September 2024

Research articles

1. 1. Neuroscience

   Age-dependent predictors of effective reinforcement motor learning across childhood

   Nayo M Hill, Haley M Tripp ... Amy J Bastian
2. 1. Computational and Systems Biology

   TopOMetry systematically learns and evaluates the latent dimensions of single-cell atlases

   Davi Sidarta-Oliveira, Ana Domingos, Licio A Velloso
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

   Malika Hale, Kennidy K Takehara ... Marion Pepper
4. 1. Ecology

   Full factorial construction of synthetic microbial communities

   Juan Diaz-Colunga, Pablo Catalan ... Alvaro Sanchez
5. 1. Neuroscience

   Odors drive feeding through gustatory receptor neurons in Drosophila

   Hong-ping Wei, Ka Chung Lam, Hokto Kazama
6. 1. Ecology
   2. Microbiology and Infectious Disease

   Variation in thermal physiology can drive the temperature-dependence of microbial community richness

   Tom Clegg, Samraat Pawar
7. 1. Chromosomes and Gene Expression

   Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

   James Lee, Leman Simpson ... Lu Bai

   The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.
8. 1. Medicine
   2. Neuroscience

   Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

   Jörn Lötsch, Khayal Gasimli ... Marco Sisignano

   Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.
9. 1. Evolutionary Biology
   2. Immunology and Inflammation

   An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

   Shang Geng, Xing Lv ... Tianjun Xu

   5’ppp-RNA, a traditional ligand for RIG-I, can be recognized by MDA5 in species such as Miichthys miiuy and Gallus gallus that lack RIG-I.
10. 1. Evolutionary Biology
    2. Neuroscience

    Neuro-evolutionary evidence for a universal fractal primate brain shape

    Yujiang Wang, Karoline Leiberg ... Bruno Mota

    Cortices from 11 primate species share the same archetypal fractal shape, indicating a universal mechanism for primate and mammalian cortical folding, and suggesting novel shape biomarkers for brains.
11. 1. Microbiology and Infectious Disease

    ATP burst is the dominant driver of antibiotic lethality in Mycobacteria

    Tejan Lodhiya, Aseem Palande ... Raju Mukherjee
12. 1. Microbiology and Infectious Disease

    Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient

    Yuki Tatekoshi, Chunlei Chen ... Hossein Ardehali

    A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.
13. 1. Neuroscience

    Task-dependent coarticulation of movement sequences

    Hari Teja Kalidindi, Frederic Crevecoeur

    Long-latency reflexes flexibly encode future goals during sequential reaching movements, reflecting the parallel and task-dependent processing of a sequence of goals in circuits that mediate fast feedback control.
14. 1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

    Ritwik Maity, Xuepei Zhang ... Javier Sancho

    Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.
15. 1. Neuroscience

    High-frequency terahertz stimulation alleviates neuropathic pain by inhibiting the pyramidal neuron activity in the anterior cingulate cortex of mice

    Wenyu Peng, Pan Wang ... Tao Chen

    For the first time, high-frequency terahertz stimulation is shown to effectively alleviate chronic pain symptoms in mice by regulating neuronal activity in the cortex.
16. 1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer

    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
17. 1. Medicine
    2. Neuroscience

    Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

    Alberto Granzotto, Bryce Vissel, Stefano L Sensi

    A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
18. 1. Neuroscience

    Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI

    Fan Nils Yang, Dante Picchioni ... Jeff H Duyn

    Whole-night fMRI-based sleep classification uncovers distinct substates within N2 and REM sleep stages, along with a transition structure between them.
19. 1. Medicine

    A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model

    Mitsuru Sugimoto, Tadayuki Takagi ... Hiromasa Ohira
20. 1. Immunology and Inflammation

    Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent

    Alannah Lejeune, Chunyi Zhou ... Ken Cadwell
21. 1. Neuroscience

    Cortico-striatal action control inherent of opponent cognitive-motivational styles

    Cassandra Avila, Martin Sarter
22. 1. Immunology and Inflammation

    Expression of a single inhibitory Ly49 receptor is sufficient to license NK cells for effector functions

    Sytse J Piersma, Shasha Li ... Wayne M Yokoyama
23. 1. Genetics and Genomics

    Confirmation of HLA-II associations with TB susceptibility in admixed African samples

    Dayna Croock, Yolandi Swart ... Caitlin Uren
24. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    Siying Zeng, Yuqi Wang ... Xun Hu
25. 1. Cell Biology
    2. Neuroscience

    Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

    Masaya Muramoto, Nozomi Hanawa ... Natsuki Shinoda
26. 1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Cellular coordination underpins rapid reversals in gliding filamentous cyanobacteria and its loss results in plectonemes

    Jerko Rosko, Kelsey Cremin ... Orkun S Soyer
27. 1. Structural Biology and Molecular Biophysics

    Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

    Aivaras Vaškevičius, Denis Baronas ... Daumantas Matulis
28. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phase transition of WTAP regulates m⁶A modification of interferon-stimulated genes

    Sihui Cai, Jie Zhou ... Jun Cui
29. 1. Neuroscience

    History-dependent spiking facilitates efficient encoding of polarization angles in neurons of the central complex

    Lisa Rother, Anna Stöckl, Keram Pfeiffer
30. 1. Cell Biology
    2. Cancer Biology

    Cell crowding induces TRPV4 inhibition and its relocation to plasma membranes, implicating pro-invasive cell volume reduction mechanotransduction pathway

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
31. 1. Medicine
    2. Immunology and Inflammation

    Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease

    Edwin A Homan, Ankit Gilani ... James C Lo
32. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

    Vineeth Vengayil, Shreyas Niphadkar ... Sunil Laxman

    A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
33. 1. Neuroscience

    Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia

    Merlin Monzel, Pitshaporn Leelaarporn ... Cornelia McCormick

    The autobiographical memory deficits seen in aphantasia are reflected by altered activation and connectivity patterns of the hippocampus and occipital cortex, corroborating the strong link between memory and mental imagery.
34. 1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis

    Kyusang Yoo, Young-Woo Jo ... Young-Yun Kong

    GDNF receptor-expressing mesenchymal progenitor subpopulation within skeletal muscle responds to peripheral nerve injury by sensing GDNF and secreting BDNF, thereby directly promoting nerve regeneration through facilitating remyelination by Schwann cells.
35. 1. Immunology and Inflammation

    Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
36. 1. Neuroscience

    Disruption of the CRF₁ receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice

