships with old information accelerates learning and enhances memory for new information and increases the likelihood of both old and new information being recalled together.
    1. Developmental Biology

    Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

    Max Henry Hills, Limei Ma ... C Ron Yu
    A transcriptomic atlas of the mouse vomeronasal organ reveals novel receptor co-expression patterns and provides a framework for understanding sensory neuron lineage and receptor specification.
    1. Immunology and Inflammation

    SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

    Somen K Mistri, Brianna M Hilton ... Jonathan E Boyson
    The SLAM/SAP signaling pathway regulates both γδ T cell developmental programming and γδ/αβ T cell lineage commitment.
    1. Structural Biology and Molecular Biophysics

    Ligand-coupled conformational changes in a cyclic nucleotide-gated ion channel revealed by time-resolved transition metal ion FRET

    Pierce Eggan, Sharona E Gordon, William N Zagotta
    Time-resolved tmFRET revealed structural and energetic changes induced by ligand binding with full agonist cAMP and partial agonist cGMP in the cyclic nucleotide-binding domain of the bacterial ion channel SthK.
    1. Microbiology and Infectious Disease

    Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

    Francesca Torelli, Diogo M da Fonseca ... Moritz Treeck
    Secreted effector proteins of Toxoplasma gondii parasites create a supportive immune environment in mice, allowing individually less fit mutants to thrive and evade detection by in vivo CRISPR screens.
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

    Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    Not revised
    Reviewed Preprint v1
    1. Medicine

    Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial

    Feilin Cao, Zhaosheng Ma ... Shifen Huang
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Developmental Biology

    Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

    Qian Wang, Hongge Li ... Xin Zhang
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression

    Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

    Rakesh Kumar, Fan Zhang ... Alan G Hinnebusch
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Calcium tunneling through the ER and transfer to other organelles for optimal signaling in Toxoplasma gondii

    Zhu-Hong Li, Beejan Asady ... Silvia NJ Moreno
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection

    Ilya A Rybak, Natalia A Shevtsova ... Alain Frigon
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos

    Marius Regin, Yingnan Lei ... Claudia Spits
    Aneuploid human embryonic cells are eliminated by p53-mediated apoptosis in a gene dosage dependent manner.
    1. Neuroscience

    Efficient value synthesis in the orbitofrontal cortex explains how loss aversion adapts to the ranges of gain and loss prospects

    Jules Brochard, Jean Daunizeau
    Computational modeling shows how neural mechanisms for mitigating biological constraints (such as neurons’ limited firing range) may eventually result in complex though predictable irrational behavior.
    1. Neuroscience

    Analysis of foothold selection during locomotion using terrain reconstruction

    Karl S Muller, Kathryn Bonnen ... Mary M Hayhoe
    The visual information walkers use for path selection during locomotion was revealed by analysis of a three-dimensional numerical representation of the natural terrain.
    1. Stem Cells and Regenerative Medicine

    Pharmacologically inducing regenerative cardiac cells by small molecule drugs

    Wei Zhou, Kezhang He ... Sheng Ding
    Induction of regenerative cardiac cells (RCCs) from human embryonic stem cell-derived cardiomyocytes and neonatal rat cardiomyocytes using a novel two-compound treatment enhances heart function following myocardial infarction and offers a promising avenue for cardiac regeneration through transcriptional and epigenetic reprogramming.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoding contextual influences on auditory perception from primary auditory cortex

    Bernhard Englitz, Sahar Akram ... Shihab Shamma
    The perception of ambiguous steps in relative tone height is predicted by direction-selective cells in the auditory cortex, rather than the brain's represented distance between the tone heights.
    1. Neuroscience

    The identification of extensive samples of motor units in human muscles reveals diverse effects of neuromodulatory inputs on the rate coding

    Simon Avrillon, François Hug ... Dario Farina
    Motor units within a pool exhibit distinct rate coding as force levels change, highlighting how gain control can transform inputs with limited bandwidth into the desired muscle force.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling

    Senem Ntourmas, Martin Sachs ... Dominic B Bernkopf
    Biochemical detection of endogenous, paralog-specific DVL2 complexes, molecular characterization of underlying protein domains and functional evidence for their importance extend the knowledge of Wnt pathway regulation through DVL2 biomolecular condensates.
    1. Neuroscience

    Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain

    Yue Li, Qinyao Sun ... Jiaojian Wang
    A novel methodological strategy based on machine learning has been developed to study brain evolution across species.
    1. Ecology

    Polarised moonlight guides nocturnal bull ants home

    Cody A Freas, Ajay Narenda ... Ken Cheng
    Large eyed bull ants are able to use the exceedingly dim lunar polarised light pattern in the overhead sky to navigate back to the nest at night.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Unified bursting strategies in ectopic and endogenous even-skipped expression patterns

    Augusto Berrocal, Nicholas C Lammers ... Michael B Eisen
    Drosophila melanogastereven-skipped enhancers control transcriptional bursting by modulating frequency and amplitude, regardless of varying transcription factor inputs, even when mutated to express in embryonic regions not under selective pressure.
    1. Biochemistry and Chemical Biology

    Decoding m6Am by simultaneous transcription-start mapping and methylation quantification

    Jianheng Fox Liu, Ben R Hawley ... Samie R Jaffrey
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Multiple and subject-specific roles of uncertainty in reward-guided decision-making

    Alexander Paunov, Maëva L’Hôtellier ... Florent Meyniel
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

    Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A toolbox for ablating excitatory and inhibitory synapses

    Aida Bareghamyan, Changfeng Deng ... Don B Arnold
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Mid1 deletion leads to cognitive dysfunction in Opitz syndrome by regulates neural rhythms through the inhibition of p-Creb by PP2Ac

    Ziye Yang, Pengxiang Li ... Dong Ming
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting fatty acid metabolism

    Hong Huang, Ying Yang ... Le Zhang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Computational and Systems Biology

    Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks

    Christopher M Kim, Carson C Chow, Bruno B Averbeck
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Neuroscience

    Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo

    Siân Wilson, Daan Christiaens ... Kiho Im
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Neuroscience

    GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain via mediating descending facilitation

    Qing Chen, Hui Wu ... Xinzhong Chen
    Not revised
    Reviewed Preprint v1
    1. Ecology
    2. Evolutionary Biology

    Defensive symbionts provide high protection against natural enemies at low cost to hosts: a meta-analysis

    Cássia Siqueira Cesar, Eduardo SA Santos, Rodrigo Cogni
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    It’s the Sound, not the Pulse: Peripheral Magnetic Stimulation Reduces Central Sensitization through Auditory Modulatory Effects

    Spencer S Abssy, Natalie R Osborne ... Massieh Moayedi
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    A brainstem circuit controls cough-like airway defensive behaviors in mice

    Xiaoshan Xu, Xiupeng Nie ... Fujun Luo
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Integrating microscopy and transcriptomics from individual uncultured eukaryotic plankton

    Catherine Gatt, Yike Xie ... Fabio Zanini
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community Resource

    Hugo Caffaratti, Ben Slater ... Christopher I Petkov
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Loss of Flower/FLWR-1 induces an increase in neuronal excitability and causes defective recycling of synaptic vesicles

    Marius Seidenthal, Jasmina Redzovic ... Alexander Gottschalk
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex

    Eun Hye Park, Kally C O’Reilly Sparks ... André A Fenton
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Dynamics of striatal action selection and reinforcement learning

    Jack Lindsey, Jeffrey E Markowitz ... Ashok Litwin-Kumar
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

    Jing Wang, Min Su ... Hailin Zhang
    NALCN and TRPC6 drive the subthreshold depolarization of VTA DA neurons and down regulation of TRPC6 contributes to reduced VTA DA neuron firing and chronic stress-induced depression-like behavior of mice.
    1. Structural Biology and Molecular Biophysics

    A cryo-electron tomography study of ciliary rootlet organization

    Chris van Hoorn, Andrew P Carter
    Cryo-electron tomography uncovers the flexible, filamentous architecture of mouse ciliary rootlets and their regular cross-striations with extensive membrane connections.
    1. Neuroscience

    Modulation of RNA processing genes during sleep-dependent memory

    Yongjun Li, Nitin S Chouhan ... Amita Sehgal
    RNA processing genes regulated during sleep-dependent memory may contribute to sleep and memory.
    1. Developmental Biology
    2. Neuroscience

    Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

    Denise M Poltavski, Alexander T Cunha ... Takako Makita
    Neural crest and placode lineages both contribute to the enteric nervous system, divergently utilizing Edn3-Ednrb and GDNF-Ret signaling.
    1. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

    Simon Perrin, Maria Ethel ... Céline Colnot
    A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
    1. Developmental Biology

    Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs

    Shuo Chao, Jun Lu ... Zhao-Jia Ge
    Maternal obesity mouse model reveal that melatonin deficiency causes the genomic hyper-methylation of oocytes via increasing the expression of DNA methyltransferases.
    1. Biochemistry and Chemical Biology

    Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)

    Bikash Adhikari, Katharina Schneider ... Elmar Wolf
    A rapamycin-induced proximity assay enables rapid identification of optimal E3 ligases for target protein degradation in living cells, streamlining early-stage proteolysis targeting chimera development.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration

    Debabrata Dey, Shir Marciano ... Gideon Schreiber
    Poor intracellular availability and diffusion of weakly basic, small molecule drugs can be greatly enhanced by preventing ion trapping in crowded cellular environments.
    1. Cancer Biology

    Increased inflammatory signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden

    Hyungtai Sim, Hyun Jung Park ... Murim Choi
    In metastatic NSCLC patients, CHIP showed minimal impact on immunotherapy response but was more prevalent and associated with inflammatory pathways in myeloid cells, particularly in lung squamous cell carcinoma.
    1. Neuroscience

    On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy

    Yuzhang Chen, Brian Litt ... Hajime Takano
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall

    Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine
    β-1,6-Glucan is crucial for Candida albicans cell wall structure and integrity, adapting dynamically to environmental stresses and compensating for mannan deficiencies in cell wall organization.
    1. Neuroscience

    Multisensory integration enhances audiovisual responses in the Mauthner cell

    Santiago Otero-Coronel, Thomas Preuss, Violeta Medan
    Multisensory enhancement of Mauthner cell activity reveals how stimulus modality, intensity, and temporal dynamics shape integration at the single-cell level in a neuron essential for fast escape responses.
    1. Neuroscience

    A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

    Hyo Jun Kwon, Devi Santhosh, Zhen Huang
    Molecular genetics identifies a novel microglial pathway essential for mouse brain development and a previously unknown anti-inflammatory activity of monomeric amyloid β that activates this pathway.
    1. Stem Cells and Regenerative Medicine

    Dynamic tracking of native precursors in adult mice

    Suying Liu, Sarah E Adams ... Peter Kurre
    A revised analytical framework grounded in the principle of binomial distribution captures the full clonality and dynamic shifts of hematopoiesis throughout ontogeny.
    1. Developmental Biology

    Spinal neural tube formation and tail development in human embryos

    Chloe Santos, Abigail R Marshall ... Andrew J Copp
    Analysis of 108 human embryos aged 3–7 weeks reveals modes of primary and secondary neurulation, regulation of body elongation, somite formation rate, and common occurrence of a split neural tube.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

    Zeinab M Chahine, Mohit Gupta ... Karine G Le Roch
    The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.
    1. Biochemistry and Chemical Biology

    Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning

    Zhe Zhang, Xu Hong ... Jian Zhan
    The minimal twister sister (TS)-like self-cleaving ribozymes, revealed by deep mutational scanning, represent some of the very few human/primate ribozymes.
    1. Computational and Systems Biology
    2. Neuroscience

    Modeled grid cells aligned by a flexible attractor

    Sabrina Benas, Ximena Fernandez, Emilio Kropff
    Continuous attractor networks can constrain population activity to manifolds with topology radically different from that of the network architecture.
    1. Neuroscience

    When abstract becomes concrete, naturalistic encoding of concepts in the brain

    Viktor Nikolaus Kewenig, Gabriella Vigliocco, Jeremy I Skipper
    A novel deep-learning-based computational method using object recognition to quantify visual context in naturalistic, multimodal stimuli demonstrates that a concept's perceived abstractness or concreteness dynamically depends on its visual context.
    1. Immunology and Inflammation

    Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

    Jasmine Rowell, Ching-In Lau ... Tessa Crompton
    The foetal thymic T-cell receptor (TCR) repertoire is distinct from adult, and it is less governed by MHC-restriction, more closely encoded by genomic sequence with distinct gene-segment usage including 3’TRAV to 5’TRAJ.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A conserved cell-pole determinant organizes proper polar flagellum formation

