December 2022

Cover articles

    1. Evolutionary Biology
    2. Neuroscience

    New insights into Sauropods

    Marco Schade, Nils Knötschke ... Sebastian Stumpf
    1. Structural Biology and Molecular Biophysics

    Desensitizing an ion channel

    James Osei-Owusu, Zheng Ruan ... Zhaozhu Qiu
    1. Neuroscience

    Detection at the double

    Flavia P Franco, Pingxi Xu ... Walter S Leal
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The activation of nucleation

    Michael J Rale, Brianna Romer ... Sabine Petry

Highlights controls:

Research articles

    1. Neuroscience

    Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation

    Yoojeong Choo, Dora Matzke ... Jan R Wessel
    Hierarchical Bayesian modeling of stop-signal task performance in humans with and without lesions to the right inferior gyrus reveals that rather than implementing inhibitory control, this brain region appears to be responsible for detecting the need to inhibit an action.
    1. Biochemistry and Chemical Biology

    The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

    Andrea Bonicelli, Hayley L Mickleburgh ... Noemi Procopio
    The integration of multiple omics panels obtained from bone tissue could aid in the evaluation of the postmortem interval in forensic investigations, expanding the boundaries of forensic research.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Calcium dependence of both lobes of calmodulin is involved in binding to a cytoplasmic domain of SK channels

    David B Halling, Ashley E Philpo, Richard W Aldrich
    Calcium drives interactions for both calcium-binding domains of calmodulin in complex with KCa2.1 peptides and both domains are required for normal channel function.
    1. Cell Biology

    Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity

    Susan Eliazer, Xuefeng Sun ... Andrew S Brack
    A gradient of Mib1-Dll4 within multinucleated muscle fibers maintains a continuum of metastable states within the muscle stem cell pool during tissue homeostasis.
    1. Developmental Biology
    2. Neuroscience

    Coordinated cadherin functions sculpt respiratory motor circuit connectivity

    Alicia N Vagnozzi, Matthew T Moore ... Polyxeni Philippidou
    1. Neuroscience

    LabNet hardware control software for the Raspberry Pi

    Alexej Schatz, York Winter
    A software distributed platform for the Raspberry Pi to simplify and unify hardware access over the Ethernet network with almost real-time latencies.
    1. Neuroscience

    Complex pattern of facial remapping in somatosensory cortex following congenital but not acquired hand loss

    Victoria Root, Dollyane Muret ... Tamar R Makin
    Both hand and face representations remain relatively stable after arm amputation in adulthood, with no link to phantom limb pain, whereas pre-natal limb loss triggers complex patterns of remapping that do not relate to cortical topography.
    1. Medicine

    Is calcium a link between inflammatory bone resorption and heart disease?

    Gordon L Klein
    A mechanism is proposed that allows investigators to study interventions to delay onset of heart disease in patients suffering from chronic inflammatory disease with bone loss.
    1. Cell Biology
    2. Neuroscience

    Protein composition of axonal dopamine release sites in the striatum

    Lauren Kershberg, Aditi Banerjee, Pascal S Kaeser
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Working strokes produced by curling protofilaments at disassembling microtubule tips can be biochemically tuned and vary with species

    Lucas E Murray, Haein Kim ... Charles L Asbury
    Laser trap measurements show that mechanical work output from curling protofilaments is enhanced by adding magnesium, and that yeast microtubules generate larger and more energetic working strokes than bovine microtubules.
    1. Neuroscience

    Clonally related, Notch-differentiated spinal neurons integrate into distinct circuits

    Saul Bello-Rojas, Martha W Bagnall
    Pairs of spinal cord neurons arising from a shared progenitor get input from and make outputs to mostly different synaptic partners.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

    Qing Ma, Liuyi Yang ... Howard Y Chang
    HOTAIR is required in an ongoing manner when it regulates epigenetic status and reprograms cancer cell gene expression in promoting breast cancer metastasis.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification

    Rebeca San Martin, Priyojit Das ... Rachel Patton McCord
    Age-stratified comparisons of gene expression in progeria patient fibroblasts reveals disruption of mesenchymal lineage pathways and points to a deficit in chondrogenic commitment in early development and a depletion of the mesenchymal lineage stem cell pool.
    1. Neuroscience

    Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum

    Sophia S Loschky, Giovanna Maria Spano ... Chiara Cirelli
    In the mouse cerebellum, the number of branched synapses is reduced in half after sleep compared to after wake.
    1. Computational and Systems Biology

    Lack of evidence for increased transcriptional noise in aged tissues

    Olga Ibañez-Solé, Alex M Ascensión ... Ander Izeta
    1. Neuroscience

    Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

    Sarah E Canetta, Emma S Holt ... Christoph Kellendonk
    Prefrontal PV interneuron activity during development is necessary for prefrontal circuit maturation, supporting adult prefrontal network function and cognitive flexibility.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Deep learning-driven insights into super protein complexes for outer membrane protein biogenesis in bacteria

    Mu Gao, Davi Nakajima An, Jeffrey Skolnick
    An example of a deep learning-based strategy to discover novel protein-protein interactions and predict their complex structures at high accuracy.
    1. Genetics and Genomics

    Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

    Joseph M Replogle, Jessica L Bonnar ... Marco Jost
    Newly developed, highly active CRISPR interference single guide RNA libraries and effectors together enable high-quality genetic screens across cell models.
    1. Neuroscience

