September 2024

Research articles

1. 1. Ecology

   Full factorial construction of synthetic microbial communities

   Juan Diaz-Colunga, Pablo Catalan ... Alvaro Sanchez
2. 1. Computational and Systems Biology

   TopOMetry systematically learns and evaluates the latent dimensions of single-cell atlases

   Davi Sidarta-Oliveira, Ana Domingos, Licio A Velloso
3. 1. Chromosomes and Gene Expression

   Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

   James Lee, Leman Simpson ... Lu Bai

   The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.
4. 1. Medicine
   2. Neuroscience

   Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

   Jörn Lötsch, Khayal Gasimli ... Marco Sisignano

   Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.
5. 1. Evolutionary Biology
   2. Neuroscience

   Neuro-evolutionary evidence for a universal fractal primate brain shape

   Yujiang Wang, Karoline Leiberg ... Bruno Mota

   Cortices from 11 primate species share the same archetypal fractal shape, indicating a universal mechanism for primate and mammalian cortical folding, and suggesting novel shape biomarkers for brains.
6. 1. Ecology
   2. Microbiology and Infectious Disease

   Variation in thermal physiology can drive the temperature-dependence of microbial community richness

   Tom Clegg, Samraat Pawar

   A novel theory demonstrates how variation in the thermal responses of microbial populations can alter coexistance and thus explain patterns of richness across thermal gradients.
7. 1. Evolutionary Biology
   2. Immunology and Inflammation

   An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

   Shang Geng, Xing Lv ... Tianjun Xu

   5’ppp-RNA, a traditional ligand for RIG-I, can be recognized by MDA5 in species such as Miichthys miiuy and Gallus gallus that lack RIG-I.
8. 1. Microbiology and Infectious Disease

   ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

   Tejan Lodhiya, Aseem Palande ... Raju Mukherjee
9. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

   Ritwik Maity, Xuepei Zhang ... Javier Sancho

   Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.
10. 1. Microbiology and Infectious Disease

    Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient

    Yuki Tatekoshi, Chunlei Chen ... Hossein Ardehali

    A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.
11. 1. Medicine
    2. Neuroscience

    Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

    Alberto Granzotto, Bryce Vissel, Stefano L Sensi

    A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
12. 1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer

    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
13. 1. Neuroscience

    High-frequency terahertz stimulation alleviates neuropathic pain by inhibiting the pyramidal neuron activity in the anterior cingulate cortex of mice

    Wenyu Peng, Pan Wang ... Tao Chen

    For the first time, high-frequency terahertz stimulation is shown to effectively alleviate chronic pain symptoms in mice by regulating neuronal activity in the cortex.
14. 1. Neuroscience

    Task-dependent coarticulation of movement sequences

    Hari Teja Kalidindi, Frederic Crevecoeur

    Long-latency reflexes flexibly encode future goals during sequential reaching movements, reflecting the parallel and task-dependent processing of a sequence of goals in circuits that mediate fast feedback control.
15. 1. Neuroscience

    Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI

    Fan Nils Yang, Dante Picchioni ... Jeff H Duyn

    Whole-night fMRI-based sleep classification uncovers distinct substates within N2 and REM sleep stages, along with a transition structure between them.
16. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    Siying Zeng, Yuqi Wang ... Xun Hu
17. 1. Neuroscience

    History-dependent spiking facilitates efficient encoding of polarization angles in neurons of the central complex

    Lisa Rother, Anna Stöckl, Keram Pfeiffer
18. 1. Neuroscience

    Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia

    Merlin Monzel, Pitshaporn Leelaarporn ... Cornelia McCormick

    The autobiographical memory deficits seen in aphantasia are reflected by altered activation and connectivity patterns of the hippocampus and occipital cortex, corroborating the strong link between memory and mental imagery.
19. 1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis

    Kyusang Yoo, Young-Woo Jo ... Young-Yun Kong

    GDNF receptor-expressing mesenchymal progenitor subpopulation within skeletal muscle responds to peripheral nerve injury by sensing GDNF and secreting BDNF, thereby directly promoting nerve regeneration through facilitating remyelination by Schwann cells.
20. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

    Vineeth Vengayil, Shreyas Niphadkar ... Sunil Laxman

    A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
21. 1. Developmental Biology

    Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
22. 1. Immunology and Inflammation

    Ly6G⁺Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar
23. 1. Medicine
    2. Neuroscience

    Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

    Naidi Sun, Yu-Yo Sun ... Song Hu
24. 1. Computational and Systems Biology

    Establishing comprehensive quaternary structural proteomes from genome sequence

    Edward Alexander Catoiu, Nathan Mih ... Bernhard Palsson
25. 1. Physics of Living Systems