    Erick E Arroyo-Pérez, John C Hook ... Simon Ringgaard
    FipA is a novel component required for bacteria that rely on FlhF/FlhG to properly localize their flagella to the cell pole.
    1. Cell Biology
    2. Neuroscience

    Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegans

    Qi Jia, Drew Young ... Derek Sieburth
    Stress-regulated secretion of an intestinal peptide positively regulates the antioxidant response by promoting neuropeptide release from the nervous system, defining a gut-to-brain-to-gut endocrine axis in the oxidative stress response.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction

    Soo-Yeon Hwang, Kyung-Hwa Jeon ... Youngjoo Kwon
    Structure-based designed chalcone and pyrazoline derivatives inhibited the ELF3-MED23 protein-protein interaction, leading to HER2 downregulation and retardation of tumor growth in HER2-positive gastric cancer.
    1. Neuroscience

    Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex

    Sara Jamali, Sophie Bagur ... Brice Bathellier
    Responses to local and global violations in sound sequences are prediction errors and not simply the consequence of stimulus-specific adaptation.
    1. Genetics and Genomics

    Genome-wide identification of stable RNA-chromatin interactions

    Xingzhao Wen, Sheng Zhong
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response

    Ling Cheng, Ian Meliala ... Mikael Björklund
    Not revised
    Reviewed Preprint v1
    1. Cancer Biology

    Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

    Yu-Chia Chen, Mamoru Takada ... Aussie Suzuki
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Blocking Toxin Function and Modulating the Gut Microbiota: Caffeic Acid and its Derivatives as Potential Treatments for Clostridioides difficile Infection

    Yan Guo, Yong Zhang ... Jiazhang Qiu
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

    Jianing Liu, Anokhi Shah ... Keni Vidilaseris
    Not revised
    Reviewed Preprint v1
    1. Medicine
    2. Immunology and Inflammation

    PD-L1+ Neutrophils mediate Susceptibility during Systemic Inflammatory Response in Non-Alcoholic Fatty Liver Disease

    Cleyson da Cruz Oliveira Barros, Alexandre Kanashiro ... Fernando Queiroz Cunha
    Not revised
    Reviewed Preprint v1
    1. Medicine

    Exploration of the Metabolomic Mechanisms of Postmenopausal Hypertension Induced by Low Estrogen State

    Yao Li, Hui Xin ... Wei Zhang
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Evolutionary Biology

    Most Beefalo cattle have no detectable bison genetic ancestry

    Beth Shapiro, Jonas Oppenheimer ... Timothy PL Smith
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50’s ATPase activities and homologous recombination

    Sugith Badugu, Kshitiza Mohan Dhyani ... Kalappa Muniyappa
    A combination of genetic and biochemical approaches suggest that yeast Rev7 promotes DNA double-strand break repair via NHEJ and inhibits homologous recombination by blocking Mre11 nuclease and Rad50’s ATPase activities.
    1. Structural Biology and Molecular Biophysics

    Role of the αC-β4 loop in protein kinase structure and dynamics

    Jian Wu, Nisha A Jonniya ... Susan S Taylor
    The importance of the αC-β4 loop at the interface between the N- and C-lobes of Protein Kinase A for synergistic high-affinity binding of ATP and a pseudo substrate inhibitor.
    1. Neuroscience

    Cortical beta oscillations map to shared brain networks modulated by dopamine

    Meera Chikermane, Liz Weerdmeester ... Wolf Julian Neumann
    Invasively recorded cortical beta oscillations form whole-brain structural and functional networks that are modulated by dopamine.
    1. Ecology

    Habitat fragmentation mediates the mechanisms underlying long-term climate-driven thermophilization in birds

    Juan Liu, Morgan W Tingley ... Xingfeng Si
    Differential colonization-extinction dynamics associated with species thermal preferences provide support for dispersal limitation and microclimate buffering as primary proxies by which habitat fragmentation mediates thermophilization in birds.
    1. Neuroscience

    Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster

    Jierui Qin, Tingting Yang ... Wei Zhang
    Multi-dendritic cibarium neurons in the fly pharynx sense mechanical force during swallowing by NOMPC, piezo, and Tmc, besides, these neurons interact with motor neurons to control food swallow.
    1. Neuroscience