    Fiber-specific structural properties relate to reading skills in children and adolescents

    Steven Lee Meisler, John DE Gabrieli
    Advanced models of diffusion-weighted imaging data reveal that intra-axonal volume, especially in left temporoparietal and cerebellar white matter, relates to reading skills in a dataset of 983 children and adolescents.
    1. Structural Biology and Molecular Biophysics

    Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain

    Phuong T Nguyen, Hai M Nguyen ... Vladimir Yarov-Yarovoy
    Rationally designed peptide inhibitors of human voltage-gated channels have transformative potential to define a new class of biologics to treat pain.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Evolutionary divergence in the conformational landscapes of tyrosine vs serine/threonine kinases

    Joan Gizzio, Abhishek Thakur ... Ronald M Levy
    Computational methods based on both sequence and structure show evidence that tyrosine kinases are energetically biased to populate the 'DFG-out' type-II inhibitor binding conformation relative to serine/threonine kinases.
    1. Neuroscience

    Cortical activity during naturalistic music listening reflects short-range predictions based on long-term experience

    Pius Kern, Micha Heilbron ... Eelke Spaak
    When a person listens to music, their brain continually predicts upcoming notes, based on that person's likely lifelong musical experience.
    1. Cancer Biology
    2. Computational and Systems Biology

    Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development

    Paul R Barber, Rami Mustapha ... Tony Ng
    Circulating immune cells reflect intra-tumoural immunity and can predict response to systemic therapy in head and neck cancer.
    1. Neuroscience

    Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1

    Brianna Vandrey, Jack Armstrong ... Matthew F Nolan
    A synaptic circuit through which 'what' streams of information associated with the lateral entorhinal cortex may influence 'where' streams of information associated with the medial entorhinal cortex prior to their integration in the hippocampus.
    1. Developmental Biology
    2. Physics of Living Systems

    On the origin of universal cell shape variability in confluent epithelial monolayers

    Souvik Sadhukhan, Saroj Kumar Nandi
    The nearly universal nature of scaled cell shape variability in an epithelial monolayer is unavoidable, irrespective of health or disease, as it comes from a mathematical property.
    1. Cell Biology
    2. Neuroscience

    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

    Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia

    Anne-Claire Godet, Emilie Roussel ... Anne-Catherine Prats
    LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.
    1. Structural Biology and Molecular Biophysics

    Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC

    James Osei-Owusu, Zheng Ruan ... Zhaozhu Qiu
    A new mechanism of receptor desensitization is revealed for the novel proton-activated chloride channel, which plays an important role in physiology and disease associated with acidic pH.
    1. Cell Biology
    2. Medicine

    Cellular features of localized microenvironments in human meniscal degeneration: a single-cell transcriptomic study

    Weili Fu, Sijie Chen ... Xuegong Zhang
    A single-cell transcriptome atlas reveals meniscal microenvironment variations during degeneration and cellular heterogeneity foundations of the inner–outer zone differences, suggesting novel cell subtypes as potential therapeutic targets.
    1. Evolutionary Biology

    Adaptation dynamics between copy-number and point mutations

    Isabella Tomanek, Călin C Guet
    In bacteria, frequent adaptive copy-number mutations can hinder the fixation of beneficial point mutations and hence the divergence of duplicated DNA sequences.
    1. Developmental Biology

    TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development

    Jifan Feng, Xia Han ... Yang Chai
    Unbiased single-cell RNAseq data analysis combined with mouse genetic approaches reveal that TGF-β signaling and perimysial-specific regulators may cooperatively define perimysial-to-myogenic signals in regulating pharyngeal myogenesis.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

    Hongchang Zhao, Stella R Hartono ... Jacqueline Barlow
    Genetic analysis of senataxin and RNase H2-deficient mice reveals that genome stability during class switch recombination and antibody generation can be uncoupled, suggesting a role for R loop metabolism dysfunction in lymphomagenesis in patients without immune deficiency.
    1. Cancer Biology
    2. Medicine

    Procalcitonin for antimicrobial stewardship among cancer patients admitted with COVID-19

    Hiba Dagher, Anne-Marie Chaftari ... Issam Raad
    Procalcitonin could be useful in enhancing antimicrobial stewardship in cancer patients with COVID-19.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain

    Michael A Kovacs, Maureen N Cowan ... Tajie H Harris
    In the setting of CNS infection, meningeal lymphatic drainage promotes dendritic cell and T cell responses in the deep cervical lymph nodes but is not necessary for maintaining control of parasite in the brain.
    1. Cell Biology

    Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice

    Rong Xie, Dan Yi ... Di Chen
    Specific gene knockout and signaling inhibition studies indicate the activation of β-catenin-bone morphogenetic protein signaling contributes to the development of fibular hemimelia disease.
    1. Neuroscience

    Thalamocortical contributions to cognitive task activity

    Kai Hwang, James M Shine ... Evan Sorenson
    Human thalamic activity transformed via thalamocortical functional connectivity to support task representations across functional domains.
    1. Cancer Biology

    Shifting the focus of zebrafish toward a model of the tumor microenvironment

    Joshua M Weiss, Dianne Lumaquin-Yin ... Richard M White
    Zebrafish provide unique resources for the study of the tumor microenvironment.
    1. Developmental Biology
    2. Plant Biology

    Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

    Dan Zhang, Roxane P Spiegelhalder ... Michael T Raissig
    The formation of stomatal 'helper cells' (=subsidiary cells) in grasses requires two opposing polarity domains with diverse roles in establishing division asymmetry.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Personality traits are consistently associated with blood mitochondrial DNA copy number estimated from genome sequences in two genetic cohort studies

    Richard F Oppong, Antonio Terracciano ... Jun Ding
    Two genome sequencing studies show a consistent association between blood mitochondrial DNA copy number (mtDNAcn) and personality traits and provide support for the hypothesis that mtDNAcn may be a biomarker that connects certain personality characteristics with mortality.
    1. Evolutionary Biology
    2. Neuroscience

    Neurovascular anatomy of dwarf dinosaur implies precociality in sauropods

    Marco Schade, Nils Knötschke ... Sebastian Stumpf
    Computed tomography data reveal large and adult-looking inner ears in very young individuals of the long-necked dinosaur Europasaurus holgeri suggesting precociality in this dwarfed island dweller from the Late Jurassic of Germany.
    1. Cell Biology
    2. Physics of Living Systems

    Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19

    Steffen M Recktenwald, Greta Simionato ... Stephan Quint
    For severe COVID-19 patients' red blood cells, healthy donor plasma reduces pathological red blood cell shape alterations and improves microcapillary flow in vitro through an interaction between red blood cells and plasma.
    1. Evolutionary Biology

    Modeling the spatiotemporal spread of beneficial alleles using ancient genomes

    Rasa A Muktupavela, Martin Petr ... Fernando Racimo
    A new method for inferring the spatiotemporal dynamics governing the spread of an advantageous mutation using ancient DNA.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

    Amanda M Hughes, Eleanor Sanderson ... Neil M Davies
    It is unclear how much a child's BMI at age 8 affects their depressive and ADHD symptoms after family-level factors are accounted for, but a substantial impact on anxiety symptoms is unlikely.
    1. Developmental Biology
    2. Evolutionary Biology

    Vocal communication is tied to interpersonal arousal coupling in caregiver-infant dyads

    Sam Wass, Emily Phillips ... Louise Goupil
    Infants' vocalisations are contingent on their own stress physiology, and alter the inter-personal dynamics of how stress states are shared across the infant-caregiver dyad.
    1. Cell Biology
    2. Neuroscience

    Desmosomal connectomics of all somatic muscles in an annelid larva

    Sanja Jasek, Csaba Verasztó ... Gáspár Jékely
    Volume-EM reconstruction of a whole-body desmosomal connectome including all muscles and their desmosomal partners in a Platynereis larva provides a detailed view of the organisation of the entire locomotor system in an animal.
    1. Cell Biology
    2. Developmental Biology

    Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation

    Katrina M Longhini, Michael Glotzer
    Centrosomal Aurora A (AIR-1), together with cortical actomyosin flows, induces polarization of ECT-2, the activator of RHO-1, during polarization and cytokinesis, in order to promote furrow formation.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Survival of mineral-bound peptides into the Miocene

    Beatrice Demarchi, Meaghan Mackie ... Julia Clarke
    Ostrich eggshell from the Liushu Formation in northwestern China push ancient protein preservation into the Miocene.
    1. Neuroscience

    Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo

    Jürgen Graf, Vahid Rahmati ... Knut Kirmse
    Two-photon Ca2+ imaging and computational modeling reveal major developmental trajectories of spontaneous activity in developing CA1 and identify important roles of network bi-stability and synaptic input characteristics for hippocampal burstiness before eye opening.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

    Martin Wilkinson, Oliver J Wilkinson ... Mark S Dillingham
    New cryoEM structures reveal how small bacteriophage proteins suppress bacterial immunity.
    1. Genetics and Genomics

    Generating colorblind-friendly scatter plots for single-cell data

    Tejas Guha, Elana J Fertig, Atul Deshpande
    scatterHatch helps users generate colorblind-friendly scatter plot visualizations by using a combination of patterns and high-contrast colors to represent distinct point groups.
    1. Neuroscience

    Population codes enable learning from few examples by shaping inductive bias

    Blake Bordelon, Cengiz Pehlevan
    Neural sensory representations impose an inductive bias over the space of learning tasks, allowing some tasks to be learned by a downstream neuron more sample-efficiently than others.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies

    Sophia A Wild, Ian G Cannell ... Kirsty Sawicka
    Lineage resolved single-cell RNA-seq of mammary carcinoma models uncovers a metabolic vulnerability of taxane-resistant clones.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

    Zhanying Feng, Zhana Duren ... Yong Wang
    Integrating chromatin accessibility and gene expression data into context-specific regulatory networks can provide better regulatory categories for heritability enrichment and relevant tissue identification.
    1. Medicine

    Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

    Phoebe M Kirkwood, Douglas A Gibson ... Philippa TK Saunders
    In a mouse model of menstruation stromal cells respond to breakdown of the tissue by changing their identity to become epithelial cells that are incorporated into the luminal epithelium which is rapidly 'healed' without scarring.
    1. Chromosomes and Gene Expression

    Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters

    Yi-Jun Sheu, Risa Karakida Kawaguchi ... Bruce Stillman
    The localization of Rad53 cell cycle checkpoint kinase to many gene promoters and the dynamic changes in response to replication stress suggests that the kinase may coordinate genome stability and gene expression.
    1. Cell Biology
    2. Immunology and Inflammation

    A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage

    Jérémy Argenty, Nelly Rouquié ... Renaud Lesourne
    Mouse deficiencies for the dynein-binding protein LIS1 reveal different cell division mechanisms across T-cell subsets.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D

    Rachel V Stadler, Shane R Nelson ... Gary E Ward
    Parasites constrict as they propel themselves through the extracellular matrix one body length at a time, in a process highly reminiscent of host cell invasion.
    1. Neuroscience

    Neural representations of naturalistic events are updated as our understanding of the past changes

    Asieh Zadbood, Samuel Nastase ... Uri Hasson
    Changes in the interpretation of specific scenes in a narrative trigger corresponding updates in the neural patterns evoked by those scenes in the default mode network.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    Structure-guided isoform identification for the human transcriptome

    Markus J Sommer, Sooyoung Cha ... Steven L Salzberg
    The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.
    1. Neuroscience

    Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold

    Jordan DeKraker, Roy AM Haast ... Ali R Khan
    Automated computational unfolding of the hippocampus allows analyses at its mesoscale and facilitates novel discoveries in the study of cognition and disease.
    1. Neuroscience

    Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity

    Shruti Thapliyal, Kristin L Arendt ... Lu Chen
    Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.
    1. Cell Biology

    A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8

    Kirill V Tarasov, Khalid Chakir ... Edward G Lakatta
    Overexpression of hAC8 engages complex, coordinate adaptation 'circuity' that has evolved in mammalian cells to defend against stress that threatens health or life, and may be important for proper healing in disease states such as heart infarction or failure.
    1. Immunology and Inflammation
    2. Neuroscience

    The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

    Xiao-Feng Zhao, Lucas D Huffman ... Roman J Giger
    Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
    1. Genetics and Genomics

    The missing link between genetic association and regulatory function

    Noah J Connally, Sumaiya Nazeen ... Shamil R Sunyaev
    A common conceptual model exists in which trait-associated genetic variants that do not alter protein structure act by changing gene expression, but, in the context in which expression is often measured, this model is inconsistent with observed data.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Piezo1 as a force-through-membrane sensor in red blood cells

    George Vaisey, Priyam Banerjee ... Roderick MacKinnon
    Super-resolution microscopy and single particle tracking analysis of Piezo1 in red blood cells demonstrate its ability to sense membrane curvature, consistent with a force-through-membrane mechanism of channel mechanosensation in these cells.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric Thomson, Mark Harfouche ... Eva A Naumann
    1. Immunology and Inflammation

    The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

    Christiane Pleuger, Dingding Ai ... Andreas Meinhardt
    A strategical positioning of resident immune cells are key in determining a tightly controlled immune environment in the different regions of the mouse epididymis that creates unique spatial milieus for sperm maturation and combatting invading pathogens.
    1. Neuroscience

    Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs

    Samuel J Barnes, Georg B Keller, Tara Keck
    Following sensory deprivation in adult mice, homeostatic synaptic strengthening occurs in non-sensory network responsive synapses, but not in sensory responsive synapses, despite homeostatic increases to the global sensory-evoked responses.
    1. Microbiology and Infectious Disease

    A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites

    Xu Zhang, Francesca Florini ... Kirk W Deitsch
    Malaria parasites avoid destruction by their host's immune response through systematic and coordinated expression switching between members of a network of variant antigen-encoding genes, a process that is mediated by a uniquely conserved gene called var2csa.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)

    Michael J Rale, Brianna Romer ... Sabine Petry
    An evolutionarily conserved protein sequence present in diverse species like yeast, frogs, chickens, and humans binds a well-known template for microtubule nucleation, the gamma-tubulin ring complex, activating and enhancing its ability to nucleate microtubules, even under low tubulin concentrations.
    1. Neuroscience

    Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors

    Flavia P Franco, Pingxi Xu ... Walter S Leal
    The southern house mosquito senses the oviposition attractants skatole and indole with two receptor proteins sharing only 50% amino acid identity, and having the residues alanine-73 and leucine-74 in the skatole and indole receptors, respectively, control their specificity.
    1. Computational and Systems Biology
    2. Neuroscience

    Emergent color categorization in a neural network trained for object recognition

    Jelmer P de Vries, Arash Akbarinia ... Karl R Gegenfurtner
    Human-like color categories emerge in a Deep Neural Network trained only on object recognition.
    1. Chromosomes and Gene Expression

    Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

    Shoji Tane, Keishi Shintomi ... Tatsuya Hirano
    In vitro assays using Xenopus egg extracts provide evidence that mitosis-specific loading of condensin I is accelerated by phosphorylation of the N-terminal tail of its kleisin subunit.
    1. Genetics and Genomics
    2. Neuroscience

    Monoallelic CRMP1 gene variants cause neurodevelopmental disorder

    Ethiraj Ravindran, Nobuto Arashiki ... Angela M Kaindl
    Genetic finding of pathogenic CRMP1 variants in three unrelated individuals with neurodevelopmental disorder, supported by structural simulation, biochemical and proof-of-principle data highlights the key role of CRMP1 in the development and functioning of the nervous system in humans.
    1. Immunology and Inflammation
    2. Neuroscience