    Alessandro Piccin, Anne-Emilie Allain ... Angelo Contarino
37. 1. Cell Biology

    Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation

    Kelsey R Baron, Samantha Oviedo ... R Luke Wiseman
38. 1. Ecology
    2. Evolutionary Biology

    Brochosomes as an antireflective camouflage coating for leafhoppers

    Wei Wu, Qianzhuo Mao ... Jian-Ping Chen
39. 1. Medicine
    2. Neuroscience

    Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

    Naidi Sun, Yu-Yo Sun ... Song Hu
40. 1. Developmental Biology

    Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
41. 1. Ecology

    Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction

    Laura Fargeot, Camille Poesy ... Simon Blanchet
42. 1. Computational and Systems Biology

    Establishing comprehensive quaternary structural proteomes from genome sequence

    Edward Alexander Catoiu, Nathan Mih ... Bernhard Palsson
43. 1. Chromosomes and Gene Expression
    2. Plant Biology

    Short heat shock factor A2 confers heat sensitivity in Arabidopsis: Insights into heat resistance and growth balance

    Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
44. 1. Immunology and Inflammation

    Ly6G⁺Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar
45. 1. Cell Biology

    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

    Xiaojiao Hua, Chen Zhao ... Yan Zhou

    An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.
46. 1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells

    Nathaniel Paul Meyer, Tania Singh ... Diane L Barber
47. 1. Neuroscience

    A neural network model of differentiation and integration of competing memories

    Victoria JH Ritvo, Alex Nguyen ... Kenneth A Norman

    A computational neural network model leverages a simple unsupervised learning principle to account for recent findings on when memories move apart (differentiate) or together (integrate) in the brain.
48. 1. Physics of Living Systems

    The exchange dynamics of biomolecular condensates

    Yaojun Zhang, Andrew GT Pyo ... Ned S Wingreen

    Exchange of components between biomolecular condensates and the surrounding dilute phase can be limited by dense-phase mixing, dilute-phase influx, or by the slow incorporation of molecules through the condensate interface.
49. 1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

    Amanda C Perofsky, John Huddleston ... Cécile Viboud

    Antigenic drift in influenza’s major surface proteins, hemagglutinin and neuraminidase, contributes to variability in epidemic magnitude across seasons but is less influential than subtype interference in shaping annual outbreaks.
50. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Differential growth and transcriptomic profile of stem cell-derived midbrain astrocytes

    Zongze Li, Lucia Fernandez Cardo ... Meng Li
51. 1. Neuroscience

    Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI

    Joonas A Autio, Ikko Kimura ... Takuya Hayashi
52. 1. Genetics and Genomics
    2. Neuroscience

    Impact of liver specific survival motor neuron (SMN) depletion on peripheral and central nervous system tissue pathology

    Monique Marylin Alves de Almeida, Yves De Repentigny ... Rashmi Kothary
53. 1. Chromosomes and Gene Expression

    Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

    Houfang Zhang, Wenhan Guo ... Yunhui Peng
54. 1. Developmental Biology

    Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    Pengzhen Dong, Yue Li ... Hai Huang
55. 1. Neuroscience

    Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation

    Hendrik Heinbockel, Gregor Leicht ... Lars Schwabe
56. 1. Neuroscience

    Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice

    Carlos A Sánchez-León, Guillermo Sánchez-Garrido Campos ... Javier Márquez-Ruiz
57. 1. Cell Biology

    Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

    Eleanor Martin, Rossana Girardello ... Alexander Ludwig
58. 1. Neuroscience

    Distractor effects in decision making are related to the individual’s style of integrating choice attributes

    Jing Jun Wong, Alessandro Bongioanni ... Bolton KH Chau

    Computational modelling reveals variations in people’s preferences towards integrating choice attributes using an additive or multiplicative approach, which affected whether the presence of valuable distractors facilitate or impair decision making.
59. 1. Medicine

    Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

    Megan M Sperry, Berenice Charrez ... Donald E Ingber

    Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue injury.
60. 1. Neuroscience

    When and why does motor preparation arise in recurrent neural network models of motor control?

    Marine Schimel, Ta-Chu Kao, Guillaume Hennequin

    A computational model shows that preparation arises as an optimal control strategy in input-driven recurrent neural networks performing a delayed-reaching task.
61. 1. Neuroscience

    3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking

    Victoria B Hosack, Fritzie I Arce-McShane
62. 1. Chromosomes and Gene Expression

    Chromatin endogenous cleavage provides a global view of RNA polymerase II transcription kinetics

    Jake VanBelzen, Bennet Sakelaris ... Jason H Brickner
63. 1. Neuroscience

    Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
64. 1. Developmental Biology
    2. Physics of Living Systems

    Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair

    Jake Turley, Isaac V Chenchiah ... Helen Weavers

    Deep Learning Artificial Intelligence tools can be developed to accurately identify cell divisions during development and wound repair of epithelial tissue.
65. 1. Cancer Biology
    2. Genetics and Genomics

    Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

    Joakim W Karlsson, Vasu R Sah ... Jonas A Nilsson

    Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
66. 1. Neuroscience

    The subthalamic nucleus contributes causally to perceptual decision-making in monkeys

    Kathryn Branam, Joshua I Gold, Long Ding

    The subthalamic nucleus contains distinct subpopulations that can support multifaceted roles for making decisions based on uncertain evidence.
67. 1. Neuroscience

    Endogenous Precision of the Number Sense

    Arthur Prat-Carrabin, Michael Woodford
68. 1. Biochemistry and Chemical Biology

    Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

    Nelson García-Vázquez, Tania J González-Robles ... Sharon Kaisari
69. 1. Neuroscience

    MLCK/MLCP regulates mammalian axon regeneration via the redistribution of the growth cone F-actin

    Saijilafu, Wei-Hua Wang ... Yan-Xia Ma
70. 1. Neuroscience

    NMDA receptor antagonist memantine selectively affects recurrent processing during perceptual inference

    Samuel Noorman, Timo Stein ... Simon van Gaal
71. 1. Neuroscience

    Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

    Astrid Rollenhagen, Akram Sadeghi Dastjerdi ... Joachim HR Lübke
72. 1. Microbiology and Infectious Disease

    The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

    Wenqin Fang, Xiaoyu Zai ... Wenhui Zheng
73. 1. Neuroscience

    Decreased Astrocytic CCL5 by MiR-324-5p Ameliorates Ischemic Stroke Injury via CCR5/ERK/CREB Pathway

