February 2021

Research articles

    1. Physics of Living Systems
    2. Stem Cells and Regenerative Medicine

    DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

    Simona Hankeova et al.
    Dual resin casting of multiple lumenized systems followed by microCT allows visualization, digitalization, and quantification of architectural parameters defining the vascular and biliary systems in liver revealing new phenotypes.
    1. Neuroscience

    Brain endothelial cell TRPA1 channels initiate neurovascular coupling

    Pratish Thakore et al.
    Activation of TRPA1 channels on cerebral capillary endothelial cells initiates a retrograde signal that propagates and dilates upstream arterioles.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integron activity accelerates the evolution of antibiotic resistance

    Célia Souque et al.
    Integrons deploy a variety of adaptive strategies including excision, shuffling, and duplication of cassettes that foster rapid bacterial adaptation and resistance evolution while protecting the genomic integrity of the host.
    1. Microbiology and Infectious Disease

    MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

    Martial Marbouty et al.
    Physical contacts of bacteria and phage genomes allow in situ exploration of underdocumented phage families in the gut.
    1. Genetics and Genomics

    DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

    Eilis Hannon et al.
    DNA methylation data can be harnessed to provide insights into molecular and phenotypic differences associated with the spectrum of psychosis diagnoses.
    1. Plant Biology

    A multifaceted analysis reveals two distinct phases of chloroplast biogenesis during de-etiolation in Arabidopsis

    Rosa Pipitone et al.
    Serial-Block-Face Scanning Electron Microscopy (SBF-SEM) associated with biomolecular analysis show that chloroplast differentiation proceeds by distinct ‘structure establishment’ and ‘chloroplast proliferation’ phases, each with differential protein and lipid regulation.
    1. Biochemistry and Chemical Biology

    Identification of host proteins differentially associated with HIV-1 RNA splice variants

    Rachel Knoener et al.
    The distinct protein-RNA interactomes of HIV-1 RNA splice forms are revealed using a powerful multiplex strategy for RNA capture and mass spectrometric analysis.
    1. Cell Biology
    2. Developmental Biology

    A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

    Neta Erez et al.
    A nuclear Non-stop identity complex (NIC) supervises enterocyte (EC) identity, preserves tissue homeostasis, and prevents premature aging by maintaining EC-specific gene expression, silencing non-relevant programs, and safeguarding large-scale nuclear organization.
    1. Cell Biology

    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

    Ahmad F Alghanem et al.
    SWELL1 is required for basal, stretch, and flow-mediated endothelial AKT-eNOS signaling in vitro and protects against angiotensin-induced hypertension and diabetes-associated vascular dysfunction in vivo.
    1. Neuroscience

    Specialized contributions of mid-tier stages of dorsal and ventral pathways to stereoscopic processing in macaque

    Toshihide W Yoshioka et al.
    Visual area MT signals binocular disparity quickly and robustly, whereas area V4 or its upstream area transforms the nature of the signals to derive a more sophisticated depth representation.
    1. Biochemistry and Chemical Biology

    Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

    Víctor M Hernández-Rocamora et al.
    The synthesis of bacterial cell wall peptidoglycan was reconstituted in lipid bilayers and detected by a novel Förster resonance energy transfer real-time assay.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

    Christopher Icke et al.
    AatD is a novel acyltransferase that mediates N-palmitoylation of glycine, a process not previously described, that results in the secretion of lipoproteins to the bacterial cell surface.
    1. Computational and Systems Biology
    2. Neuroscience

    Graphical-model framework for automated annotation of cell identities in dense cellular images

    Shivesh Chaudhary et al.
    Unbiased and automatic annotation using structured prediction framework with efficiently built data-driven atlases is more accurate than registration-based methods for cell identifications in dense images and enables fast whole-brain analysis.
    1. Developmental Biology

    Deficient spermiogenesis in mice lacking Rlim

    Feng Wang et al.
    Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest

    Albert Tian Chen et al.
    COVID-19 CG is an open source web resource that allows vaccine, therapeutics, and diagnostics developers to track SARS-CoV-2 mutations and lineages by location and time.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

    Hélène Duplus-Bottin et al.
    A single protein catalyzes site-specific DNA recombination upon blue-light illumination.
    1. Computational and Systems Biology

    Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

    Lucile Megret et al.
    Cell-type-specific molecular systems mapping reveals that striatal neuron degeneration in Huntington's disease is primarily driven by the loss of homeostatic responses.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide

    Phillip Wulfridge, Kavitha Sarma
    BisMapR reveals strand-specific R-loops with high resolution at small-scale genomic features including bidirectionally transcribed promoters and enhancers.
    1. Cell Biology
    2. Developmental Biology

    Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

    Radek Jankele et al.
    Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events

    Ashish Goyal et al.
    A mathematical model was used to establish a simple conceptual basis for why super-spreader events fundamentally drive the spread of SARS-CoV-2 but not influenza.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels

    Carlos AZ Bassetto et al.
    A chain of residues connecting the voltage sensing domain and the pore domain is responsible for a noncanonical communication between these domains.
    1. Developmental Biology

    Three-dimensional reconstruction of a whole insect reveals its phloem sap-sucking mechanism at nano-resolution

    Xin-Qiu Wang et al.
    3D reconstruction for an insect provides new internal structures at nanometer resolution, and the reconstructed feeding insect reveals unexpected contraction of stylet protractors and suggested a novel phloem sap-sucking model.
    1. Cancer Biology

    Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

    Yogev Sela et al.
    A photoconversion-based isolation technique enables systematic investigation of spatially distinct small metastases (microcolonies) versus large lesions (macrometastases).
    1. Developmental Biology
    2. Neuroscience

    Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization

    Andriy S Yatsenko et al.
    Neuronal interacting proteome reveals that the cellular dynamics of the lissencephaly-associated extracellular matrix receptor dystroglycan are governed by the exocyst complex, which is key for proper brain assembly.
    1. Cell Biology
    2. Computational and Systems Biology

    Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

    Taraneh Zarin et al.
    A statistical model systematically associates functions of intrinsically disordered regions with sequence-distributed molecular features such as charge, residue composition, or repeat content.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

    Lorraine De Jesús-Kim et al.
    A multi-step process of helicase activation sensitizes replication initiation to the extent of replicative helicase phosphorylation.
    1. Neuroscience

    Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii

    Hany KM Dweck et al.
    The evolutionary transition of the agricultural pest Drosophila suzukii to egg laying on ripe fruits was paralleled with several gustatory innovations.
    1. Immunology and Inflammation

    Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

    Rabina Mainali et al.
    Integrative multi-omics reveals global dysregulation in hepatic metabolism during prolonged sepsis.
    1. Neuroscience

    Functional reallocation of sensory processing resources caused by long-term neural adaptation to altered optics

    Antoine Barbot et al.
    Chronic exposure to poor optical quality causes a functional reallocation of sensory processing resources that favors perceptual information less affected by the eye's optics.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells

    Seongjin Park et al.
    RNA chaperone Hfq dynamically binds various pools of cellular RNAs to execute different regulatory functions.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy

    Julie Y Zhou et al.
    Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.
    1. Neuroscience

    Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse

    Timothy S Balmer et al.
    Extracellular levels of the neurotransmitter glutamate are maintained at physiologically significant levels at some synapses even in the absence of action potentials.
    1. Genetics and Genomics
    2. Neuroscience

    Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules

    Savannah G Brovero et al.
    Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar et al.
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Ecology

    A remote sensing derived data set of 100 million individual tree crowns for the National Ecological Observatory Network

    Ben G Weinstein et al.
    A first continental data set of tree crown predictions is derived across the United States for the National Ecological Observatory Network.
    1. Structural Biology and Molecular Biophysics

    Molecular structures of the eukaryotic retinal importer ABCA4

    Fangyu Liu et al.
    The structures of ABCA4 in two conformations provide a framework to understand its transport mechanism.
    1. Cell Biology

    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

    Nana Naetar et al.
    The lamin A/C binding protein LAP2α inhibits formation of higher order lamin structures in the nuclear interior in a lamin A/C-phosphorylation-independent manner, thereby regulating chromatin mobility.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil

    Aaron Snoberger et al.
    Mechanochemical defects of a β-cardiac myosin mutation that results in severe hypertrophic cardiomyopathy are reported and the heart failure drug omecamtiv mecarbil rescues these defects.
    1. Microbiology and Infectious Disease

    Redox controls RecA protein activity via reversible oxidation of its methionine residues

    Camille Henry et al.
    RecA is inactivated by oxidative stress and repaired by the MsrA/B anti-ROS defense system.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

    Qiuying Liu et al.
    Repressing the conserved pro-differentiation let-7 microRNAs through limiting Ago2 levels is critical to maintaining pluripotency in stem cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

    Olga A Maximova et al.
    Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
    1. Neuroscience