    T cells modulate the microglial response to brain ischemia

    Corinne Benakis, Alba Simats ... Arthur Liesz
    Transcriptional signature and cell morphology of the stroke-associated microglia are reprogrammed by distinct T cell subpopulations.
    1. Neuroscience

    Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

    Remi Ronzano, Sophie Skarlatou ... Marco Beato
    Multiple trans-synaptic tracing methods reveal that there is no spatial segregation between flexor and extensor premotor interneurons in the lumbar spinal cord.
    1. Neuroscience

    Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys

    Miki Kaneshige, Kei Obara ... Yukio Nishimura
    Spinal stimulation at balanced currents of excitation and inhibition boosts voluntarily produced torque production.
    1. Cell Biology

    Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1

    Qi-Shan Wang, Kai-Jian Fan ... Ting-Yu Wang
    MiR 204/211 antagonize synovial inflammation and hyperproliferation by regulation of its downstream target gene Ssrp1, and decelerated RA progression.
    1. Cancer Biology
    2. Computational and Systems Biology

    Defining cellular population dynamics at single-cell resolution during prostate cancer progression

    Alexandre A Germanos, Sonali Arora ... Andrew C Hsieh
    A large-scale single-cell RNA sequencing experiment explores single-cell dynamics in epithelial and immune populations within murine prostates upon cancer initiation and progression and validates key findings across orthogonal models and patient specimens.
    1. Physics of Living Systems

    Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer

    Yang Joon Kim, Kaitlin Rhee ... Hernan G Garcia
    The combination of theoretical modeling and quantitative live imaging revealed that the repressor proteins work cooperatively or anti-cooperatively depending on enhancer architecture.
    1. Cell Biology

    Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts

    Charlotte Guyomar, Clément Bousquet ... Denis Chrétien
    Tubulin engages unique lateral interactions without longitudinal ones during microtubule polymerization, leaving holes of a few subunits size potentially at the origin of tubulin exchange within their shaft.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Bidirectional promoter activity from expression cassettes can drive off-target repression of neighboring gene translation

    Emily Nicole Powers, Charlene Chan ... Gloria Ann Brar
    Bidirectional promoter activity, which is inherent to the promoters of selection cassettes used for genome editing, causes divergent transcription that can disrupt expression of genes neighboring cassette insertion sites, causing potent off-target effects.
    1. Medicine

    Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB

    Gretchen A Meyer, Stavros Thomopoulos ... Karen C Shen
    Blocking an atrophic 'master regulator' pathway following tendon tear does not affect resulting skeletal muscle atrophy.
    1. Genetics and Genomics

    Comprehensive re-analysis of hairpin small RNAs in fungi reveals loci with conserved links

    Nathan R Johnson, Luis F Larrondo ... Elena A Vidal
    A critical assessment of published microRNA/microRNA-like provides clues on features and conservation of these hairpin RNAs in fungi in addition to a centralized loci annotation resource for the community.
    1. Cancer Biology
    2. Immunology and Inflammation

    VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

    Jiaqian Li, Di Huang ... Ying Wang
    Senescence signals in tumor-specific cytotoxic T lymphocytes inhibit their trafficking from deep cervical lymph nodes to meninges via downregulating VLA-4, leading to leptomeningeal metastasis.
    1. Neuroscience

    Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making

    Claire A Symanski, John H Bladon ... Shantanu P Jadhav
    A novel mechanism of long-range coordination mediated by beta oscillations across sensory and cognitive netowrks for utilization of odor-cued associations and translating them into decisions.
    1. Microbiology and Infectious Disease

    Critical roles for ‘housekeeping’ nucleases in type III CRISPR-Cas immunity

    Lucy Chou-Zheng, Asma Hatoum-Aslan
    Genetic and biochemical analyses reveal that the bacterial nucleases PNPase and RNase R work in concert with a type III-A CRISPR-Cas immune system to process small CRISPR RNAs and ensure robust immunity against foreign nucleic acid invaders.
    1. Developmental Biology

    Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis

    Masahide Sakabe, Michael Thompson ... Mei Xin
    Pharmacological and genetic blockade of β1-AR-Gαs signaling prolongs the cardiac regenerative window in juvenile mouse by activating YAP.
    1. Neuroscience

    Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy

    Huasheng Yu, Jingwei Xiong ... Wenqin Luo
    Scratch-AID, a deep learning-based system for automatic quantification of mouse scratching behavior, could replace labor-intensive manual quantification and facilitate high through-put anti-itch drug screening.
    1. Cancer Biology
    2. Genetics and Genomics

    Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

    Minsu Kang, Hee Young Na ... Jong Seok Lee
    As the first to track clonal evolution from precancerous to metastatic lesions in gallbladder cancer patients, spatial and temporal analyses reveal how subclonal diversity in precancerous stage changes toward the metastasis, which help early detection and effective treatment of cancer.
    1. Immunology and Inflammation

    Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

    Shojiro Haji, Taiki Ito ... Sho Yamasaki
    While Dectin-1 is a well-known C-type lectin receptor recognizing b-glucan and involved in anti-fungal immunity, human Dectin-1 is O-glycosylated and acts as a ligand for another C-type lectin receptor, CLEC-2, expressed by platelets that mediates homeostatic responses such as lymphangiogenesis.
    1. Neuroscience