    The exchange dynamics of biomolecular condensates

    Yaojun Zhang, Andrew GT Pyo ... Ned S Wingreen

    Exchange of components between biomolecular condensates and the surrounding dilute phase can be limited by dense-phase mixing, dilute-phase influx, or by the slow incorporation of molecules through the condensate interface.
26. 1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells

    Nathaniel Paul Meyer, Tania Singh ... Diane L Barber

    Clonal naïve human embryonic stem cells assemble an Arp2/3 complex-dependent contractile actin filament ring around colonies that promotes tensional forces favoring cell-cell adhesion and nuclear translocation of YAP to maintain ground-state pluripotency.
27. 1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

    Amanda C Perofsky, John Huddleston ... Cécile Viboud

    Antigenic drift in influenza’s major surface proteins, hemagglutinin and neuraminidase, contributes to variability in epidemic magnitude across seasons but is less influential than subtype interference in shaping annual outbreaks.
28. 1. Neuroscience

    A neural network model of differentiation and integration of competing memories

    Victoria JH Ritvo, Alex Nguyen ... Kenneth A Norman

    A computational neural network model leverages a simple unsupervised learning principle to account for recent findings on when memories move apart (differentiate) or together (integrate) in the brain.
29. 1. Cell Biology

    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

    Xiaojiao Hua, Chen Zhao ... Yan Zhou

    An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.
30. 1. Chromosomes and Gene Expression

    Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

    Houfang Zhang, Wenhan Guo ... Yunhui Peng
31. 1. Cell Biology

    Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

    Eleanor Martin, Rossana Girardello ... Alexander Ludwig

    Membrane tension controls the dynamic assembly and disassembly of caveolae and their association with the F-actin cortex in migrating cells.
32. 1. Medicine

    Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

    Megan M Sperry, Berenice Charrez ... Donald E Ingber

    Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue injury.
33. 1. Neuroscience

    Distractor effects in decision making are related to the individual’s style of integrating choice attributes

    Jing Jun Wong, Alessandro Bongioanni ... Bolton KH Chau

    Computational modelling reveals variations in people’s preferences towards integrating choice attributes using an additive or multiplicative approach, which affected whether the presence of valuable distractors facilitate or impair decision making.
34. 1. Neuroscience

    When and why does motor preparation arise in recurrent neural network models of motor control?

    Marine Schimel, Ta-Chu Kao, Guillaume Hennequin

    A computational model shows that preparation arises as an optimal control strategy in input-driven recurrent neural networks performing a delayed-reaching task.
35. 1. Neuroscience

    Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
36. 1. Cancer Biology
    2. Genetics and Genomics

    Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

    Joakim W Karlsson, Vasu R Sah ... Jonas A Nilsson

    Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
37. 1. Neuroscience

    The subthalamic nucleus contributes causally to perceptual decision-making in monkeys

    Kathryn Branam, Joshua I Gold, Long Ding

    The subthalamic nucleus contains distinct subpopulations that can support multifaceted roles for making decisions based on uncertain evidence.
38. 1. Developmental Biology
    2. Physics of Living Systems

    Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair

    Jake Turley, Isaac V Chenchiah ... Helen Weavers

    Deep Learning Artificial Intelligence tools can be developed to accurately identify cell divisions during development and wound repair of epithelial tissue.
39. 1. Microbiology and Infectious Disease

    The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

    Wenqin Fang, Xiaoyu Zai ... Wenhui Zheng
40. 1. Neuroscience

    Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

    Dirk EM Geurts, Hanneke EM den Ouden ... Roshan Cools
41. 1. Neuroscience

    Endogenous Precision of the Number Sense

    Arthur Prat-Carrabin, Michael Woodford
42. 1. Neuroscience

    Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory

    Daniel Reznik, Piotr Majka ... Christian F Doeller
43. 1. Neuroscience

    Decreased Astrocytic CCL5 by MiR-324-5p Ameliorates Ischemic Stroke Injury via CCR5/ERK/CREB Pathway

    Jingxiu Li, Keyuan Gao ... Chenxi Sun
44. 1. Neuroscience

    MLCK/MLCP regulates mammalian axon regeneration and redistributes the growth cone F-actin

    Saijilafu, Wei-Hua Wang ... Yan-Xia Ma
45. 1. Cancer Biology
    2. Neuroscience

    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

    Jeffrey Barr, Austin Walz ... Paola D Vermeer

    Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
46. 1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