    Control of feeding by Piezo-mediated gut mechanosensation in Drosophila

    Soohong Min et al.
    Gut-innervating sensory neurons detect large food volumes and inhibit feeding in Drosophila through the mechanically gated ion channel Piezo.
    1. Chromosomes and Gene Expression

    Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

    Gang Wu et al.
    RNA profiles from lungs of mice exposed to intermittent hypoxia shared similarity with gene expression changes in human lung from patients with pulmonary diseases, including pulmonary hypertension, COPD, and asthma.
    1. Ecology

    Volatile DMNT directly protects plants against Plutella xylostella by disrupting the peritrophic matrix barrier in insect midgut

    Chen Chen et al.
    The natural volatile component DMNT protects plants from insect attacks by damaging peritropic matrix barriers in insect midguts, paving a promising way for the molecular breeding of plant protection.
    1. Neuroscience

    Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum

    Javier Alegre-Cortés et al.
    Analysis of slow wave brain state unravels the functional connectivity and the biological substrate of the rodent dorsolateral and dorsomedial striatum, demonstrating its organization in two non-overlapping circuits.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-quality carnivoran genomes from roadkill samples enable comparative species delineation in aardwolf and bat-eared fox

    Rémi Allio et al.
    High-quality genomes can be obtained from roadkill samples and used in population genomics for species delimitation with conservation implications.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

    Alicia Tapias et al.
    The Trrap-HAT-Sp1 axis operates a conserved transcriptional program to control proper microtubule dynamics in brain homeostasis and prevents neurodegeneration.
    1. Developmental Biology

    Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors

    Diana Rodrigues et al.
    Comprehensive developmental in situ analysis of the Drosophila lymph gland provides markers highlighting blood progenitor diversity and reveals that JAK-STAT signaling prevents posterior progenitor differentiation, promoting survival after immune challenge.
    1. Chromosomes and Gene Expression

    Cohesin architecture and clustering in vivo

    Siheng Xiang, Douglas Koshland
    Cohesin adopts a flexible butterfly conformation in vivo and forms spatial and temporal regulated ordered clusters to maintain cohesion and condensation.
    1. Neuroscience

    The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception

    Andreas Strube et al.
    Key variables required for pain perception in the context of a predictive coding model are correlated with distinct oscillatory profiles.
    1. Immunology and Inflammation

    The kinase PDK1 is critical for promoting T follicular helper cell differentiation

    Zhen Sun et al.
    PDK1 serves as a critical role for intrinsically promoting T follicular helper cell differentiation and effector functions via controlling expression level of TCF1.
    1. Ecology
    2. Microbiology and Infectious Disease

    Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing

    Heidi A Arjes et al.
    Novel high-throughput co-culture assays reveal how the spatial structure of colony biofilms provides opportunities for nutrient and matrix sharing and may drive the evolution of cooperative behaviors.
    1. Genetics and Genomics

    Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

    Briana E Mittleman et al.
    A comparative analysis of human and chimpanzee polyadenylation site usage establishes alternative polyadenylation as another key mechanism underlying the genetic regulation of transcript and protein expression levels in primates.
    1. Cell Biology

    One-shot analysis of translated mammalian lncRNAs with AHARIBO

    Luca Minati et al.
    Detection of translated lncRNAs through selective isolation of active ribosomes, ribosome-associated RNAs and corresponding de novo synthesised peptides.
    1. Neuroscience

    Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

    Melissa J Polonenko, Ross K Maddox
    The response from discrete stages of the early auditory pathway can be measured by subtle manipulations to long-form natural speech stimuli paired with deconvolution analysis of electroencephalography data.
    1. Physics of Living Systems

    Theory for the optimal detection of time-varying signals in cellular sensing systems

    Giulia Malaguti, Pieter Rein ten Wolde
    A theory is presented for the optimal design of cellular sensing systems that maximizes the sensing precision given resource constraints.
    1. Developmental Biology

    An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution

    Aubrey GA Howard IV et al.
    Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

    Xinyu Zhu et al.
    Ancient evolutionary signatures reveal mechanistic details of substrate specificity in copper-transporting mitochondria carrier family proteins.
    1. Cell Biology

    In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish

    Zherui Xiong et al.
    BLITZ system enables proximity-dependent biotin labelling in live zebrafish embryos with cell and tissue specificity, providing a versatile and valuable tool for proteomic discovery using the zebrafish model.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

    Katina D Hulme et al.
    Patients with paucigranulocytic asthma may be more susceptible to severe influenza and could potentially be source of new, more virulent, influenza virus variants.
    1. Epidemiology and Global Health