    Jingxiu Li, Keyuan Gao ... Chenxi Sun
74. 1. Microbiology and Infectious Disease

    Linalool’s Multifaceted Antimicrobial Potential: Unveiling its Antimicrobial Efficacy and Immunomodulatory Role Against Saprolegnia parasitica

    Tao Tang, Weiming Zhong ... Zhipeng Gao
75. 1. Neuroscience

    Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

    Dirk EM Geurts, Hanneke EM den Ouden ... Roshan Cools
76. 1. Neuroscience

    Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking

    Claire Cooper, Daniel Parthier ... Dietmar Schmitz
77. 1. Neuroscience

    Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory

    Daniel Reznik, Piotr Majka ... Christian F Doeller
78. 1. Cancer Biology
    2. Neuroscience

    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

    Jeffrey Barr, Austin Walz ... Paola D Vermeer

    Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
79. 1. Neuroscience

    Sensitivity to vocal emotions emerges in newborns at 37 weeks gestational age

    Xinlin Hou, Peng Zhang ... Dandan Zhang

    Analysis of neonatal response reveals that at 37 weeks gestational age, infants exhibit a marked developmental shift in their ability to perceive emotional vocal prosody, highlighting a critical period for social emotional development with potential implications for early neurodevelopmental assessments.
80. 1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

    Matthew C Pahl, Prabhat Sharma ... Andrew D Wells

    The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.
81. 1. Cancer Biology

    PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

    Samarjit Jana, Mainak Mondal ... Kumaravel Somasundaram

    PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.
82. 1. Medicine

    Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes

    Jiang Li, Yuefeng Yu ... Bin Wang

    Lipoprotein particle size and composition, fatty acids, and amino acids were associated with the risk of incident diabetes, and adding the selected metabolites could significantly improve the risk prediction of progression from prediabetes to diabetes beyond the conventional clinical variables.
83. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

    Kristina Ehring, Sophia Friederike Ehlers ... Kay Grobe

    A composite hedgehog release model that incorporates and supports a previously disparate set of observations has been presented.
84. 1. Cell Biology
    2. Immunology and Inflammation

    Arpin deficiency increases actomyosin contractility and vascular permeability

    Armando Montoya-Garcia, Idaira M Guerrero-Fonseca ... Michael Schnoor

    Arpin regulates actomyosin contractility and endothelial barrier integrity by controlling the activity of the kinases ROCK1 and ZIPK, but not Arp2/3.
85. 1. Neuroscience

    Mechanism of barotaxis in marine zooplankton

    Luis Alberto Bezares Calderón, Réza Shahidi, Gáspár Jékely

    Ciliated zooplankton larvae sense pressure by ciliary photoreceptor cells, which increase the beating of locomotor cilia via a serotonergic motor circuit leading to rapid upward swimming during barotaxis.
86. 1. Cell Biology

    Exploring the role of macromolecular crowding and TNFR1 in cell volume control

    Parijat Biswas, Priyanka Roy ... Deepak Kumar Sinha
87. 1. Neuroscience

    Laminar specificity and coverage of viral-mediated gene expression restricted to GABAergic interneurons and their parvalbumin subclass in marmoset primary visual cortex

    Frederick Federer, Justin Balsor ... Alessandra Angelucci

    The gene-regulatory enhancers h56D and S5E2 restrict transgene expression to GABAergic and parvalbumin-positive interneurons, respectively, across marmoset cortical layers, thus representing a promising tool for circuit dissection in non-human primates.
88. 1. Cancer Biology

    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

    Anne Fajac, Iva Simeonova ... Franck Toledo

    The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
89. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

    Jie Luo, Jeff Ranish
90. 1. Neuroscience

    Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

    Kevin C Lister, Calvin Wong ... Arkady Khoutorsky
91. 1. Immunology and Inflammation
    2. Neuroscience

    Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation

    Alina Malita, Olga Kubrak ... Kim Rewitz
92. 1. Ecology

    Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?

    Chao Wen, Yuyi Lu ... Lars Chittka

    Behavioral studies reveal that bumblebees distinguish between continuous and interrupted strings by using a combination of image matching and associative learning.
93. 1. Neuroscience

    Ca²⁺ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles

    In vivo analysis of endogenously tagged Ca²⁺ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
94. 1. Chromosomes and Gene Expression
    2. Developmental Biology

    OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline

    Leif Benner, Savannah Muron ... Brian Oliver

    Many well-studied maternal developmental pathways that are required for embryonic development in Drosophila are regulated by the transcription factor OVO in the Drosophila female germline.
95. 1. Immunology and Inflammation

    The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

    Alexandra a Aybar-Torres, Lennon A Saldarriaga ... Lei Jin

    The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.
96. 1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
97. 1. Cell Biology

    Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

    Iuliia Ferling, Steffen Pfalzgraf ... Spencer A Freeman
98. 1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

    Affiong I Oqua, Kin Chao ... Alejandra Tomas
99. 1. Computational and Systems Biology
    2. Physics of Living Systems

    A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

    Sean A Ridout, Priyathama Vellanki, Ilya Nemenman
100. 1. Immunology and Inflammation

     The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes

     GL Barlow, CM Schürch ... PL Bollyky
101. 1. Computational and Systems Biology

     CausalXtract: a flexible pipeline to extract causal effects from live-cell time-lapse imaging data

     Franck Simon, Maria Colomba Comes ... Hervé Isambert
102. 1. Neuroscience

     Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes

     Yuan Chang, Savannah Lusk ... Russell S Ray

     Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for baseline breathing and hypercapnic, hypoxic chemosensory reflexes, which challenges the current understanding of central noradrenergic neurons in breathing control.
103. 1. Biochemistry and Chemical Biology
     2. Plant Biology

     Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production

     Hao Wang, Biying Zhu ... Zhaoliang Zhang

     Comparative structural analysis and biochemical characterization unraveled the mechanisms behind enzymatic substrate selectivity, leading to an amplified theanine yield through active mutant protein screening, thus refining strategies for theanine production.
104. 1. Plant Biology

     OsNF-YB7 inactivates OsGLK1 to inhibit chlorophyll biosynthesis in rice embryo

     Zongju Yang, Tianqi Bai ... Chen Chen

     OsNF-YB7, an ortholog of Arabidopsis LEC1, is a negative regulator of Chl biosynthesis in rice embryos by interacting with OsGLK1 to inhibit the transactivity of OsGLK1.
105. 1. Neuroscience

     Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

     Moneeza A Agha, Sandeep Kishore, David L McLean

     Unexpected complexity in the synaptic basis of locomotor rhythmogenesis is linked to cell type and speed in larval zebrafish.
106. 1. Neuroscience

     Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure

     Stefan Passlick, Ghanim Ullah, Christian Henneberger

     Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.
107. 1. Neuroscience

     DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

     Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez

     DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
108. 1. Neuroscience

     Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

     Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
109. 1. Neuroscience

     Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep

     Gergely F Turi, Sasa Teng ... Yueqing Peng
110. 1. Neuroscience

     Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

     Besma Brahmia, Yahaira Naaldijk ... Sabine Hilfiker
111. 1. Neuroscience

     Supralinear dendritic integration in murine dendrite-targeting interneurons

     Simonas Griesius, Amy Richardson, Dimitri M Kullmann
112. 1. Neuroscience

     Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019)

     Francesca S Wong, Alina B Thomas ... Nathan M Holmes
113. 1. Neuroscience

     Normative evidence weighting and accumulation in correlated environments

     Nathan Tardiff, Jiwon Kang, Joshua I Gold
114. 1. Developmental Biology

     Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

     Saira Amir, Olatunbosun Arowolo ... Alexander Suvorov

     For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.
115. 1. Structural Biology and Molecular Biophysics

     Cryo-EM structure of the CBC-ALYREF complex

     Bradley P Clarke, Alexia E Angelos ... Yi Ren

     Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
116. 1. Structural Biology and Molecular Biophysics

     PPI-hotspot^ID for detecting protein–protein interaction hot spots from the free protein structure

     Yao Chi Chen, Karen Sargsyan ... Carmay Lim

     PPI-hotspot^ID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.
117. 1. Structural Biology and Molecular Biophysics

     Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

     Julia Belyaeva, Matthias Elgeti

     Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
118. 1. Medicine
     2. Neuroscience

     Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

     Tomohiro Umeda, Ayumi Sakai ... Takami Tomiyama
119. 1. Cell Biology

     Inclusive, Exclusive and Hierarchical Atlas of NFATc1⁺/PDGFR-α⁺ Cells in Dental and Periodontal Mesenchyme

     Xue Yang, Chuyi Han ... Fanyuan Yu
120. 1. Neuroscience

     Robust variability of grid cell properties within individual grid modules enhances encoding of local space

     William T Redman, Santiago Acosta-Mendoza ... Michael J Goard
121. 1. Neuroscience

     Single dopaminergic neuron DAN-c1 in Drosophila larval brain mediates aversive olfactory learning through D2-like receptors

     Cheng Qi, Cheng Qian ... Daewoo Lee
122. 1. Computational and Systems Biology

     Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

     David Dierks, Ran Shachar ... Schraga Schwartz
123. 1. Immunology and Inflammation

     The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

     Arijit Chakraborty, Arunava Bandyopadhaya ... Laurence G Rahme

     The Pseudomonas aeruginosa secreted signaling molecule 2'-aminoacetophenone modulates cellular immunometabolism to promote persistence in infected tissues.
124. 1. Cell Biology
     2. Developmental Biology

     Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

     Sarah Rubin, Ankit Agrawal ... Elazar Zelzer
125. 1. Epidemiology and Global Health
     2. Genetics and Genomics

     Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

     Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee

     Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
126. 1. Immunology and Inflammation

     Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

     Jiansen Lu, Jiahuan Zhang ... Xiao Yu

     Vangl2 induced by inflammation recruits ubiquitin ligase PDLIM2 and increases K63-linked ubiquitination on p65, which promotes the recognition of p65 by cargo receptor NDP52 and the autophagic degradation of p65.
127. 1. Immunology and Inflammation

     Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

     Alessandra Machado Araujo, Joseph D Dekker ... Haley O Tucker

     Single-cell RNA-seq data and transgenic models revealed B-plasmacytoid dendritic cells (B-pDCs) represent a phenotypically and functionally distinct common lymphoid progenitor-derived pDC lineage specialized in T cell activation and previously not described in mice.
128. 1. Developmental Biology

     TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

     Jing Wang, Yingying Yin ... Zhaojian Liu

     Experiments on mice show that TMC7, a transmembrane channel-like protein, localizes to the cis-Golgi region in spermatids and that this is essential for acrosome biogenesis and male fertility.
129. 1. Cancer Biology
     2. Structural Biology and Molecular Biophysics

     Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

     Gabriella O Estevam, Edmond M Linossi ... James S Fraser

     Deep mutational scanning reveals interactions in the MET kinase domain that are critical for regulation and cancer-related signaling.
130. 1. Neuroscience

     Language experience shapes predictive coding of rhythmic sound sequences

     Piermatteo Morucci, Sanjeev Nara ... Nicola Molinaro

     A magnetoencephalography study across different languages shows that life-long listening experience influences the neural mechanisms underlying rhythm perception.
131. 1. Cancer Biology

     Engineering PEG10-assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

     Ruijing Tang, Luobin Guo ... Xiaolong Liu

     ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
132. 1. Medicine
     2. Computational and Systems Biology

     Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

     Hong Yang, Cheng Zhang ... Adil Mardinoglu
133. 1. Cell Biology
     2. Neuroscience

     CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

     Longxin Xie, Jessica Merjane ... Christopher J Donnelly
134. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     A General Mechanism for the General Stress Response in Bacteria

     Rishika Baral, Kristin Ho ... Niels Bradshaw
135. 1. Neuroscience

     AVN: A Deep Learning Approach for the Analysis of Birdsong

     Therese MI Koch, Ethan S Marks, Todd F Roberts
136. 1. Neuroscience

     Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

     Odessa R Yabut, Hector Gomez ... Samuel J Pleasure
137. 1. Cancer Biology
     2. Stem Cells and Regenerative Medicine

     Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

     Alison G Barber, Cynthia M Quintero ... Tannishtha Reya
138. 1. Cell Biology
     2. Neuroscience

     Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

     Luting Yang, Chunqing Hu ... Yaping Yan

     Cell biology and animal model analysis in mice shows that molecules involved in glycolytic metabolism could potentially serve as therapeutic targets for the treatment of neurological diseases.
139. 1. Genetics and Genomics

     Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

     Wenjing Liu, Shujin Li ... Xianjun Zhu

     Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
140. 1. Neuroscience

     Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

     Felix Michaud, Ruggiero Francavilla ... Lisa Topolnik

     Early alterations in VIP interneuron activity may contribute to disruptions in CA1 hippocampal circuits and cognitive deficits in the 3xTg mouse model of Alzheimer's disease.
141. 1. Ecology