    Matthew C Pahl, Prabhat Sharma ... Andrew D Wells

    The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.
47. 1. Neuroscience

    Sensitivity to vocal emotions emerges in newborns at 37 weeks gestational age

    Xinlin Hou, Peng Zhang ... Dandan Zhang

    Analysis of neonatal response reveals that at 37 weeks gestational age, infants exhibit a marked developmental shift in their ability to perceive emotional vocal prosody, highlighting a critical period for social emotional development with potential implications for early neurodevelopmental assessments.
48. 1. Cancer Biology

    PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

    Samarjit Jana, Mainak Mondal ... Kumaravel Somasundaram

    PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.
49. 1. Medicine

    Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes

    Jiang Li, Yuefeng Yu ... Bin Wang

    Lipoprotein particle size and composition, fatty acids, and amino acids were associated with the risk of incident diabetes, and adding the selected metabolites could significantly improve the risk prediction of progression from prediabetes to diabetes beyond the conventional clinical variables.
50. 1. Neuroscience

    Mechanism of barotaxis in marine zooplankton

    Luis Alberto Bezares Calderón, Réza Shahidi, Gáspár Jékely

    Ciliated zooplankton larvae sense pressure by ciliary photoreceptor cells, which increase the beating of locomotor cilia via a serotonergic motor circuit leading to rapid upward swimming during barotaxis.
51. 1. Cell Biology
    2. Immunology and Inflammation

    Arpin deficiency increases actomyosin contractility and vascular permeability

    Armando Montoya-Garcia, Idaira M Guerrero-Fonseca ... Michael Schnoor

    Arpin regulates actomyosin contractility and endothelial barrier integrity by controlling the activity of the kinases ROCK1 and ZIPK, but not Arp2/3.
52. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

    Kristina Ehring, Sophia Friederike Ehlers ... Kay Grobe

    A composite hedgehog release model that incorporates and supports a previously disparate set of observations has been presented.
53. 1. Neuroscience

    Laminar specificity and coverage of viral-mediated gene expression restricted to GABAergic interneurons and their parvalbumin subclass in marmoset primary visual cortex

    Frederick Federer, Justin Balsor ... Alessandra Angelucci

    The gene-regulatory enhancers h56D and S5E2 restrict transgene expression to GABAergic and parvalbumin-positive interneurons, respectively, across marmoset cortical layers, thus representing a promising tool for circuit dissection in non-human primates.
54. 1. Cancer Biology

    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

    Anne Fajac, Iva Simeonova ... Franck Toledo

    The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
55. 1. Cell Biology

    Exploring the role of macromolecular crowding and TNFR1 in cell volume control

    Parijat Biswas, Priyanka Roy ... Deepak Kumar Sinha

    Cells adapt to extracellular hypertonicities using regulatory volume increase (RVI), and TNFR1-mediated NFkB activation is indispensable for RVI, but the increased cytoplasmic macromolecular crowding can inhibit TNFR1 signaling and prevent RVI at severe hypertonicities.
56. 1. Neuroscience

    Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

    Kevin C Lister, Calvin Wong ... Arkady Khoutorsky
57. 1. Immunology and Inflammation

    The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

    Alexandra a Aybar-Torres, Lennon A Saldarriaga ... Lei Jin

    The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.
58. 1. Chromosomes and Gene Expression
    2. Developmental Biology

    OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline

    Leif Benner, Savannah Muron ... Brian Oliver

    Many well-studied maternal developmental pathways that are required for embryonic development in Drosophila are regulated by the transcription factor OVO in the Drosophila female germline.
59. 1. Ecology

    Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?

    Chao Wen, Yuyi Lu ... Lars Chittka

    Behavioral studies reveal that bumblebees distinguish between continuous and interrupted strings by using a combination of image matching and associative learning.
60. 1. Neuroscience

    Ca²⁺ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles

    In vivo analysis of endogenously tagged Ca²⁺ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
61. 1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
62. 1. Cell Biology

    Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

    Iuliia Ferling, Steffen Pfalzgraf ... Spencer A Freeman
63. 1. Biochemistry and Chemical Biology
    2. Plant Biology

    Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production

    Hao Wang, Biying Zhu ... Zhaoliang Zhang

    Comparative structural analysis and biochemical characterization unraveled the mechanisms behind enzymatic substrate selectivity, leading to an amplified theanine yield through active mutant protein screening, thus refining strategies for theanine production.
64. 1. Neuroscience

    Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

    Moneeza A Agha, Sandeep Kishore, David L McLean

    Unexpected complexity in the synaptic basis of locomotor rhythmogenesis is linked to cell type and speed in larval zebrafish.
65. 1. Neuroscience

    DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

    Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez

    DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
66. 1. Plant Biology

    OsNF-YB7 inactivates OsGLK1 to inhibit chlorophyll biosynthesis in rice embryo

    Zongju Yang, Tianqi Bai ... Chen Chen

    OsNF-YB7, an ortholog of Arabidopsis LEC1, is a negative regulator of Chl biosynthesis in rice embryos by interacting with OsGLK1 to inhibit the transactivity of OsGLK1.
67. 1. Neuroscience

    Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure

    Stefan Passlick, Ghanim Ullah, Christian Henneberger

    Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.
68. 1. Neuroscience

    Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes

    Yuan Chang, Savannah Lusk ... Russell S Ray

    Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for baseline breathing and hypercapnic, hypoxic chemosensory reflexes, which challenges the current understanding of central noradrenergic neurons in breathing control.
69. 1. Neuroscience

    Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

    Besma Brahmia, Yahaira Naaldijk ... Sabine Hilfiker
70. 1. Neuroscience

    Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

    Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
71. 1. Structural Biology and Molecular Biophysics

    Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

    Julia Belyaeva, Matthias Elgeti

    Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
72. 1. Structural Biology and Molecular Biophysics

    PPI-hotspot^ID for detecting protein–protein interaction hot spots from the free protein structure

    Yao Chi Chen, Karen Sargsyan ... Carmay Lim

    PPI-hotspot^ID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.
73. 1. Developmental Biology

    Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

    Saira Amir, Olatunbosun Arowolo ... Alexander Suvorov

    For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.
74. 1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the CBC-ALYREF complex

    Bradley P Clarke, Alexia E Angelos ... Yi Ren

    Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
75. 1. Developmental Biology

    TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

    Jing Wang, Yingying Yin ... Zhaojian Liu

    Experiments on mice show that TMC7, a transmembrane channel-like protein, localizes to the cis-Golgi region in spermatids and that this is essential for acrosome biogenesis and male fertility.
76. 1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser

    Deep mutational scanning reveals interactions in the MET kinase domain that are critical for regulation and cancer-related signaling.
77. 1. Immunology and Inflammation

    Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

    Jiansen Lu, Jiahuan Zhang ... Xiao Yu

    Vangl2 induced by inflammation recruits ubiquitin ligase PDLIM2 and increases K63-linked ubiquitination on p65, which promotes the recognition of p65 by cargo receptor NDP52 and the autophagic degradation of p65.
78. 1. Neuroscience

    Language experience shapes predictive coding of rhythmic sound sequences

    Piermatteo Morucci, Sanjeev Nara ... Nicola Molinaro

    A magnetoencephalography study across different languages shows that life-long listening experience influences the neural mechanisms underlying rhythm perception.
79. 1. Cell Biology
    2. Developmental Biology

    Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

    Sarah Rubin, Ankit Agrawal ... Elazar Zelzer

    Modulation of division plane rotation in proliferating chondrocytes determines the ratio of clusters and columns, which may support the multifunctional design of the growth plate.
80. 1. Immunology and Inflammation

    Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

    Alessandra Machado Araujo, Joseph D Dekker ... Haley O Tucker

    Single-cell RNA-seq data and transgenic models revealed B-plasmacytoid dendritic cells (B-pDCs) represent a phenotypically and functionally distinct common lymphoid progenitor-derived pDC lineage specialized in T cell activation and previously not described in mice.
81. 1. Epidemiology and Global Health
    2. Genetics and Genomics

    Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

    Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee

    Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
82. 1. Cancer Biology

    Engineering PEG10-assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

    Ruijing Tang, Luobin Guo ... Xiaolong Liu

    ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
83. 1. Immunology and Inflammation

    The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

    Arijit Chakraborty, Arunava Bandyopadhaya ... Laurence G Rahme

    The Pseudomonas aeruginosa secreted signaling molecule 2'-aminoacetophenone modulates cellular immunometabolism to promote persistence in infected tissues.
84. 1. Cell Biology
    2. Neuroscience

    CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

    Longxin Xie, Jessica Merjane ... Christopher J Donnelly
85. 1. Neuroscience

    AVN: A Deep Learning Approach for the Analysis of Birdsong

    Therese MI Koch, Ethan S Marks, Todd F Roberts
86. 1. Evolutionary Biology

    Improved inference of population histories by integrating genomic and epigenomic data

    Thibaut Sellinger, Frank Johannes, Aurélien Tellier

    The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
87. 1. Cell Biology
    2. Immunology and Inflammation

    S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

    Daniel M Williams, Andrew A Peden

    Recruitment of NLRP3 to the Golgi is controlled by the reversible addition of a lipid anchor adjacent to the polybasic region.
88. 1. Ecology