    Antimicrobial resistance and COVID-19: Intersections and implications

    Gwenan M Knight et al.
    COVID-19 will have an ongoing impact on antimicrobial resistance acquisition, transmission, and burden, requiring the close attention of researchers globally to generate a complete evidence base for the shifted dynamics.
    1. Developmental Biology
    2. Medicine

    Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

    Jingyi Chi et al.
    The regulation of sympathetic innervation density by beige adipocytes in subcutaneous fat is important during a critical developmental window, but dispensable during adulthood.
    1. Neuroscience

    A spinoparabrachial circuit defined by Tacr1 expression drives pain

    Arnab Barik et al.
    A circuit involving Tacr1-expressing neurons in the spinal cord and the parabrachial nucleus controls how mice respond to a wide range of persistently painful stimuli.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Proximity proteomics in a marine diatom reveals a putative cell surface-to-chloroplast iron trafficking pathway

    Jernej Turnšek et al.
    An iron-sensitive gene cluster encodes proteins that co-localize with phytotransferrin endosomes and are involved in key intracellular iron transformation and trafficking processes in a model marine diatom.
    1. Structural Biology and Molecular Biophysics

    A critical residue in the α1M2–M3 linker regulating mammalian GABAA receptor pore gating by diazepam

    Joseph W Nors et al.
    The role of an important gating domain in linkage between the benzodiazepine drug-binding site and the pore gate in GABAA receptors.
    1. Computational and Systems Biology
    2. Medicine

    Individual variation in Achilles tendon morphology and geometry changes susceptibility to injury

    Nai-Hao Yin et al.
    Studying individual Achilles tendon geometry and interface sliding capacity may allow prediction of injury sites, and targeted training on specific muscle-(sub-)tendon units may boost beneficial outcomes for Achilles tendinopathy.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of Stu2 recruitment to yeast kinetochores

    Jacob A Zahm et al.
    The results here show that Stu2 binds kinetochores by associating with the Ndc80 complex and that the interaction is critical for accurate chromosome segregation during cell division.
    1. Developmental Biology
    2. Neuroscience

    Olig3 regulates early cerebellar development

    Elijah D Lowenstein et al.
    The transcription factor Olig3 safeguards the correct specification of early born cerebellar neuron derivatives and curtails an inhibitory interneuron differentiation program.
    1. Microbiology and Infectious Disease

    BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in Vibrio cholerae

    Teresa del Peso Santos et al.
    Vibrio cholerae uses a conserved ribosome assembly factor to repress biofilm formation at low temperatures.
    1. Developmental Biology
    2. Physics of Living Systems

    From local resynchronization to global pattern recovery in the zebrafish segmentation clock

    Koichiro Uriu et al.
    Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
    1. Genetics and Genomics

    GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

    Nasa Sinnott-Armstrong et al.
    Across urate, IGF-1, and testosterone, thousands of dispersed variants contribute to heritability, while previously characterized core pathways are highly enriched for associations and reveal feedback mechanisms governing serum biomarker levels.
    1. Developmental Biology

    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

    Qiuyu Guo et al.
    β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
    1. Neuroscience

    α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

    Reeba Susan Jacob et al.
    Plasma membrane clusters of the Parkinson's disease protein α-synuclein colocalize with negatively charged phospholipids involved in endocytosis and exocytosis.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Phasic oxygen dynamics confounds fast choline-sensitive biosensor signals in the brain of behaving rodents

    Ricardo M Santos, Anton Sirota
    Fast fluctuations of oxygen, linked to behavioral and neural dynamics in vivo, cause phasic transients is amperometry-measured cholinergic signals via the mechanism of non-steady-state enzyme kinetics in the choline-oxidase-based biosensor.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

    Charlotte P Choi et al.
    snpc-1.3 specifies male piRNA transcription and is regulated by the sex determination pathway.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

    Haibin Yang et al.
    Structural, biochemical, and cell biology study revealed that Rsu1, through binding to PINCH1, inhibits the actin bundling ability of ILK/PINCH/Parvin to regulate the actin dynamics at focal adhesion.
    1. Cell Biology

    Bardet–Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome

    Yan-Xia Liu et al.
    Bardet–Biedl syndrome 3 (BBS3) protein promotes phospholipase D to load onto the BBSome at the ciliary tip for moving out of the cilium via intraflagellar transport.
    1. Neuroscience