    Feedback inhibition underlies new computational functions of cerebellar interneurons

    Hunter E Halverson, Jinsook Kim ... George J Augustine
    An inhibitory feedback circuit from Purkinje cells to molecular layer interneurons within the cerebellum has been characterized and found to be employed in vivo during motor learning.
    1. Structural Biology and Molecular Biophysics

    Structure of the mitoribosomal small subunit with streptomycin reveals Fe-S clusters and physiological molecules

    Yuzuru Itoh, Vivek Singh ... Alexey Amunts
    Structural analysis of the mitoribosomal small subunit with streptomycin reveals the molecular basis for antibiotic binding and new physiological components such as FeS clusters that assemble between mitochondria specific proteins.
    1. Cancer Biology
    2. Evolutionary Biology

    Parallel evolution of reduced cancer risk and tumor suppressor duplications in Xenarthra

    Juan Manuel Vazquez, Maria T Pena ... Vincent J Lynch
    Sloths, armadillos, and anteaters evolved genetic and cellular traits that make them remarkably cancer resistant.
    1. Neuroscience

    Emotional learning retroactively promotes memory integration through rapid neural reactivation and reorganization

    Yannan Zhu, Yimeng Zeng ... Shaozheng Qin
    Emotional learning retroactively promotes memory integration for previously neutral events into episodic memory to foster future event predictions, through rapidly stimulating trial-specific reactivation of overlapping memory traces and reorganization of associated memories among the amygdala, hippocampal, and neocortical circuits.
    1. Cell Biology

    Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

    Xiaoqin Fu, Lu Rao ... Judy Shih-Hwa Liu
    DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to microtubules and regulating the composition of dynein/dyactin/JIP3 motor complex.
    1. Cell Biology
    2. Neuroscience

    The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila

    Arnau Llobet Rosell, Maria Paglione ... Lukas Jakob Neukomm
    Levels of the metabolite NMN, the precursor of NAD+, determine whether dSarm-mediated axon death signaling is activated and injury-induced axon degeneration executed in the fruit fly Drosophila.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

    Luca Costantino, Stefania Ferrari ... Maria Paola Costi
    The dimer destabilizers cause a dimer-to-monomer equilibrium shift favoring the human thymidylate synthase monomer more degradable by the proteasome, thus breaking the long-standing link between inhibition and enhanced expression of the protein to fight cancer drug resistance.
    1. Cancer Biology

    Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

    Samantha C Schwager, Katherine M Young ... Cynthia A Reinhart-King
    Weakly migratory cancer cells facilitate their own escape from the primary tumor by releasing microvesicles that activate fibroblasts to remodel matrix and facilitate cancer cell metastasis.
    1. Immunology and Inflammation

    DNA damage independent inhibition of NF-κB transcription by anthracyclines

    Angelo Ferreira Chora, Dora Pedroso ... Luis Ferreira Moita
    The mechanistic characterization of NF-κB transcription inhibition by anthracyclines opens new possibilities for improved cancer chemotherapy and the treatment of inflammation-driven conditions.
    1. Genetics and Genomics

    A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel’s first law across a large sample of human sperm

    Sara A Carioscia, Kathryn J Weaver ... Rajiv C McCoy
    A computational method and genome-wide scan of low-coverage single-cell sequencing data from a large sample of human sperm suggests balanced transmission of alleles to the gamete pool.
    1. Chromosomes and Gene Expression

    Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells

    Karin Purshouse, Elias T Friman ... Wendy A Bickmore
    In glioblastoma stem cells, oncogenes on extrachromosomal DNA do not cluster at distances in keeping with coordinated transcription, with amplified gene expression driven by copy number rather increased transcriptional efficiency.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Overcoming the cytoplasmic retention of GDOWN1 modulates global transcription and facilitates stress adaptation

    Zhanwu Zhu, Jingjing Liu ... Bo Cheng
    Human GDOWN1 is identified as an extremely tightly controlled nucleocytoplasmic shuttling protein, and its translocation into the nucleus plays a crucial role in modulating the global transcription and facilitating the cellular adaptation to certain stresses.
    1. Neuroscience

    Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex

    Kasra Manoocheri, Adam G Carter
    The prelimbic and infralimbic prefrontal cortex (PFC) process distinct inputs from rostral and caudal basolateral amygdala (BLA), which engage different populations of projection neurons, via both direct connections and polysynaptic activity within the local network.
    1. Microbiology and Infectious Disease

    eDNA-stimulated cell dispersion from Caulobacter crescentus biofilms upon oxygen limitation is dependent on a toxin–antitoxin system

    Cecile Berne, Sébastien Zappa, Yves V Brun
    Genetic and microscopy analyses identify a programmed cell death mechanism that kills a cell subpopulation in a bacterial biofilm where oxygen is limiting, thereby promoting dispersion of newborn motile cells through the action of DNA released by dead cells.
    1. Ecology
    2. Microbiology and Infectious Disease