    Fine-scale tracking reveals visual field use for predator detection and escape in collective foraging of pigeon flocks

    Mathilde Delacoux, Fumihiro Kano

    Foveal vision in pigeons plays a crucial role in predator detection while the flock is collectively foraging and being vigilant.
89. 1. Cell Biology
    2. Neuroscience

    Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

    Luting Yang, Chunqing Hu ... Yaping Yan

    Cell biology and animal model analysis in mice shows that molecules involved in glycolytic metabolism could potentially serve as therapeutic targets for the treatment of neurological diseases.
90. 1. Genetics and Genomics

    Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu

    Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
91. 1. Neuroscience

    Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

    Felix Michaud, Ruggiero Francavilla ... Lisa Topolnik

    Early alterations in VIP interneuron activity may contribute to disruptions in CA1 hippocampal circuits and cognitive deficits in the 3xTg mouse model of Alzheimer's disease.
92. 1. Neuroscience

    A unifying account of replay as context-driven memory reactivation

    Zhenglong Zhou, Michael J Kahana, Anna C Schapiro
93. 1. Microbiology and Infectious Disease

    Mechanistic Insights into MinD Regulation and Pattern Formation in Bacillus subtilis

    Helge Feddersen, Marc Bramkamp
94. 1. Microbiology and Infectious Disease

    Cyclical MinD membrane affinity differences are not necessary for MinD gradient formation in Bacillus subtilis

    Laura C Bohorquez, Henrik Strahl ... Leendert W Hamoen
95. 1. Computational and Systems Biology

    Identifying images in the biology literature that are problematic for people with a color-vision deficiency

    Harlan P Stevens, Carly V Winegar ... Stephen R Piccolo

    Approximately 13% of figures in biology-related research articles are difficult for people with red/green colorblindness to decipher, but machine-learning models can help to identify these.
96. 1. Neuroscience

    Neuroelectrophysiology-compatible electrolytic lesioning

    Iliana E Bray, Stephen E Clarke ... Paul Nuyujukian

    Neuronal loss can be studied by passing electrical current through the same electrodes used for neuron measurement without disrupting recording ability.
97. 1. Developmental Biology
    2. Neuroscience

    Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

    Yuqi Cai, Zhirong Zhao ... Miao He

    Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.
98. 1. Structural Biology and Molecular Biophysics

    Revealing a hidden conducting state by manipulating the intracellular domains in K_V10.1 exposes the coupling between two gating mechanisms

    Reham Abdelaziz, Adam P Tomczak ... Luis A Pardo

    The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.
99. 1. Cancer Biology

    Targeting ribosome biogenesis as a novel therapeutic approach to overcome EMT-related chemoresistance in breast cancer

    Yi Ban, Yue Zou ... Dingcheng Gao

    Inhibiting the RiBi pathway impedes both EMT and MET processes, enhancing chemotherapy efficacy and presenting a novel avenue to tackle advanced breast cancer treatment resistance.
100. 1. Ecology

     Developmental stage shapes the realized energy landscape for a flight specialist

     Elham Nourani, Louise Faure ... Kamran Safi

     The realized energy landscape expands as animals improve their movement behaviors with age.
101. 1. Developmental Biology
     2. Neuroscience

     Lateral/caudal ganglionic eminence makes limited contribution to cortical oligodendrocytes

     Jialin Li, Feihong Yang ... Zhuangzhi Zhang

     The contribution of the lateral/caudal ganglionic eminence to the pool of cortical oligodendrocyte precursor cells is minimal.
102. 1. Cancer Biology

     Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

     Elazar Besser, Anat Gelfand ... David Meiri

     The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
103. 1. Ecology

     Different coexistence patterns between apex carnivores and mesocarnivores based on temporal, spatial, and dietary niche partitioning analysis in Qilian Mountain National Park, China

     Wei Cong, Jia Li ... Yuguang Zhang

     Spatial segregation is identified as the primary mechanism facilitating the coexistence of apex and mesocarnivores in the Qilian Mountain National Park, China.
104. 1. Cell Biology

     Dysregulated Ca²⁺ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s disease

     Kai-Ting Huang, Larry E Wagner ... David I Yule

     In a mouse model of Sjogren's disease, mitochondrial function and Ca²⁺ signaling are disrupted resulting in altered coupling between Ca²⁺ release and Ca²⁺ activated Cl^- channels and salivary gland hypofunction.
105. 1. Microbiology and Infectious Disease
     2. Physics of Living Systems

     Should I stay or should I go? Spatio-temporal dynamics of bacterial biofilms in confined flows