    Temporo-parietal cortex involved in modeling one’s own and others’ attention

    Arvid Guterstam et al.
    Functional brain scans of human participants show that the brain encodes other people's attention in enough richness to distinguish whether that attention was directed exogenously (stimulus-driven) or endogenously (internally driven).
    1. Neuroscience

    Anatomy and activity patterns in a multifunctional motor neuron and its surrounding circuits

    Mária Ashaber et al.
    Voltage-dye imaging followed by serial blockface electron microscopy of the same ganglion reveals structure–function relationships of leech motor behaviors.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Basis of specificity for a conserved and promiscuous chromatin remodeling protein

    Drake A Donovan et al.
    The identification of a novel mechanism of chromatin remodeling, including a conserved remodeler domain and regulatory epitopes, provides targets for the design of therapeutics to modulate transcriptional regulation in cells.
    1. Neuroscience

    Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

    Leon P Munting et al.
    The causal link between capillary amyloid‑β accumulation in the brain and cerebrovascular dysfunction, previously established in the Tg‑SwDI mouse model, is to be mitigated and remains to be fully uncovered.
    1. Developmental Biology
    2. Genetics and Genomics

    Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish

    Marion Rosello et al.
    Base editors, with improved specificity and expanded PAM sequence recognition, can be used in zebrafish for the rapid and efficient introduction of single base pair mutations.
    1. Neuroscience

    Transsynaptic mapping of Drosophila mushroom body output neurons

    Kristin M Scaplen et al.
    Transsynaptic mapping of the postsynaptic connections of mushroom body output neurons reveal both divergent and convergent projections allowing for multimodal integration prior to initiation of an output response.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    The allosteric modulation of complement C5 by knob domain peptides

    Alex Macpherson et al.
    Structural and functional analysis of a new class of low-molecular-weight antibody fragments, derived from bovine immunoglobulins, reveals their therapeutic potential against C5, a target for refractory inflammatory diseases.
    1. Cell Biology
    2. Developmental Biology

    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

    Eric T Hall et al.
    Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.
    1. Developmental Biology

    EKLF/KLF1 expression defines a unique macrophage subset during mouse erythropoiesis

    Kaustav Mukherjee et al.
    Mouse fetal liver macrophages that support erythroid differentiation within erythroblastic islands exhibit a unique and transient expression signature under transcriptional control of EKLF/KLF1.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

    Zharko Daniloski et al.
    A pervasive mutation in the Spike protein of the coronavirus that causes COVID-19 results in virions that are up to eightfold more infectious.
    1. Neuroscience

    Dissociation of task engagement and arousal effects in auditory cortex and midbrain

    Daniela Saderi et al.
    Data collected from two important auditory brain areas distinguish effects of generalized arousal and specific task engagement on neural sensory coding.
    1. Computational and Systems Biology
    2. Developmental Biology

    Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain

    David M Young et al.
    A computational tool developed to construct three-dimensional anatomical atlases from two-dimensional data generates volumetrically complete and aligned atlases for all stages of development in the Allen Developing Mouse Brain Atlas.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    To lie or not to lie: Super-relaxing with myosins

    Suman Nag, Darshan V Trivedi
    A perspective of the energy-sparing super-relaxed state of myosin and its evolutionary role in modulating skeletal and cardiac muscle power under different physiological and pathophysiological perturbations.
    1. Immunology and Inflammation
    2. Neuroscience

    Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

    Sina C Rosenkranz et al.
    Inducing neuronal mitochondrial activity during central nervous system inflammation counteracts inflammation-induced neuronal electron transport chain deficiency and calcium toxicity, thereby protecting against neuronal loss in a multiple sclerosis mouse model.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

    Xiaohu Guo et al.
    The first structure of a bacteriophage-encoded S-adenosyl methionine degrading enzyme was solved and demonstrated to catalyze a unimolecular lyase reaction occurring at the domain interface of a trimeric structure.
    1. Immunology and Inflammation
    2. Medicine

    Perinatal granulopoiesis and risk of pediatric asthma

    Benjamin A Turturice et al.
    Perinatal granulopoiesis and cord blood serum PGLYRP-1, a specific granule protein, are altered prior to onset of childhood asthma and provide potential targets for early identification of at-risk populations.
    1. Cell Biology
    2. Developmental Biology

    Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila

    Shichao Yu et al.
    Rab5 and Rab11 regulate hematopoietic homeostasis in Drosophila, and this process involves the JNK, Toll, and Ras/EGFR signaling pathways and autophagy.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