    The transformation of sensory to perceptual braille letter representations in the visually deprived brain

    Marleen Haupt, Monika Graumann ... Radoslaw Cichy
    The visually deprived brain processes sensory letter information in tactile areas but perceptual letter information in sighted reading areas, revealing experience-dependent brain plasticity.
    1. Genetics and Genomics

    PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

    Thomas E Forman, Marcin P Sajek ... Katherine A Fantauzzo
    Upon PDGFRα signaling in mouse embryonic palatal mesenchyme cells, Srsf3 exhibits differential transcript binding, resulting in retention of the receptor in early endosomes and increased downstream PI3K-mediated Akt signaling.
    1. Neuroscience

    Dual-format attentional template during preparation in human visual cortex

    Yilin Chen, Taosheng Liu ... Mengyuan Gong
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology

    Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye

    Alicia Hurtado, Víctor López-Soriano ... Francisco J Barrionuevo
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Twist is the key to the gating of mechanosensitive ion channel NOMPC

    Jingze Duan, Chen Song
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast

    Jyotsna Kumar, Swati Haldar ... Jagmohan Singh
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

    Anamari Brdar, Christian Osterburg ... Volker Dötsch
    Not revised
    Reviewed Preprint v1
    1. Cell Biology

    Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis

    Kaili Du, Hongyu Chen ... Dan Li
    Not revised
    Reviewed Preprint v1
    1. Ecology
    2. Evolutionary Biology

    Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

    Adrián Moreno-Borrallo, Sarahi Jaramillo-Ortiz ... François Criscuolo
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA

    Zhuo Bi, Yu-Xiang Chen ... Babak Javid
    Not revised
    Reviewed Preprint v1
    1. Ecology

    Quantifying Feral Pig Interactions to Inform Disease Transmission Networks

    Tatiana Proboste, Abigail Turnlund ... Ricardo J Soares Magalhães
    Not revised
    Reviewed Preprint v1
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human Aging

    Siqi Wang, Danyue Dong ... Zefeng Wang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Brainstem neurons coordinate the bladder and urethra sphincter for urination

    Xing Li, Xianping Li ... Jiwei Yao
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Multimodal neural correlates of childhood psychopathology

    Jessica Royer, Valeria Kebets ... Boris C Bernhardt
    1. Neuroscience

    The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells

    Hannah R Martin, Anna Lysakowski, Ruth Anne Eatock
    A striking and consequential conductance in vestibular type I hair cells is finally shown to depend on a little-known Shaker subunit that contributes to conventional conductances in other hair cells.
    1. Cell Biology
    2. Neuroscience

    Sympathetic motor neuron dysfunction is a missing link in age-associated sympathetic overactivity

    Lizbeth de La Cruz, Derek Bui ... Oscar Vivas
    Aging reduces the potassium M current in sympathetic motor neurons, resulting in a hyperactive phenotype that can be reversed by pharmacological activation of these channels.
    1. Medicine

    Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model

    Jeong-Oh Shin, Jong-Bin Lee ... Jin-Woo Kim
    rhPTH(1-34) and dimeric R25CPTH(1-34) significantly promoted bone regeneration and titanium implant osseointegration in an osteoporotic beagle model.
    1. Structural Biology and Molecular Biophysics

    RNA tertiary structure and conformational dynamics revealed by BASH MaP

    Maxim Oleynikov, Samie R Jaffrey
    BASH MaP quantitatively reveals alternative RNA tertiary structures by enabling dimethyl sulfate to probe the presence of nucleobase interactions on the Watson-Crick and Hoogsteen faces of single RNA molecules.
    1. Cell Biology
    2. Neuroscience

    An acute microglial metabolic response controls metabolism and improves memory

    Anne Drougard, Eric H Ma ... John Andrew Pospisilik
    High-fat ingestion triggers microglial metabolic activation within a single feeding cycle, and enhances whole-body metabolism and memory by converting fatty acids into protective substrates for surrounding neurons.
    1. Microbiology and Infectious Disease

    Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

    Kiwon Park, Dohoon Lee ... Kwangseog Ahn
    Investigation of the role of triple-stranded nucleic acid, R-loops, in HIV-1 genome integration.
    1. Genetics and Genomics