     Fine-scale tracking reveals visual field use for predator detection and escape in collective foraging of pigeon flocks

     Mathilde Delacoux, Fumihiro Kano

     Foveal vision in pigeons plays a crucial role in predator detection while the flock is collectively foraging and being vigilant.
142. 1. Evolutionary Biology

     Improved inference of population histories by integrating genomic and epigenomic data

     Thibaut Sellinger, Frank Johannes, Aurélien Tellier

     The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
143. 1. Cell Biology
     2. Immunology and Inflammation

     S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

     Daniel M Williams, Andrew A Peden

     Recruitment of NLRP3 to the Golgi is controlled by the reversible addition of a lipid anchor adjacent to the polybasic region.
144. 1. Developmental Biology

     Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

     Shuo Chen, Jie Yin ... Peidong Han
145. 1. Neuroscience

     An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

     Lauren J Kreeger, Suraj Honnuraiah ... Lisa V Goodrich
146. 1. Microbiology and Infectious Disease

     Efficacy and mechanism of actions of cipargamin as an antibabesial drug candidate

     Hang Li, Shengwei Ji ... Xuenan Xuan
147. 1. Medicine
     2. Immunology and Inflammation

     Preeclampsia-specific immune cell network in placenta revealed by Cytometry by time of flight and single-cell RNA-seq

     Haiyi Fei, Xiaowen Lu ... Lingling Jiang
148. 1. Evolutionary Biology

     Effective population size does not explain long-term variation in genome size and transposable element content in animals

     Alba Marino, Gautier Debaecker ... Benoit Nabholz
149. 1. Neuroscience

     POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons

     Rajae Talbi, Todd L Stincic ... Víctor M Navarro
150. 1. Microbiology and Infectious Disease

     Cyclical MinD membrane affinity differences are not necessary for MinD gradient formation in Bacillus subtilis

     Laura C Bohorquez, Henrik Strahl ... Leendert W Hamoen
151. 1. Microbiology and Infectious Disease

     Mechanistic Insights into MinD Regulation and Pattern Formation in Bacillus subtilis

     Helge Feddersen, Marc Bramkamp
152. 1. Neuroscience

     A unifying account of replay as context-driven memory reactivation

     Zhenglong Zhou, Michael J Kahana, Anna C Schapiro
153. 1. Cancer Biology

     Targeting ribosome biogenesis as a novel therapeutic approach to overcome EMT-related chemoresistance in breast cancer

     Yi Ban, Yue Zou ... Dingcheng Gao

     Inhibiting the RiBi pathway impedes both EMT and MET processes, enhancing chemotherapy efficacy and presenting a novel avenue to tackle advanced breast cancer treatment resistance.
154. 1. Neuroscience

     Neuroelectrophysiology-compatible electrolytic lesioning

     Iliana E Bray, Stephen E Clarke ... Paul Nuyujukian

     Neuronal loss can be studied by passing electrical current through the same electrodes used for neuron measurement without disrupting recording ability.
155. 1. Ecology

     Different coexistence patterns between apex carnivores and mesocarnivores based on temporal, spatial, and dietary niche partitioning analysis in Qilian Mountain National Park, China

     Wei Cong, Jia Li ... Yuguang Zhang

     Spatial segregation is identified as the primary mechanism facilitating the coexistence of apex and mesocarnivores in the Qilian Mountain National Park, China.
156. 1. Structural Biology and Molecular Biophysics

     Revealing a hidden conducting state by manipulating the intracellular domains in K_V10.1 exposes the coupling between two gating mechanisms

     Reham Abdelaziz, Adam P Tomczak ... Luis A Pardo

     The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.
157. 1. Cell Biology

     Dysregulated Ca²⁺ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s disease

     Kai-Ting Huang, Larry E Wagner ... David I Yule

     In a mouse model of Sjogren's disease, mitochondrial function and Ca²⁺ signaling are disrupted resulting in altered coupling between Ca²⁺ release and Ca²⁺ activated Cl^- channels and salivary gland hypofunction.
158. 1. Ecology

     Developmental stage shapes the realized energy landscape for a flight specialist

     Elham Nourani, Louise Faure ... Kamran Safi

     The realized energy landscape expands as animals improve their movement behaviors with age.
159. 1. Cancer Biology

     Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

     Elazar Besser, Anat Gelfand ... David Meiri

     The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
160. 1. Computational and Systems Biology

     Identifying images in the biology literature that are problematic for people with a color-vision deficiency

     Harlan P Stevens, Carly V Winegar ... Stephen R Piccolo

     Approximately 13% of figures in biology-related research articles are difficult for people with red/green colorblindness to decipher, but machine-learning models can help to identify these.
161. 1. Developmental Biology
     2. Neuroscience

     Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

     Yuqi Cai, Zhirong Zhao ... Miao He

     Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.
162. 1. Developmental Biology
     2. Neuroscience

     Lateral/caudal ganglionic eminence makes limited contribution to cortical oligodendrocytes

     Jialin Li, Feihong Yang ... Zhuangzhi Zhang

     The contribution of the lateral/caudal ganglionic eminence to the pool of cortical oligodendrocyte precursor cells is minimal.
163. 1. Neuroscience

     α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

     Rixu Cong, Huiran Li ... Chen Zhang
164. 1. Neuroscience

     Age-related changes in “cortical” 1/f dynamics are linked to cardiac activity

     Fabian Schmidt, Sarah K Danböck ... Nathan Weisz
165. 1. Microbiology and Infectious Disease
     2. Physics of Living Systems

     Should I stay or should I go? Spatio-temporal dynamics of bacterial biofilms in confined flows

     Massinissa Benbelkacem, Gabriel Ramos ... Yohan Davit
166. 1. Neuroscience

     Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

     Erin M Ritchie, Siming Zhong ... Yishi Jin
167. 1. Cell Biology
     2. Neuroscience

     The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus

     Lei Li, Guanghao Wu ... Yinchuan Li
168. 1. Neuroscience

     Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila

     Martina Held, Rituja S Bisen ... Jan M Ache
169. 1. Plant Biology

     Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation

     Yicong Wang, Masato Abe ... Nobutoshi Yamaguchi
170. 1. Neuroscience

     Individuals with anxiety and depression use atypical decision strategies in an uncertain world