     Massinissa Benbelkacem, Gabriel Ramos ... Yohan Davit
106. 1. Neuroscience

     α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

     Rixu Cong, Huiran Li ... Chen Zhang
107. 1. Plant Biology

     Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation

     Yicong Wang, Masato Abe ... Nobutoshi Yamaguchi
108. 1. Neuroscience

     Individuals with anxiety and depression use atypical decision strategies in an uncertain world

     Zeming Fang, Meihua Zhao ... Ru-Yuan Zhang

     A model with a mixture of three different decision strategies is developed to characterize several atypical behavioral patterns of individuals with depression and anxiety in an uncertain reward environment.
109. 1. Neuroscience

     Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

     Guoqiang Wang, Ryan J Guasp ... Monica Driscoll

     Large extracellular vesicle extrusion that eliminates neuronal protein aggregates and organelles is potentiated by uterine filling, linking reproductive status to maternal nervous system health, and demonstrating mechanobiology components in exophergenesis.
110. 1. Neuroscience

     Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

     Minsik Yun, Do-Hyoung Kim ... Young-Joon Kim

     Identification of central neural circuits and sensory pathways underlying social-sexual modulation of sperm ejection in female Drosophila unraveled cryptic mate choice, a mechanism of post-copulatory sexual selection.
111. 1. Stem Cells and Regenerative Medicine

     Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila

     Zhixin Ma, Wenshu Wang ... Su Wang

     Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.
112. 1. Computational and Systems Biology

     A three filament mechanistic model of musculotendon force and impedance

     Matthew Millard, David W Franklin, Walter Herzog

     Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
113. 1. Neuroscience

     DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment

     Ran-Der Hwang, YuNing Lu ... Jiou Wang

     A genome-wide screen identifies the BCAA catabolizing enzyme DBT as a master metabolic switch in the regulation of protein quality control when proteasomal activity is impaired.
114. 1. Computational and Systems Biology
     2. Evolutionary Biology

     Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

     Kara Schmidlin, Sam Apodaca ... Kerry Geiler-Samerotte

     Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to environmental change.
115. 1. Neuroscience

     Speech-induced suppression and vocal feedback sensitivity in human cortex

     Muge Ozker, Leyao Yu ... Adeen Flinker

     During speech production, auditory regions that show speech-induced suppression are sensitive to changes in auditory feedback, suggesting that suppression may be a key mechanism underlying speech monitoring.
116. 1. Epidemiology and Global Health

     From multiplicity of infection to force of infection for sparsely sampled Plasmodium falciparum populations at high transmission

     Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
117. 1. Developmental Biology
     2. Genetics and Genomics

     Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

     Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
118. 1. Developmental Biology

     SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development

     Rula Sha, Ruochen Guo ... Ying Feng

     Genetic mouse models combined with single-cell RNA sequencing reveal the essential role of SRSF2 in directing MyoD progenitors to distinct skeletal muscle domains and controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.
119. 1. Cell Biology

     Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

     Roberto Notario Manzano, Thibault Chaze ... Christel Brou

     Proteomic analysis of tunneling nanotubes (TNTs) identifies CD9 and CD81 as major positive regulators of TNT formation.
120. 1. Microbiology and Infectious Disease

     Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

     Srinivasan Vijay, Nguyen Le Hoai Bao ... Nguyen Thuy Thuong

     Isoniazid resistance in Mycobacterium tuberculosis is linked to higher rifampicin tolerance, necessitating evaluation and potential adjustment of treatment regimens to combat emerging multi-drug resistant variants.
121. 1. Microbiology and Infectious Disease

     Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

     Lesia Semenova, Yingfan Wang ... Edward P Browne

     Dimension reduction and machine learning tools were used to identify novel associations between the HIV reservoir and the immune systems of people with HIV.
122. 1. Immunology and Inflammation

     Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

     Eva M García-Cuesta, Pablo Martínez ... Mario Mellado

     In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.
123. 1. Cell Biology
     2. Physics of Living Systems

     Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

     Bret A Unger, Chun Ying Wu ... Ke Xu
124. 1. Structural Biology and Molecular Biophysics

     Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE

     Xinyu Gu, Akashnathan Aranganathan, Pratyush Tiwary

     AlphaFold2's inability to generate non-native conformations for docking is addressed by AI-molecular dynamics method AlphaFold2-RAVE, which produces Boltzmann-ranked conformations, enabling the retrospective discovery of type II kinase inhibitors.
125. 1. Neuroscience

     The function of juvenile–adult transition axis in female sexual receptivity of Drosophila melanogaster