    Jiahui Si et al.
    Lifestyle interventions and statins may target different components of the lipid profile, suggesting that they are not redundant strategies but could be combined for better benefits.
    1. Stem Cells and Regenerative Medicine

    Heterogeneity of murine periosteum progenitors involved in fracture healing

    Brya G Matthews et al.
    Murine periosteum is highly enriched for osteoprogenitors, many of which express αSMA, but fracture callus chondrocytes are partially derived from other sources.
    1. Cell Biology
    2. Genetics and Genomics

    An integrative study of five biological clocks in somatic and mental health

    Rick Jansen et al.
    An integrative study of five biological clocks in somatic and mental health indicate that one's biological age is best reflected by combining aging measures from multiple cellular levels.
    1. Epidemiology and Global Health
    2. Medicine

    Epidemiological transition to mortality and refracture following an initial fracture

    Thao Phuong Ho-Le et al.
    The concept of compound fracture risk is redefined to combine the risk that an individual will sustain a fracture and the risk of mortality once the fracture has occurred.
    1. Evolutionary Biology
    2. Neuroscience

    Shore crabs reveal novel evolutionary attributes of the mushroom body

    Nicholas Strausfeld, Marcel E Sayre
    Dramatic phenotypic divergence of crustacean mushroom bodies map to phylogenetic lineages, thereby offering unexplored opportunities for relating divergent cognitive centers to different ecologies and behavioral repertoires required to negotiate them.
    1. Developmental Biology
    2. Evolutionary Biology

    Developmental hourglass and heterochronic shifts in fin and limb development

    Koh Onimaru et al.
    Omics approaches reveal conserved and diversified gene regulation between fin and limb development.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

    Jürgen Tuvikene et al.
    An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
    1. Cancer Biology
    2. Immunology and Inflammation

    Human primed ILCPs support endothelial activation through NF-κB signaling

    Giulia Vanoni et al.
    Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety et al.
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Neuroscience

    Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

    Robert AR Drake et al.
    Alterations to brain network communication leading to a progressive loss in descending inhibitory modulation of the spinal cord is a key determinate of pain state development following peripheral nerve injury.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

    Palur V Raghuvamsi et al.
    SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.
    1. Cancer Biology
    2. Computational and Systems Biology

    shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data

    Kenichi Shimada et al.
    shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.
    1. Cell Biology
    2. Developmental Biology

    Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription

    Sherzod A Tokamov et al.
    Kibra-mediated Hippo complex assembly promotes Kibra degradation in a negative feedback loop that is regulated by mechanical tension.
    1. Developmental Biology
    2. Neuroscience

    Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia

    Laura Fontenas, Sarah Kucenas
    Motor exit point (MEP) glia utilize mechanisms most commonly attributed to neural crest cells for their development from spinal cord precursors.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

    Michelle C Ward et al.
    Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.
    1. Ecology

    Regularities in species’ niches reveal the world’s climate regions

    Joaquín Calatayud et al.
    Similarities in climatic niches of terrestrial vertebrates indicate the Earth's climate regions, which differ among groups and from previous plant-based climate classifications.
    1. Neuroscience

    Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

    Colleen N McLaughlin et al.
    Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
    1. Neuroscience

    The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

    Carlos Manlio Díaz-García et al.
    When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Residue-by-residue analysis of cotranslational membrane protein integration in vivo

    Felix Nicolaus et al.
    The cotranslational membrane integration of three multispanning Escherichia coli inner membrane proteins is followed using force profile analysis, uncovering unexpected complexities in the membrane integration process.
    1. Cell Biology
    2. Developmental Biology

    TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

    Xiaochen Fan et al.
    Network propagation connects TWIST1 with epigenetic regulators CHD7, CHD8, and WHSC1, which collectively promote the bias toward neural crest while suppressing neural stem cell programmes, and subsequently enhance ectomesenchyme potential.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pentameric protein ring with novel architecture is required for herpesviral packaging

    Allison L Didychuk et al.
    The first structures of Kaposi’s sarcoma-associated herpesvirus ORF68 and Epstein–Barr virus BFLF1, conserved and essential proteins required in herpesviruses, reveal new insights into viral genome packaging.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of transposable elements in bdelloid rotifers

    Reuben W Nowell et al.
    An investigation of transposable element evolution in a group of long-term asexual animals shows that many of the predicted effects of asexuality are not observed.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

    Dina Simkin et al.
    An inducedpluripotent stem cell (iPSC)-based model of KCNQ2-associated developmental epileptic encephalopathy suggests that disease is driven by dyshomeostaic neuronal mechanisms that are downstream of loss of M-current.
    1. Computational and Systems Biology