     Zeming Fang, Meihua Zhao ... Ru-Yuan Zhang

     A model with a mixture of three different decision strategies is developed to characterize several atypical behavioral patterns of individuals with depression and anxiety in an uncertain reward environment.
171. 1. Stem Cells and Regenerative Medicine

     Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila

     Zhixin Ma, Wenshu Wang ... Su Wang

     Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.
172. 1. Computational and Systems Biology
     2. Evolutionary Biology

     Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

     Kara Schmidlin, Sam Apodaca ... Kerry Geiler-Samerotte

     Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to environmental change.
173. 1. Neuroscience

     Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

     Guoqiang Wang, Ryan J Guasp ... Monica Driscoll

     Large extracellular vesicle extrusion that eliminates neuronal protein aggregates and organelles is potentiated by uterine filling, linking reproductive status to maternal nervous system health, and demonstrating mechanobiology components in exophergenesis.
174. 1. Computational and Systems Biology

     A three filament mechanistic model of musculotendon force and impedance

     Matthew Millard, David W Franklin, Walter Herzog

     Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
175. 1. Neuroscience

     Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

     Minsik Yun, Do-Hyoung Kim ... Young-Joon Kim

     Identification of central neural circuits and sensory pathways underlying social-sexual modulation of sperm ejection in female Drosophila unraveled cryptic mate choice, a mechanism of post-copulatory sexual selection.
176. 1. Neuroscience

     Speech-induced suppression and vocal feedback sensitivity in human cortex

     Muge Ozker, Leyao Yu ... Adeen Flinker

     During speech production, auditory regions that show speech-induced suppression are sensitive to changes in auditory feedback, suggesting that suppression may be a key mechanism underlying speech monitoring.
177. 1. Neuroscience

     DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment

     Ran-Der Hwang, YuNing Lu ... Jiou Wang

     A genome-wide screen identifies the BCAA catabolizing enzyme DBT as a master metabolic switch in the regulation of protein quality control when proteasomal activity is impaired.
178. 1. Developmental Biology
     2. Genetics and Genomics

     Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

     Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
179. 1. Epidemiology and Global Health

     From multiplicity of infection to force of infection for sparsely sampled Plasmodium falciparum populations at high transmission

     Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
180. 1. Structural Biology and Molecular Biophysics
     2. Neuroscience

     Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

     Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
181. 1. Neuroscience

     APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

     Mengxun Luo, Jia Zhou ... Yelin Chen
182. 1. Medicine
     2. Neuroscience

     Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

     Chi Zhang, Qian Huang ... Yun Guan
183. 1. Developmental Biology

     BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

     Guozhu Ning, Yu Lin ... Qiang Wang
184. 1. Biochemistry and Chemical Biology

     Coordinated regulation of chemotaxis and resistance to copper by CsoR in Pseudomonas putida

     Meina He, Yongxin Tao ... Wenli Chen
185. 1. Immunology and Inflammation

     Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

     Eva M García-Cuesta, Pablo Martínez ... Mario Mellado

     In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.
186. 1. Microbiology and Infectious Disease

     Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

     Lesia Semenova, Yingfan Wang ... Edward P Browne

     Dimension reduction and machine learning tools were used to identify novel associations between the HIV reservoir and the immune systems of people with HIV.
187. 1. Cell Biology

     Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

     Roberto Notario Manzano, Thibault Chaze ... Christel Brou

     Proteomic analysis of tunneling nanotubes (TNTs) identifies CD9 and CD81 as major positive regulators of TNT formation.
188. 1. Microbiology and Infectious Disease

     Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

     Srinivasan Vijay, Nguyen Le Hoai Bao ... Nguyen Thuy Thuong

     Isoniazid resistance in Mycobacterium tuberculosis is linked to higher rifampicin tolerance, necessitating evaluation and potential adjustment of treatment regimens to combat emerging multi-drug resistant variants.
189. 1. Developmental Biology

     SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development

     Rula Sha, Ruochen Guo ... Ying Feng

     Genetic mouse models combined with single-cell RNA sequencing reveal the essential role of SRSF2 in directing MyoD progenitors to distinct skeletal muscle domains and controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.
190. 1. Genetics and Genomics

     Intergenerational transport of double-stranded RNA limits heritable epigenetic changes

     Nathan Shugarts, Aishwarya Sathya ... Antony M Jose
191. 1. Cell Biology
     2. Neuroscience

     CellSeg3D: self-supervised 3D cell segmentation for microscopy

     Cyril Achard, Timokleia Kousi ... Mackenzie Weygandt Mathis
192. 1. Evolutionary Biology

     Prophage-encoded Hm-oscar gene recapitulates Wolbachia-induced male killing in the tea tortrix moth Homona magnanima

     Hiroshi Arai, Susumu Katsuma ... Daisuke Kageyama
193. 1. Neuroscience

     Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Cognitive Decision-Making, and Reward Prediction

     Xinyu Du, Haoxuan Xu ... Xiongjie Yu
194. 1. Structural Biology and Molecular Biophysics

     PROTAC-induced Protein Functional Dynamics in Targeted Protein Degradation

     Kingsley Y Wu, Ta I Hung, Chia-en A Chang
195. 1. Genetics and Genomics
     2. Neuroscience

     Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

     Tom Bonnifet, Sandra Sinnassamy ... Julia Fuchs
196. 1. Cell Biology
     2. Cancer Biology

     RUNX2 Isoform II Protects Cancer Cells from Ferroptosis by Promoting PRDX2 Expression in Oral Squamous Cell Carcinoma

     Junjun Huang, Rong Jia, Jihua Guo
197. 1. Cell Biology
     2. Physics of Living Systems

     Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

     Bret A Unger, Chun Ying Wu ... Ke Xu
198. 1. Developmental Biology
     2. Genetics and Genomics

     Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

     Mitchell Bestry, Alexander N Larcombe ... David Martino

     Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.
199. 1. Evolutionary Biology
     2. Genetics and Genomics

     The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

     Catherine A Weibel, Andrew L Wheeler ... Joanna Masel

     Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.
200. 1. Neuroscience

     Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

     Yoav Ger, Moni Shahar, Nitzan Shahar

     Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.
201. 1. Computational and Systems Biology
     2. Immunology and Inflammation

     ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

     Jing Sun, Desmond Choy ... Shahram Kordasti

     ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.
202. 1. Neuroscience

     Novel cyclic homogeneous oscillation detection method for high accuracy and specific characterization of neural dynamics