    Host-microbiome metabolism of a plant toxin in bees

    Erick VS Motta, Alejandra Gage ... Nancy Moran
    1. Neuroscience

    Clarifying the role of an unavailable distractor in human multiattribute choice

    Yinan Cao, Konstantinos Tsetsos
    A previously reported positive influence of a distractor alternative on decision accuracy was driven by an unintended covariation between key variables, beyond which the distractor has a modest negative influence on accuracy, possibly mirroring asymmetric multiattribute context effects.
    1. Structural Biology and Molecular Biophysics

    Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations

    I Can Kazan, Prerna Sharma ... S Banu Ozkan
    Integrating co-evolution with long-range dynamic coupling analysis allows to identify allosteric mutations that modulate binding affinity, and this approach can be used to design lectins with enhanced binding affinity.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis

    James A Watson, Robert J Commons ... Nicholas J White
    The currently recommended adult dose of tafenoquine is insufficient for radical cure in all adults.
    1. Ecology
    2. Evolutionary Biology

    Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons

    Zinan Wang, Joseph P Receveur ... Henry Chung
    Evolutionary changes in cuticular hydrocarbons, a lipid layer on the insect epicuticle, underlie the evolution of desiccation resistance in Drosophila species.
    1. Computational and Systems Biology

    A unified framework for measuring selection on cellular lineages and traits

    Shunpei Yamauchi, Takashi Nozoe ... Yuichi Wakamoto
    A unified framework for cell lineage statistics enables quantification of fitness landscapes and selection strength for any cellular lineage traits in a model-independent manner, and reveals the contributions of growth heterogeneity to population growth in diverse experimental model systems.
    1. Physics of Living Systems

    How enzymatic activity is involved in chromatin organization

    Rakesh Das, Takahiro Sakaue ... Tetsuya Hiraiwa
    Computer simulations considering actions of the intranuclear enzyme, Topoisomerase-II, in a mechanistic scheme elucidated a capability of enzymes to contribute to controlling chromatin spatial organizations and discovered new characteristic features in eu- and heterochromatin organization caused by the enzymatic activity.
    1. Computational and Systems Biology

    Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

    Jeffrey Molendijk, Ronnie Blazev ... Benjamin L Parker
    The maintenance of skeletal muscle function improves the quality of life, and therefore understanding how changes in the genome drive changes in the skeletal muscle proteome has revealed novel regulators of muscle physiology.
    1. Developmental Biology

    Glycolytic flux-signaling controls mouse embryo mesoderm development

    Hidenobu Miyazawa, Marteinn T Snaebjornsson ... Alexander Aulehla
    The functional link between glycolytic flux, cell signalling and mesoderm patterning is investigated in mouse embryo.
    1. Genetics and Genomics

    Neuroendocrinology of the lung revealed by single-cell RNA sequencing

    Christin S Kuo, Spyros Darmanis ... Mark A Krasnow
    Single-cell transcriptomic profiling and systematic analysis of pulmonary neuroendocrine cells identifies over 40 hormones and neuropeptides expressed in myriad combinations, and predicts their targets in mouse and human lung, revealing extraordinary sensory and signaling diversity and potential physiological functions.
    1. Cell Biology
    2. Immunology and Inflammation

    Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

    Jazlyn P Borges, Ragnhild SR Sætra ... Benjamin Ethan Steinberg
    Biochemical and microscopy-based approaches in mouse and human macrophages reveal that glycine cytoprotection acts at the level of the newly identified pan-death protein NINJ1 to inhibit multiple lytic cell death pathways, thereby resolving a long-standing mechanism of glycine cytoprotection.
    1. Evolutionary Biology

    Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird

    Min Wang, Thomas A Stidham ... Zhonghe Zhou
    Three-dimensional digital reconstruction shows the temporal and palatal regions of stemward avialans are evolutionarily and functionally conservative, and the mixture of plesiomorphic cranial morphologies together with derived postcranial skeleton manifests the key role of mosaicism in early bird diversification.
    1. Neuroscience

    Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers

    Nace Mikus, Sebastian Korb ... Christoph Mathys
    Blocking D2 dopamine receptors increases goal-directed (“model-based”) control when alternative habitual ("model-free") actions are available, whereas blocking opioid receptors does not seem to have an effect on the arbitration between the two modes of acting.
    1. Structural Biology and Molecular Biophysics

    A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

    Jasenko Zivanov, Joaquín Otón ... Sjors HW Scheres
    New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.
    1. Cell Biology
    2. Physics of Living Systems

    Dependence of diffusion in Escherichia coli cytoplasm on protein size, environmental conditions, and cell growth

    Nicola Bellotto, Jaime Agudo-Canalejo ... Victor Sourjik
    Diffusion of differently sized proteins in bacterial cytoplasm is nearly Brownian and consistent with the Stokes-Einstein relation, once protein shape and cell geometry are taken into account, and effects of various perturbation can be described as changes in cytoplasmic viscosity.
    1. Neuroscience

    Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer’s circuit dysfunction

    Rong Zhao, Stacy D Grunke ... Joanna L Jankowsky
    Chemogenetic silencing reveals that entorhinal neurons require ongoing activity for survival, suggesting that their normal physiology may render them vulnerable to pathologies that impair transmission.
    1. Neuroscience

    Adaptation of Drosophila larva foraging in response to changes in food resources

    Marina E Wosniack, Dylan Festa ... Jimena Berni
    Drosophila larvae foraging adapt to different food quality and distributions modulating specific motor programs, as revealed by behavioral and modeling experiments.
    1. Structural Biology and Molecular Biophysics

    Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS

    Metehan Ilter, Ramazan Kasmer ... Ozge Sensoy
    The impact of phosphorylation on the dynamics of RAS is considered to find allosteric binding sites on the flat surface of the protein, to which small molecules could bind and perturb the RAS-RAF interaction interface.
    1. Cancer Biology
    2. Immunology and Inflammation

    VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer

    Lei Yang, Xichen Dong ... Zhenjun Wang
    Overexpression of VPS9D1-AS1 is a lncRNA to activate TGF-β and IFN signaling pathways, regulates crosstalk between cancer cells and T lymphocytes in the tumor microenvironment.
    1. Developmental Biology

    m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

    Yanling Xin, Qinghai He ... Shuyi Chen
    m6A fine-tunes transcriptomic transition from neural progenitors to glial cells in the retina.
    1. Developmental Biology
    2. Genetics and Genomics

    Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

    Xiaodong Li, Patrick J Gordon ... Edward M Levine
    The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

    Sofia N Moraes, Jordan T Becker ... Reuben S Harris
    The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to present day.
    1. Cell Biology

    Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo

    Joris P Nassal, Fiona H Murphy ... Matthijs Verhage
    In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.
    1. Epidemiology and Global Health

    Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study

    Bingyi Yang, Bernardo García-Carreras ... Derek A Cummings
    Cross-sectional serological data and mathematical models suggest the existence of long-term periodicity in human antibody responses arising from multiple exposures to influenza A(H3N2), providing insights into the interactions between exposure histories and future risks of infections.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Drosophila SUMM4 complex couples insulator function and DNA replication control

    Evgeniya N Andreyeva, Alexander V Emelyanov ... Dmitry V Fyodorov
    1. Cell Biology

    Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation

    Dawafuti Sherpa, Judith Mueller ... Arno F Alpi
    Erythroid maturation-dependent remodelling of CTLH E3 complex, along with its cognate E2, controls the orderly progression of human erythropoiesis, thus establishing a paradigm for other E2-E3 ubiquitylation modules involved in developmental processes.
    1. Neuroscience

    Uncertainty alters the balance between incremental learning and episodic memory

    Jonathan Nicholas, Nathaniel D Daw, Daphna Shohamy
    People use uncertainty for effective arbitration between episodic memory and incremental learning.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells

    Harry Kane, Nelson M LaMarche ... Lydia Lynch
    Invariant natural killer T (iNKT) cells have some shared yet some distinct metabolic and transcriptional programs for their in vivo effector functions, including a novel population of memory-like regulatory iNKT cells.
    1. Developmental Biology
    2. Genetics and Genomics

    Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

    Elizabeth A Bearce, Zoe H Irons ... Daniel T Grimes
    Urp1 and Urp2 peptides, expressed in CSF-contacting neurons in the spinal canal, prevent abnormal curvature of the zebrafish spine.
    1. Physics of Living Systems

    The importance of intermediate filaments in the shape maintenance of myoblast model tissues

    Irène Nagle, Florence Delort ... Myriam Reffay
    Specific to muscles and essential for their development, desmin is revealed to be fundamental to the mechanics and shape maintenance of model muscle tissue even in early differentiating and unorganized systems through an integrated magnetic tensiometer approach.
    1. Developmental Biology

    Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

    Zhongxiao Wang, Felix Yemanyi ... Jing Chen
    Experimental analysis of SLC38A5 (solute carrier family 38 member 5) in mouse models and cell culture reveals its novel role as a metabolic regulator of retinal angiogenesis by controlling nutrient uptake and homeostasis in blood vessel endothelium.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2, and HBB associated with haemoglobinopathies

    Stella Tamana, Maria Xenophontos ... Petros Kountouris
    The calibration of decision thresholds will provide evidence for the optimal use of in silico predictors for the standardised classification of globin gene variants under the American College of Medical Genetics and Genomics/Association for Molecular Pathology framework.
    1. Neuroscience

    Human hippocampal responses to network intracranial stimulation vary with theta phase

    Sarah M Lurie, James E Kragel ... Joel L Voss
    Human hippocampal connectivity to network afferents varies continuously with the phase of the local theta oscillation, confirming a putative mechanism by which neural oscillations modulate human hippocampal function.
    1. Cell Biology
    2. Medicine

    Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo

    Sharon Elliot, Paola Catanuto ... Marilyn K Glassberg
    A systemic feature of idiopathic pulmonary fibrosis whereby urine-derived exosomes contain pro-fibrotic microRNAs and interfere with response to tissue injury.
    1. Evolutionary Biology
    2. Neuroscience

    The evolution and biological correlates of hand preferences in anthropoid primates

    Kai R Caspar, Fabian Pallasdies ... Sabine Begall
    Primate hand preference strength but not direction (left vs. right) generally reflects phylogeny and ecology at species level, but human handedness deviates markedly from all other species.
    1. Immunology and Inflammation

    CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

    Yang Li, Yan Wu ... Yong-Guang Yang
    Extracellular vesicles released from cells overexpressing CD47 mediate CD47 cross-dressing on surrounding cells, leading to protection against phagocytosis.

Magazine

  1. Point of View: eLife’s new model and its impact on science communication

    Lara Urban, Mariana De Niz ... Lamis Yahia Mohamed Elkheir