     Jing Li, Chao Ning ... Chuan Zhou

     Prothoracicotropic hormone and ecdysone belonging to the insect PG axis modulate virgin female sexual receptivity.
126. 1. Neuroscience

     Novel cyclic homogeneous oscillation detection method for high accuracy and specific characterization of neural dynamics

     Hohyun Cho, Markus Adamek ... Peter Brunner

     Detecting neural oscillations in time and frequency domains enables the detailed study of spatiotemporal dynamics of oscillations throughout the brain and the investigation of biomarkers that index functional brain areas.
127. 1. Evolutionary Biology
     2. Genetics and Genomics

     The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

     Catherine A Weibel, Andrew L Wheeler ... Joanna Masel

     Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.
128. 1. Evolutionary Biology
     2. Microbiology and Infectious Disease

     Reversions mask the contribution of adaptive evolution in microbiomes

     Paul A Torrillo, Tami D Lieberman

     The timescale dependence of d_N/d_S in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.
129. 1. Developmental Biology
     2. Genetics and Genomics

     Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

     Mitchell Bestry, Alexander N Larcombe ... David Martino

     Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.
130. 1. Computational and Systems Biology
     2. Immunology and Inflammation

     ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

     Jing Sun, Desmond Choy ... Shahram Kordasti

     ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.
131. 1. Neuroscience

     Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

     Yoav Ger, Moni Shahar, Nitzan Shahar

     Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.
132. 1. Neuroscience

     Connectome-Based Attractor Dynamics Underlie Brain Activity in Rest, Task, and Disease

     Robert Englert, Balint Kincses ... Tamas Spisak
133. 1. Neuroscience

     Flexible neural representations of abstract structural knowledge in the human Entorhinal Cortex

     Shirley Mark, Phillipp Schwartenbeck ... Timothy E Behrens
134. 1. Developmental Biology
     2. Genetics and Genomics

     PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

     Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
135. 1. Medicine

     Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration

     Thomas M Hallam, Emanuela Gardenal ... Amy V Jones
136. 1. Neuroscience

     Analysis of fast calcium dynamics of honey bee olfactory coding

     Marco Paoli, Antoine Wystrach ... Martin Giurfa

     Fast calcium dynamics of honey bee olfactory projection neurons revealed an unprecedented heterogeneity of response profile dynamics and explained fundamental aspects of olfactory discrimination and associative learning.
137. 1. Immunology and Inflammation

     Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components

     Fani Roumelioti, Christos Tzaferis ... George Kollias

     A novel in vivo role for miRNAs Mir221/222 in arthritogenic synovial fibroblasts and progression of arthritis is presented.
138. 1. Physics of Living Systems

     Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women

     Alex James, Franca Buelow ... Ann Brower

     There is a systemic bias in research evaluation, i.e., disciplines with a higher proportion of women have lower evaluations and funding success for all researchers, regardless of gender.
139. 1. Neuroscience

     A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

     Yihe Weng, Johann Kruschwitz ... IMAGEN Consortium

     Differences in behavior and brain connectivity in young adolescents predicted future substance use.
140. 1. Developmental Biology
     2. Neuroscience

     UPR^ER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

     Pengfei Liu, Xinyi Liu, Bin Qi

     The cellular stress response pathway helps animals evaluate food quality and regulate feeding behavior to adapt in nutrient-deficient environments.
141. 1. Neuroscience

     Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

     Katrin Franke, Chenchen Cai ... Andreas Savas Tolias

     Widespread color-opponency in mouse V1 enhances object decoding in the sky, highlighting the evolutionary importance of color processing in non-primate species.
142. 1. Cancer Biology

     Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

     Sila Gerlevik, Nogayhan Seymen ... Mohammad M Karimi

     Multi-omics factor analysis reveals transposable element expression as a risk factor and inflammation as a protective factor in myelodysplastic syndromes (MDS).
143. 1. Cell Biology

     Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

     Ming Zhang, Guangyi Du ... Wei Chen

     Cardiovascular disease, the top cause of diabetic deaths, progresses via vascular endothelial dysfunction, with circHMGCS1 and miR4521 highlighted as potential markers for the development of this condition.
144. 1. Computational and Systems Biology
     2. Neuroscience

     White matter structural bases for phase accuracy during tapping synchronization

     Pamela Garcia-Saldivar, Cynthia de León ... Hugo Merchant

     Comparison between tapping performance of humans during a synchronization task and new metrics that characterize the U-fiber system of white matter revealed large intersubject correlations between phase accuracy at specific tempos and the strength of connectivity in their audiomotor system.
145. 1. Biochemistry and Chemical Biology

     Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

     Aleksandar Bartolome, Julia C Heiby ... Alessandro Ori

     Proximity labeling combined with mass spectrometry enables to map the proteasome proximal proteome in cells and mouse tissues.
146. 1. Cell Biology

     STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm

     Sam Weeks, Dubravka Pezic ... Suzana Hadjur
147. 1. Immunology and Inflammation

     Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

     Yujie Fang, Zihan Guan ... Ke Peng
148. 1. Medicine
     2. Microbiology and Infectious Disease

     Multiomics reveals gut dysbiosis contributes to fatty acid dysmetabolism in early phase of acute myocardial infarction

     Yong Fan, Jiajun Ying ... Hanbin Cui
149. 1. Biochemistry and Chemical Biology

     Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication

     Jack A Bryant, Kara A Staunton ... Manuel Banzhaf
150. 1. Biochemistry and Chemical Biology

     A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

     Brennan J Wadsworth, Marina Leiwe ... Randall S Johnson

     The metabolite 2-hydroxybutyrate is an important aspect of exhaustion which leads to increased capacity in the branched chain amino acid degradation pathway.
151. 1. Neuroscience

     Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

     Jixing Li, Qixuan Wang ... Zhiwu Huang
152. 1. Microbiology and Infectious Disease

     Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

     Giorgia Greter, Claudia Moresi ... Markus Arnoldini
153. 1. Developmental Biology
     2. Genetics and Genomics

     Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

     Tao Cheng, Xiang Liu ... Peng-Fei Xu
154. 1. Developmental Biology
     2. Evolutionary Biology

     Insect metamorphosis is regulated differently between sexes by members of a microRNA cluster

     Chade Li, Ki Kei Chan ... Jerome HL Hui
155. 1. Genetics and Genomics

     Resetting of H3K4me2 during mammalian parental-to-zygote transition

     Chong Wang, Yong Shi ... Jiawei Xu
156. 1. Stem Cells and Regenerative Medicine

     Sox9 marks limbal stem cells and is required for asymmetric cell fate switch in the corneal epithelium

     Gabriella Rice, Olivia Farrelly ... Panteleimon Rompolas
157. 1. Immunology and Inflammation
     2. Microbiology and Infectious Disease

     Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

     Patrick KA Kearns, Charles Dixon ... Nick Gilbert
158. 1. Cancer Biology

     Mitochondrial stress-induced protein carboxyl-terminal alanine threonine tailing (msiCAT-tailing) facilitates glioblastoma tumorigenesis through the modulation of mitochondrial functions

     Bei Zhang, Ting Cai ... Zhihao Wu
159. 1. Structural Biology and Molecular Biophysics

     The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

     Artem N Bonchuk, Konstantin I Balagurov ... Pavel G Georgiev

     The cryo-EM structure of the CG6765 BTB domain and solution scattering experiments revealed a unique three-dimer hexameric assembly for the arthropod Tramtrack group BTB domains.
160. 1. Neuroscience

     Future movement plans interact in sequential arm movements

     Mehrdad Kashefi, Sasha Reschechtko ... J Andrew Pruszynski

     To ensure smooth sequential actions, reaches to at least two future targets are planned during the execution of the current reach and the planning processes of the future reaches interact.
161. 1. Computational and Systems Biology
     2. Developmental Biology

     Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo

     Juan Manuel Gomez, Hendrik Nolte ... Maria Leptin

     An encompassing resource of differentially phosphorylated proteins forms the basis for identifying missing links in cell fate determination and morphogenesis, including, for example, microtubules as mediators of different functions in cells along the dorso-ventral axis.
162. 1. Structural Biology and Molecular Biophysics

     Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

     Po-Lin Chiu, Juan D Orjuela ... Thomas Walz

     Electron crystallography and molecular dynamics simulations show that a cholesterol sandwiched in between two neighboring aquaporin-0 tetramers stabilizes the association between the tetramers and thus promotes array formation.
163. 1. Structural Biology and Molecular Biophysics

     Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

     Dipti Ranjan Lenka, Shakti Virendra Dahe ... Atul Kumar

     The new insights into the activation mechanism of Parkin E3 ligase could be useful for designing small-molecule activators against Parkinson’s disease.
164. 1. Chromosomes and Gene Expression

     CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

     Ryo Kariyazono, Takashi Osanai

     cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.
165. 1. Evolutionary Biology

     The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles in Arabidopsis halleri and Arabidopsis lyrata

     Audrey Le Veve, Mathieu Genete ... Vincent Castric

     By modulating the intensity of balancing selection at the S-locus, dominance between self-incompatibility alleles shapes the genetic load linked to each allele, creating inbreeding depression in some S-locus homozygotes.