     Hohyun Cho, Markus Adamek ... Peter Brunner

     Detecting neural oscillations in time and frequency domains enables the detailed study of spatiotemporal dynamics of oscillations throughout the brain and the investigation of biomarkers that index functional brain areas.
203. 1. Neuroscience

     The function of juvenile–adult transition axis in female sexual receptivity of Drosophila melanogaster

     Jing Li, Chao Ning ... Chuan Zhou

     Prothoracicotropic hormone and ecdysone belonging to the insect PG axis modulate virgin female sexual receptivity.
204. 1. Structural Biology and Molecular Biophysics

     Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE

     Xinyu Gu, Akashnathan Aranganathan, Pratyush Tiwary

     AlphaFold2's inability to generate non-native conformations for docking is addressed by AI-molecular dynamics method AlphaFold2-RAVE, which produces Boltzmann-ranked conformations, enabling the retrospective discovery of type II kinase inhibitors.
205. 1. Evolutionary Biology
     2. Microbiology and Infectious Disease

     Reversions mask the contribution of adaptive evolution in microbiomes

     Paul A Torrillo, Tami D Lieberman

     The timescale dependence of d_N/d_S in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.
206. 1. Neuroscience

     Connectome-Based Attractor Dynamics Underlie Brain Activity in Rest, Task, and Disease

     Robert Englert, Balint Kincses ... Tamas Spisak
207. 1. Developmental Biology
     2. Genetics and Genomics

     PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

     Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
208. 1. Neuroscience

     Flexible neural representations of abstract structural knowledge in the human Entorhinal Cortex

     Shirley Mark, Phillipp Schwartenbeck ... Timothy E Behrens
209. 1. Neuroscience

     Reevaluating the Neural Noise Hypothesis in Dyslexia: Insights from EEG and 7T MRS Biomarkers

     Agnieszka Glica, Katarzyna Wasilewska ... Katarzyna Jednoróg
210. 1. Neuroscience

     Multi-dimensional oscillatory activity of mouse GnRH neurons in vivo

     Su Young Han, Shel-Hwa Yeo ... Allan E Herbison
211. 1. Medicine

     Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration

     Thomas M Hallam, Emanuela Gardenal ... Amy V Jones
212. 1. Evolutionary Biology

     Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids

     Nagatoshi Machii, Ryo Hatashima ... Masato Nikaido
213. 1. Neuroscience

     Mixed representations of choice and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus

     Julianna Locantore, Yijun Liu ... Michael L Wallace
214. 1. Neuroscience

     A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

     Yihe Weng, Johann Kruschwitz ... IMAGEN Consortium

     Differences in behavior and brain connectivity in young adolescents predicted future substance use.
215. 1. Developmental Biology
     2. Neuroscience

     UPR^ER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

     Pengfei Liu, Xinyi Liu, Bin Qi

     The cellular stress response pathway helps animals evaluate food quality and regulate feeding behavior to adapt in nutrient-deficient environments.
216. 1. Neuroscience

     Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

     Katrin Franke, Chenchen Cai ... Andreas Savas Tolias

     Widespread color-opponency in mouse V1 enhances object decoding in the sky, highlighting the evolutionary importance of color processing in non-primate species.
217. 1. Physics of Living Systems

     Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women

     Alex James, Franca Buelow ... Ann Brower

     There is a systemic bias in research evaluation, i.e., disciplines with a higher proportion of women have lower evaluations and funding success for all researchers, regardless of gender.
218. 1. Immunology and Inflammation

     Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components

     Fani Roumelioti, Christos Tzaferis ... George Kollias

     A novel in vivo role for miRNAs Mir221/222 in arthritogenic synovial fibroblasts and progression of arthritis is presented.
219. 1. Cell Biology

     Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

     Ming Zhang, Guangyi Du ... Wei Chen

     Cardiovascular disease, the top cause of diabetic deaths, progresses via vascular endothelial dysfunction, with circHMGCS1 and miR4521 highlighted as potential markers for the development of this condition.
220. 1. Cancer Biology

     Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

     Sila Gerlevik, Nogayhan Seymen ... Mohammad M Karimi

     Multi-omics factor analysis reveals transposable element expression as a risk factor and inflammation as a protective factor in myelodysplastic syndromes (MDS).
221. 1. Neuroscience

     Analysis of fast calcium dynamics of honey bee olfactory coding

     Marco Paoli, Antoine Wystrach ... Martin Giurfa

     Fast calcium dynamics of honey bee olfactory projection neurons revealed an unprecedented heterogeneity of response profile dynamics and explained fundamental aspects of olfactory discrimination and associative learning.
222. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates

     Yi-Hsuan Lin, Tae Hun Kim ... Hue Sun Chan
223. 1. Cell Biology

     Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis

     Davinder Singh, Yajun Liu ... Jian-Qiu Wu
224. 1. Microbiology and Infectious Disease

     A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

     Gabriele Baniulyte, Joseph T Wade
225. 1. Microbiology and Infectious Disease

     Unraveling CRP/cAMP-Mediated Metabolic Regulation In Escherichia coli Persister Cells

     Han G Ngo, Sayed Golam Mohiuddin ... Mehmet A Orman
226. 1. Cancer Biology
     2. Evolutionary Biology

     On the discovered Cancer Driving Nucleotides (CDNs) –Distributions across genes, cancer types and patients

     Lingjie Zhang, Tong Deng ... Chung-I Wu
227. 1. Genetics and Genomics
     2. Cancer Biology

     NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors

     Connor M Hill, Alexandra Indeglia ... Alessandro Gardini
228. 1. Neuroscience

     Encoding of cerebellar dentate neuronal activity during visual attention in rhesus macaques

     Nico A Flierman, Sue Ann Koay ... Chris I De Zeeuw
229. 1. Epidemiology and Global Health

     Lifestyles and their relative contribution to biological aging across multiple organ systems: change analysis from the China Multi-Ethnic Cohort Study

     Yuan Zhang, Dan Tang ... Xing Zhao
230. 1. Computational and Systems Biology
     2. Neuroscience

     White matter structural bases for phase accuracy during tapping synchronization

     Pamela Garcia-Saldivar, Cynthia de León ... Hugo Merchant
231. 1. Biochemistry and Chemical Biology

     Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

     Aleksandar Bartolome, Julia C Heiby ... Alessandro Ori

     Proximity labeling combined with mass spectrometry enables to map the proteasome proximal proteome in cells and mouse tissues.
232. 1. Biochemistry and Chemical Biology

     Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication

     Jack A Bryant, Kara A Staunton ... Manuel Banzhaf
233. 1. Medicine
     2. Microbiology and Infectious Disease

     Multiomics reveals gut dysbiosis contributes to fatty acid dysmetabolism in early phase of acute myocardial infarction

     Yong Fan, Jiajun Ying ... Hanbin Cui
234. 1. Cell Biology

     STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm

     Sam Weeks, Dubravka Pezic ... Suzana Hadjur
235. 1. Neuroscience

     Stimulus representation in human frontal cortex supports flexible control in working memory

     Zhujun Shao, Mengya Zhang, Qing Yu
236. 1. Immunology and Inflammation

     Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

     Yujie Fang, Zihan Guan ... Ke Peng
237. 1. Genetics and Genomics

     Dynamics and Regulatory Roles of RNA m⁶A Methylation in Unbalanced Genomes

     Shuai Zhang, Xinyu Liu ... Lin Sun
238. 1. Microbiology and Infectious Disease

     Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

     Yajun Zhai, Peiyi Liu ... Yajun Zhai
239. 1. Microbiology and Infectious Disease
     2. Physics of Living Systems

     Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

     Ka Kiu Lee, Urszula Łapińska ... Stefano Pagliara
240. 1. Cancer Biology
     2. Evolutionary Biology

     The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

     Lingjie Zhang, Tong Deng ... Chung-I Wu
241. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Control of 3’ splice site selection by the yeast splicing factor Fyv6

     Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
242. 1. Biochemistry and Chemical Biology

     A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

     Brennan J Wadsworth, Marina Leiwe ... Randall S Johnson

     The metabolite 2-hydroxybutyrate is an important aspect of exhaustion which leads to increased capacity in the branched chain amino acid degradation pathway.
243. 1. Genetics and Genomics

     Resetting of H3K4me2 during mammalian parental-to-zygote transition

     Chong Wang, Yong Shi ... Jiawei Xu
244. 1. Stem Cells and Regenerative Medicine

     Sox9 marks limbal stem cells and is required for asymmetric cell fate switch in the corneal epithelium

     Gabriella Rice, Olivia Farrelly ... Panteleimon Rompolas
245. 1. Microbiology and Infectious Disease

     Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

     Giorgia Greter, Claudia Moresi ... Markus Arnoldini
246. 1. Cell Biology

     Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

     Masroor Ahmad Paddar, Fulong Wang ... Vojo Deretic
247. 1. Developmental Biology
     2. Evolutionary Biology

     Insect metamorphosis is regulated differently between sexes by members of a microRNA cluster

     Chade Li, Ki Kei Chan ... Jerome HL Hui
248. 1. Neuroscience

     Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

     Jixing Li, Qixuan Wang ... Zhiwu Huang
249. 1. Immunology and Inflammation
     2. Microbiology and Infectious Disease

     Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

     Patrick KA Kearns, Charles Dixon ... Nick Gilbert
250. 1. Cancer Biology

     A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

     Kailai Li, Junyi Liang ... Hui Meng
251. 1. Developmental Biology
     2. Genetics and Genomics

     Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

     Tao Cheng, Xiang Liu ... Peng-Fei Xu
252. 1. Developmental Biology

     Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

     Akiko Hozumi, Nozomu M Totsuka ... Yasunori Sasakura
253. 1. Cancer Biology

     Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

     Xin Zhang, Guangyu Zhang ... Chunjie Liu
254. 1. Cancer Biology

     The mitochondrial stress-induced protein carboxyl-terminal alanine and threonine tailing (msiCAT-tailing) promotes glioblastoma tumorigenesis by modulating mitochondrial functions

     Ting Cai, Bei Zhang ... Zhihao Wu
255. 1. Neuroscience

     DeePosit: an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments

     David Peles, Shai Netser ... Shlomo Wagner
256. 1. Medicine

     Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

     Zhen Wang, Jie Zhu ... Xiang Zhou
257. 1. Neuroscience

     When Do Visual Category Representations Emerge in Infants’ Brains?

     Xiaoqian Yan, Sarah Tung ... Kalanit Grill-Spector
258. 1. Neuroscience

     Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

     Tania Fuchsberger, Imogen Stockwell ... Ole Paulsen
259. 1. Biochemistry and Chemical Biology
     2. Microbiology and Infectious Disease

     β-1,6-glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall

     Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine
260. 1. Evolutionary Biology

     The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles in Arabidopsis halleri and Arabidopsis lyrata

     Audrey Le Veve, Mathieu Genete ... Vincent Castric

     By modulating the intensity of balancing selection at the S-locus, dominance between self-incompatibility alleles shapes the genetic load linked to each allele, creating inbreeding depression in some S-locus homozygotes.
261. 1. Neuroscience

     Future movement plans interact in sequential arm movements

     Mehrdad Kashefi, Sasha Reschechtko ... J Andrew Pruszynski

     To ensure smooth sequential actions, reaches to at least two future targets are planned during the execution of the current reach and the planning processes of the future reaches interact.
262. 1. Structural Biology and Molecular Biophysics

     Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

     Dipti Ranjan Lenka, Shakti Virendra Dahe ... Atul Kumar

     The new insights into the activation mechanism of Parkin E3 ligase could be useful for designing small-molecule activators against Parkinson’s disease.
263. 1. Chromosomes and Gene Expression

     CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

     Ryo Kariyazono, Takashi Osanai

     cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.
264. 1. Structural Biology and Molecular Biophysics

     Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

     Po-Lin Chiu, Juan D Orjuela ... Thomas Walz

     Electron crystallography and molecular dynamics simulations show that a cholesterol sandwiched in between two neighboring aquaporin-0 tetramers stabilizes the association between the tetramers and thus promotes array formation.
265. 1. Structural Biology and Molecular Biophysics

     The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

     Artem N Bonchuk, Konstantin I Balagurov ... Pavel G Georgiev

     The cryo-EM structure of the CG6765 BTB domain and solution scattering experiments revealed a unique three-dimer hexameric assembly for the arthropod Tramtrack group BTB domains.
266. 1. Computational and Systems Biology
     2. Developmental Biology

     Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo

     Juan Manuel Gomez, Hendrik Nolte ... Maria Leptin

     An encompassing resource of differentially phosphorylated proteins forms the basis for identifying missing links in cell fate determination and morphogenesis, including, for example, microtubules as mediators of different functions in cells along the dorso-ventral axis.