Systematic proteomic approaches identify several cell junction regulators as substrates for the homophilic receptor tyrosine phosphatase PTPRK and implicate its pseudophosphatase domain in substrate recognition.
Neural correlates of somatosensory target detection are restricted to secondary somatosensory cortex, whereas activity in insular, cingulate, and motor regions reflects stimulus uncertainty and overt reports.
Optical recordings reveal previously unknown neuromodulator dynamics in the striatum during animal movements that suggest a new interpretation of the underpinnings of bradykinetic movements exhibited in Parkinson's Disease patients.
Antigen receptor control of methionine transport is critical to co-ordinate protein synthesis and the production of methyl donors for nucleotide and protein methylations which are required for T cell differentiation.
Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
Cryo-EM structures of RNA polymerase I reveal considerable 'transformers-like' rearrangements where one subcomplex dissociates and is replaced by one domain of another subunit, possibly as an additional layer of transcriptional control.
Development and application of highly sensitive in situ transcriptomics method, Flura-seq, in identifying dynamic organ-specific transcriptomes in early stage breast cancer metastasis have been described.
Unique heterochrony in the cranial segments in bichirs triggers the early formation of their external gills, and might be informative about developmental mechanisms facilitating increased breathing capacity.
3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to regulate growth, shape, and cellular topology.
A single neonatal inflammatory event induces long-term impairments in two forms of adult respiratory motor plasticity, an important aspect of the control of breathing for compensation after injury or disease.
TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.
mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.
OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
Natural step-to-step variations show how human running is stabilized, underscoring the importance of center of mass control and showing how humans run without falling despite muscle noise and uneven terrain.
The budding yeast transcription factors Reb1 and Cbf1 function as pioneer factors by slowly dissociating from nucleosomes, allowing them to target and unwrap nucleosomes efficiently to regulate transcription.
A direct relationship between pupil diameter and electrophysiological correlates of attention, sensory stimulus processing and target detection was observed demonstrating that arousal has a substantial influence on perceptual decision-making.
Subtypes of dendrite-targeting somatostatin cells segregate into separate networks by specifically connecting with neurons in different layers, forming circuits that could independently control different input pathways to the neocortex.
Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.
The extent of (proteotoxic) endoplasmic reticulum stress, and the ensuing unfolded protein response activation, are commensurate with the extent of the chaperone BiP being sequestered by its client proteins.
Empirical evaluations demonstrate the low probability of finding and replicating significant associations between psychological tests and brain structure in healthy adults, highlighting the importance out-of-sample replication of exploratory findings.
A multipartite virus functionally spreads its distinct genome segments in distinct individual cells of the host plant, and complementation of the viral genes across cells allows a pluricellular infection cycle.
The pro-apoptotic BH3-protein Bim contains two distinct binding sites for anti-apoptotic proteins that together confer resistance of Bim/Bcl-2 and Bim/Bcl-XL complexes to BH3-mimetic drugs under development for use in humans.
Faithful models of RMC require SMARCB1 loss for survival, and genetic and small-molecule screens identify inhibition of the ubiquitin-proteasome system (UPS) as a potential therapeutic approach for SMARCB1 deficient cancers.
Epidermal cells in vertebrates and invertebrates ensheath portions of somatosensory neurons via a conserved morphogenetic mechanism, and this ensheathment regulates morphogenesis and function of Drosophila nociceptive neurons.
A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.
Mechanical instabilities are shown to underlie the development of bacterial biofilm morphology, suggesting an ancient origin for mechano-morphogenesis, which is known to drive developmental processes in tissues in higher organisms.
Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
The zebrafish lateral line utilizes multiple, genetically distinct, independently regulated progenitors to generate new hair cells during homeostasis and regeneration, and to maintain progenitor pools.
Infection and metabolic syndrome lead to a loss of molecular regulation, and changes in molecular correlations are under genetic control as revealed by the presence of correlation quantitative trait loci.
Endothelial cells express a soluble isoform of the L1CAM cell adhesion molecule that is generated by the splicing factor NOVA2 and induces angiogenesis, with relevant implications for ovarian cancer vascularization.