    Understanding genetic variants in context

    Nasa Sinnott-Armstrong, Stanley Fields ... Christine Queitsch
    Multiplexed assays of variant effect are an increasingly important tool in genetic research and including more context specificity in their design would aid interpretation and discovery.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TPR is required for cytoplasmic chromatin fragment formation during senescence

    Bethany M Bartlett, Yatendra Kumar ... Wendy A Bickmore
    Evidence is provided suggesting that heterochromatin re-organisation during cell senescence can compromise the structural integrity of the nucleus, leading to activation of an inflammatory process.
    1. Microbiology and Infectious Disease

    FtsK Initiates the Assembly of a Unique Divisome Complex in the FtsZ-less Chlamydia trachomatis

    McKenna Harpring, Junghoon Lee ... John V Cox
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Neuroscience

    Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

    Eric R Wengert, Melody A Cheng ... Ethan M Goldberg
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Dependence of Contextual Modulation in Macaque V1 on Interlaminar Signal Flow

    Shude Zhu, Yu Jin Oh ... Tirin Moore
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Circuit function is more robust to changes in synaptic than intrinsic conductances

    Zachary Fournier, Leandro M Alonso, Eve Marder
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    AI-enabled Alkaline-resistant Evolution of Protein to Apply in Mass Production

    Liqi Kang, Banghao Wu ... Liang Hong
    Not revised
    Reviewed Preprint v1
    1. Microbiology and Infectious Disease

    Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans

    Catia Mota, Kiseung Kim ... Hyun Ah Kang
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Ecology

    Drift in Individual Behavioral Phenotype as a Strategy for Unpredictable Worlds

    Ryan Maloney, Athena Ye ... Benjamin L de Bivort
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Genetics and Genomics

    Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters

    Jennifer Madrigal, Heidi L Schubert ... Christopher P Hill
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Criterion placement threatens the construct validity of neural measures of consciousness

    Johannes J Fahrenfort, Philippa A Johnson ... Simon van Gaal
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Taste triggers a homeostatic temperature control in hungry flies

    Yujiro Umezaki, Sergio Hidalgo ... Fumika Hamada
    Hungry flies shifting from cooler to warmer temperature preferences in response to non-nutritive food indicates a taste-triggered response, similar to the cephalic phase response observed in mammals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand response of guanidine-IV riboswitch at single-molecule level

    Lingzhi Gao, Dian Chen, Yu Liu
    A folding-function model for the guanidine-IV riboswitch under both guanidine-free and guanidine-present conditions offers valuable insights into its regulatory mechanism.
    1. Immunology and Inflammation

    Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

    Donal J Cox, Sarah A Connolly ... Joseph Keane
    The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory medicine.
    1. Neuroscience

    The neural dynamics of positive and negative expectations of pain

    Christoph Arne Wittkamp, Maren-Isabel Wolf, Michael Rose
    Pain expectation processing shifts from uniform anticipatory activation to valence-specific differentiation during sensory input.

Magazine

  1. An isopod, well-adapted to the harsh conditions of arid-lands, crawls on the desert floor in search of leaf litter

    Episode 96: December 2024

    1. Developmental Biology

    Brain Development: Single cells tell it all

    Margaret Hines, Elias Oxman ... Irene Zohn
    1. Computational and Systems Biology

    Cellular Respiration: Mapping mitochondrial aging

    Alessandro Bitto
    1. Ecology

    Disease Transmission: Interactions between wild pigs and the spread of disease

    Mercury Shitindo
    1. Cell Biology

    Cytoskeleton: Rearranging to resist cell death

    Dominik Brokatzky, Serge Mostowy
    1. Developmental Biology

    Lung Development: Exploring a complex constellation of signaling pathways

    Nathaniel C Nelson, Matthias C Kugler
    1. Neuroscience

    Locomotion: How vision shapes the paths we choose

    Arthur D Kuo
    1. Neuroscience

    Cochlear Synaptopathy: Unravelling hidden hearing loss

    Emmanuel Ponsot
    1. Neuroscience

    Point of View: An annotated introductory reading list for neurodiversity

    Mirela Zaneva, Tao Coll-Martín ... Alyssa Hillary Zisk
    1. Evolutionary Biology

    Fecal Microbiomes: Baboons, bacteria, and biological clocks address an age-old question

    Amanda D Melin