    Cycles, sources, and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks

    Ritu Gupta, Sunil Laxman
    A theoretical conceptualization of how phosphates control metabolic information flow and predictably regulate the metabolic state of the cell.
    1. Epidemiology and Global Health
    2. Medicine

    Quantifying the impact of quarantine duration on COVID-19 transmission

    Peter Ashcroft et al.
    Test-and-release quarantine strategies for traced contacts of confirmed SARS-CoV-2 cases and returning travellers can reduce average quarantine durations while remaining as effective as 10 days of quarantine without testing.
    1. Biochemistry and Chemical Biology

    Membrane-partitioned cell wall synthesis in mycobacteria

    Alam García-Heredia et al.
    Mycobacteria employ plasma membrane compartments to organize their cell wall synthesis, and the finalized cell wall compartmentalizes the plasma membrane to promote an environment conducive to its own synthesis.
    1. Developmental Biology
    2. Genetics and Genomics

    Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

    Ryan J Geusz et al.
    Analysis of epigenome maps from human pancreatic progenitors and functional validation in zebrafish identify LAMA1 and CRB2 as type 2 diabetes risk-associated genes with roles in pancreatic development.
    1. Epidemiology and Global Health

    Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

    Ghulam R Awab et al.
    The Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency confers a strong gene-dose proportional protective effect against symptomatic Plasmodium vivax malaria in the Pashtun ethnic group.
    1. Physics of Living Systems

    Single molecule microscopy reveals key physical features of repair foci in living cells

    Judith Miné-Hattab et al.
    Upon DNA damage, Rad52 forms a membraneless sub-compartment where Rad52 molecules are highly dynamic and share properties with liquid-liquid phase-separated molecules, reflecting the existence of a liquid droplet around damaged DNA.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

    Christoph Heier et al.
    An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
    1. Chromosomes and Gene Expression

    Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

    Evelyn L Eastwood et al.
    Heterochromatin formation at transposon loci depends on dimerisation of the effector complex that elicits co-transcriptional silencing and this requirement is fulfilled by co-option of the conserved dimerisation hub protein, Cut-up/LC8.
    1. Immunology and Inflammation

    Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

    Mariona Baliu-Piqué et al.
    Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.
    1. Neuroscience

    Spatial modulation of visual responses arises in cortex with active navigation

    E Mika Diamanti et al.
    Spatial modulation along the visual pathway arises in the cortex and strengthens with active navigation and experience.
    1. Neuroscience

    Coupling between fast and slow oscillator circuits in Cancer borealis is temperature-compensated

    Daniel Powell et al.
    The mechanism that couples two rhythmic circuits is maintained over a large temperature range although both circuits are temperature-sensitive.
    1. Neuroscience

    Distinct neural networks for the volitional control of vocal and manual actions in the monkey homologue of Broca's area

    Natalja Gavrilov, Andreas Nieder
    Single-neuron recordings in the inferior frontal cortex of trained macaques show neurons that are selective to the volitional preparation of either vocal or manual actions.
    1. Neuroscience

    Drosophila uses a tripod gait across all walking speeds, and the geometry of the tripod is important for speed control

    Chanwoo Chun et al.
    Drosophila uses a gait close to the tripod throughout its speed range, and changes in speed are accompanied by changes in the geometry of the tripod.
    1. Cell Biology

    Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase

    Tomoyuki Fukuda et al.
    Sea3, a presumed subunit of the GATOR2 complex in fission yeast, is required for the GATOR1 function that attenuates TORC1 in parallel with the TSC complex and Gcn2 kinase.
    1. Immunology and Inflammation

    Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation

    Emilie V Russler-Germain et al.
    In vitro and in vivo studies show that multiple dendritic cell subsets are capable of presenting gut Helicobacter antigens to induce regulatory T cells.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

    Jumpei Ito et al.
    Iron derived from autophagy-mediated ferritin degradation in response to pressure overload induces lipid peroxidation, necrotic cardiomyocyte death, and heart failure in mice.
    1. Neuroscience

    Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism

    Chelsea L Faber et al.
    Synchronized feeding and metabolic patterns with environmental light–dark cycles is critical to maintain energy homeostasis and requires the activity of leptin-receptor neurons in the dorsomedial hypothalamus.
    1. Cancer Biology

    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

    Sumiko Takao et al.
    Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.
    1. Immunology and Inflammation

    Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

    Bruce Zhang, David Gems
    The absence of helminth parasites in developed countries may be exacerbating pathological, age-associated inflammation, known as inflammaging, suggesting that helminth therapies could provide protection against age-related disease.
    1. Computational and Systems Biology

    Emergence and propagation of epistasis in metabolic networks

    Sergey Kryazhimskiy
    Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
    1. Neuroscience

    Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

    Hadeel Alyenbaawi et al.
    A traumatic brain injury model is invented for larval zebrafish and applied to a new fluorescent 'tauopathy reporter fish', revealing a role for seizures in progression towards dementias.
    1. Epidemiology and Global Health

    A modular approach to integrating multiple data sources into real-time clinical prediction for pediatric diarrhea

    Ben J Brintz et al.
    Using a modular approach to integrate multiple data sources for the prediction of diarrhea etiology has the potential to reduce inappropriate antibiotics prescription in low-resource settings.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication

    Neale J Harrison et al.
    Neuronal Ia-2 and glial Kon coordinate an injury-response insulin relay that restores glial cell populations and induces neural stem cells from glia, enabling central nervous system regeneration.
    1. Cell Biology

    A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

    Xue Chen et al.
    Knockout of the methyltransferase ICMT prevents progerin methylation and improves survival in mice with Hutchinson-Gilford progeria syndrome (HGPS) and an ICMT inhibitor delays senescence and stimulates proliferation of HGPS cells.
    1. Cell Biology
    2. Developmental Biology

    Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes

    Sara N Stahley et al.
    Planar cell polarity protein Celsr1 clusters into punctate assemblies through lateral cis-interactions to function as an organizer of intercellular Frizzled6 and Vangl2 asymmetry.
    1. Cancer Biology

    SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

    Maurizio Fazio et al.
    A genetic discovery screen for epigenetic factors accelerating melanoma development in vivo identifies SATB2 as a driver of tumor invasion and resistance to FDA-approved BRAF-targeted inhibitor Vemurafenib.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    In-host population dynamics of Mycobacterium tuberculosis complex during active disease

    Roger Vargas et al.
    Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.
    1. Cell Biology
    2. Physics of Living Systems

    Non-genetic inheritance restraint of cell-to-cell variation

    Harsh Vashistha et al.
    Quantitative measurement of epigenetic memory and inheritance dynamics.
    1. Developmental Biology
    2. Neuroscience

    Dual midbrain and forebrain origins of thalamic inhibitory interneurons

    Polona Jager et al.
    Thalamic interneurons in the mouse thalamus are often overlooked because of their extremely low numbers, however they are developmentally complex and related to those of larger-brained species.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou et al.
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Neuroscience

    Performance in even a simple perceptual task depends on mouse secondary visual areas

    Hannah C Goldbach et al.
    In a simple visual task, that in principle could be performed using information in V1 alone, perturbations of secondary visual areas impair perception.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets

    Valeria Zoni et al.
    In parallel to protein-driven processes, characteristic physicochemical properties of the endoplasmic reticulum membrane modulate intracellular fat accumulation and lipid droplet formation.
    1. Neuroscience

    Laminar-specific cortico-cortical loops in mouse visual cortex

    Hedi Young et al.
    Ascending and descending cortico-cortical inputs are stronger on projection neurons that project back to the source of the inputs, forming selective interareal loops in deep but not superficial cortical layers.
    1. Chromosomes and Gene Expression

    Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

    Brandon R Lowe et al.
    H3-G34R, V, and W oncohistonesin fission yeast cause differential K36 modification, DNA damage sensitivity and genome stability outcomes, highlighting the need for a thorough evaluation of distinct mutations.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans

    Holly E Kinser et al.
    Expression of almost half of a library of fluorescent reporters distinguish long- from short-lived individual Caenorhabditis elegans, suggesting that organism-wide differences in gene expression drive future lifespan.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length

    Mirna Marinić et al.
    The transcription factor HAND2 evolved uterine expression during the origins of pregnancy and may be important for maternal-fetal immune signaling and parturition.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer’s disease mutations

    Mireia Seuma et al.
    A massively parallel analysis of the effects of mutations on amyloid beta nucleation provide the first comprehensive atlas of how mutations alter the formation of amyloid fibrils.
    1. Cell Biology

    Robustness of the microtubule network self-organization in epithelia

    Aleksandra Z Płochocka et al.
    Computational, theoretical, and in vivo studies reveal that in epithelia the self-organization of apical microtubules is robustly determined by cell geometry and minus-end distribution, not organism environment or genetics.